Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis
Affiliates | Benoît Marin [1,2,3,4,5,6], Farid Boumdiene [1,2,3], Giancarlo Logroscino [5,6], Philippe Couratier [1,2,7], Marie-Claude Babron [8,9], Anne Louise Leutenegger [8,9] Massimilano Copetti [10], Pierre-Marie Preux [1,2,3], and Ettore Beghi [4]
[1] INSERM, U1094, Tropical Neuroepidemiology |
Journal | International Journal of Epidemiology |
Summary | To estimate the overall pooled worldwide crude ALS incidence, 44 studies were selected, covering 45 geographical areas in 11 sub-continents. Differences in ALS incidence rate estimates were identified between North Europe and East Asia or South Asia. However, incidence rates were similar for those in Europe, North America, and New Zealand. This review confirms a heterogeneous distribution worldwide of ALS and sets the scene to sustain a collaborative study involving a wide international consortium to investigate the link between ancestry, environment, and ALS incidence. |
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