Shared polygenic risk and causal inferences in Amyotrophic Lateral Sclerosis

Publication
Affiliates	Sara Bandres-Ciga [1,2], Alastair J. Noyce [3,4], Gibran Hemani [5], Aude Nicolas [6], Andrea Calvo [7], Gabriele Mora [8], The ITALSGEN Consortium, The International ALS Genomics Consortium, Pentti J. Tienari [9], David J. Stone [10], Mike A. Nalls [1,11], Andrew B. Singleton [1], Adriano Chiò [7,12,13], & Bryan J. Traynor [6,14] [1] Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health [2] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA) [3] Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London [4] Department of Clinical and Movement Neurosciences, University College London, Institute of Neurology [5] MRC Integrative Epidemiology Unit, University of Bristol [6] Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health [7] ‘Rita Levi Montalcini’ Department of Neuroscience, University of Turin [8] ALS Center, Istituti Clinici Scientifici Maugeri, IRCCS [9] Department of Neurology, Helsinki University Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki [10] Genetics and Pharmacogenomics, Merck Research Laboratories, Merck & Co., Inc. [11] Institute of Cognitive Sciences and Technologies, C.N.R [12] Azienda Ospedaliero Universitaria Città della Salute e della Scienza [13] Department of Neurology, Johns Hopkins University
Journal	Annals of Neurology
Summary	This study identifies shared polygenic risk and causal associations in ALS; moreover, a public resource for the ALS community was generated to understand these risks and causal associations (https://lng-nia.shinyapps.io/mrshiny). Shared polygenic risk exists between ALS and educational attainment, physical activity, smoking, and tenseness/restlessness. Additionally, elevated low-density lipoprotein cholesterol was identified as a causal risk factor for ALS.
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