ADRB1 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs1801252
|
Ex1+231A>G |
Ser49Gly |
MGB Eclipse |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1801252 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
86.8 (84.5, 88.8) |
13.2 (11.2, 15.5) |
<0.001 |
75.8 (72.2, 79.0) |
22.0 (19.4, 24.9) |
2.2 (1.4, 3.6) |
<0.001 |
0.11 |
| Non-Hispanic Black |
77.5 (76.0, 79.0) |
22.5 (21.0, 24.0) |
60.3 (57.5, 63.1) |
34.4 (31.2, 37.8) |
5.2 (4.1, 6.7) |
0.78 |
| Mexican American |
72.0 (70.1, 73.8) |
28.0 (26.2, 29.9) |
51.8 (48.8, 54.9) |
40.3 (37.7, 42.9) |
7.9 (6.8, 9.1) |
0.83 |
| Total* |
84.3 (82.3, 86.2) |
15.7 (13.8, 17.7) |
|
71.5 (68.3, 74.5) |
25.6 (23.3, 28.1) |
2.8 (2.1, 3.8) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801252 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
83.2 (78.5, 87.0) |
16.8 (13.0, 21.5) |
0.245 |
69.3 (61.5, 76.2) |
27.6 (21.7, 34.5) |
3.0 (1.8, 5.2) |
0.364 |
| 20-39 |
83.5 (81.4, 85.5) |
16.5 (14.5, 18.6) |
70.2 (66.8, 73.4) |
26.6 (23.6, 29.8) |
3.2 (2.0, 4.9) |
| 40-59 |
85.4 (82.5, 87.9) |
14.6 (12.1, 17.5) |
73.1 (68.2, 77.5) |
24.6 (20.7, 28.9) |
2.3 (1.4, 3.8) |
| >=60 |
85.3 (83.5, 87.0) |
14.7 (13.0, 16.5) |
73.5 (69.8, 76.8) |
23.7 (20.3, 27.5) |
2.8 (2.2, 3.5) |
| Total |
84.3 (82.3, 86.2) |
15.7 (13.8, 17.7) |
|
71.5 (68.3, 74.5) |
25.6 (23.3, 28.1) |
2.8 (2.1, 3.8) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801252 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
84.2 (81.7, 86.5) |
15.8 (13.5, 18.3) |
0.858 |
71.4 (67.5, 74.9) |
25.7 (23.1, 28.6) |
2.9 (1.8, 4.5) |
0.984 |
| Female |
84.4 (82.3, 86.4) |
15.6 (13.6, 17.7) |
71.7 (68.0, 75.1) |
25.5 (22.5, 28.8) |
2.8 (2.1, 3.7) |
| Total |
84.3 (82.3, 86.2) |
15.7 (13.8, 17.7) |
|
71.5 (68.3, 74.5) |
25.6 (23.3, 28.1) |
2.8 (2.1, 3.8) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801252 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
86.9 (80.9, 91.2) |
13.1 (8.8, 19.1) |
76.0 (66.5, 83.5) |
21.8 (15.4, 29.9) |
2.2 (0.7, 6.4) |
| 20-39 |
86.4 (83.8, 88.7) |
13.6 (11.3, 16.2) |
75.4 (71.5, 78.8) |
22.1 (18.9, 25.8) |
2.5 (1.1, 5.7) |
| 40-59 |
87.7 (84.9, 90.1) |
12.3 (9.9, 15.1) |
76.8 (71.7, 81.3) |
21.8 (17.5, 26.7) |
1.4 (0.7, 2.9) |
| >=60 |
86.0 (84.4, 87.5) |
14.0 (12.5, 15.6) |
74.9 (71.7, 77.9) |
22.2 (19.1, 25.8) |
2.8 (2.2, 3.6) |
| Non-Hispanic Black |
12-19 |
77.9 (74.7, 80.8) |
22.1 (19.2, 25.3) |
60.5 (55.3, 65.5) |
34.8 (30.0, 40.0) |
4.7 (2.9, 7.5) |
| 20-39 |
76.9 (75.2, 78.6) |
23.1 (21.4, 24.8) |
60.0 (56.8, 63.2) |
33.8 (29.7, 38.1) |
6.2 (4.3, 8.8) |
| 40-59 |
76.5 (73.6, 79.1) |
23.5 (20.9, 26.4) |
58.3 (53.6, 62.8) |
36.4 (31.9, 41.0) |
5.3 (3.6, 7.8) |
| >=60 |
80.8 (77.4, 83.8) |
19.2 (16.2, 22.6) |
64.6 (58.2, 70.6) |
32.4 (26.4, 39.0) |
3.0 (1.8, 4.9) |
| Mexican American |
12-19 |
70.5 (65.6, 75.1) |
29.5 (24.9, 34.4) |
50.5 (42.7, 58.3) |
40.0 (33.2, 47.2) |
9.4 (7.0, 12.7) |
| 20-39 |
71.9 (69.2, 74.4) |
28.1 (25.6, 30.8) |
51.3 (47.0, 55.7) |
41.0 (37.3, 44.9) |
7.6 (6.3, 9.1) |
| 40-59 |
73.0 (70.7, 75.2) |
27.0 (24.8, 29.3) |
53.3 (49.8, 56.7) |
39.6 (35.9, 43.4) |
7.2 (5.2, 9.8) |
| >=60 |
73.4 (67.2, 78.8) |
26.6 (21.2, 32.8) |
54.2 (44.3, 63.8) |
38.4 (29.8, 47.8) |
7.4 (4.7, 11.6) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801252 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
86.6 (83.6, 89.0) |
13.4 (11.0, 16.4) |
75.3 (70.8, 79.4) |
22.4 (19.2, 26.1) |
2.2 (1.1, 4.3) |
| Female |
87.0 (84.5, 89.1) |
13.0 (10.9, 15.5) |
76.2 (72.1, 79.8) |
21.6 (18.4, 25.2) |
2.2 (1.3, 3.8) |
| Non-Hispanic Black |
Male |
78.1 (76.1, 80.1) |
21.9 (19.9, 23.9) |
60.9 (57.6, 64.1) |
34.4 (31.0, 38.1) |
4.7 (3.1, 7.0) |
| Female |
77.1 (75.2, 78.8) |
22.9 (21.2, 24.8) |
59.9 (56.4, 63.3) |
34.4 (30.6, 38.4) |
5.7 (4.5, 7.3) |
| Mexican American |
Male |
71.9 (69.8, 73.9) |
28.1 (26.1, 30.2) |
52.2 (48.8, 55.6) |
39.4 (36.3, 42.6) |
8.4 (7.2, 9.7) |
| Female |
72.1 (69.2, 74.8) |
27.9 (25.2, 30.8) |
51.5 (46.8, 56.1) |
41.2 (37.1, 45.5) |
7.3 (5.8, 9.1) |
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