ADRB2 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs1042713
|
Ex1+265G>A |
Gly16Arg |
TaqMan |
| rs1042714 |
Ex1+298G>C |
Glu27Gln |
Pyrosequencing |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1042713 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
38.9 (36.9, 40.9) |
61.1 (59.1, 63.1) |
<0.001 |
15.7 (13.4, 18.2) |
46.4 (43.6, 49.3) |
37.9 (35.4, 40.4) |
<0.001 |
0.96 |
| Non-Hispanic Black |
49.7 (47.7, 51.6) |
50.3 (48.4, 52.3) |
25.0 (23.1, 27.1) |
49.3 (47.0, 51.7) |
25.6 (23.2, 28.3) |
0.43 |
| Mexican American |
41.8 (40.3, 43.2) |
58.2 (56.8, 59.7) |
15.6 (14.4, 16.9) |
52.3 (50.1, 54.4) |
32.1 (29.9, 34.4) |
0.14 |
| Total* |
40.5 (38.9, 42.2) |
59.5 (57.8, 61.1) |
|
16.9 (15.0, 18.9) |
47.3 (45.0, 49.6) |
35.8 (33.7, 38.0) |
|
|
| rs1042714 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
58.1 (56.0, 60.1) |
41.9 (39.9, 44.0) |
<0.001 |
34.5 (31.6, 37.5) |
47.3 (44.4, 50.1) |
18.3 (16.3, 20.4) |
<0.001 |
0.74 |
| Non-Hispanic Black |
82.0 (80.4, 83.4) |
18.0 (16.6, 19.6) |
67.6 (64.9, 70.2) |
28.8 (26.2, 31.5) |
3.7 (2.7, 5.0) |
0.16 |
| Mexican American |
78.7 (77.1, 80.2) |
21.3 (19.8, 22.9) |
61.4 (58.8, 63.9) |
34.6 (32.1, 37.2) |
4.0 (3.1, 5.2) |
0.66 |
| Total* |
64.0 (62.1, 65.9) |
36.0 (34.1, 37.9) |
|
42.5 (40.2, 44.8) |
43.0 (41.0, 45.0) |
14.5 (12.7, 16.5) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1042713 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
41.8 (38.2, 45.4) |
58.2 (54.6, 61.8) |
0.624 |
18.9 (15.5, 22.8) |
45.8 (40.4, 51.4) |
35.3 (30.3, 40.7) |
0.377 |
| 20-39 |
40.7 (37.9, 43.5) |
59.3 (56.5, 62.1) |
16.7 (13.9, 19.9) |
48.0 (44.0, 52.1) |
35.3 (31.5, 39.3) |
| 40-59 |
40.9 (37.9, 43.9) |
59.1 (56.1, 62.1) |
17.7 (14.9, 20.9) |
46.3 (42.7, 50.0) |
36.0 (32.2, 40.0) |
| >=60 |
39.0 (36.9, 41.1) |
61.0 (58.9, 63.1) |
14.8 (13.3, 16.5) |
48.3 (46.0, 50.6) |
36.9 (33.9, 39.9) |
| Total |
40.5 (38.9, 42.2) |
59.5 (57.8, 61.1) |
|
16.9 (15.0, 18.9) |
47.3 (45.0, 49.6) |
35.8 (33.7, 38.0) |
|
| rs1042714 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
65.3 (62.0, 68.6) |
34.7 (31.4, 38.0) |
0.010 |
45.2 (41.3, 49.3) |
40.2 (36.1, 44.4) |
14.6 (11.2, 18.8) |
0.038 |
| 20-39 |
66.0 (63.8, 68.2) |
34.0 (31.8, 36.2) |
45.5 (42.5, 48.6) |
41.1 (38.4, 43.7) |
13.4 (11.5, 15.6) |
| 40-59 |
61.7 (58.0, 65.2) |
38.3 (34.8, 42.0) |
39.3 (35.1, 43.6) |
44.9 (40.7, 49.2) |
15.9 (12.2, 20.4) |
| >=60 |
62.2 (60.1, 64.3) |
37.8 (35.7, 39.9) |
39.0 (36.0, 42.2) |
46.3 (43.0, 49.6) |
14.7 (12.6, 16.9) |
| Total |
64.0 (62.1, 65.9) |
36.0 (34.1, 37.9) |
|
42.5 (40.2, 44.8) |
43.0 (41.0, 45.0) |
14.5 (12.7, 16.5) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1042713 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
40.3 (38.1, 42.5) |
59.7 (57.5, 61.9) |
0.702 |
16.0 (13.7, 18.5) |
48.6 (44.8, 52.4) |
35.4 (32.1, 38.9) |
0.424 |
| Female |
40.8 (38.6, 43.0) |
59.2 (57.0, 61.4) |
17.8 (15.5, 20.3) |
46.1 (43.0, 49.2) |
36.2 (33.3, 39.2) |
| Total |
40.5 (38.9, 42.2) |
59.5 (57.8, 61.1) |
|
16.9 (15.0, 18.9) |
47.3 (45.0, 49.6) |
35.8 (33.7, 38.0) |
|
| rs1042714 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
64.6 (62.1, 67.0) |
35.4 (33.0, 37.9) |
0.435 |
42.5 (39.6, 45.5) |
44.2 (41.2, 47.2) |
13.3 (10.8, 16.4) |
0.306 |
| Female |
63.4 (61.1, 65.8) |
36.6 (34.2, 38.9) |
42.5 (39.4, 45.5) |
42.0 (39.4, 44.5) |
15.6 (13.5, 17.9) |
| Total |
64.0 (62.1, 65.9) |
36.0 (34.1, 37.9) |
|
42.5 (40.2, 44.8) |
43.0 (41.0, 45.0) |
14.5 (12.7, 16.5) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1042713 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
40.4 (35.8, 45.2) |
59.6 (54.8, 64.2) |
18.1 (13.8, 23.3) |
44.6 (37.5, 52.0) |
37.3 (30.6, 44.5) |
| 20-39 |
39.2 (35.3, 43.2) |
60.8 (56.8, 64.7) |
15.6 (11.9, 20.1) |
47.1 (42.0, 52.3) |
37.3 (32.2, 42.7) |
| 40-59 |
38.6 (35.1, 42.2) |
61.4 (57.8, 64.9) |
15.9 (12.6, 20.0) |
45.4 (41.3, 49.5) |
38.7 (34.4, 43.3) |
| >=60 |
37.9 (35.4, 40.5) |
62.1 (59.5, 64.6) |
14.1 (12.2, 16.2) |
47.8 (45.3, 50.2) |
38.2 (34.8, 41.7) |
| Non-Hispanic Black |
12-19 |
47.8 (42.0, 53.7) |
52.2 (46.3, 58.0) |
24.6 (19.4, 30.6) |
46.5 (41.3, 51.8) |
29.0 (22.3, 36.6) |
| 20-39 |
49.5 (47.0, 52.0) |
50.5 (48.0, 53.0) |
25.0 (22.6, 27.5) |
49.0 (45.7, 52.4) |
26.0 (22.7, 29.6) |
| 40-59 |
51.6 (46.9, 56.2) |
48.4 (43.8, 53.1) |
25.5 (20.2, 31.6) |
52.2 (47.4, 56.9) |
22.3 (18.0, 27.4) |
| >=60 |
49.3 (44.6, 54.1) |
50.7 (45.9, 55.4) |
24.8 (20.5, 29.8) |
49.0 (43.8, 54.2) |
26.2 (20.6, 32.7) |
| Mexican American |
12-19 |
44.3 (40.6, 48.2) |
55.7 (51.8, 59.4) |
17.3 (12.7, 23.2) |
54.1 (48.9, 59.2) |
28.6 (24.9, 32.6) |
| 20-39 |
41.1 (38.9, 43.4) |
58.9 (56.6, 61.1) |
13.9 (12.4, 15.5) |
54.5 (50.7, 58.2) |
31.6 (27.9, 35.6) |
| 40-59 |
41.4 (39.0, 43.8) |
58.6 (56.2, 61.0) |
18.3 (15.2, 21.8) |
46.2 (40.1, 52.5) |
35.5 (31.1, 40.2) |
| >=60 |
40.1 (35.8, 44.7) |
59.9 (55.3, 64.2) |
14.9 (11.0, 20.0) |
50.4 (43.8, 57.0) |
34.6 (28.5, 41.4) |
| rs1042714 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
57.6 (52.7, 62.4) |
42.4 (37.6, 47.3) |
35.9 (30.2, 41.9) |
43.6 (37.7, 49.7) |
20.6 (15.5, 26.7) |
| 20-39 |
59.5 (56.7, 62.2) |
40.5 (37.8, 43.3) |
36.8 (32.9, 40.9) |
45.3 (41.7, 49.0) |
17.9 (15.5, 20.5) |
| 40-59 |
56.1 (51.5, 60.6) |
43.9 (39.4, 48.5) |
31.4 (26.4, 36.9) |
49.4 (44.4, 54.3) |
19.2 (14.7, 24.8) |
| >=60 |
58.7 (56.6, 60.7) |
41.3 (39.3, 43.4) |
33.8 (31.0, 36.8) |
49.7 (46.2, 53.3) |
16.5 (14.1, 19.0) |
| Non-Hispanic Black |
12-19 |
80.0 (77.2, 82.6) |
20.0 (17.4, 22.8) |
64.5 (59.6, 69.1) |
31.1 (26.1, 36.6) |
4.4 (2.5, 7.6) |
| 20-39 |
82.7 (79.8, 85.3) |
17.3 (14.7, 20.2) |
69.4 (64.5, 74.0) |
26.5 (22.2, 31.4) |
4.0 (2.7, 6.0) |
| 40-59 |
81.6 (78.6, 84.3) |
18.4 (15.7, 21.4) |
66.7 (61.4, 71.6) |
29.8 (25.1, 34.9) |
3.5 (2.3, 5.4) |
| >=60 |
82.9 (79.5, 85.9) |
17.1 (14.1, 20.5) |
67.6 (60.8, 73.7) |
30.6 (24.2, 37.9) |
1.8 (0.7, 4.2) |
| Mexican American |
12-19 |
79.7 (73.7, 84.7) |
20.3 (15.3, 26.3) |
63.2 (54.1, 71.5) |
33.0 (26.3, 40.6) |
3.7 (1.6, 8.4) |
| 20-39 |
78.2 (75.9, 80.3) |
21.8 (19.7, 24.1) |
60.1 (56.7, 63.4) |
36.2 (33.3, 39.2) |
3.7 (2.4, 5.6) |
| 40-59 |
79.6 (74.7, 83.8) |
20.4 (16.2, 25.3) |
63.3 (55.3, 70.7) |
32.6 (26.3, 39.6) |
4.1 (2.6, 6.4) |
| >=60 |
76.8 (70.2, 82.3) |
23.2 (17.7, 29.8) |
59.7 (49.8, 68.9) |
34.2 (26.9, 42.2) |
6.1 (3.6, 10.1) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1042713 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
38.9 (36.4, 41.4) |
61.1 (58.6, 63.6) |
15.0 (12.4, 17.9) |
47.9 (42.7, 53.1) |
37.1 (33.0, 41.5) |
| Female |
38.9 (36.2, 41.6) |
61.1 (58.4, 63.8) |
16.3 (13.8, 19.2) |
45.1 (41.7, 48.5) |
38.6 (35.0, 42.3) |
| Non-Hispanic Black |
Male |
49.7 (46.7, 52.8) |
50.3 (47.2, 53.3) |
24.9 (21.8, 28.3) |
49.7 (45.8, 53.6) |
25.4 (21.7, 29.6) |
| Female |
49.6 (47.3, 52.0) |
50.4 (48.0, 52.7) |
25.1 (22.9, 27.5) |
49.0 (46.0, 52.0) |
25.8 (22.8, 29.2) |
| Mexican American |
Male |
41.7 (39.7, 43.7) |
58.3 (56.3, 60.3) |
15.5 (13.6, 17.7) |
52.4 (49.4, 55.4) |
32.1 (29.2, 35.0) |
| Female |
41.8 (39.5, 44.1) |
58.2 (55.9, 60.5) |
15.7 (13.8, 17.8) |
52.1 (49.0, 55.3) |
32.2 (28.8, 35.7) |
| rs1042714 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
58.9 (56.5, 61.4) |
41.1 (38.6, 43.5) |
34.8 (31.8, 38.0) |
48.3 (44.5, 52.1) |
16.9 (14.0, 20.3) |
| Female |
57.3 (54.2, 60.3) |
42.7 (39.7, 45.8) |
34.2 (30.2, 38.4) |
46.3 (42.7, 49.9) |
19.6 (16.9, 22.6) |
| Non-Hispanic Black |
Male |
82.5 (80.5, 84.4) |
17.5 (15.6, 19.5) |
67.9 (64.8, 70.8) |
29.3 (26.8, 31.9) |
2.8 (1.8, 4.4) |
| Female |
81.5 (79.7, 83.2) |
18.5 (16.8, 20.3) |
67.4 (64.0, 70.6) |
28.3 (24.9, 32.0) |
4.3 (3.1, 6.0) |
| Mexican American |
Male |
78.7 (76.8, 80.5) |
21.3 (19.5, 23.2) |
61.5 (57.9, 65.0) |
34.4 (30.5, 38.5) |
4.1 (2.8, 6.1) |
| Female |
78.7 (76.8, 80.4) |
21.3 (19.6, 23.2) |
61.2 (58.7, 63.7) |
34.9 (32.9, 36.9) |
3.9 (2.6, 5.8) |
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