ADRB3 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs4994
|
Ex1+387T>C |
Trp64Arg |
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs4994 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
6.9 (5.9, 8.0) |
93.1 (92.0, 94.1) |
<0.001 |
0.6 (0.3, 1.1) |
12.5 (10.8, 14.4) |
86.9 (84.8, 88.7) |
<0.001 |
0.27 |
| Non-Hispanic Black |
11.7 (10.3, 13.1) |
88.3 (86.9, 89.7) |
1.4 (0.8, 2.5) |
20.5 (18.4, 22.7) |
78.1 (75.7, 80.3) |
0.78 |
| Mexican American |
16.6 (14.7, 18.7) |
83.4 (81.3, 85.3) |
2.7 (1.9, 3.8) |
27.7 (24.6, 31.1) |
69.5 (65.9, 72.9) |
0.82 |
| Total* |
8.6 (7.8, 9.5) |
91.4 (90.5, 92.2) |
|
0.9 (0.7, 1.2) |
15.5 (14.0, 17.0) |
83.6 (82.0, 85.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs4994 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
9.4 (6.9, 12.7) |
90.6 (87.3, 93.1) |
0.278 |
0.7 (0.3, 1.5) |
17.4 (12.6, 23.6) |
81.9 (75.5, 86.8) |
0.016 |
| 20-39 |
8.8 (7.4, 10.5) |
91.2 (89.5, 92.6) |
0.9 (0.5, 1.5) |
15.9 (13.1, 19.1) |
83.3 (80.0, 86.1) |
| 40-59 |
9.2 (7.5, 11.1) |
90.8 (88.9, 92.5) |
1.4 (0.9, 2.1) |
15.6 (12.7, 18.9) |
83.0 (79.5, 86.1) |
| >=60 |
7.0 (6.2, 7.9) |
93.0 (92.1, 93.8) |
0.5 (0.2, 1.0) |
13.0 (11.5, 14.7) |
86.5 (84.8, 88.0) |
| Total |
8.6 (7.8, 9.5) |
91.4 (90.5, 92.2) |
|
0.9 (0.7, 1.2) |
15.5 (14.0, 17.0) |
83.6 (82.0, 85.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs4994 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
8.3 (7.1, 9.7) |
91.7 (90.3, 92.9) |
0.464 |
0.9 (0.6, 1.5) |
14.8 (12.6, 17.4) |
84.3 (81.6, 86.6) |
0.736 |
| Female |
8.9 (7.9, 10.1) |
91.1 (89.9, 92.1) |
0.9 (0.6, 1.2) |
16.1 (14.1, 18.2) |
83.0 (80.8, 85.0) |
| Total |
8.6 (7.8, 9.5) |
91.4 (90.5, 92.2) |
|
0.9 (0.7, 1.2) |
15.5 (14.0, 17.0) |
83.6 (82.0, 85.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs4994 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
6.0 (3.5, 10.2) |
94.0 (89.8, 96.5) |
0.4 (0.0, 3.2) |
11.2 (6.5, 18.7) |
88.4 (80.6, 93.3) |
| 20-39 |
7.0 (5.3, 9.1) |
93.0 (90.9, 94.7) |
0.6 (0.2, 1.5) |
12.9 (9.8, 16.8) |
86.6 (82.6, 89.8) |
| 40-59 |
7.5 (5.5, 10.1) |
92.5 (89.9, 94.5) |
0.9 (0.3, 2.4) |
13.2 (9.6, 17.9) |
85.9 (81.0, 89.7) |
| >=60 |
6.3 (5.5, 7.2) |
93.7 (92.8, 94.5) |
0.5 (0.2, 1.2) |
11.5 (10.1, 13.2) |
87.9 (86.3, 89.4) |
| Non-Hispanic Black |
12-19 |
11.2 (8.9, 14.0) |
88.8 (86.0, 91.1) |
0.8 (0.4, 1.3) |
20.8 (16.4, 26.1) |
78.4 (73.0, 83.0) |
| 20-39 |
11.6 (9.4, 14.1) |
88.4 (85.9, 90.6) |
1.6 (0.8, 3.2) |
20.0 (16.9, 23.6) |
78.4 (74.3, 82.0) |
| 40-59 |
12.6 (10.3, 15.3) |
87.4 (84.7, 89.7) |
2.4 (1.0, 5.6) |
20.4 (16.1, 25.4) |
77.3 (72.6, 81.3) |
| >=60 |
11.0 (9.4, 12.9) |
89.0 (87.1, 90.6) |
0.2 (0.0, 1.4) |
21.7 (18.1, 25.7) |
78.2 (74.3, 81.6) |
| Mexican American |
12-19 |
19.8 (17.1, 22.8) |
80.2 (77.2, 82.9) |
4.1 (2.4, 7.0) |
31.4 (25.7, 37.8) |
64.5 (58.8, 69.7) |
| 20-39 |
15.6 (13.0, 18.5) |
84.4 (81.5, 87.0) |
2.4 (1.5, 3.7) |
26.4 (21.9, 31.5) |
71.2 (65.9, 76.0) |
| 40-59 |
16.5 (15.1, 17.9) |
83.5 (82.1, 84.9) |
2.4 (1.3, 4.3) |
28.2 (25.1, 31.6) |
69.4 (66.6, 72.0) |
| >=60 |
15.1 (12.4, 18.2) |
84.9 (81.8, 87.6) |
2.4 (1.5, 3.9) |
25.3 (20.5, 30.8) |
72.3 (66.6, 77.3) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs4994 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
6.8 (5.3, 8.6) |
93.2 (91.4, 94.7) |
0.7 (0.3, 1.6) |
12.1 (9.4, 15.5) |
87.1 (83.7, 89.9) |
| Female |
6.9 (5.8, 8.2) |
93.1 (91.8, 94.2) |
0.5 (0.2, 1.1) |
12.8 (10.7, 15.3) |
86.7 (84.2, 88.9) |
| Non-Hispanic Black |
Male |
11.9 (10.0, 14.0) |
88.1 (86.0, 90.0) |
1.8 (0.8, 3.8) |
20.2 (17.0, 23.8) |
78.0 (74.4, 81.3) |
| Female |
11.5 (10.1, 13.1) |
88.5 (86.9, 89.9) |
1.1 (0.5, 2.3) |
20.7 (18.7, 22.9) |
78.2 (75.6, 80.5) |
| Mexican American |
Male |
17.8 (15.8, 19.9) |
82.2 (80.1, 84.2) |
3.1 (2.0, 4.9) |
29.3 (25.9, 33.0) |
67.6 (63.9, 71.0) |
| Female |
15.4 (13.3, 17.7) |
84.6 (82.3, 86.7) |
2.3 (1.4, 3.9) |
26.1 (22.2, 30.4) |
71.6 (67.4, 75.5) |
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