ALAD Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs1800435
|
Ex4+13G>C G177C |
Lys68Asn Lys88Asn |
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1800435 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
8.1 (7.0, 9.3) |
91.9 (90.7, 93.0) |
<0.001 |
0.6 (0.3, 1.2) |
15.1 (13.3, 17.0) |
84.4 (82.2, 86.3) |
<0.001 |
0.63 |
| Non-Hispanic Black |
1.3 (1.0, 1.9) |
98.7 (98.1, 99.0) |
0.0 (NA) |
2.7 (1.9, 3.7) |
97.3 (96.3, 98.1) |
0.48 |
| Mexican American |
4.5 (3.6, 5.5) |
95.5 (94.5, 96.4) |
0.3 (0.1, 1.0) |
8.4 (6.8, 10.5) |
91.3 (89.3, 93.0) |
0.69 |
| Total* |
6.5 (5.7, 7.4) |
93.5 (92.6, 94.3) |
|
0.4 (0.2, 0.9) |
12.2 (10.9, 13.6) |
87.4 (85.9, 88.8) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
Top of Page
By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800435 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
6.4 (4.3, 9.4) |
93.6 (90.6, 95.7) |
0.196 |
0.6 (0.1, 2.3) |
11.7 (7.9, 16.8) |
87.7 (82.3, 91.7) |
0.218 |
| 20-39 |
5.5 (4.5, 6.7) |
94.5 (93.3, 95.5) |
0.4 (0.1, 1.6) |
10.2 (8.3, 12.5) |
89.4 (87.1, 91.2) |
| 40-59 |
7.4 (5.8, 9.4) |
92.6 (90.6, 94.2) |
0.4 (0.1, 1.1) |
14.0 (11.1, 17.6) |
85.6 (81.9, 88.7) |
| >=60 |
7.3 (5.9, 9.0) |
92.7 (91.0, 94.1) |
0.5 (0.2, 1.6) |
13.6 (11.1, 16.6) |
85.8 (82.7, 88.5) |
| Total |
6.5 (5.7, 7.4) |
93.5 (92.6, 94.3) |
|
0.4 (0.2, 0.9) |
12.2 (10.9, 13.6) |
87.4 (85.9, 88.8) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800435 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
6.5 (5.3, 7.9) |
93.5 (92.1, 94.7) |
0.903 |
0.7 (0.3, 1.6) |
11.6 (9.7, 13.7) |
87.8 (85.4, 89.8) |
0.156 |
| Female |
6.6 (5.7, 7.6) |
93.4 (92.4, 94.3) |
0.2 (0.1, 0.6) |
12.7 (11.0, 14.6) |
87.1 (85.2, 88.8) |
| Total |
6.5 (5.7, 7.4) |
93.5 (92.6, 94.3) |
|
0.4 (0.2, 0.9) |
12.2 (10.9, 13.6) |
87.4 (85.9, 88.8) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800435 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
8.9 (6.0, 13.1) |
91.1 (86.9, 94.0) |
0.8 (0.2, 3.5) |
16.2 (10.9, 23.4) |
82.9 (75.5, 88.5) |
| 20-39 |
6.8 (5.5, 8.4) |
93.2 (91.6, 94.5) |
0.5 (0.1, 2.5) |
12.6 (10.3, 15.4) |
86.9 (84.0, 89.3) |
| 40-59 |
9.0 (6.9, 11.6) |
91.0 (88.4, 93.1) |
0.5 (0.2, 1.4) |
17.0 (13.3, 21.6) |
82.5 (77.7, 86.4) |
| >=60 |
8.5 (6.9, 10.5) |
91.5 (89.5, 93.1) |
0.6 (0.2, 1.9) |
15.9 (12.9, 19.5) |
83.5 (79.8, 86.6) |
| Non-Hispanic Black |
12-19 |
1.2 (0.7, 2.1) |
98.8 (97.9, 99.3) |
0.0 (NA) |
2.3 (1.3, 4.1) |
97.7 (95.9, 98.7) |
| 20-39 |
1.6 (1.0, 2.5) |
98.4 (97.5, 99.0) |
0.0 (NA) |
3.1 (2.0, 4.9) |
96.9 (95.1, 98.0) |
| 40-59 |
1.1 (0.6, 1.9) |
98.9 (98.1, 99.4) |
0.0 (NA) |
2.1 (1.2, 3.8) |
97.9 (96.2, 98.8) |
| >=60 |
1.4 (0.6, 2.8) |
98.6 (97.2, 99.4) |
0.0 (NA) |
2.7 (1.3, 5.6) |
97.3 (94.4, 98.7) |
| Mexican American |
12-19 |
4.5 (3.1, 6.6) |
95.5 (93.4, 96.9) |
0.4 (0.1, 3.5) |
8.2 (5.1, 12.9) |
91.4 (87.1, 94.3) |
| 20-39 |
4.8 (3.7, 6.3) |
95.2 (93.7, 96.3) |
0.3 (0.1, 1.1) |
9.1 (6.8, 12.1) |
90.6 (87.7, 92.9) |
| 40-59 |
4.4 (3.0, 6.4) |
95.6 (93.6, 97.0) |
0.2 (0.0, 1.5) |
8.4 (5.6, 12.3) |
91.4 (87.5, 94.2) |
| >=60 |
2.6 (1.6, 4.3) |
97.4 (95.7, 98.4) |
0.0 (NA) |
5.3 (3.2, 8.6) |
94.7 (91.4, 96.8) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800435 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
8.0 (6.4, 10.0) |
92.0 (90.0, 93.6) |
0.9 (0.4, 2.3) |
14.2 (11.8, 17.1) |
84.8 (81.5, 87.6) |
| Female |
8.1 (7.0, 9.4) |
91.9 (90.6, 93.0) |
0.2 (0.1, 0.7) |
15.8 (13.8, 18.1) |
84.0 (81.6, 86.1) |
| Non-Hispanic Black |
Male |
1.6 (0.9, 2.7) |
98.4 (97.3, 99.1) |
0.0 (NA) |
3.2 (1.9, 5.4) |
96.8 (94.6, 98.1) |
| Female |
1.1 (0.7, 1.8) |
98.9 (98.2, 99.3) |
0.0 (NA) |
2.3 (1.4, 3.6) |
97.7 (96.4, 98.6) |
| Mexican American |
Male |
4.8 (4.0, 5.8) |
95.2 (94.2, 96.0) |
0.2 (0.0, 1.3) |
9.3 (7.3, 11.6) |
90.6 (88.4, 92.4) |
| Female |
4.2 (3.0, 5.7) |
95.8 (94.3, 97.0) |
0.4 (0.1, 1.2) |
7.6 (5.5, 10.3) |
92.1 (89.2, 94.2) |
Top of Page