CAPN10 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs3792267
|
IVS3-176G>A |
|
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs3792267 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
25.8 (23.7, 27.9) |
74.2 (72.1, 76.3) |
<0.001 |
6.8 (5.8, 8.0) |
38.0 (35.3, 40.7) |
55.2 (51.9, 58.6) |
<0.001 |
0.65 |
| Non-Hispanic Black |
16.2 (14.3, 18.2) |
83.8 (81.8, 85.7) |
2.4 (1.7, 3.4) |
27.5 (24.5, 30.7) |
70.1 (66.6, 73.4) |
0.64 |
| Mexican American |
27.3 (25.3, 29.5) |
72.7 (70.5, 74.7) |
7.3 (6.1, 8.9) |
40.0 (37.4, 42.6) |
52.7 (49.5, 55.9) |
0.42 |
| Total* |
24.6 (23.1, 26.1) |
75.4 (73.9, 76.9) |
|
6.4 (5.7, 7.3) |
36.3 (34.4, 38.2) |
57.3 (54.8, 59.7) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs3792267 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
23.1 (19.8, 26.7) |
76.9 (73.3, 80.2) |
0.546 |
6.3 (4.7, 8.4) |
33.5 (27.4, 40.3) |
60.2 (53.6, 66.4) |
0.359 |
| 20-39 |
25.5 (23.1, 28.0) |
74.5 (72.0, 76.9) |
7.2 (5.7, 9.1) |
36.5 (33.2, 39.9) |
56.3 (52.4, 60.1) |
| 40-59 |
23.9 (21.2, 26.8) |
76.1 (73.2, 78.8) |
5.7 (4.0, 8.2) |
36.3 (32.1, 40.8) |
57.9 (53.3, 62.4) |
| >=60 |
24.8 (22.3, 27.4) |
75.2 (72.6, 77.7) |
5.8 (4.7, 7.1) |
37.9 (33.9, 42.1) |
56.3 (51.8, 60.7) |
| Total |
24.6 (23.1, 26.1) |
75.4 (73.9, 76.9) |
|
6.4 (5.7, 7.3) |
36.3 (34.4, 38.2) |
57.3 (54.8, 59.7) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs3792267 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
24.4 (22.2, 26.7) |
75.6 (73.3, 77.8) |
0.749 |
6.8 (5.4, 8.5) |
35.2 (33.0, 37.4) |
58.0 (54.9, 61.1) |
0.313 |
| Female |
24.7 (23.2, 26.4) |
75.3 (73.6, 76.8) |
6.1 (5.0, 7.3) |
37.4 (34.7, 40.1) |
56.6 (53.8, 59.3) |
| Total |
24.6 (23.1, 26.1) |
75.4 (73.9, 76.9) |
|
6.4 (5.7, 7.3) |
36.3 (34.4, 38.2) |
57.3 (54.8, 59.7) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs3792267 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
24.5 (19.9, 29.8) |
75.5 (70.2, 80.1) |
7.0 (4.6, 10.7) |
35.0 (27.4, 43.3) |
58.0 (49.4, 66.1) |
| 20-39 |
26.9 (23.6, 30.4) |
73.1 (69.6, 76.4) |
7.9 (5.8, 10.7) |
37.8 (33.7, 42.1) |
54.2 (49.1, 59.3) |
| 40-59 |
24.6 (20.9, 28.7) |
75.4 (71.3, 79.1) |
5.4 (3.5, 8.4) |
38.3 (32.4, 44.6) |
56.3 (49.6, 62.7) |
| >=60 |
26.2 (23.3, 29.2) |
73.8 (70.8, 76.7) |
6.5 (5.2, 8.0) |
39.5 (34.8, 44.3) |
54.1 (48.9, 59.2) |
| Non-Hispanic Black |
12-19 |
16.2 (13.8, 18.9) |
83.8 (81.1, 86.2) |
2.1 (1.0, 4.1) |
28.3 (23.8, 33.3) |
69.6 (64.7, 74.2) |
| 20-39 |
16.0 (13.6, 18.7) |
84.0 (81.3, 86.4) |
2.5 (1.5, 4.1) |
27.1 (23.4, 31.2) |
70.4 (65.9, 74.6) |
| 40-59 |
16.2 (14.0, 18.6) |
83.8 (81.4, 86.0) |
2.7 (1.6, 4.5) |
27.0 (22.5, 32.0) |
70.3 (65.7, 74.6) |
| >=60 |
16.5 (13.0, 20.6) |
83.5 (79.4, 87.0) |
2.1 (0.9, 4.6) |
28.8 (22.7, 35.7) |
69.2 (61.9, 75.6) |
| Mexican American |
12-19 |
29.7 (26.7, 33.0) |
70.3 (67.0, 73.3) |
7.4 (5.2, 10.4) |
44.7 (39.1, 50.4) |
47.9 (42.6, 53.3) |
| 20-39 |
26.3 (24.3, 28.3) |
73.7 (71.7, 75.7) |
6.7 (5.5, 8.1) |
39.2 (36.9, 41.5) |
54.1 (51.1, 57.1) |
| 40-59 |
28.0 (22.8, 33.8) |
72.0 (66.2, 77.2) |
9.2 (6.1, 13.8) |
37.5 (31.3, 44.2) |
53.3 (45.0, 61.3) |
| >=60 |
26.1 (23.9, 28.4) |
73.9 (71.6, 76.1) |
6.3 (4.2, 9.3) |
39.6 (34.9, 44.5) |
54.1 (50.2, 58.1) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs3792267 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
25.4 (22.5, 28.5) |
74.6 (71.5, 77.5) |
7.3 (5.4, 9.8) |
36.3 (33.2, 39.4) |
56.5 (52.1, 60.7) |
| Female |
26.1 (24.1, 28.2) |
73.9 (71.8, 75.9) |
6.3 (4.8, 8.2) |
39.6 (35.6, 43.7) |
54.1 (50.4, 57.8) |
| Non-Hispanic Black |
Male |
16.3 (14.1, 18.8) |
83.7 (81.2, 85.9) |
2.4 (1.5, 3.9) |
27.9 (24.1, 32.0) |
69.7 (65.4, 73.8) |
| Female |
16.0 (13.8, 18.6) |
84.0 (81.4, 86.2) |
2.4 (1.6, 3.7) |
27.2 (23.8, 31.0) |
70.4 (66.1, 74.3) |
| Mexican American |
Male |
26.6 (24.5, 28.9) |
73.4 (71.1, 75.5) |
7.1 (5.4, 9.2) |
39.2 (36.6, 41.8) |
53.8 (50.7, 56.8) |
| Female |
28.1 (25.0, 31.3) |
71.9 (68.7, 75.0) |
7.6 (6.0, 9.7) |
40.8 (36.3, 45.5) |
51.5 (46.3, 56.7) |
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