CAT Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs769214
|
-843A>G |
|
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs769214 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
66.1 (63.4, 68.7) |
33.9 (31.3, 36.6) |
<0.001 |
43.6 (40.0, 47.2) |
45.0 (42.5, 47.6) |
11.4 (9.4, 13.7) |
<0.001 |
0.68 |
| Non-Hispanic Black |
58.8 (57.0, 60.6) |
41.2 (39.4, 43.0) |
35.0 (32.5, 37.6) |
47.6 (44.8, 50.3) |
17.4 (15.6, 19.4) |
0.82 |
| Mexican American |
49.7 (48.8, 50.6) |
50.3 (49.4, 51.2) |
24.0 (22.0, 26.1) |
51.5 (47.4, 55.5) |
24.6 (22.3, 27.0) |
0.32 |
| Total* |
62.4 (60.0, 64.7) |
37.6 (35.3, 40.0) |
|
39.5 (36.3, 42.7) |
45.8 (43.4, 48.2) |
14.8 (13.0, 16.7) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs769214 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
63.4 (59.0, 67.5) |
36.6 (32.5, 41.0) |
0.498 |
39.5 (34.3, 44.9) |
47.8 (43.7, 51.9) |
12.7 (9.2, 17.2) |
0.145 |
| 20-39 |
61.0 (57.6, 64.3) |
39.0 (35.7, 42.4) |
38.4 (33.0, 44.2) |
45.1 (39.9, 50.5) |
16.4 (14.3, 18.8) |
| 40-59 |
62.6 (57.6, 67.3) |
37.4 (32.7, 42.4) |
39.1 (33.0, 45.6) |
46.9 (42.3, 51.6) |
14.0 (10.3, 18.7) |
| >=60 |
64.0 (62.1, 65.9) |
36.0 (34.1, 37.9) |
42.0 (39.2, 44.9) |
44.0 (41.5, 46.6) |
14.0 (12.5, 15.6) |
| Total |
62.4 (60.0, 64.7) |
37.6 (35.3, 40.0) |
|
39.5 (36.3, 42.7) |
45.8 (43.4, 48.2) |
14.8 (13.0, 16.7) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs769214 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
63.0 (59.2, 66.7) |
37.0 (33.3, 40.8) |
0.471 |
40.4 (35.5, 45.5) |
45.2 (41.1, 49.4) |
14.4 (11.3, 18.1) |
0.747 |
| Female |
61.8 (59.8, 63.6) |
38.2 (36.4, 40.2) |
38.6 (35.9, 41.4) |
46.3 (43.7, 48.9) |
15.1 (13.4, 16.9) |
| Total |
62.4 (60.0, 64.7) |
37.6 (35.3, 40.0) |
|
39.5 (36.3, 42.7) |
45.8 (43.4, 48.2) |
14.8 (13.0, 16.7) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs769214 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
67.9 (61.6, 73.5) |
32.1 (26.5, 38.4) |
44.8 (37.2, 52.7) |
46.1 (40.8, 51.5) |
9.1 (5.2, 15.4) |
| 20-39 |
65.8 (61.2, 70.2) |
34.2 (29.8, 38.8) |
43.8 (36.7, 51.2) |
44.0 (37.5, 50.8) |
12.2 (9.4, 15.6) |
| 40-59 |
65.0 (58.9, 70.7) |
35.0 (29.3, 41.1) |
41.6 (33.9, 49.7) |
46.9 (41.1, 52.7) |
11.6 (7.5, 17.3) |
| >=60 |
67.1 (65.2, 68.8) |
32.9 (31.2, 34.8) |
45.2 (42.5, 47.9) |
43.8 (41.1, 46.5) |
11.1 (9.5, 12.8) |
| Non-Hispanic Black |
12-19 |
58.3 (55.7, 60.8) |
41.7 (39.2, 44.3) |
31.8 (27.1, 36.8) |
53.0 (46.0, 59.8) |
15.2 (11.9, 19.3) |
| 20-39 |
58.2 (55.4, 61.0) |
41.8 (39.0, 44.6) |
34.9 (31.9, 37.9) |
46.7 (43.0, 50.5) |
18.4 (15.0, 22.4) |
| 40-59 |
60.6 (56.8, 64.2) |
39.4 (35.8, 43.2) |
36.7 (31.6, 42.2) |
47.7 (42.5, 52.9) |
15.6 (12.2, 19.6) |
| >=60 |
58.1 (52.9, 63.2) |
41.9 (36.8, 47.1) |
36.8 (30.1, 44.1) |
42.6 (36.0, 49.6) |
20.5 (15.8, 26.2) |
| Mexican American |
12-19 |
51.5 (48.0, 55.1) |
48.5 (44.9, 52.0) |
23.6 (17.6, 30.8) |
55.9 (47.8, 63.7) |
20.5 (17.1, 24.4) |
| 20-39 |
49.6 (47.5, 51.7) |
50.4 (48.3, 52.5) |
23.6 (20.0, 27.5) |
52.1 (46.4, 57.7) |
24.3 (21.2, 27.8) |
| 40-59 |
48.1 (43.8, 52.4) |
51.9 (47.6, 56.2) |
24.6 (19.5, 30.4) |
47.0 (40.4, 53.8) |
28.4 (23.2, 34.3) |
| >=60 |
50.1 (45.6, 54.7) |
49.9 (45.3, 54.4) |
25.9 (19.8, 33.2) |
48.3 (42.0, 54.7) |
25.7 (21.9, 30.0) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs769214 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
66.8 (62.7, 70.8) |
33.2 (29.2, 37.3) |
44.3 (38.7, 50.1) |
45.1 (40.1, 50.1) |
10.6 (7.6, 14.8) |
| Female |
65.4 (63.1, 67.7) |
34.6 (32.3, 36.9) |
42.9 (39.5, 46.4) |
45.0 (42.1, 47.9) |
12.1 (10.4, 14.0) |
| Non-Hispanic Black |
Male |
60.3 (56.9, 63.7) |
39.7 (36.3, 43.1) |
38.0 (33.8, 42.4) |
44.7 (41.4, 48.0) |
17.4 (14.4, 20.7) |
| Female |
57.6 (55.2, 59.9) |
42.4 (40.1, 44.8) |
32.6 (29.9, 35.4) |
50.0 (47.0, 53.0) |
17.4 (14.8, 20.5) |
| Mexican American |
Male |
49.5 (47.8, 51.2) |
50.5 (48.8, 52.2) |
24.5 (22.9, 26.2) |
50.0 (47.0, 53.0) |
25.5 (22.9, 28.3) |
| Female |
49.9 (48.1, 51.7) |
50.1 (48.3, 51.9) |
23.4 (19.6, 27.7) |
53.0 (46.9, 59.1) |
23.6 (20.7, 26.6) |
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