CCL5 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs2280788
|
-95C>G |
|
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs2280788 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
97.2 (96.8, 97.5) |
2.8 (2.5, 3.2) |
<0.001 |
94.6 (93.9, 95.2) |
5.2 (4.6, 5.9) |
0.2 (0.1, 0.5) |
<0.001 |
0.04 |
| Non-Hispanic Black |
99.3 (98.9, 99.6) |
0.7 (0.4, 1.1) |
98.7 (97.8, 99.2) |
1.3 (0.8, 2.2) |
0.0 (NA) |
0.79 |
| Mexican American |
98.7 (98.3, 99.0) |
1.3 (1.0, 1.7) |
97.4 (96.6, 98.0) |
2.6 (2.0, 3.4) |
0.0 (NA) |
0.63 |
| Total* |
97.4 (97.0, 97.7) |
2.6 (2.3, 3.0) |
|
94.9 (94.2, 95.5) |
5.0 (4.4, 5.6) |
0.1 (0.0, 0.4) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs2280788 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
98.0 (95.5, 99.1) |
2.0 (0.9, 4.5) |
0.250 |
96.0 (91.2, 98.2) |
4.0 (1.8, 8.8) |
0.0 (NA) |
0.019 |
| 20-39 |
96.8 (96.1, 97.4) |
3.2 (2.6, 3.9) |
93.7 (92.4, 94.8) |
6.2 (5.2, 7.4) |
0.1 (0.0, 0.6) |
| 40-59 |
97.6 (96.7, 98.2) |
2.4 (1.8, 3.3) |
95.3 (93.4, 96.6) |
4.6 (3.2, 6.6) |
0.1 (0.0, 0.8) |
| >=60 |
97.9 (97.1, 98.5) |
2.1 (1.5, 2.9) |
96.0 (94.5, 97.0) |
3.8 (2.9, 5.1) |
0.2 (0.1, 0.7) |
| Total |
97.4 (97.0, 97.7) |
2.6 (2.3, 3.0) |
|
94.9 (94.2, 95.5) |
5.0 (4.4, 5.6) |
0.1 (0.0, 0.4) |
|
* Includes all participants, regardless of race/ethnicity.
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VariantSexAllele
% (95% CI)Chi-square
P-valueGenotype
% (95% CI)Chi-square
P-value
By Sex
| rs2280788 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
97.8 (97.1, 98.3) |
2.2 (1.7, 2.9) |
0.172 |
95.6 (94.4, 96.6) |
4.4 (3.4, 5.6) |
0.1 (0.0, 0.5) |
0.452 |
| Female |
97.0 (96.1, 97.7) |
3.0 (2.3, 3.9) |
94.2 (92.6, 95.5) |
5.6 (4.4, 7.1) |
0.2 (0.1, 0.6) |
| Total |
97.4 (97.0, 97.7) |
2.6 (2.3, 3.0) |
|
94.9 (94.2, 95.5) |
5.0 (4.4, 5.6) |
0.1 (0.0, 0.4) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs2280788 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
97.9 (95.2, 99.1) |
2.1 (0.9, 4.8) |
95.9 (90.4, 98.3) |
4.1 (1.7, 9.6) |
0.0 (NA) |
| 20-39 |
96.4 (95.5, 97.2) |
3.6 (2.8, 4.5) |
93.1 (91.4, 94.4) |
6.7 (5.4, 8.3) |
0.2 (0.0, 0.8) |
| 40-59 |
97.5 (96.5, 98.2) |
2.5 (1.8, 3.5) |
95.1 (93.0, 96.6) |
4.7 (3.2, 7.0) |
0.2 (0.0, 1.0) |
| >=60 |
97.7 (96.8, 98.4) |
2.3 (1.6, 3.2) |
95.7 (94.1, 96.9) |
4.0 (3.0, 5.4) |
0.2 (0.1, 0.9) |
| Non-Hispanic Black |
12-19 |
99.5 (98.6, 99.8) |
0.5 (0.2, 1.4) |
98.9 (97.2, 99.6) |
1.1 (0.4, 2.8) |
0.0 (NA) |
| 20-39 |
99.2 (98.4, 99.6) |
0.8 (0.4, 1.6) |
98.5 (96.8, 99.3) |
1.5 (0.7, 3.2) |
0.0 (NA) |
| 40-59 |
99.2 (98.1, 99.7) |
0.8 (0.3, 1.9) |
98.5 (96.1, 99.4) |
1.5 (0.6, 3.9) |
0.0 (NA) |
| >=60 |
99.7 (98.7, 99.9) |
0.3 (0.1, 1.3) |
99.4 (97.4, 99.9) |
0.6 (0.1, 2.6) |
0.0 (NA) |
| Mexican American |
12-19 |
98.2 (96.2, 99.1) |
1.8 (0.9, 3.8) |
96.3 (92.5, 98.2) |
3.7 (1.8, 7.5) |
0.0 (NA) |
| 20-39 |
98.9 (98.2, 99.4) |
1.1 (0.6, 1.8) |
97.8 (96.4, 98.7) |
2.2 (1.3, 3.6) |
0.0 (NA) |
| 40-59 |
98.7 (98.0, 99.1) |
1.3 (0.9, 2.0) |
97.3 (95.9, 98.2) |
2.7 (1.8, 4.1) |
0.0 (NA) |
| >=60 |
98.9 (97.5, 99.5) |
1.1 (0.5, 2.5) |
97.7 (95.1, 99.0) |
2.3 (1.0, 4.9) |
0.0 (NA) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs2280788 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
97.4 (96.5, 98.0) |
2.6 (2.0, 3.5) |
94.9 (93.2, 96.2) |
5.0 (3.8, 6.7) |
0.1 (0.0, 0.7) |
| Female |
97.0 (96.3, 97.6) |
3.0 (2.4, 3.7) |
94.3 (93.0, 95.4) |
5.4 (4.4, 6.7) |
0.3 (0.1, 0.9) |
| Non-Hispanic Black |
Male |
99.3 (98.6, 99.7) |
0.7 (0.3, 1.4) |
98.6 (97.1, 99.4) |
1.4 (0.6, 2.9) |
0.0 (NA) |
| Female |
99.4 (98.8, 99.7) |
0.6 (0.3, 1.2) |
98.7 (97.6, 99.4) |
1.3 (0.6, 2.4) |
0.0 (NA) |
| Mexican American |
Male |
98.9 (97.8, 99.4) |
1.1 (0.6, 2.2) |
97.7 (95.6, 98.8) |
2.3 (1.2, 4.4) |
0.0 (NA) |
| Female |
98.5 (97.6, 99.1) |
1.5 (0.9, 2.4) |
97.1 (95.1, 98.3) |
2.9 (1.7, 4.9) |
0.0 (NA) |
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