CCR2 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
|
rs1799864
|
Ex2+241G>A |
Val64Ile |
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1799864 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
9.5 (8.1, 11.1) |
90.5 (88.9, 91.9) |
<0.001 |
1.2 (0.6, 2.2) |
16.5 (14.1, 19.3) |
82.3 (79.4, 84.8) |
<0.001 |
0.34 |
| Non-Hispanic Black |
14.5 (13.6, 15.4) |
85.5 (84.6, 86.4) |
1.7 (1.1, 2.4) |
25.7 (24.0, 27.4) |
72.7 (71.0, 74.3) |
0.06 |
| Mexican American |
21.7 (19.8, 23.7) |
78.3 (76.3, 80.2) |
4.5 (3.3, 6.2) |
34.4 (32.1, 36.6) |
61.1 (58.2, 63.9) |
0.74 |
| Total* |
11.2 (10.1, 12.6) |
88.8 (87.4, 89.9) |
|
1.6 (1.0, 2.4) |
19.3 (17.4, 21.4) |
79.1 (76.9, 81.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1799864 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
12.7 (10.6, 15.1) |
87.3 (84.9, 89.4) |
0.043 |
0.8 (0.4, 1.5) |
23.8 (19.7, 28.5) |
75.4 (70.7, 79.6) |
0.066 |
| 20-39 |
12.0 (10.3, 13.9) |
88.0 (86.1, 89.7) |
2.2 (1.2, 3.9) |
19.7 (17.1, 22.6) |
78.2 (75.1, 80.9) |
| 40-59 |
9.9 (8.4, 11.8) |
90.1 (88.2, 91.6) |
1.4 (0.7, 2.6) |
17.2 (14.6, 20.0) |
81.5 (78.4, 84.2) |
| >=60 |
10.6 (9.2, 12.2) |
89.4 (87.8, 90.8) |
1.3 (0.7, 2.6) |
18.5 (16.3, 21.0) |
80.1 (77.5, 82.6) |
| Total |
11.2 (10.1, 12.6) |
88.8 (87.4, 89.9) |
|
1.6 (1.0, 2.4) |
19.3 (17.4, 21.4) |
79.1 (76.9, 81.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1799864 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
10.7 (9.4, 12.0) |
89.3 (88.0, 90.6) |
0.422 |
1.8 (1.1, 3.2) |
17.6 (15.4, 20.2) |
80.5 (78.1, 82.7) |
0.227 |
| Female |
11.8 (9.6, 14.3) |
88.2 (85.7, 90.4) |
1.3 (0.9, 2.1) |
20.9 (17.2, 25.1) |
77.8 (73.2, 81.8) |
| Total |
11.2 (10.1, 12.6) |
88.8 (87.4, 89.9) |
|
1.6 (1.0, 2.4) |
19.3 (17.4, 21.4) |
79.1 (76.9, 81.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1799864 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
10.3 (7.8, 13.6) |
89.7 (86.4, 92.2) |
0.4 (0.1, 2.3) |
19.8 (15.0, 25.6) |
79.8 (73.7, 84.7) |
| 20-39 |
9.4 (7.4, 11.8) |
90.6 (88.2, 92.6) |
1.5 (0.6, 3.9) |
15.8 (12.4, 19.9) |
82.7 (78.5, 86.2) |
| 40-59 |
9.1 (7.2, 11.4) |
90.9 (88.6, 92.8) |
1.2 (0.5, 3.0) |
15.8 (12.6, 19.5) |
83.0 (79.0, 86.4) |
| >=60 |
9.7 (8.0, 11.6) |
90.3 (88.4, 92.0) |
1.1 (0.5, 2.8) |
17.0 (14.6, 19.8) |
81.8 (78.7, 84.6) |
| Non-Hispanic Black |
12-19 |
14.0 (11.9, 16.4) |
86.0 (83.6, 88.1) |
1.2 (0.4, 3.7) |
25.6 (21.9, 29.8) |
73.2 (69.0, 77.0) |
| 20-39 |
15.2 (13.8, 16.8) |
84.8 (83.2, 86.2) |
2.0 (1.3, 3.1) |
26.5 (23.8, 29.4) |
71.5 (68.6, 74.2) |
| 40-59 |
13.2 (10.9, 16.0) |
86.8 (84.0, 89.1) |
1.4 (0.5, 3.9) |
23.6 (19.7, 28.1) |
75.0 (70.2, 79.1) |
| >=60 |
15.1 (12.2, 18.5) |
84.9 (81.5, 87.8) |
1.7 (0.8, 3.4) |
26.9 (21.5, 32.9) |
71.5 (65.3, 77.0) |
| Mexican American |
12-19 |
19.5 (15.8, 23.8) |
80.5 (76.2, 84.2) |
3.5 (2.0, 6.1) |
32.0 (25.2, 39.7) |
64.5 (56.8, 71.5) |
| 20-39 |
23.6 (21.4, 26.1) |
76.4 (73.9, 78.6) |
5.1 (3.5, 7.4) |
37.1 (34.6, 39.8) |
57.8 (54.5, 61.0) |
| 40-59 |
20.9 (18.2, 23.9) |
79.1 (76.1, 81.8) |
4.9 (2.3, 10.0) |
32.0 (27.0, 37.4) |
63.1 (58.9, 67.2) |
| >=60 |
17.7 (13.9, 22.2) |
82.3 (77.8, 86.1) |
3.0 (1.4, 6.4) |
29.3 (22.8, 36.9) |
67.6 (60.0, 74.5) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1799864 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
8.9 (7.3, 10.9) |
91.1 (89.1, 92.7) |
1.6 (0.8, 3.4) |
14.6 (11.8, 17.9) |
83.8 (80.5, 86.6) |
| Female |
10.0 (7.7, 12.8) |
90.0 (87.2, 92.3) |
0.8 (0.4, 1.5) |
18.4 (14.1, 23.6) |
80.8 (75.5, 85.3) |
| Non-Hispanic Black |
Male |
13.6 (12.1, 15.3) |
86.4 (84.7, 87.9) |
1.3 (0.9, 2.1) |
24.5 (21.7, 27.5) |
74.1 (71.0, 77.0) |
| Female |
15.2 (14.0, 16.5) |
84.8 (83.5, 86.0) |
1.9 (1.2, 3.0) |
26.6 (24.1, 29.2) |
71.5 (69.0, 73.8) |
| Mexican American |
Male |
20.7 (18.3, 23.4) |
79.3 (76.6, 81.7) |
4.0 (2.2, 7.2) |
33.5 (30.5, 36.6) |
62.5 (59.0, 66.0) |
| Female |
22.8 (20.7, 25.1) |
77.2 (74.9, 79.3) |
5.1 (3.7, 7.1) |
35.3 (32.7, 38.0) |
59.6 (56.3, 62.7) |
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