CYP1A1 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
| rs number |
Nucleotide change |
Amino acid |
Genotyping method |
| rs2472299 |
-17961C>T |
|
TaqMan |
| rs2606345 |
IVS1+606G>T |
|
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs2472299 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
71.8 (70.3, 73.3) |
28.2 (26.7, 29.7) |
<0.001 |
52.8 (50.6, 55.0) |
37.9 (35.8, 40.0) |
9.3 (7.9, 10.8) |
<0.001 |
0.01 |
| Non-Hispanic Black |
61.5 (59.3, 63.7) |
38.5 (36.3, 40.7) |
37.7 (34.7, 40.7) |
47.8 (45.3, 50.2) |
14.6 (12.8, 16.6) |
0.61 |
| Mexican American |
73.3 (71.1, 75.4) |
26.7 (24.6, 28.9) |
53.9 (50.3, 57.4) |
38.8 (35.7, 42.0) |
7.3 (6.0, 8.8) |
0.65 |
| Total* |
70.2 (68.7, 71.6) |
29.8 (28.4, 31.3) |
|
50.2 (47.8, 52.5) |
40.0 (37.7, 42.3) |
9.9 (8.8, 11.0) |
|
|
| rs2606345 |
|
G |
T |
|
GG |
GT |
TT |
|
|
| Non-Hispanic White |
33.8 (31.8, 35.8) |
66.2 (64.2, 68.2) |
<0.001 |
11.2 (9.2, 13.6) |
45.1 (41.8, 48.5) |
43.7 (40.7, 46.7) |
<0.001 |
0.71 |
| Non-Hispanic Black |
84.1 (81.3, 86.5) |
15.9 (13.5, 18.7) |
70.8 (65.8, 75.3) |
26.6 (22.4, 31.3) |
2.6 (2.1, 3.4) |
0.21 |
| Mexican American |
61.7 (59.1, 64.2) |
38.3 (35.8, 40.9) |
38.4 (34.4, 42.6) |
46.5 (42.5, 50.6) |
15.1 (13.1, 17.2) |
0.72 |
| Total* |
44.0 (41.7, 46.3) |
56.0 (53.7, 58.3) |
|
22.6 (20.5, 24.8) |
42.8 (40.1, 45.5) |
34.6 (31.6, 37.8) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
Top of Page
By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs2472299 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
70.7 (67.0, 74.1) |
29.3 (25.9, 33.0) |
0.945 |
50.0 (43.9, 56.0) |
41.5 (35.7, 47.5) |
8.6 (6.6, 11.2) |
0.795 |
| 20-39 |
69.8 (67.3, 72.1) |
30.2 (27.9, 32.7) |
49.4 (46.0, 52.7) |
40.8 (37.8, 43.9) |
9.8 (7.8, 12.3) |
| 40-59 |
70.3 (68.0, 72.5) |
29.7 (27.5, 32.0) |
51.0 (47.6, 54.4) |
38.6 (34.9, 42.5) |
10.4 (8.2, 13.1) |
| >=60 |
70.3 (68.3, 72.3) |
29.7 (27.7, 31.7) |
50.7 (47.2, 54.3) |
39.2 (35.5, 42.9) |
10.1 (8.6, 11.8) |
| Total |
70.2 (68.7, 71.6) |
29.8 (28.4, 31.3) |
|
50.2 (47.8, 52.5) |
40.0 (37.7, 42.3) |
9.9 (8.8, 11.0) |
|
| rs2606345 |
|
G |
T |
|
GG |
GT |
TT |
|
| 12-19 |
48.5 (44.7, 52.4) |
51.5 (47.6, 55.3) |
0.001 |
27.8 (22.9, 33.2) |
41.5 (34.9, 48.4) |
30.7 (25.9, 36.1) |
<0.001 |
| 20-39 |
45.5 (42.0, 49.0) |
54.5 (51.0, 58.0) |
23.4 (20.3, 26.9) |
44.0 (40.1, 48.0) |
32.5 (28.1, 37.4) |
| 40-59 |
42.2 (39.5, 45.1) |
57.8 (54.9, 60.5) |
22.3 (19.5, 25.4) |
39.9 (36.5, 43.3) |
37.8 (34.3, 41.5) |
| >=60 |
40.3 (37.8, 42.8) |
59.7 (57.2, 62.2) |
17.6 (14.8, 20.8) |
45.4 (41.8, 49.0) |
37.0 (33.9, 40.3) |
| Total |
44.0 (41.7, 46.3) |
56.0 (53.7, 58.3) |
|
22.6 (20.5, 24.8) |
42.8 (40.1, 45.5) |
34.6 (31.6, 37.8) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs2472299 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
70.3 (68.0, 72.6) |
29.7 (27.4, 32.0) |
0.838 |
50.7 (47.3, 54.1) |
39.2 (36.1, 42.4) |
10.1 (8.3, 12.3) |
0.869 |
| Female |
70.0 (68.1, 71.8) |
30.0 (28.2, 31.9) |
49.7 (45.8, 53.5) |
40.7 (36.3, 45.2) |
9.6 (8.4, 11.1) |
| Total |
70.2 (68.7, 71.6) |
29.8 (28.4, 31.3) |
|
50.2 (47.8, 52.5) |
40.0 (37.7, 42.3) |
9.9 (8.8, 11.0) |
|
| rs2606345 |
|
G |
T |
|
GG |
GT |
TT |
|
| Male |
44.8 (42.0, 47.7) |
55.2 (52.3, 58.0) |
0.220 |
22.7 (20.1, 25.4) |
44.3 (41.1, 47.5) |
33.0 (29.4, 36.9) |
0.171 |
| Female |
43.2 (40.7, 45.7) |
56.8 (54.3, 59.3) |
22.5 (20.0, 25.2) |
41.4 (38.1, 44.7) |
36.1 (32.8, 39.6) |
| Total |
44.0 (41.7, 46.3) |
56.0 (53.7, 58.3) |
|
22.6 (20.5, 24.8) |
42.8 (40.1, 45.5) |
34.6 (31.6, 37.8) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs2472299 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
72.7 (67.2, 77.6) |
27.3 (22.4, 32.8) |
54.1 (45.5, 62.5) |
37.2 (29.9, 45.2) |
8.7 (6.1, 12.3) |
| 20-39 |
71.4 (68.3, 74.2) |
28.6 (25.8, 31.7) |
52.1 (48.2, 55.9) |
38.5 (35.1, 42.1) |
9.4 (6.8, 12.8) |
| 40-59 |
71.7 (69.3, 73.9) |
28.3 (26.1, 30.7) |
52.9 (49.6, 56.3) |
37.4 (33.5, 41.6) |
9.6 (7.2, 12.6) |
| >=60 |
72.2 (70.0, 74.2) |
27.8 (25.8, 30.0) |
53.3 (49.6, 56.9) |
37.8 (34.1, 41.6) |
9.0 (7.5, 10.7) |
| Non-Hispanic Black |
12-19 |
65.0 (61.6, 68.3) |
35.0 (31.7, 38.4) |
40.6 (35.7, 45.8) |
48.8 (43.8, 54.0) |
10.5 (7.8, 14.1) |
| 20-39 |
61.8 (59.1, 64.5) |
38.2 (35.5, 40.9) |
37.8 (34.2, 41.7) |
48.0 (43.9, 52.2) |
14.1 (11.4, 17.5) |
| 40-59 |
59.3 (54.8, 63.6) |
40.7 (36.4, 45.2) |
36.1 (30.5, 42.0) |
46.5 (41.6, 51.4) |
17.5 (13.6, 22.1) |
| >=60 |
60.0 (54.1, 65.6) |
40.0 (34.4, 45.9) |
36.1 (28.6, 44.3) |
47.7 (38.4, 57.2) |
16.2 (10.3, 24.5) |
| Mexican American |
12-19 |
72.6 (67.3, 77.2) |
27.4 (22.8, 32.7) |
53.5 (46.8, 60.1) |
38.1 (32.4, 44.1) |
8.4 (4.8, 14.4) |
| 20-39 |
73.0 (70.6, 75.4) |
27.0 (24.6, 29.4) |
53.8 (50.6, 57.0) |
38.5 (35.8, 41.3) |
7.7 (5.7, 10.2) |
| 40-59 |
75.5 (71.2, 79.2) |
24.5 (20.8, 28.8) |
56.4 (48.6, 63.9) |
38.2 (30.5, 46.4) |
5.5 (3.6, 8.2) |
| >=60 |
71.0 (67.3, 74.5) |
29.0 (25.5, 32.7) |
49.0 (43.1, 55.0) |
43.9 (37.7, 50.3) |
7.1 (4.4, 11.1) |
| rs2606345 |
|
|
G |
T |
GG |
GT |
TT |
| Non-Hispanic White |
12-19 |
35.7 (31.3, 40.3) |
64.3 (59.7, 68.7) |
12.8 (8.9, 18.1) |
45.7 (36.9, 54.7) |
41.5 (34.0, 49.4) |
| 20-39 |
33.8 (30.6, 37.2) |
66.2 (62.8, 69.4) |
10.5 (7.4, 14.6) |
46.7 (41.5, 51.9) |
42.9 (38.2, 47.6) |
| 40-59 |
33.0 (29.6, 36.7) |
67.0 (63.3, 70.4) |
12.3 (9.2, 16.2) |
41.5 (37.9, 45.2) |
46.2 (41.8, 50.7) |
| >=60 |
33.6 (31.6, 35.7) |
66.4 (64.3, 68.4) |
10.1 (8.2, 12.4) |
47.0 (43.4, 50.6) |
42.9 (39.7, 46.2) |
| Non-Hispanic Black |
12-19 |
84.3 (81.2, 87.0) |
15.7 (13.0, 18.8) |
71.7 (66.1, 76.8) |
25.2 (20.2, 31.0) |
3.0 (1.8, 5.2) |
| 20-39 |
83.6 (80.4, 86.4) |
16.4 (13.6, 19.6) |
69.8 (64.3, 74.7) |
27.7 (23.2, 32.7) |
2.5 (1.4, 4.2) |
| 40-59 |
86.2 (81.9, 89.6) |
13.8 (10.4, 18.1) |
74.9 (67.7, 80.9) |
22.6 (17.4, 28.9) |
2.5 (1.4, 4.5) |
| >=60 |
81.3 (76.7, 85.2) |
18.7 (14.8, 23.3) |
65.4 (58.4, 71.8) |
31.8 (26.1, 38.2) |
2.8 (0.9, 7.9) |
| Mexican American |
12-19 |
61.0 (56.0, 65.8) |
39.0 (34.2, 44.0) |
38.4 (31.0, 46.3) |
45.2 (38.0, 52.5) |
16.5 (12.9, 20.8) |
| 20-39 |
63.0 (60.0, 65.8) |
37.0 (34.2, 40.0) |
40.3 (36.5, 44.2) |
45.3 (42.1, 48.5) |
14.4 (11.9, 17.2) |
| 40-59 |
61.0 (56.3, 65.5) |
39.0 (34.5, 43.7) |
35.6 (27.6, 44.6) |
50.7 (41.5, 59.9) |
13.7 (10.5, 17.6) |
| >=60 |
57.5 (53.7, 61.2) |
42.5 (38.8, 46.3) |
34.3 (30.8, 38.0) |
46.4 (39.6, 53.3) |
19.3 (13.8, 26.3) |
Top of Page
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs2472299 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
71.9 (69.0, 74.6) |
28.1 (25.4, 31.0) |
53.1 (49.0, 57.1) |
37.6 (34.0, 41.3) |
9.3 (7.1, 12.2) |
| Female |
71.7 (69.9, 73.4) |
28.3 (26.6, 30.1) |
52.6 (48.8, 56.4) |
38.2 (33.6, 43.0) |
9.2 (7.7, 11.0) |
| Non-Hispanic Black |
Male |
61.3 (58.4, 64.2) |
38.7 (35.8, 41.6) |
37.5 (33.3, 41.9) |
47.7 (43.7, 51.8) |
14.8 (12.4, 17.6) |
| Female |
61.7 (58.6, 64.7) |
38.3 (35.3, 41.4) |
37.8 (33.6, 42.2) |
47.8 (44.4, 51.2) |
14.4 (12.0, 17.1) |
| Mexican American |
Male |
73.4 (69.5, 77.0) |
26.6 (23.0, 30.5) |
53.7 (48.4, 58.9) |
39.5 (35.8, 43.2) |
6.9 (4.6, 10.1) |
| Female |
73.2 (71.1, 75.2) |
26.8 (24.8, 28.9) |
54.1 (50.8, 57.4) |
38.1 (34.9, 41.5) |
7.8 (6.2, 9.6) |
| rs2606345 |
|
|
G |
T |
GG |
GT |
TT |
| Non-Hispanic White |
Male |
35.6 (32.3, 39.1) |
64.4 (60.9, 67.7) |
12.3 (9.0, 16.6) |
46.8 (42.4, 51.2) |
41.0 (36.8, 45.3) |
| Female |
32.0 (29.9, 34.1) |
68.0 (65.9, 70.1) |
10.2 (8.2, 12.7) |
43.6 (39.8, 47.4) |
46.2 (42.9, 49.5) |
| Non-Hispanic Black |
Male |
84.2 (81.4, 86.7) |
15.8 (13.3, 18.6) |
70.8 (65.6, 75.6) |
26.8 (22.2, 31.9) |
2.4 (1.6, 3.5) |
| Female |
84.0 (80.7, 86.8) |
16.0 (13.2, 19.3) |
70.8 (65.0, 76.0) |
26.4 (21.6, 31.8) |
2.8 (2.0, 4.1) |
| Mexican American |
Male |
61.1 (58.5, 63.8) |
38.9 (36.2, 41.5) |
38.4 (34.1, 42.9) |
45.4 (40.0, 51.0) |
16.1 (13.3, 19.5) |
| Female |
62.3 (59.3, 65.1) |
37.7 (34.9, 40.7) |
38.4 (34.1, 43.0) |
47.7 (44.0, 51.5) |
13.9 (12.1, 16.0) |
Top of Page