CYP2A6 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid change |
Genotyping method
|
| rs1801272 |
Ex3-15T>A |
Leu160His |
TaqMan |
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1801272 |
|
A |
T |
|
AA |
AT |
TT |
|
|
| Non-Hispanic White |
3.3 (2.8, 3.8) |
96.7 (96.2, 97.2) |
<0.001 |
0.1 (0.0, 0.3) |
6.4 (5.5, 7.4) |
93.5 (92.5, 94.5) |
<0.001 |
0.79 |
| Non-Hispanic Black |
0.6 (0.4, 0.9) |
99.4 (99.1, 99.6) |
0.0 (NA) |
1.2 (0.8, 1.8) |
98.8 (98.2, 99.2) |
0.79 |
| Mexican American |
2.0 (1.6, 2.5) |
98.0 (97.5, 98.4) |
0.0 (0.0, 0.3) |
3.9 (3.2, 4.8) |
96.0 (95.1, 96.8) |
0.93 |
| Total* |
2.7 (2.4, 3.1) |
97.3 (96.9, 97.6) |
|
0.1 (0.0, 0.3) |
5.3 (4.7, 6.1) |
94.6 (93.8, 95.3) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801272 |
|
A |
T |
|
AA |
AT |
TT |
|
| 12-19 |
2.7 (1.8, 4.1) |
97.3 (95.9, 98.2) |
0.107 |
0.2 (0.0, 1.6) |
5.0 (3.3, 7.6) |
94.8 (92.2, 96.5) |
0.026 |
| 20-39 |
2.4 (1.8, 3.0) |
97.6 (97.0, 98.2) |
0.1 (0.0, 0.6) |
4.6 (3.6, 5.8) |
95.4 (94.1, 96.4) |
| 40-59 |
3.6 (2.7, 4.6) |
96.4 (95.4, 97.3) |
0.0 (0.0, 0.1) |
7.1 (5.5, 9.2) |
92.9 (90.8, 94.5) |
| >=60 |
2.3 (1.6, 3.4) |
97.7 (96.6, 98.4) |
0.0 (NA) |
4.7 (3.2, 6.8) |
95.3 (93.2, 96.8) |
| Total |
2.7 (2.4, 3.1) |
97.3 (96.9, 97.6) |
|
0.1 (0.0, 0.3) |
5.3 (4.7, 6.1) |
94.6 (93.8, 95.3) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801272 |
|
A |
T |
|
AA |
AT |
TT |
|
| Male |
2.9 (2.2, 3.8) |
97.1 (96.2, 97.8) |
0.478 |
0.1 (0.0, 0.5) |
5.6 (4.3, 7.2) |
94.3 (92.6, 95.6) |
0.336 |
| Female |
2.6 (2.1, 3.1) |
97.4 (96.9, 97.9) |
0.0 (NA) |
5.1 (4.2, 6.2) |
94.9 (93.8, 95.8) |
| Total |
2.7 (2.4, 3.1) |
97.3 (96.9, 97.6) |
|
0.1 (0.0, 0.3) |
5.3 (4.7, 6.1) |
94.6 (93.8, 95.3) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801272 |
|
|
A |
T |
AA |
AT |
TT |
| Non-Hispanic White |
12-19 |
3.9 (2.6, 5.7) |
96.1 (94.3, 97.4) |
0.3 (0.0, 2.4) |
7.1 (4.5, 10.8) |
92.6 (89.0, 95.1) |
| 20-39 |
3.0 (2.3, 4.0) |
97.0 (96.0, 97.7) |
0.1 (0.0, 0.9) |
5.9 (4.5, 7.6) |
94.0 (92.3, 95.4) |
| 40-59 |
4.0 (3.0, 5.3) |
96.0 (94.7, 97.0) |
0.0 (NA) |
8.0 (6.0, 10.6) |
92.0 (89.4, 94.0) |
| >=60 |
2.4 (1.6, 3.5) |
97.6 (96.5, 98.4) |
0.0 (NA) |
4.7 (3.2, 6.9) |
95.3 (93.1, 96.8) |
| Non-Hispanic Black |
12-19 |
0.4 (0.2, 1.2) |
99.6 (98.8, 99.8) |
0.0 (NA) |
0.9 (0.3, 2.4) |
99.1 (97.6, 99.7) |
| 20-39 |
0.4 (0.2, 0.7) |
99.6 (99.3, 99.8) |
0.0 (NA) |
0.8 (0.4, 1.4) |
99.2 (98.6, 99.6) |
| 40-59 |
1.0 (0.5, 2.3) |
99.0 (97.7, 99.5) |
0.0 (NA) |
2.1 (1.0, 4.5) |
97.9 (95.5, 99.0) |
| >=60 |
0.7 (0.2, 2.1) |
99.3 (97.9, 99.8) |
0.0 (NA) |
1.4 (0.4, 4.1) |
98.6 (95.9, 99.6) |
| Mexican American |
12-19 |
1.5 (1.0, 2.4) |
98.5 (97.6, 99.0) |
0.0 (NA) |
3.1 (1.9, 4.9) |
96.9 (95.1, 98.1) |
| 20-39 |
2.3 (1.5, 3.5) |
97.7 (96.5, 98.5) |
0.0 (NA) |
4.6 (3.0, 6.9) |
95.4 (93.1, 97.0) |
| 40-59 |
1.9 (1.3, 2.7) |
98.1 (97.3, 98.7) |
0.2 (0.0, 1.5) |
3.5 (2.4, 5.0) |
96.4 (94.9, 97.5) |
| >=60 |
1.7 (0.7, 3.8) |
98.3 (96.2, 99.3) |
0.0 (NA) |
3.4 (1.5, 7.5) |
96.6 (92.5, 98.5) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801272 |
|
|
A |
T |
AA |
AT |
TT |
| Non-Hispanic White |
Male |
3.6 (2.6, 4.8) |
96.4 (95.2, 97.4) |
0.2 (0.0, 0.7) |
6.8 (5.0, 9.1) |
93.1 (90.7, 94.8) |
| Female |
3.0 (2.4, 3.8) |
97.0 (96.2, 97.6) |
0.0 (NA) |
6.0 (4.8, 7.5) |
94.0 (92.5, 95.2) |
| Non-Hispanic Black |
Male |
0.6 (0.3, 1.3) |
99.4 (98.7, 99.7) |
0.0 (NA) |
1.2 (0.6, 2.5) |
98.8 (97.5, 99.4) |
| Female |
0.6 (0.3, 1.1) |
99.4 (98.9, 99.7) |
0.0 (NA) |
1.2 (0.6, 2.2) |
98.8 (97.8, 99.4) |
| Mexican American |
Male |
2.0 (1.4, 2.8) |
98.0 (97.2, 98.6) |
0.1 (0.0, 0.6) |
3.9 (2.8, 5.3) |
96.1 (94.6, 97.2) |
| Female |
2.0 (1.4, 2.8) |
98.0 (97.2, 98.6) |
0.0 (NA) |
4.0 (2.8, 5.6) |
96.0 (94.4, 97.2) |
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