F5 Allele and Genotype Frequencies
Available polymorphism(s)
| rs number |
Nucleotide change Amino acid
|
Genotyping method |
|
rs6025
|
Ex10-11G>A
|
Arg534Gln
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs6025 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
2.6 (2.1, 3.2) |
97.4 (96.8, 97.9) |
<0.001 |
0.0 (0.0, 0.1) |
5.2 (4.2, 6.3) |
94.8 (93.7, 95.8) |
<0.001 |
0.49 |
| Non-Hispanic Black |
0.6 (0.4, 1.0) |
99.4 (99.0, 99.6) |
0.0 (NA) |
1.3 (0.8, 2.1) |
98.7 (97.9, 99.2) |
0.80 |
| Mexican American |
1.0 (0.8, 1.4) |
99.0 (98.6, 99.2) |
0.0 (0.0, 0.3) |
2.0 (1.4, 2.8) |
98.0 (97.2, 98.5) |
0.03 |
| Total* |
2.2 (1.8, 2.7) |
97.8 (97.3, 98.2) |
|
0.0 (0.0, 0.1) |
4.3 (3.5, 5.3) |
95.7 (94.6, 96.5) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs6025 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
2.3 (1.4, 3.7) |
97.7 (96.3, 98.6) |
0.128 |
0.0 (NA) |
4.5 (2.7, 7.4) |
95.5 (92.6, 97.3) |
0.264 |
| 20-39 |
1.7 (1.0, 2.8) |
98.3 (97.2, 99.0) |
0.0 (0.0, 0.1) |
3.4 (2.0, 5.6) |
96.6 (94.4, 98.0) |
| 40-59 |
3.0 (2.3, 4.0) |
97.0 (96.0, 97.7) |
0.0 (NA) |
6.0 (4.5, 8.0) |
94.0 (92.0, 95.5) |
| >=60 |
1.9 (1.2, 3.0) |
98.1 (97.0, 98.8) |
0.1 (0.0, 0.5) |
3.7 (2.3, 5.9) |
96.3 (94.0, 97.7) |
| Total |
2.2 (1.8, 2.7) |
97.8 (97.3, 98.2) |
|
0.0 (0.0, 0.1) |
4.3 (3.5, 5.3) |
95.7 (94.6, 96.5) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs6025 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
2.4 (1.7, 3.4) |
97.6 (96.6, 98.3) |
0.323 |
0.0 (0.0, 0.2) |
4.7 (3.3, 6.7) |
95.3 (93.3, 96.7) |
0.496 |
| Female |
2.0 (1.7, 2.4) |
98.0 (97.6, 98.3) |
0.0 (0.0, 0.0) |
4.0 (3.3, 4.7) |
96.0 (95.3, 96.7) |
| Total |
2.2 (1.8, 2.7) |
97.8 (97.3, 98.2) |
|
0.0 (0.0, 0.1) |
4.3 (3.5, 5.3) |
95.7 (94.6, 96.5) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs6025 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
2.8 (1.7, 4.4) |
97.2 (95.6, 98.3) |
0.0 (NA) |
5.5 (3.4, 8.8) |
94.5 (91.2, 96.6) |
| 20-39 |
2.2 (1.3, 3.8) |
97.8 (96.2, 98.7) |
0.0 (NA) |
4.4 (2.6, 7.6) |
95.6 (92.4, 97.4) |
| 40-59 |
3.4 (2.6, 4.5) |
96.6 (95.5, 97.4) |
0.0 (NA) |
6.8 (5.1, 9.0) |
93.2 (91.0, 94.9) |
| >=60 |
2.1 (1.3, 3.4) |
97.9 (96.6, 98.7) |
0.1 (0.0, 0.6) |
4.0 (2.4, 6.6) |
95.9 (93.3, 97.5) |
| Non-Hispanic Black |
12-19 |
0.8 (0.3, 2.2) |
99.2 (97.8, 99.7) |
0.0 (NA) |
1.7 (0.7, 4.3) |
98.3 (95.7, 99.3) |
| 20-39 |
0.6 (0.3, 1.2) |
99.4 (98.8, 99.7) |
0.0 (NA) |
1.1 (0.6, 2.3) |
98.9 (97.7, 99.4) |
| 40-59 |
0.8 (0.3, 2.1) |
99.2 (97.9, 99.7) |
0.0 (NA) |
1.6 (0.6, 4.2) |
98.4 (95.8, 99.4) |
| >=60 |
0.1 (0.0, 1.2) |
99.9 (98.8, 100.0) |
0.0 (NA) |
0.3 (0.0, 2.4) |
99.7 (97.6, 100.0) |
| Mexican American |
12-19 |
1.4 (0.5, 3.4) |
98.6 (96.6, 99.5) |
0.0 (NA) |
2.8 (1.1, 6.8) |
97.2 (93.2, 98.9) |
| 20-39 |
0.9 (0.6, 1.5) |
99.1 (98.5, 99.4) |
0.1 (0.0, 0.7) |
1.7 (1.0, 2.8) |
98.2 (97.1, 98.9) |
| 40-59 |
0.9 (0.4, 2.4) |
99.1 (97.6, 99.6) |
0.0 (NA) |
1.9 (0.7, 4.7) |
98.1 (95.3, 99.3) |
| >=60 |
1.0 (0.4, 2.9) |
99.0 (97.1, 99.6) |
0.0 (NA) |
2.1 (0.7, 5.8) |
97.9 (94.2, 99.3) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs6025 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
2.7 (1.8, 3.8) |
97.3 (96.2, 98.2) |
0.0 (0.0, 0.3) |
5.3 (3.6, 7.6) |
94.7 (92.4, 96.3) |
| Female |
2.5 (2.1, 3.1) |
97.5 (96.9, 97.9) |
0.0 (NA) |
5.1 (4.2, 6.1) |
94.9 (93.9, 95.8) |
| Non-Hispanic Black |
Male |
0.6 (0.4, 1.0) |
99.4 (99.0, 99.6) |
0.0 (NA) |
1.2 (0.8, 2.0) |
98.8 (98.0, 99.2) |
| Female |
0.6 (0.3, 1.3) |
99.4 (98.7, 99.7) |
0.0 (NA) |
1.3 (0.6, 2.6) |
98.7 (97.4, 99.4) |
| Mexican American |
Male |
1.3 (0.8, 2.1) |
98.7 (97.9, 99.2) |
0.0 (NA) |
2.6 (1.6, 4.3) |
97.4 (95.7, 98.4) |
| Female |
0.7 (0.4, 1.3) |
99.3 (98.7, 99.6) |
0.1 (0.0, 0.7) |
1.3 (0.7, 2.4) |
98.6 (97.6, 99.2) |
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