FAM82A* Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs163086
|
IVS10-1363C>T
|
|
TaqMan
|
* FAM82A is a hypothetical protein that lies immediately 5′ of CYP1B1. This variant may be an intronic polymorphism of FAM82A or a CYP1B1 variant that lies 3’ of the gene
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs163086 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
77.2 (75.5, 78.8) |
22.8 (21.2, 24.5) |
<0.001 |
59.8 (57.0, 62.6) |
34.7 (32.0, 37.5) |
5.5 (4.3, 6.9) |
<0.001 |
0.73 |
| Non-Hispanic Black |
80.9 (79.0, 82.6) |
19.1 (17.4, 21.0) |
65.0 (62.1, 67.8) |
31.7 (29.3, 34.2) |
3.3 (2.3, 4.6) |
0.18 |
| Mexican American |
85.5 (83.7, 87.0) |
14.5 (13.0, 16.3) |
73.4 (70.6, 76.0) |
24.1 (21.9, 26.4) |
2.5 (1.8, 3.4) |
0.18 |
| Total* |
78.7 (77.4, 80.0) |
21.3 (20.0, 22.6) |
|
62.3 (60.2, 64.2) |
32.9 (31.2, 34.8) |
4.8 (3.9, 5.9) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs163086 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
74.7 (70.2, 78.6) |
25.3 (21.4, 29.8) |
0.035 |
56.0 (49.7, 62.2) |
37.2 (32.6, 42.0) |
6.7 (4.5, 9.9) |
0.036 |
| 20-39 |
78.7 (76.9, 80.5) |
21.3 (19.5, 23.1) |
62.4 (59.2, 65.5) |
32.6 (29.6, 35.8) |
5.0 (3.9, 6.3) |
| 40-59 |
79.1 (76.3, 81.6) |
20.9 (18.4, 23.7) |
62.6 (58.4, 66.6) |
33.0 (29.6, 36.5) |
4.5 (3.0, 6.6) |
| >=60 |
81.1 (79.3, 82.9) |
18.9 (17.1, 20.7) |
|
65.9 (63.0, 68.7) |
30.4 (27.7, 33.2) |
3.7 (2.5, 5.4) |
| Total |
78.7 (77.4, 80.0) |
21.3 (20.0, 22.6) |
|
62.3 (60.2, 64.2) |
32.9 (31.2, 34.8) |
4.8 (3.9, 5.9) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs163086 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
78.5 (76.4, 80.5) |
21.5 (19.5, 23.6) |
0.826 |
61.6 (58.4, 64.8) |
33.8 (30.8, 36.9) |
4.6 (3.1, 6.6) |
0.615 |
| Female |
78.9 (76.9, 80.8) |
21.1 (19.2, 23.1) |
62.8 (60.1, 65.5) |
32.1 (30.1, 34.3) |
5.1 (3.7, 6.9) |
| Total |
78.7 (77.4, 80.0) |
21.3 (20.0, 22.6) |
|
62.3 (60.2, 64.2) |
32.9 (31.2, 34.8) |
4.8 (3.9, 5.9) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs163086 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
72.1 (65.7, 77.6) |
27.9 (22.4, 34.3) |
53.3 (44.5, 61.9) |
37.6 (31.3, 44.3) |
9.2 (5.9, 14.0) |
| 20-39 |
76.8 (73.9, 79.5) |
23.2 (20.5, 26.1) |
59.3 (54.5, 63.9) |
35.1 (30.6, 39.8) |
5.6 (3.9, 8.0) |
| 40-59 |
77.5 (74.0, 80.6) |
22.5 (19.4, 26.0) |
59.7 (54.2, 65.0) |
35.5 (30.7, 40.6) |
4.8 (3.0, 7.4) |
| >=60 |
80.3 (78.0, 82.4) |
19.7 (17.6, 22.0) |
64.6 (61.2, 67.8) |
31.4 (28.6, 34.4) |
4.0 (2.6, 6.1) |
| Non-Hispanic Black |
12-19 |
78.5 (75.0, 81.6) |
21.5 (18.4, 25.0) |
60.7 (54.9, 66.3) |
35.4 (30.2, 41.1) |
3.8 (2.2, 6.6) |
| 20-39 |
81.3 (78.5, 83.8) |
18.7 (16.2, 21.5) |
65.5 (60.8, 69.9) |
31.6 (27.3, 36.2) |
2.9 (1.6, 5.3) |
| 40-59 |
80.7 (78.7, 82.7) |
19.3 (17.3, 21.3) |
65.6 (62.7, 68.3) |
30.3 (27.3, 33.6) |
4.1 (2.4, 7.0) |
| >=60 |
83.1 (79.5, 86.2) |
16.9 (13.8, 20.5) |
68.3 (61.2, 74.6) |
29.7 (22.9, 37.4) |
2.1 (0.8, 5.5) |
| Mexican American |
12-19 |
86.3 (82.7, 89.4) |
13.7 (10.6, 17.3) |
74.6 (68.1, 80.1) |
23.5 (18.4, 29.5) |
1.9 (1.0, 3.5) |
| 20-39 |
85.0 (83.2, 86.7) |
15.0 (13.3, 16.8) |
73.1 (70.3, 75.7) |
23.9 (21.7, 26.3) |
3.0 (2.0, 4.4) |
| 40-59 |
86.0 (84.1, 87.7) |
14.0 (12.3, 15.9) |
74.0 (69.4, 78.1) |
24.0 (19.1, 29.6) |
2.0 (1.1, 3.6) |
| >=60 |
84.5 (79.8, 88.3) |
15.5 (11.7, 20.2) |
71.3 (63.4, 78.1) |
26.5 (20.5, 33.5) |
2.2 (1.2, 4.3) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs163086 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
76.8 (74.3, 79.2) |
23.2 (20.8, 25.7) |
58.8 (54.7, 62.8) |
36.0 (32.1, 40.2) |
5.1 (3.5, 7.5) |
| Female |
77.5 (74.9, 79.9) |
22.5 (20.1, 25.1) |
60.8 (57.3, 64.1) |
33.5 (30.8, 36.2) |
5.7 (3.9, 8.4) |
| Non-Hispanic Black |
Male |
80.5 (78.3, 82.5) |
19.5 (17.5, 21.7) |
64.5 (61.0, 67.8) |
32.0 (29.0, 35.2) |
3.5 (2.3, 5.3) |
| Female |
81.2 (78.4, 83.7) |
18.8 (16.3, 21.6) |
65.5 (61.0, 69.7) |
31.4 (27.9, 35.3) |
3.1 (2.0, 4.7) |
| Mexican American |
Male |
84.9 (82.0, 87.4) |
15.1 (12.6, 18.0) |
72.2 (67.1, 76.8) |
25.3 (21.1, 30.0) |
2.5 (1.9, 3.2) |
| Female |
86.1 (84.6, 87.4) |
13.9 (12.6, 15.4) |
74.7 (71.9, 77.3) |
22.8 (19.9, 25.9) |
2.5 (1.6, 4.0) |
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