FCGR2A Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1801274
|
Ex4-120A>G
|
His166Arg
His167Arg
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1801274 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
49.4 (47.6, 51.1) |
50.6 (48.9, 52.4) |
0.096 |
24.9 (23.0, 26.9) |
48.9 (46.8, 51.1) |
26.2 (24.1, 28.4) |
0.127 |
0.06 |
| Non-Hispanic Black |
47.4 (45.8, 49.0) |
52.6 (51.0, 54.2) |
21.8 (20.2, 23.5) |
51.3 (49.5, 53.1) |
26.9 (25.0, 29.0) |
0.32 |
| Mexican American |
48.6 (47.1, 50.1) |
51.4 (49.9, 52.9) |
23.7 (22.1, 25.4) |
49.8 (47.1, 52.5) |
26.5 (24.3, 28.8) |
0.50 |
| Total* |
50.0 (48.5, 51.6) |
50.0 (48.4, 51.5) |
|
25.6 (23.9, 27.3) |
48.9 (47.4, 50.5) |
25.5 (23.8, 27.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801274 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
52.3 (48.3, 56.4) |
47.7 (43.6, 51.7) |
0.161 |
26.6 (22.2, 31.6) |
51.4 (47.4, 55.3) |
22.0 (18.0, 26.6) |
0.014 |
| 20-39 |
48.6 (46.6, 50.6) |
51.4 (49.4, 53.4) |
24.0 (22.0, 26.2) |
49.2 (45.7, 52.6) |
26.8 (23.9, 30.0) |
| 40-59 |
51.5 (48.5, 54.5) |
48.5 (45.5, 51.5) |
26.5 (23.0, 30.3) |
50.0 (45.8, 54.2) |
23.5 (20.1, 27.4) |
| >=60 |
49.2 (46.8, 51.7) |
50.8 (48.3, 53.2) |
26.7 (24.4, 29.1) |
45.1 (42.5, 47.8) |
28.2 (25.1, 31.5) |
| Total |
50.0 (48.5, 51.6) |
50.0 (48.4, 51.5) |
|
25.6 (23.9, 27.3) |
48.9 (47.4, 50.5) |
25.5 (23.8, 27.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801274 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
49.0 (46.4, 51.6) |
51.0 (48.4, 53.6) |
0.248 |
25.1 (22.4, 28.0) |
47.9 (45.0, 50.9) |
27.0 (24.0, 30.3) |
0.395 |
| Female |
51.0 (48.9, 53.0) |
49.0 (47.0, 51.1) |
26.1 (23.7, 28.5) |
49.8 (47.7, 52.0) |
24.1 (22.0, 26.4) |
| Total |
50.0 (48.5, 51.6) |
50.0 (48.4, 51.5) |
|
25.6 (23.9, 27.3) |
48.9 (47.4, 50.5) |
25.5 (23.8, 27.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801274 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
52.4 (46.9, 57.9) |
47.6 (42.1, 53.1) |
26.4 (20.4, 33.4) |
52.1 (46.4, 57.8) |
21.5 (16.2, 27.9) |
| 20-39 |
47.6 (45.0, 50.1) |
52.4 (49.9, 55.0) |
23.3 (20.8, 26.1) |
48.4 (43.6, 53.3) |
28.2 (24.2, 32.6) |
| 40-59 |
51.4 (48.0, 54.8) |
48.6 (45.2, 52.0) |
25.8 (22.0, 29.8) |
51.3 (46.9, 55.7) |
22.9 (18.9, 27.5) |
| >=60 |
48.1 (44.9, 51.2) |
51.9 (48.8, 55.1) |
25.7 (22.8, 28.8) |
44.8 (41.8, 47.8) |
29.6 (25.8, 33.6) |
| Non-Hispanic Black |
12-19 |
50.2 (46.0, 54.5) |
49.8 (45.5, 54.0) |
25.1 (20.0, 30.9) |
50.3 (45.5, 55.2) |
24.6 (20.5, 29.2) |
| 20-39 |
46.9 (44.1, 49.6) |
53.1 (50.4, 55.9) |
20.1 (17.5, 23.0) |
53.5 (49.0, 57.9) |
26.4 (22.4, 30.8) |
| 40-59 |
45.8 (42.5, 49.0) |
54.2 (51.0, 57.5) |
21.5 (18.5, 25.0) |
48.4 (42.8, 54.1) |
30.0 (25.1, 35.4) |
| >=60 |
48.4 (43.5, 53.4) |
51.6 (46.6, 56.5) |
22.9 (18.0, 28.7) |
51.0 (46.2, 55.7) |
26.1 (20.8, 32.1) |
| Mexican American |
12-19 |
53.3 (51.0, 55.7) |
46.7 (44.3, 49.0) |
29.8 (27.0, 32.7) |
47.1 (42.8, 51.5) |
23.1 (19.7, 26.9) |
| 20-39 |
47.6 (45.9, 49.4) |
52.4 (50.6, 54.1) |
23.1 (20.3, 26.1) |
49.1 (44.6, 53.5) |
27.9 (25.2, 30.7) |
| 40-59 |
47.5 (43.5, 51.6) |
52.5 (48.4, 56.5) |
21.9 (17.1, 27.5) |
51.3 (45.8, 56.9) |
26.8 (22.5, 31.6) |
| >=60 |
45.8 (39.8, 51.9) |
54.2 (48.1, 60.2) |
17.6 (13.2, 23.0) |
56.5 (50.0, 62.8) |
26.0 (18.5, 35.2) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801274 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
48.1 (44.9, 51.3) |
51.9 (48.7, 55.1) |
24.1 (20.7, 27.8) |
47.9 (44.4, 51.5) |
28.0 (24.3, 32.0) |
| Female |
50.6 (48.5, 52.8) |
49.4 (47.2, 51.5) |
25.7 (23.3, 28.3) |
49.8 (47.1, 52.6) |
24.5 (21.9, 27.2) |
| Non-Hispanic Black |
Male |
46.8 (44.4, 49.2) |
53.2 (50.8, 55.6) |
21.6 (19.3, 24.1) |
50.3 (47.1, 53.6) |
28.0 (24.8, 31.5) |
| Female |
48.0 (45.9, 50.0) |
52.0 (50.0, 54.1) |
21.9 (19.2, 24.8) |
52.1 (49.2, 55.0) |
26.0 (23.8, 28.3) |
| Mexican American |
Male |
48.9 (46.7, 51.1) |
51.1 (48.9, 53.3) |
24.0 (21.5, 26.7) |
49.8 (45.8, 53.7) |
26.2 (23.1, 29.6) |
| Female |
48.3 (45.6, 51.0) |
51.7 (49.0, 54.4) |
23.4 (21.0, 25.9) |
49.8 (46.5, 53.1) |
26.8 (23.2, 30.7) |
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