FGB Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1800790
|
-462G>A
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1800790 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
19.4 (18.1, 20.7) |
80.6 (79.3, 81.9) |
<0.001 |
3.4 (2.6, 4.5) |
31.9 (30.1, 33.8) |
64.6 (62.6, 66.6) |
<0.001 |
0.81 |
| Non-Hispanic Black |
5.5 (4.6, 6.6) |
94.5 (93.4, 95.4) |
0.6 (0.3, 1.3) |
9.8 (8.0, 11.9) |
89.6 (87.5, 91.3) |
0.01 |
| Mexican American |
15.0 (13.5, 16.6) |
85.0 (83.4, 86.5) |
2.5 (2.0, 3.1) |
24.9 (22.3, 27.8) |
72.6 (69.6, 75.4) |
0.82 |
| Total* |
17.6 (16.2, 19.1) |
82.4 (80.9, 83.8) |
|
3.3 (2.4, 4.4) |
28.7 (26.8, 30.7) |
68.0 (65.7, 70.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800790 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
17.0 (13.8, 20.8) |
83.0 (79.2, 86.2) |
0.357 |
3.3 (1.8, 5.9) |
27.5 (22.3, 33.4) |
69.2 (62.9, 74.9) |
0.163 |
| 20-39 |
18.3 (16.3, 20.5) |
81.7 (79.5, 83.7) |
3.0 (2.0, 4.5) |
30.6 (28.0, 33.3) |
66.4 (63.1, 69.6) |
| 40-59 |
16.4 (14.2, 18.8) |
83.6 (81.2, 85.8) |
3.1 (2.1, 4.5) |
26.6 (22.4, 31.3) |
70.3 (65.8, 74.5) |
| >=60 |
18.5 (17.1, 20.0) |
81.5 (80.0, 82.9) |
4.0 (2.8, 5.7) |
29.0 (26.7, 31.3) |
67.0 (64.7, 69.2) |
| Total |
17.6 (16.2, 19.1) |
82.4 (80.9, 83.8) |
|
3.3 (2.4, 4.4) |
28.7 (26.8, 30.7) |
68.0 (65.7, 70.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800790 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
18.0 (16.4, 19.8) |
82.0 (80.2, 83.6) |
0.447 |
3.4 (2.4, 4.8) |
29.3 (26.7, 32.1) |
67.3 (64.4, 70.1) |
0.709 |
| Female |
17.3 (15.5, 19.2) |
82.7 (80.8, 84.5) |
3.2 (2.1, 4.8) |
28.2 (26.1, 30.4) |
68.6 (65.9, 71.3) |
| Total |
17.6 (16.2, 19.1) |
82.4 (80.9, 83.8) |
|
3.3 (2.4, 4.4) |
28.7 (26.8, 30.7) |
68.0 (65.7, 70.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800790 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
20.4 (15.7, 26.1) |
79.6 (73.9, 84.3) |
3.9 (1.9, 7.8) |
33.0 (25.4, 41.6) |
63.1 (53.8, 71.6) |
| 20-39 |
19.9 (18.2, 21.8) |
80.1 (78.2, 81.8) |
2.8 (2.0, 4.1) |
34.2 (31.4, 37.0) |
63.0 (59.8, 66.0) |
| 40-59 |
18.0 (15.7, 20.5) |
82.0 (79.5, 84.3) |
3.3 (2.2, 5.0) |
29.4 (25.2, 34.0) |
67.3 (62.8, 71.5) |
| >=60 |
19.8 (18.3, 21.3) |
80.2 (78.7, 81.7) |
4.3 (2.9, 6.2) |
31.0 (28.6, 33.5) |
64.7 (62.4, 66.9) |
| Non-Hispanic Black |
12-19 |
6.4 (4.6, 8.9) |
93.6 (91.1, 95.4) |
0.4 (0.1, 1.8) |
12.1 (8.5, 16.9) |
87.5 (82.7, 91.2) |
| 20-39 |
5.5 (4.3, 7.0) |
94.5 (93.0, 95.7) |
0.6 (0.2, 1.6) |
9.9 (7.6, 12.7) |
89.6 (86.8, 91.8) |
| 40-59 |
5.7 (4.2, 7.8) |
94.3 (92.2, 95.8) |
0.9 (0.3, 3.0) |
9.7 (7.2, 12.9) |
89.4 (86.1, 92.0) |
| >=60 |
4.1 (2.8, 5.9) |
95.9 (94.1, 97.2) |
0.6 (0.1, 3.0) |
6.9 (4.4, 10.5) |
92.5 (89.1, 94.9) |
| Mexican American |
12-19 |
15.8 (13.2, 18.7) |
84.2 (81.3, 86.8) |
3.5 (1.8, 6.7) |
24.7 (19.4, 30.8) |
71.9 (66.5, 76.7) |
| 20-39 |
15.6 (12.9, 18.6) |
84.4 (81.4, 87.1) |
2.4 (1.4, 3.8) |
26.4 (21.3, 32.3) |
71.2 (65.4, 76.4) |
| 40-59 |
13.3 (11.6, 15.1) |
86.7 (84.9, 88.4) |
2.5 (1.0, 5.7) |
21.6 (19.4, 24.1) |
75.9 (73.7, 78.0) |
| >=60 |
13.6 (11.0, 16.6) |
86.4 (83.4, 89.0) |
1.0 (0.3, 3.5) |
25.1 (21.0, 29.6) |
73.9 (68.8, 78.4) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800790 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
19.5 (17.8, 21.3) |
80.5 (78.7, 82.2) |
3.2 (2.4, 4.3) |
32.5 (29.7, 35.5) |
64.3 (61.2, 67.2) |
| Female |
19.3 (17.5, 21.2) |
80.7 (78.8, 82.5) |
3.6 (2.3, 5.7) |
31.4 (29.4, 33.5) |
65.0 (62.5, 67.4) |
| Non-Hispanic Black |
Male |
5.7 (4.7, 6.9) |
94.3 (93.1, 95.3) |
0.6 (0.2, 2.0) |
10.3 (8.4, 12.7) |
89.1 (86.9, 91.0) |
| Female |
5.4 (4.0, 7.1) |
94.6 (92.9, 96.0) |
0.7 (0.3, 1.6) |
9.4 (6.9, 12.7) |
89.9 (86.6, 92.5) |
| Mexican American |
Male |
15.5 (14.0, 17.1) |
84.5 (82.9, 86.0) |
2.7 (2.0, 3.8) |
25.5 (23.4, 27.7) |
71.7 (69.1, 74.2) |
| Female |
14.4 (12.5, 16.4) |
85.6 (83.6, 87.5) |
2.2 (1.5, 3.4) |
24.3 (20.6, 28.4) |
73.5 (69.5, 77.1) |
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