IL10 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1800871
|
-853C>T
-819C>T
|
|
TaqMan
|
|
rs1800872
|
-626C>A
-592C>A
|
|
TaqMan
|
|
rs1800896
|
-1116A>G
-1082A>G
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1800871 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
75.8 (73.8, 77.7) |
24.2 (22.3, 26.2) |
<0.001 |
58.4 (55.6, 61.1) |
34.9 (32.4, 37.5) |
6.7 (5.1, 8.9) |
<0.001 |
0.06 |
| Non-Hispanic Black |
60.4 (58.5, 62.2) |
39.6 (37.8, 41.5) |
36.3 (33.5, 39.3) |
48.1 (45.3, 50.9) |
15.6 (14.0, 17.2) |
0.66 |
| Mexican American |
61.9 (58.4, 65.3) |
38.1 (34.7, 41.6) |
39.2 (35.2, 43.4) |
45.4 (43.2, 47.6) |
15.4 (12.5, 18.8) |
0.02 |
| Total* |
71.0 (69.1, 72.9) |
29.0 (27.1, 30.9) |
|
52.2 (49.5, 54.8) |
37.7 (35.3, 40.3) |
10.1 (8.4, 12.0) |
|
|
| rs1800872 |
|
A |
G |
|
AA |
AC |
CC |
|
|
| Non-Hispanic White |
24.3 (22.4, 26.4) |
75.7 (73.6, 77.6) |
<0.001 |
6.9 (5.1, 9.2) |
35.0 (32.3, 37.7) |
58.2 (55.4, 60.9) |
<0.001 |
0.06 |
| Non-Hispanic Black |
39.3 (37.4, 41.2) |
60.7 (58.8, 62.6) |
15.0 (13.4, 16.8) |
48.5 (45.4, 51.6) |
36.5 (33.5, 39.5) |
0.98 |
| Mexican American |
37.9 (34.6, 41.4) |
62.1 (58.6, 65.4) |
15.1 (12.3, 18.5) |
45.6 (43.0, 48.3) |
39.3 (35.2, 43.4) |
0.03 |
| Total* |
29.0 (27.1, 31.0) |
71.0 (69.0, 72.9) |
|
10.1 (8.4, 12.1) |
37.9 (35.3, 40.5) |
52.1 (49.4, 54.8) |
|
|
| rs1800896 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
53.1 (50.7, 55.5) |
46.9 (44.5, 49.3) |
<0.001 |
28.6 (25.6, 31.8) |
49.0 (46.4, 51.6) |
22.4 (20.1, 24.8) |
<0.001 |
0.89 |
| Non-Hispanic Black |
64.4 (62.5, 66.2) |
35.6 (33.8, 37.5) |
40.6 (37.4, 43.8) |
47.6 (44.3, 50.9) |
11.8 (10.4, 13.4) |
0.35 |
| Mexican American |
69.5 (66.7, 72.2) |
30.5 (27.8, 33.3) |
48.7 (43.9, 53.4) |
41.7 (37.0, 46.5) |
9.6 (7.8, 11.8) |
0.36 |
| Total* |
57.7 (56.0, 59.4) |
42.3 (40.6, 44.0) |
|
34.4 (32.3, 36.6) |
46.6 (44.3, 48.9) |
19.0 (17.2, 20.9) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800871 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
69.4 (63.9, 74.4) |
30.6 (25.6, 36.1) |
0.164 |
53.1 (45.9, 60.1) |
32.7 (27.2, 38.7) |
14.2 (10.3, 19.3) |
0.081 |
| 20-39 |
69.6 (66.8, 72.4) |
30.4 (27.6, 33.2) |
|
49.9 (45.8, 54.1) |
39.4 (35.1, 43.9) |
10.7 (8.1, 13.9) |
|
| 40-59 |
73.3 (70.5, 75.8) |
26.7 (24.2, 29.5) |
|
54.2 (49.8, 58.6) |
38.1 (34.2, 42.1) |
7.7 (6.3, 9.4) |
|
| >=60 |
71.9 (69.2, 74.4) |
28.1 (25.6, 30.8) |
|
53.1 (49.5, 56.8) |
37.5 (34.4, 40.8) |
9.3 (7.3, 11.8) |
|
| Total |
71.0 (69.1, 72.9) |
29.0 (27.1, 30.9) |
|
52.2 (49.5, 54.8) |
37.7 (35.3, 40.3) |
10.1 (8.4, 12.0) |
|
| rs1800872 |
|
A |
C |
|
AA |
AC |
CC |
|
| 12-19 |
30.7 (25.7, 36.2) |
69.3 (63.8, 74.3) |
0.182 |
14.2 (10.4, 19.2) |
32.9 (27.5, 38.9) |
52.8 (45.6, 59.9) |
0.074 |
| 20-39 |
30.4 (27.6, 33.4) |
69.6 (66.6, 72.4) |
|
10.7 (8.1, 14.0) |
39.5 (35.1, 44.0) |
49.8 (45.6, 54.1) |
|
| 40-59 |
27.0 (24.3, 29.8) |
73.0 (70.2, 75.7) |
|
7.9 (6.4, 9.7) |
38.1 (34.5, 42.0) |
54.0 (49.5, 58.4) |
|
| >=60 |
27.9 (25.4, 30.4) |
72.1 (69.6, 74.6) |
|
9.0 (7.0, 11.4) |
37.8 (34.2, 41.4) |
53.3 (49.5, 57.0) |
|
| Total |
29.0 (27.1, 31.0) |
71.0 (69.0, 72.9) |
|
10.1 (8.4, 12.1) |
37.9 (35.3, 40.5) |
52.1 (49.4, 54.8) |
|
| rs1800896 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
58.0 (54.2, 61.7) |
42.0 (38.3, 45.8) |
0.127 |
35.8 (30.5, 41.5) |
44.4 (38.8, 50.1) |
19.8 (16.4, 23.7) |
0.188 |
| 20-39 |
59.5 (57.0, 62.0) |
40.5 (38.0, 43.0) |
|
37.3 (33.8, 40.8) |
44.5 (40.8, 48.3) |
18.2 (15.6, 21.1) |
|
| 40-59 |
55.8 (52.6, 58.9) |
44.2 (41.1, 47.4) |
|
31.8 (27.5, 36.3) |
48.0 (43.2, 52.9) |
20.2 (16.8, 24.0) |
|
| >=60 |
56.6 (54.2, 59.0) |
43.4 (41.0, 45.8) |
|
31.5 (28.2, 34.9) |
50.3 (46.9, 53.6) |
18.3 (16.0, 20.8) |
|
| Total |
57.7 (56.0, 59.4) |
42.3 (40.6, 44.0) |
|
34.4 (32.3, 36.6) |
46.6 (44.3, 48.9) |
19.0 (17.2, 20.9) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800871 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
71.4 (68.7, 74.0) |
28.6 (26.0, 31.3) |
0.574 |
52.7 (49.0, 56.5) |
37.3 (34.4, 40.3) |
10.0 (8.0, 12.3) |
0.839 |
| Female |
70.7 (68.9, 72.5) |
29.3 (27.5, 31.1) |
|
51.6 (48.7, 54.5) |
38.2 (34.7, 41.8) |
10.2 (8.3, 12.5) |
|
| Total |
71.0 (69.1, 72.9) |
29.0 (27.1, 30.9) |
|
52.2 (49.5, 54.8) |
37.7 (35.3, 40.3) |
10.1 (8.4, 12.0) |
|
| rs1800872 |
|
A |
C |
|
AA |
AC |
CC |
|
| Male |
28.7 (26.1, 31.5) |
71.3 (68.5, 73.9) |
0.647 |
9.9 (7.9, 12.4) |
37.6 (34.6, 40.7) |
52.5 (48.7, 56.2) |
0.898 |
| Female |
29.3 (27.5, 31.1) |
70.7 (68.9, 72.5) |
|
10.2 (8.2, 12.6) |
38.2 (34.5, 41.9) |
51.7 (48.7, 54.7) |
|
| Total |
29.0 (27.1, 31.0) |
71.0 (69.0, 72.9) |
|
10.1 (8.4, 12.1) |
37.9 (35.3, 40.5) |
52.1 (49.4, 54.8) |
|
| rs1800896 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
58.2 (56.2, 60.2) |
41.8 (39.8, 43.8) |
0.353 |
34.8 (31.6, 38.1) |
46.8 (43.2, 50.5) |
18.4 (16.3, 20.6) |
0.573 |
| Female |
57.2 (55.3, 59.1) |
42.8 (40.9, 44.7) |
|
34.0 (31.5, 36.6) |
46.4 (43.3, 49.6) |
19.5 (17.2, 22.1) |
|
| Total |
57.7 (56.0, 59.4) |
42.3 (40.6, 44.0) |
|
34.4 (32.3, 36.6) |
46.6 (44.3, 48.9) |
19.0 (17.2, 20.9) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800871 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
76.1 (70.1, 81.3) |
23.9 (18.7, 29.9) |
62.3 (53.3, 70.5) |
27.7 (20.6, 36.0) |
10.0 (6.6, 14.9) |
| 20-39 |
74.3 (71.4, 77.0) |
25.7 (23.0, 28.6) |
56.1 (51.8, 60.3) |
36.4 (31.1, 42.0) |
7.5 (4.7, 11.8) |
| 40-59 |
78.2 (74.7, 81.2) |
21.8 (18.8, 25.3) |
60.5 (54.9, 65.8) |
35.4 (30.7, 40.3) |
4.2 (2.7, 6.3) |
| >=60 |
75.2 (72.2, 77.9) |
24.8 (22.1, 27.8) |
57.4 (53.2, 61.4) |
35.7 (32.1, 39.4) |
7.0 (4.9, 9.9) |
| Non-Hispanic Black |
12-19 |
60.6 (56.4, 64.6) |
39.4 (35.4, 43.6) |
37.7 (33.2, 42.4) |
45.8 (42.2, 49.4) |
16.5 (12.6, 21.3) |
| 20-39 |
61.2 (58.9, 63.5) |
38.8 (36.5, 41.1) |
37.0 (34.3, 39.7) |
48.6 (45.8, 51.4) |
14.5 (11.9, 17.5) |
| 40-59 |
59.1 (55.6, 62.6) |
40.9 (37.4, 44.4) |
35.4 (29.9, 41.2) |
47.5 (41.4, 53.6) |
17.2 (14.0, 20.8) |
| >=60 |
59.8 (55.4, 64.0) |
40.2 (36.0, 44.6) |
34.4 (27.1, 42.4) |
50.8 (42.1, 59.6) |
14.8 (11.1, 19.5) |
| Mexican American |
12-19 |
62.1 (58.8, 65.3) |
37.9 (34.7, 41.2) |
39.0 (34.2, 44.1) |
46.1 (38.0, 54.5) |
14.8 (10.1, 21.3) |
| 20-39 |
62.9 (58.1, 67.5) |
37.1 (32.5, 41.9) |
41.2 (35.2, 47.5) |
43.4 (40.0, 47.0) |
15.3 (12.1, 19.3) |
| 40-59 |
59.5 (54.8, 64.0) |
40.5 (36.0, 45.2) |
35.3 (30.3, 40.7) |
48.3 (44.8, 51.7) |
16.4 (12.3, 21.5) |
| >=60 |
61.5 (58.4, 64.5) |
38.5 (35.5, 41.6) |
37.5 (31.2, 44.3) |
48.0 (38.7, 57.3) |
14.5 (10.6, 19.6) |
| rs1800872 |
|
|
A |
C |
AA |
AC |
CC |
| Non-Hispanic White |
12-19 |
24.1 (18.9, 30.1) |
75.9 (69.9, 81.1) |
10.1 (6.7, 14.9) |
28.0 (21.0, 36.3) |
61.9 (52.9, 70.2) |
| 20-39 |
25.9 (23.0, 28.9) |
74.1 (71.1, 77.0) |
7.6 (4.8, 12.0) |
36.4 (31.1, 42.0) |
55.9 (51.5, 60.3) |
| 40-59 |
22.2 (19.0, 25.9) |
77.8 (74.1, 81.0) |
4.5 (3.0, 6.8) |
35.4 (31.0, 40.1) |
60.1 (54.5, 65.5) |
| >=60 |
24.8 (22.2, 27.6) |
75.2 (72.4, 77.8) |
6.9 (4.8, 9.9) |
35.7 (31.7, 40.0) |
57.3 (53.2, 61.4) |
| Non-Hispanic Black |
12-19 |
39.3 (35.6, 43.1) |
60.7 (56.9, 64.4) |
16.6 (13.2, 20.7) |
45.5 (41.7, 49.2) |
38.0 (33.5, 42.7) |
| 20-39 |
38.4 (36.2, 40.7) |
61.6 (59.3, 63.8) |
14.0 (11.5, 16.8) |
48.9 (46.1, 51.8) |
37.1 (34.5, 39.8) |
| 40-59 |
40.6 (36.9, 44.5) |
59.4 (55.5, 63.1) |
16.6 (12.7, 21.2) |
48.1 (41.7, 54.6) |
35.3 (29.9, 41.2) |
| >=60 |
39.6 (35.3, 44.0) |
60.4 (56.0, 64.7) |
13.6 (9.8, 18.7) |
51.9 (42.6, 61.1) |
34.5 (27.1, 42.7) |
| Mexican American |
12-19 |
37.6 (34.4, 40.9) |
62.4 (59.1, 65.6) |
14.2 (9.7, 20.3) |
46.7 (39.0, 54.5) |
39.1 (34.3, 44.1) |
| 20-39 |
36.9 (32.4, 41.6) |
63.1 (58.4, 67.6) |
15.1 (11.9, 19.0) |
43.5 (39.9, 47.2) |
41.4 (35.5, 47.5) |
| 40-59 |
40.6 (36.1, 45.1) |
59.4 (54.9, 63.9) |
16.3 (12.4, 21.1) |
48.5 (44.9, 52.0) |
35.2 (30.1, 40.7) |
| >=60 |
38.4 (35.3, 41.5) |
61.6 (58.5, 64.7) |
14.1 (10.2, 19.2) |
48.6 (39.7, 57.5) |
37.3 (31.3, 43.8) |
| rs1800896 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
52.9 (46.6, 59.0) |
47.1 (41.0, 53.4) |
29.2 (21.9, 37.7) |
47.4 (40.1, 54.8) |
23.4 (17.6, 30.5) |
| 20-39 |
54.2 (51.8, 56.6) |
45.8 (43.4, 48.2) |
30.9 (27.7, 34.4) |
46.5 (41.9, 51.1) |
22.5 (19.4, 26.0) |
| 40-59 |
51.6 (47.5, 55.7) |
48.4 (44.3, 52.5) |
26.4 (21.6, 31.9) |
50.4 (45.5, 55.2) |
23.2 (19.1, 27.9) |
| >=60 |
53.4 (50.6, 56.2) |
46.6 (43.8, 49.4) |
27.3 (23.6, 31.3) |
52.3 (48.6, 55.9) |
20.4 (17.8, 23.4) |
| Non-Hispanic Black |
12-19 |
63.3 (59.2, 67.3) |
36.7 (32.7, 40.8) |
40.2 (34.6, 46.2) |
46.1 (40.7, 51.5) |
13.7 (10.3, 17.8) |
| 20-39 |
64.9 (60.8, 68.8) |
35.1 (31.2, 39.2) |
40.5 (34.0, 47.5) |
48.7 (42.8, 54.6) |
10.8 (9.0, 12.8) |
| 40-59 |
64.0 (59.6, 68.2) |
36.0 (31.8, 40.4) |
40.3 (35.0, 45.8) |
47.3 (43.4, 51.3) |
12.3 (8.9, 16.8) |
| >=60 |
64.8 (60.8, 68.7) |
35.2 (31.3, 39.2) |
41.5 (34.7, 48.7) |
46.6 (39.2, 54.2) |
11.8 (8.9, 15.6) |
| Mexican American |
12-19 |
68.1 (64.6, 71.4) |
31.9 (28.6, 35.4) |
46.7 (40.3, 53.3) |
42.8 (35.1, 50.9) |
10.5 (7.4, 14.5) |
| 20-39 |
69.4 (66.5, 72.2) |
30.6 (27.8, 33.5) |
48.2 (43.3, 53.1) |
42.5 (37.1, 48.1) |
9.4 (7.0, 12.4) |
| 40-59 |
70.9 (63.6, 77.3) |
29.1 (22.7, 36.4) |
51.5 (41.2, 61.7) |
38.8 (30.4, 48.0) |
9.7 (5.7, 16.0) |
| >=60 |
69.9 (65.0, 74.4) |
30.1 (25.6, 35.0) |
49.1 (41.4, 56.8) |
41.7 (34.4, 49.4) |
9.2 (6.3, 13.4) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800871 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
76.0 (73.0, 78.8) |
24.0 (21.2, 27.0) |
58.9 (54.4, 63.3) |
34.1 (30.4, 38.1) |
6.9 (5.1, 9.3) |
| Female |
75.7 (73.5, 77.7) |
24.3 (22.3, 26.5) |
57.9 (55.2, 60.5) |
35.6 (32.6, 38.6) |
6.6 (4.5, 9.4) |
| Non-Hispanic Black |
Male |
60.3 (57.6, 63.0) |
39.7 (37.0, 42.4) |
35.7 (31.6, 40.1) |
49.1 (44.7, 53.5) |
15.1 (12.8, 17.8) |
| Female |
60.4 (57.9, 62.9) |
39.6 (37.1, 42.1) |
36.8 (33.3, 40.5) |
47.3 (43.8, 50.7) |
15.9 (13.7, 18.5) |
| Mexican American |
Male |
62.1 (57.9, 66.1) |
37.9 (33.9, 42.1) |
38.6 (34.5, 42.9) |
46.9 (44.6, 49.3) |
14.5 (10.6, 19.4) |
| Female |
61.7 (58.4, 64.9) |
38.3 (35.1, 41.6) |
39.8 (35.4, 44.5) |
43.8 (40.3, 47.3) |
16.4 (14.0, 19.0) |
| rs1800872 |
|
|
A |
C |
AA |
AC |
CC |
| Non-Hispanic White |
Male |
24.2 (21.5, 27.3) |
75.8 (72.7, 78.5) |
7.1 (5.1, 9.6) |
34.4 (30.6, 38.4) |
58.6 (54.1, 62.9) |
| Female |
24.4 (22.5, 26.5) |
75.6 (73.5, 77.5) |
6.7 (4.6, 9.6) |
35.5 (32.4, 38.7) |
57.8 (55.1, 60.5) |
| Non-Hispanic Black |
Male |
39.3 (36.8, 41.9) |
60.7 (58.1, 63.2) |
14.3 (12.1, 17.0) |
49.9 (45.2, 54.6) |
35.7 (31.6, 40.1) |
| Female |
39.3 (36.8, 41.8) |
60.7 (58.2, 63.2) |
15.6 (13.4, 18.1) |
47.3 (43.6, 51.1) |
37.1 (33.5, 40.8) |
| Mexican American |
Male |
37.8 (33.8, 41.9) |
62.2 (58.1, 66.2) |
14.1 (10.4, 18.9) |
47.3 (44.6, 50.1) |
38.5 (34.2, 43.0) |
| Female |
38.1 (35.0, 41.3) |
61.9 (58.7, 65.0) |
16.1 (13.7, 18.9) |
43.9 (40.1, 47.7) |
40.0 (35.6, 44.6) |
| rs1800896 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
53.9 (51.2, 56.7) |
46.1 (43.3, 48.8) |
29.2 (25.4, 33.4) |
49.4 (45.1, 53.7) |
21.4 (18.6, 24.5) |
| Female |
52.3 (49.5, 55.2) |
47.7 (44.8, 50.5) |
28.0 (24.4, 32.0) |
48.6 (44.8, 52.5) |
23.3 (20.4, 26.5) |
| Non-Hispanic Black |
Male |
64.2 (61.5, 66.9) |
35.8 (33.1, 38.5) |
41.0 (36.8, 45.4) |
46.5 (42.2, 50.8) |
12.5 (10.4, 15.1) |
| Female |
64.5 (62.0, 66.8) |
35.5 (33.2, 38.0) |
40.2 (36.4, 44.1) |
48.5 (44.4, 52.6) |
11.3 (9.3, 13.7) |
| Mexican American |
Male |
68.4 (64.9, 71.7) |
31.6 (28.3, 35.1) |
46.2 (40.4, 52.1) |
44.3 (38.5, 50.4) |
9.4 (7.1, 12.4) |
| Female |
70.7 (68.1, 73.2) |
29.3 (26.8, 31.9) |
51.2 (47.1, 55.3) |
39.0 (35.1, 43.0) |
9.8 (7.9, 12.1) |
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