IL1B Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1143623
|
-2022G>C
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1143623 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
28.5 (26.0, 31.1) |
71.5 (68.9, 74.0) |
<0.001 |
9.0 (7.2, 11.1) |
39.1 (36.8, 41.4) |
52.0 (48.5, 55.4) |
<0.001 |
0.76 |
| Non-Hispanic Black |
11.2 (10.0, 12.7) |
88.8 (87.3, 90.0) |
1.1 (0.6, 1.9) |
20.3 (18.4, 22.3) |
78.6 (76.3, 80.8) |
0.58 |
| Mexican American |
42.9 (40.5, 45.4) |
57.1 (54.6, 59.5) |
19.4 (16.9, 22.2) |
47.1 (44.1, 50.2) |
33.5 (30.4, 36.8) |
0.44 |
| Total* |
28.7 (26.5, 31.0) |
71.3 (69.0, 73.5) |
|
9.6 (7.9, 11.6) |
38.1 (36.4, 39.9) |
52.2 (49.4, 55.0) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1143623 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
29.0 (23.4, 35.4) |
71.0 (64.6, 76.6) |
0.386 |
10.0 (6.0, 16.3) |
38.0 (31.3, 45.1) |
52.0 (43.6, 60.3) |
0.362 |
| 20-39 |
28.9 (26.9, 31.0) |
71.1 (69.0, 73.1) |
9.8 (7.4, 12.9) |
38.3 (35.6, 41.1) |
51.9 (49.7, 54.0) |
| 40-59 |
29.9 (26.3, 33.8) |
70.1 (66.2, 73.7) |
11.0 (8.3, 14.3) |
37.9 (33.7, 42.3) |
51.1 (45.7, 56.5) |
| >=60 |
26.3 (23.5, 29.3) |
73.7 (70.7, 76.5) |
7.1 (5.3, 9.6) |
38.2 (34.3, 42.3) |
54.6 (50.1, 59.1) |
| Total |
28.7 (26.5, 31.0) |
71.3 (69.0, 73.5) |
|
9.6 (7.9, 11.6) |
38.1 (36.4, 39.9) |
52.2 (49.4, 55.0) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1143623 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
29.6 (26.8, 32.6) |
70.4 (67.4, 73.2) |
0.115 |
10.3 (8.3, 12.8) |
38.6 (35.5, 41.8) |
51.1 (47.0, 55.2) |
0.338 |
| Female |
27.9 (25.8, 30.0) |
72.1 (70.0, 74.2) |
9.0 (7.0, 11.4) |
37.7 (35.3, 40.2) |
53.3 (50.7, 55.9) |
| Total |
28.7 (26.5, 31.0) |
71.3 (69.0, 73.5) |
|
9.6 (7.9, 11.6) |
38.1 (36.4, 39.9) |
52.2 (49.4, 55.0) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1143623 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
30.0 (23.7, 37.2) |
70.0 (62.8, 76.3) |
9.4 (5.3, 16.1) |
41.2 (31.8, 51.2) |
49.4 (39.0, 59.9) |
| 20-39 |
27.8 (25.5, 30.3) |
72.2 (69.7, 74.5) |
8.7 (6.2, 12.0) |
38.3 (35.3, 41.5) |
53.0 (50.2, 55.8) |
| 40-59 |
30.1 (25.9, 34.8) |
69.9 (65.2, 74.1) |
10.3 (7.5, 13.8) |
39.8 (34.0, 45.9) |
50.0 (43.1, 56.8) |
| >=60 |
26.6 (23.3, 30.1) |
73.4 (69.9, 76.7) |
7.5 (5.3, 10.4) |
38.2 (34.1, 42.5) |
54.3 (49.3, 59.3) |
| Non-Hispanic Black |
12-19 |
12.0 (9.5, 15.0) |
88.0 (85.0, 90.5) |
0.8 (0.4, 1.6) |
22.4 (17.5, 28.1) |
76.9 (71.1, 81.8) |
| 20-39 |
12.2 (10.2, 14.6) |
87.8 (85.4, 89.8) |
1.4 (0.8, 2.6) |
21.7 (18.4, 25.4) |
76.9 (72.9, 80.5) |
| 40-59 |
9.6 (7.1, 12.9) |
90.4 (87.1, 92.9) |
1.1 (0.3, 3.8) |
17.0 (13.0, 22.0) |
81.9 (76.4, 86.3) |
| >=60 |
10.1 (7.5, 13.4) |
89.9 (86.6, 92.5) |
0.4 (0.1, 3.6) |
19.2 (13.6, 26.5) |
80.3 (73.5, 85.7) |
| Mexican American |
12-19 |
39.3 (36.5, 42.2) |
60.7 (57.8, 63.5) |
17.9 (14.8, 21.4) |
42.9 (36.4, 49.7) |
39.2 (34.1, 44.6) |
| 20-39 |
44.9 (41.2, 48.6) |
55.1 (51.4, 58.8) |
20.9 (17.1, 25.3) |
47.9 (44.5, 51.3) |
31.2 (27.3, 35.3) |
| 40-59 |
42.9 (37.3, 48.8) |
57.1 (51.2, 62.7) |
19.1 (13.8, 25.7) |
47.7 (40.1, 55.5) |
33.2 (25.9, 41.4) |
| >=60 |
40.0 (37.1, 43.0) |
60.0 (57.0, 62.9) |
14.6 (10.9, 19.3) |
50.9 (44.6, 57.1) |
34.5 (30.2, 39.2) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1143623 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
28.9 (25.9, 32.0) |
71.1 (68.0, 74.1) |
9.3 (7.4, 11.7) |
39.1 (35.1, 43.2) |
51.6 (46.9, 56.3) |
| Female |
28.1 (25.3, 31.2) |
71.9 (68.8, 74.7) |
8.6 (6.3, 11.7) |
39.0 (35.9, 42.3) |
52.3 (48.4, 56.2) |
| Non-Hispanic Black |
Male |
11.3 (9.9, 12.8) |
88.7 (87.2, 90.1) |
1.2 (0.5, 2.9) |
20.1 (18.0, 22.4) |
78.7 (76.2, 80.9) |
| Female |
11.2 (9.6, 13.1) |
88.8 (86.9, 90.4) |
1.0 (0.5, 1.9) |
20.5 (17.8, 23.4) |
78.6 (75.3, 81.5) |
| Mexican American |
Male |
44.5 (40.9, 48.2) |
55.5 (51.8, 59.1) |
21.6 (17.9, 25.7) |
46.0 (40.8, 51.3) |
32.5 (27.7, 37.7) |
| Female |
41.2 (39.1, 43.4) |
58.8 (56.6, 60.9) |
17.1 (14.6, 19.9) |
48.3 (44.7, 51.9) |
34.6 (31.8, 37.5) |
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