IL4 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
|
Genotyping method
|
|
rs2243248
|
-1098T>G
|
|
TaqMan
|
|
rs2243250
|
-588C>T
-524C>T
-590C>T
|
|
TaqMan
|
|
rs2243270
|
IVS2-1297A>G
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs2243248 |
|
G |
T |
|
GG |
GT |
TT |
|
|
| Non-Hispanic White |
7.5 (6.7, 8.4) |
92.5 (91.6, 93.3) |
<0.001 |
0.4 (0.2, 0.8) |
14.1 (12.7, 15.7) |
85.4 (83.7, 87.0) |
<0.001 |
0.68 |
| Non-Hispanic Black |
15.7 (14.3, 17.3) |
84.3 (82.7, 85.7) |
2.5 (1.7, 3.5) |
26.6 (24.3, 29.0) |
71.0 (68.3, 73.5) |
0.46 |
| Mexican American |
12.0 (10.0, 14.4) |
88.0 (85.6, 90.0) |
1.9 (1.3, 2.8) |
20.3 (17.1, 23.9) |
77.8 (73.7, 81.4) |
0.03 |
| Total* |
9.0 (8.1, 9.9) |
91.0 (90.1, 91.9) |
|
0.8 (0.6, 1.1) |
16.3 (14.8, 18.0) |
82.9 (81.1, 84.5) |
|
|
| rs2243250 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
84.0 (82.7, 85.2) |
16.0 (14.8, 17.3) |
<0.001 |
70.8 (68.9, 72.6) |
26.4 (24.9, 28.0) |
2.8 (2.0, 4.0) |
<0.001 |
0.53 |
| Non-Hispanic Black |
36.0 (34.2, 37.9) |
64.0 (62.1, 65.8) |
14.1 (12.3, 16.2) |
43.8 (41.0, 46.7) |
42.0 (39.4, 44.7) |
0.03 |
| Mexican American |
57.7 (55.6, 59.8) |
42.3 (40.2, 44.4) |
34.3 (30.9, 37.8) |
46.9 (43.3, 50.5) |
18.9 (17.1, 20.7) |
0.07 |
| Total* |
74.5 (72.7, 76.2) |
25.5 (23.8, 27.3) |
|
58.9 (56.6, 61.1) |
31.2 (29.6, 32.9) |
9.9 (8.6, 11.4) |
|
|
| rs2243270 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
83.6 (82.4, 84.8) |
16.4 (15.2, 17.6) |
<0.001 |
69.9 (68.1, 71.7) |
27.4 (25.8, 29.1) |
2.6 (1.8, 3.8) |
<0.001 |
0.71 |
| Non-Hispanic Black |
36.3 (34.6, 38.1) |
63.7 (61.9, 65.4) |
14.5 (13.4, 15.8) |
43.5 (40.4, 46.7) |
41.9 (38.9, 45.0) |
0.01 |
| Mexican American |
58.2 (55.7, 60.7) |
41.8 (39.3, 44.3) |
34.9 (31.5, 38.6) |
46.6 (43.3, 49.9) |
18.5 (16.2, 21.0) |
0.08 |
| Total* |
74.3 (72.4, 76.0) |
25.7 (24.0, 27.6) |
|
58.3 (55.9, 60.7) |
31.8 (30.1, 33.6) |
9.8 (8.4, 11.4) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs2243248 |
|
G |
T |
|
GG |
GT |
TT |
|
| 12-19 |
9.9 (8.1, 11.9) |
90.1 (88.1, 91.9) |
0.114 |
1.1 (0.4, 3.2) |
17.5 (15.1, 20.1) |
81.4 (78.2, 84.2) |
0.045 |
| 20-39 |
9.5 (7.9, 11.2) |
90.5 (88.8, 92.1) |
0.7 (0.5, 1.0) |
17.4 (14.6, 20.7) |
81.8 (78.5, 84.8) |
| 40-59 |
9.2 (7.6, 11.0) |
90.8 (89.0, 92.4) |
0.9 (0.5, 1.8) |
16.4 (13.6, 19.7) |
82.6 (79.3, 85.6) |
| >=60 |
7.2 (6.0, 8.5) |
92.8 (91.5, 94.0) |
0.5 (0.2, 1.2) |
13.2 (11.2, 15.6) |
86.2 (83.8, 88.3) |
| Total |
9.0 (8.1, 9.9) |
91.0 (90.1, 91.9) |
|
0.8 (0.6, 1.1) |
16.3 (14.8, 18.0) |
82.9 (81.1, 84.5) |
|
| rs2243250 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
71.7 (67.8, 75.4) |
28.3 (24.6, 32.2) |
0.015 |
54.9 (49.9, 59.9) |
33.6 (29.6, 37.8) |
11.5 (8.4, 15.5) |
0.079 |
| 20-39 |
73.0 (70.0, 75.9) |
27.0 (24.1, 30.0) |
57.3 (53.1, 61.4) |
31.5 (28.5, 34.8) |
11.2 (9.2, 13.6) |
| 40-59 |
76.1 (73.4, 78.5) |
23.9 (21.5, 26.6) |
61.2 (57.1, 65.1) |
29.8 (26.1, 33.7) |
9.0 (7.2, 11.4) |
| >=60 |
77.1 (75.3, 78.7) |
22.9 (21.3, 24.7) |
61.5 (58.9, 64.1) |
31.1 (28.3, 33.9) |
7.4 (5.9, 9.2) |
| Total |
74.5 (72.7, 76.2) |
25.5 (23.8, 27.3) |
|
58.9 (56.6, 61.1) |
31.2 (29.6, 32.9) |
9.9 (8.6, 11.4) |
|
| rs2243270 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
71.4 (67.5, 75.0) |
28.6 (25.0, 32.5) |
0.016 |
54.3 (49.5, 59.0) |
34.3 (30.4, 38.4) |
11.4 (8.2, 15.7) |
0.100 |
| 20-39 |
72.8 (69.5, 75.8) |
27.2 (24.2, 30.5) |
56.9 (52.4, 61.2) |
31.7 (28.7, 34.9) |
11.4 (9.3, 13.9) |
| 40-59 |
76.0 (73.3, 78.5) |
24.0 (21.5, 26.7) |
60.7 (56.2, 65.1) |
30.5 (26.2, 35.3) |
8.8 (6.9, 11.1) |
| >=60 |
76.8 (74.9, 78.6) |
23.2 (21.4, 25.1) |
60.7 (57.7, 63.6) |
32.2 (29.3, 35.3) |
7.1 (5.5, 8.9) |
| Total |
74.3 (72.4, 76.0) |
25.7 (24.0, 27.6) |
|
58.3 (55.9, 60.7) |
31.8 (30.1, 33.6) |
9.8 (8.4, 11.4) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs2243248 |
|
G |
T |
|
GG |
GT |
TT |
|
| Male |
9.3 (8.3, 10.6) |
90.7 (89.4, 91.7) |
0.202 |
0.7 (0.4, 1.2) |
17.3 (15.1, 19.7) |
82.0 (79.6, 84.2) |
0.315 |
| Female |
8.6 (7.6, 9.7) |
91.4 (90.3, 92.4) |
0.9 (0.5, 1.6) |
15.4 (13.8, 17.2) |
83.7 (81.7, 85.4) |
| Total |
9.0 (8.1, 9.9) |
91.0 (90.1, 91.9) |
|
0.8 (0.6, 1.1) |
16.3 (14.8, 18.0) |
82.9 (81.1, 84.5) |
|
| rs2243250 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
75.2 (72.9, 77.3) |
24.8 (22.7, 27.1) |
0.112 |
59.7 (56.3, 63.0) |
31.0 (28.5, 33.8) |
9.3 (7.9, 10.9) |
0.095 |
| Female |
73.8 (72.2, 75.4) |
26.2 (24.6, 27.8) |
58.1 (55.7, 60.5) |
31.4 (29.0, 33.9) |
10.5 (9.0, 12.2) |
| Total |
74.5 (72.7, 76.2) |
25.5 (23.8, 27.3) |
|
58.9 (56.6, 61.1) |
31.2 (29.6, 32.9) |
9.9 (8.6, 11.4) |
|
| rs2243270 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
74.9 (72.6, 77.2) |
25.1 (22.8, 27.4) |
0.156 |
59.2 (55.6, 62.6) |
31.6 (28.8, 34.4) |
9.3 (7.9, 10.9) |
0.217 |
| Female |
73.6 (71.9, 75.3) |
26.4 (24.7, 28.1) |
57.6 (55.2, 60.0) |
32.1 (29.8, 34.5) |
10.3 (8.7, 12.2) |
| Total |
74.3 (72.4, 76.0) |
25.7 (24.0, 27.6) |
|
58.3 (55.9, 60.7) |
31.8 (30.1, 33.6) |
9.8 (8.4, 11.4) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs2243248 |
|
|
G |
T |
GG |
GT |
TT |
| Non-Hispanic White |
12-19 |
8.3 (5.9, 11.6) |
91.7 (88.4, 94.1) |
0.8 (0.1, 7.1) |
15.1 (12.1, 18.6) |
84.2 (79.5, 87.9) |
| 20-39 |
7.5 (5.9, 9.4) |
92.5 (90.6, 94.1) |
0.3 (0.1, 0.7) |
14.4 (11.3, 18.1) |
85.3 (81.6, 88.4) |
| 40-59 |
8.6 (6.9, 10.7) |
91.4 (89.3, 93.1) |
0.5 (0.1, 2.1) |
16.2 (13.1, 19.9) |
83.3 (79.5, 86.5) |
| >=60 |
5.7 (4.7, 6.8) |
94.3 (93.2, 95.3) |
0.4 (0.1, 1.3) |
10.4 (8.7, 12.5) |
89.1 (87.0, 90.9) |
| Non-Hispanic Black |
12-19 |
16.1 (12.2, 21.1) |
83.9 (78.9, 87.8) |
2.7 (1.3, 5.3) |
26.9 (21.4, 33.2) |
70.4 (62.6, 77.2) |
| 20-39 |
16.7 (15.4, 18.0) |
83.3 (82.0, 84.6) |
2.5 (1.7, 3.7) |
28.3 (26.0, 30.7) |
69.2 (66.9, 71.4) |
| 40-59 |
13.7 (11.1, 16.9) |
86.3 (83.1, 88.9) |
2.7 (1.1, 6.1) |
22.2 (18.0, 27.1) |
75.2 (70.2, 79.5) |
| >=60 |
16.0 (12.5, 20.1) |
84.0 (79.9, 87.5) |
1.7 (0.5, 5.1) |
28.6 (22.3, 35.9) |
69.7 (62.4, 76.2) |
| Mexican American |
12-19 |
10.4 (6.8, 15.5) |
89.6 (84.5, 93.2) |
1.8 (0.8, 3.9) |
17.1 (11.4, 24.8) |
81.1 (72.4, 87.5) |
| 20-39 |
13.7 (10.8, 17.1) |
86.3 (82.9, 89.2) |
1.7 (0.7, 4.2) |
23.9 (20.0, 28.3) |
74.4 (69.0, 79.1) |
| 40-59 |
11.2 (8.5, 14.5) |
88.8 (85.5, 91.5) |
2.5 (1.0, 6.0) |
17.4 (14.2, 21.2) |
80.1 (75.4, 84.1) |
| >=60 |
8.4 (6.1, 11.5) |
91.6 (88.5, 93.9) |
1.6 (0.8, 3.3) |
13.7 (10.0, 18.3) |
84.7 (79.5, 88.8) |
| rs2243250 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
83.4 (79.5, 86.6) |
16.6 (13.4, 20.5) |
69.4 (62.4, 75.6) |
27.9 (21.7, 35.2) |
2.7 (1.2, 5.9) |
| 20-39 |
84.3 (82.1, 86.3) |
15.7 (13.7, 17.9) |
72.1 (68.6, 75.4) |
24.4 (21.0, 28.1) |
3.5 (2.1, 5.8) |
| 40-59 |
84.2 (81.4, 86.6) |
15.8 (13.4, 18.6) |
70.5 (65.9, 74.7) |
27.4 (23.7, 31.5) |
2.1 (1.2, 3.9) |
| >=60 |
83.6 (81.3, 85.6) |
16.4 (14.4, 18.7) |
69.8 (65.8, 73.5) |
27.6 (24.2, 31.4) |
2.6 (1.7, 3.9) |
| Non-Hispanic Black |
12-19 |
38.2 (34.6, 42.0) |
61.8 (58.0, 65.4) |
16.7 (13.6, 20.4) |
43.0 (37.2, 49.1) |
40.2 (34.6, 46.1) |
| 20-39 |
35.5 (32.9, 38.2) |
64.5 (61.8, 67.1) |
13.1 (10.6, 16.0) |
44.9 (40.4, 49.4) |
42.0 (38.0, 46.2) |
| 40-59 |
34.9 (31.7, 38.1) |
65.1 (61.9, 68.3) |
13.6 (10.4, 17.7) |
42.5 (37.8, 47.3) |
43.9 (39.7, 48.2) |
| >=60 |
36.8 (31.9, 42.0) |
63.2 (58.0, 68.1) |
14.7 (9.9, 21.2) |
44.2 (38.9, 49.7) |
41.1 (35.3, 47.1) |
| Mexican American |
12-19 |
60.0 (56.8, 63.2) |
40.0 (36.8, 43.2) |
36.5 (32.9, 40.3) |
47.1 (39.5, 54.8) |
16.4 (11.2, 23.5) |
| 20-39 |
56.3 (52.5, 60.0) |
43.7 (40.0, 47.5) |
32.5 (26.3, 39.5) |
47.5 (41.3, 53.7) |
20.0 (18.2, 21.9) |
| 40-59 |
58.6 (54.1, 63.0) |
41.4 (37.0, 45.9) |
35.5 (28.8, 42.8) |
46.2 (37.3, 55.3) |
18.3 (13.3, 24.6) |
| >=60 |
58.5 (53.6, 63.3) |
41.5 (36.7, 46.4) |
36.3 (31.0, 42.0) |
44.5 (37.8, 51.3) |
19.2 (13.7, 26.4) |
| rs2243270 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
83.3 (79.6, 86.4) |
16.7 (13.6, 20.4) |
68.9 (61.8, 75.2) |
28.7 (22.0, 36.5) |
2.4 (1.0, 5.6) |
| 20-39 |
83.9 (81.7, 85.8) |
16.1 (14.2, 18.3) |
71.1 (67.9, 74.1) |
25.5 (22.6, 28.6) |
3.4 (2.0, 5.7) |
| 40-59 |
83.9 (81.0, 86.4) |
16.1 (13.6, 19.0) |
69.8 (64.6, 74.5) |
28.1 (23.6, 33.2) |
2.0 (1.2, 3.5) |
| >=60 |
83.2 (80.6, 85.5) |
16.8 (14.5, 19.4) |
68.6 (64.3, 72.6) |
29.1 (25.5, 32.9) |
2.3 (1.3, 4.0) |
| Non-Hispanic Black |
12-19 |
36.9 (33.4, 40.7) |
63.1 (59.3, 66.6) |
14.8 (11.6, 18.8) |
44.3 (39.4, 49.2) |
40.9 (36.0, 46.1) |
| 20-39 |
35.8 (32.8, 38.9) |
64.2 (61.1, 67.2) |
14.7 (12.7, 16.8) |
42.2 (38.4, 46.2) |
43.1 (38.5, 47.8) |
| 40-59 |
35.7 (32.7, 38.9) |
64.3 (61.1, 67.3) |
13.5 (10.8, 16.6) |
44.5 (37.2, 52.1) |
42.0 (35.9, 48.3) |
| >=60 |
38.2 (33.5, 43.1) |
61.8 (56.9, 66.5) |
15.8 (11.2, 21.8) |
44.8 (36.9, 53.0) |
39.4 (32.5, 46.8) |
| Mexican American |
12-19 |
60.5 (57.4, 63.5) |
39.5 (36.5, 42.6) |
37.1 (34.1, 40.2) |
46.8 (39.7, 54.0) |
16.1 (11.0, 22.9) |
| 20-39 |
57.0 (53.1, 60.9) |
43.0 (39.1, 46.9) |
33.4 (27.3, 40.2) |
47.2 (41.6, 52.8) |
19.4 (17.5, 21.4) |
| 40-59 |
59.0 (54.3, 63.6) |
41.0 (36.4, 45.7) |
35.9 (29.1, 43.2) |
46.3 (38.1, 54.7) |
17.9 (13.2, 23.8) |
| >=60 |
58.1 (52.7, 63.3) |
41.9 (36.7, 47.3) |
36.6 (31.3, 42.3) |
43.1 (34.8, 51.8) |
20.4 (13.5, 29.4) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs2243248 |
|
|
G |
T |
GG |
GT |
TT |
| Non-Hispanic White |
Male |
8.5 (7.4, 9.7) |
91.5 (90.3, 92.6) |
0.5 (0.2, 1.3) |
16.0 (13.6, 18.7) |
83.5 (81.0, 85.8) |
| Female |
6.6 (5.8, 7.5) |
93.4 (92.5, 94.2) |
0.4 (0.1, 1.4) |
12.3 (10.9, 14.0) |
87.2 (85.6, 88.7) |
| Non-Hispanic Black |
Male |
15.8 (14.2, 17.6) |
84.2 (82.4, 85.8) |
2.5 (1.5, 4.1) |
26.7 (23.8, 29.8) |
70.8 (67.8, 73.7) |
| Female |
15.7 (13.9, 17.7) |
84.3 (82.3, 86.1) |
2.5 (1.6, 3.9) |
26.4 (23.3, 29.7) |
71.1 (67.7, 74.3) |
| Mexican American |
Male |
12.0 (10.2, 14.2) |
88.0 (85.8, 89.8) |
1.4 (0.9, 2.2) |
21.2 (18.2, 24.6) |
77.3 (73.6, 80.7) |
| Female |
12.0 (9.4, 15.2) |
88.0 (84.8, 90.6) |
2.4 (1.4, 4.1) |
19.3 (15.6, 23.7) |
78.3 (73.1, 82.7) |
| rs2243250 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
84.4 (82.4, 86.1) |
15.6 (13.9, 17.6) |
71.4 (68.3, 74.4) |
25.8 (22.9, 29.0) |
2.7 (1.6, 4.7) |
| Female |
83.7 (82.0, 85.2) |
16.3 (14.8, 18.0) |
70.2 (67.4, 72.8) |
27.0 (24.5, 29.6) |
2.9 (1.9, 4.2) |
| Non-Hispanic Black |
Male |
35.2 (31.6, 38.9) |
64.8 (61.1, 68.4) |
13.4 (10.4, 16.9) |
43.6 (39.7, 47.6) |
43.0 (38.3, 47.9) |
| Female |
36.8 (34.3, 39.3) |
63.2 (60.7, 65.7) |
14.8 (12.5, 17.3) |
44.0 (40.3, 47.8) |
41.2 (37.5, 45.0) |
| Mexican American |
Male |
57.1 (54.2, 60.0) |
42.9 (40.0, 45.8) |
32.6 (27.4, 38.2) |
49.0 (43.1, 54.9) |
18.4 (16.2, 20.9) |
| Female |
58.4 (56.7, 60.1) |
41.6 (39.9, 43.3) |
36.1 (33.9, 38.3) |
44.6 (42.1, 47.2) |
19.3 (17.4, 21.4) |
| rs2243270 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
84.0 (82.1, 85.9) |
16.0 (14.1, 17.9) |
70.8 (67.5, 73.8) |
26.5 (23.4, 29.9) |
2.7 (1.5, 4.8) |
| Female |
83.2 (81.7, 84.7) |
16.8 (15.3, 18.3) |
69.1 (66.5, 71.6) |
28.3 (25.9, 30.8) |
2.6 (1.8, 3.8) |
| Non-Hispanic Black |
Male |
35.0 (32.0, 38.1) |
65.0 (61.9, 68.0) |
13.4 (11.1, 16.0) |
43.3 (39.0, 47.7) |
43.3 (38.7, 48.1) |
| Female |
37.4 (35.2, 39.6) |
62.6 (60.4, 64.8) |
15.5 (13.6, 17.7) |
43.7 (40.4, 47.1) |
40.8 (37.5, 44.1) |
| Mexican American |
Male |
57.7 (54.3, 61.1) |
42.3 (38.9, 45.7) |
33.5 (28.5, 38.9) |
48.5 (43.7, 53.3) |
18.0 (15.5, 20.9) |
| Female |
58.8 (56.7, 60.8) |
41.2 (39.2, 43.3) |
36.5 (34.1, 39.0) |
44.6 (41.9, 47.2) |
18.9 (16.6, 21.5) |
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