ITGA2 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1126643
|
Ex7-21C>T
|
Phe253Phe
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1126643 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
58.8 (56.7, 60.9) |
41.2 (39.1, 43.3) |
<0.001 |
34.7 (32.8, 36.6) |
48.3 (46.3, 50.3) |
17.0 (14.5, 19.8) |
<0.001 |
0.64 |
| Non-Hispanic Black |
70.4 (68.0, 72.7) |
29.6 (27.3, 32.0) |
48.5 (45.3, 51.8) |
43.7 (41.3, 46.0) |
7.8 (6.1, 9.8) |
0.14 |
| Mexican American |
55.4 (53.8, 56.9) |
44.6 (43.1, 46.2) |
30.3 (28.3, 32.4) |
50.1 (47.9, 52.3) |
19.6 (17.9, 21.3) |
0.99 |
| Total* |
60.3 (58.8, 61.8) |
39.7 (38.2, 41.2) |
|
36.5 (35.1, 37.9) |
47.6 (46.2, 49.1) |
15.9 (14.1, 17.9) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1126643 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
57.5 (53.1, 61.9) |
42.5 (38.1, 46.9) |
0.477 |
34.2 (29.9, 38.8) |
46.6 (42.2, 51.2) |
19.2 (14.3, 25.2) |
0.432 |
| 20-39 |
60.9 (58.2, 63.4) |
39.1 (36.6, 41.8) |
36.5 (33.7, 39.4) |
48.7 (45.8, 51.7) |
14.8 (11.9, 18.2) |
| 40-59 |
60.5 (57.2, 63.7) |
39.5 (36.3, 42.8) |
37.5 (33.3, 41.9) |
45.9 (42.4, 49.4) |
16.6 (13.8, 19.8) |
| >=60 |
60.9 (58.9, 62.8) |
39.1 (37.2, 41.1) |
36.6 (34.3, 39.0) |
48.6 (46.3, 50.8) |
14.8 (12.8, 17.1) |
| Total |
60.3 (58.8, 61.8) |
39.7 (38.2, 41.2) |
|
36.5 (35.1, 37.9) |
47.6 (46.2, 49.1) |
15.9 (14.1, 17.9) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1126643 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
60.3 (58.0, 62.6) |
39.7 (37.4, 42.0) |
1.000 |
37.2 (34.5, 40.1) |
46.1 (44.0, 48.2) |
16.7 (14.5, 19.0) |
0.225 |
| Female |
60.3 (58.4, 62.2) |
39.7 (37.8, 41.6) |
35.8 (33.6, 38.0) |
49.0 (46.3, 51.8) |
15.2 (12.9, 17.8) |
| Total |
60.3 (58.8, 61.8) |
39.7 (38.2, 41.2) |
|
36.5 (35.1, 37.9) |
47.6 (46.2, 49.1) |
15.9 (14.1, 17.9) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1126643 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
54.1 (48.3, 59.8) |
45.9 (40.2, 51.7) |
30.4 (24.5, 37.0) |
47.5 (40.9, 54.1) |
22.1 (15.9, 30.0) |
| 20-39 |
59.5 (56.4, 62.5) |
40.5 (37.5, 43.6) |
34.2 (30.8, 37.7) |
50.6 (46.5, 54.6) |
15.2 (11.8, 19.5) |
| 40-59 |
58.8 (54.6, 63.0) |
41.2 (37.0, 45.4) |
36.3 (31.0, 42.0) |
45.1 (40.5, 49.7) |
18.6 (15.0, 22.8) |
| >=60 |
60.3 (58.3, 62.4) |
39.7 (37.6, 41.7) |
35.6 (33.0, 38.3) |
49.4 (46.6, 52.2) |
15.0 (12.8, 17.4) |
| Non-Hispanic Black |
12-19 |
70.6 (66.0, 74.9) |
29.4 (25.1, 34.0) |
49.8 (42.2, 57.4) |
41.6 (34.8, 48.8) |
8.6 (6.5, 11.2) |
| 20-39 |
69.3 (65.7, 72.7) |
30.7 (27.3, 34.3) |
47.9 (43.6, 52.3) |
42.7 (38.8, 46.7) |
9.4 (6.3, 13.7) |
| 40-59 |
70.7 (68.4, 72.9) |
29.3 (27.1, 31.6) |
47.0 (43.1, 50.8) |
47.5 (43.6, 51.4) |
5.5 (4.0, 7.6) |
| >=60 |
72.8 (68.0, 77.2) |
27.2 (22.8, 32.0) |
51.6 (44.5, 58.6) |
42.5 (36.4, 48.9) |
5.9 (3.3, 10.4) |
| Mexican American |
12-19 |
53.1 (49.3, 56.9) |
46.9 (43.1, 50.7) |
26.9 (21.7, 32.9) |
52.4 (46.1, 58.6) |
20.6 (16.8, 25.2) |
| 20-39 |
55.7 (53.5, 57.9) |
44.3 (42.1, 46.5) |
31.5 (29.1, 34.0) |
48.4 (45.7, 51.1) |
20.1 (17.6, 22.9) |
| 40-59 |
57.0 (53.6, 60.3) |
43.0 (39.7, 46.4) |
30.8 (27.5, 34.3) |
52.3 (47.4, 57.2) |
16.9 (12.6, 22.3) |
| >=60 |
54.9 (50.9, 58.8) |
45.1 (41.2, 49.1) |
30.3 (26.1, 34.8) |
49.2 (44.2, 54.2) |
20.5 (15.9, 26.0) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1126643 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
59.1 (56.4, 61.7) |
40.9 (38.3, 43.6) |
35.4 (32.2, 38.7) |
47.4 (44.5, 50.3) |
17.2 (14.6, 20.2) |
| Female |
58.6 (56.0, 61.2) |
41.4 (38.8, 44.0) |
34.0 (31.6, 36.5) |
49.2 (46.1, 52.4) |
16.8 (13.6, 20.6) |
| Non-Hispanic Black |
Male |
69.6 (66.2, 72.8) |
30.4 (27.2, 33.8) |
46.2 (41.3, 51.2) |
46.7 (42.5, 51.0) |
7.1 (4.9, 10.0) |
| Female |
71.0 (68.6, 73.3) |
29.0 (26.7, 31.4) |
50.4 (47.2, 53.7) |
41.2 (39.1, 43.3) |
8.4 (6.8, 10.3) |
| Mexican American |
Male |
55.2 (52.6, 57.8) |
44.8 (42.2, 47.4) |
31.3 (28.2, 34.6) |
47.8 (43.7, 51.9) |
20.9 (17.7, 24.5) |
| Female |
55.6 (53.9, 57.2) |
44.4 (42.8, 46.1) |
29.3 (27.0, 31.6) |
52.6 (50.1, 55.1) |
18.2 (16.3, 20.1) |
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