ITGB3 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs5918
|
Ex3+11T>C
|
Leu59Pro
|
MGB Eclipse
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs5918 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
16.3 (15.0, 17.6) |
83.7 (82.4, 85.0) |
<0.001 |
2.7 (1.8, 4.0) |
27.2 (25.1, 29.4) |
70.1 (67.9, 72.2) |
<0.001 |
0.81 |
| Non-Hispanic Black |
10.1 (9.2, 11.0) |
89.9 (89.0, 90.8) |
1.1 (0.7, 1.7) |
18.0 (16.3, 19.8) |
81.0 (79.2, 82.6) |
0.59 |
| Mexican American |
9.7 (8.2, 11.3) |
90.3 (88.7, 91.8) |
1.3 (0.8, 2.1) |
16.8 (14.8, 19.0) |
81.9 (79.2, 84.4) |
0.22 |
| Total* |
14.4 (13.3, 15.6) |
85.6 (84.4, 86.7) |
|
2.2 (1.5, 3.3) |
24.4 (22.7, 26.2) |
73.4 (71.4, 75.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs5918 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
12.6 (10.2, 15.4) |
87.4 (84.6, 89.8) |
0.306 |
1.7 (0.7, 4.4) |
21.7 (18.3, 25.7) |
76.5 (72.1, 80.4) |
0.629 |
| 20-39 |
14.4 (12.7, 16.4) |
85.6 (83.6, 87.3) |
2.4 (1.3, 4.4) |
24.0 (21.5, 26.7) |
73.6 (70.7, 76.3) |
| 40-59 |
15.3 (13.4, 17.3) |
84.7 (82.7, 86.6) |
2.2 (1.2, 3.9) |
26.2 (22.5, 30.4) |
71.6 (67.8, 75.2) |
| >=60 |
14.5 (13.3, 15.9) |
85.5 (84.1, 86.7) |
2.3 (1.7, 3.1) |
24.5 (22.4, 26.7) |
73.2 (70.9, 75.5) |
| Total |
14.4 (13.3, 15.6) |
85.6 (84.4, 86.7) |
|
2.2 (1.5, 3.3) |
24.4 (22.7, 26.2) |
73.4 (71.4, 75.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs5918 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
14.3 (12.6, 16.1) |
85.7 (83.9, 87.4) |
0.762 |
2.7 (1.8, 4.1) |
23.1 (20.3, 26.2) |
74.2 (71.0, 77.1) |
0.069 |
| Female |
14.6 (13.3, 16.0) |
85.4 (84.0, 86.7) |
1.8 (1.1, 2.9) |
25.6 (23.7, 27.5) |
72.6 (70.4, 74.8) |
| Total |
14.4 (13.3, 15.6) |
85.6 (84.4, 86.7) |
|
2.2 (1.5, 3.3) |
24.4 (22.7, 26.2) |
73.4 (71.4, 75.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs5918 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
14.3 (11.1, 18.1) |
85.7 (81.9, 88.9) |
1.7 (0.5, 5.2) |
25.1 (19.7, 31.6) |
73.2 (66.6, 78.9) |
| 20-39 |
16.8 (14.7, 19.2) |
83.2 (80.8, 85.3) |
3.1 (1.6, 6.0) |
27.4 (24.4, 30.6) |
69.5 (66.1, 72.6) |
| 40-59 |
16.8 (14.7, 19.0) |
83.2 (81.0, 85.3) |
2.6 (1.3, 5.0) |
28.4 (24.5, 32.8) |
69.0 (65.0, 72.7) |
| >=60 |
15.8 (14.3, 17.4) |
84.2 (82.6, 85.7) |
2.6 (1.8, 3.7) |
26.4 (24.2, 28.7) |
71.0 (68.4, 73.5) |
| Non-Hispanic Black |
12-19 |
9.2 (7.6, 11.1) |
90.8 (88.9, 92.4) |
1.0 (0.5, 1.7) |
16.4 (13.6, 19.7) |
82.6 (79.1, 85.6) |
| 20-39 |
10.1 (8.7, 11.8) |
89.9 (88.2, 91.3) |
0.9 (0.4, 1.9) |
18.4 (15.5, 21.9) |
80.6 (77.4, 83.6) |
| 40-59 |
10.9 (9.1, 13.2) |
89.1 (86.8, 90.9) |
1.6 (0.7, 3.4) |
18.7 (15.5, 22.4) |
79.7 (75.9, 83.0) |
| >=60 |
9.4 (6.8, 12.7) |
90.6 (87.3, 93.2) |
0.8 (0.2, 3.2) |
17.2 (12.2, 23.7) |
82.0 (75.6, 87.0) |
| Mexican American |
12-19 |
7.5 (4.9, 11.5) |
92.5 (88.5, 95.1) |
0.0 (NA) |
15.1 (9.7, 22.7) |
84.9 (77.3, 90.3) |
| 20-39 |
10.9 (9.3, 12.8) |
89.1 (87.2, 90.7) |
2.0 (1.1, 3.7) |
17.8 (15.4, 20.5) |
80.2 (77.2, 82.9) |
| 40-59 |
8.6 (6.9, 10.7) |
91.4 (89.3, 93.1) |
0.6 (0.2, 2.1) |
16.1 (13.3, 19.2) |
83.3 (79.8, 86.4) |
| >=60 |
10.0 (6.5, 15.0) |
90.0 (85.0, 93.5) |
1.6 (0.2, 10.3) |
16.8 (11.7, 23.7) |
81.6 (74.1, 87.3) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs5918 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
16.3 (14.3, 18.5) |
83.7 (81.5, 85.7) |
3.2 (2.1, 4.9) |
26.2 (22.7, 30.0) |
70.6 (66.8, 74.1) |
| Female |
16.3 (14.7, 18.0) |
83.7 (82.0, 85.3) |
2.2 (1.3, 3.6) |
28.2 (25.8, 30.7) |
69.7 (66.9, 72.3) |
| Non-Hispanic Black |
Male |
9.6 (8.5, 10.8) |
90.4 (89.2, 91.5) |
1.0 (0.5, 2.0) |
17.1 (15.2, 19.2) |
81.9 (79.7, 83.8) |
| Female |
10.5 (9.4, 11.7) |
89.5 (88.3, 90.6) |
1.1 (0.6, 2.1) |
18.7 (16.4, 21.2) |
80.2 (77.9, 82.3) |
| Mexican American |
Male |
10.2 (8.7, 11.8) |
89.8 (88.2, 91.3) |
1.4 (0.7, 2.7) |
17.5 (14.9, 20.5) |
81.1 (78.1, 83.7) |
| Female |
9.1 (7.2, 11.5) |
90.9 (88.5, 92.8) |
1.1 (0.5, 2.4) |
16.0 (12.8, 19.9) |
82.9 (78.7, 86.3) |
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