MBL2 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs11003125
|
-618G>C
-550G>C
|
|
TaqMan
|
|
rs1800450
|
Ex1-27G>A
|
Gly54Asp
|
TaqMan
|
|
rs1800451
|
Ex1-18G>A
|
Gly57Glu
|
TaqMan
|
|
rs5030737
|
Ex1-34C>T
|
Arg52Cys
|
TaqMan
|
|
rs7096206
|
-289G<C
-221G>C
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs11003125 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
63.6 (61.9, 65.3) |
36.4 (34.7, 38.1) |
<0.001 |
40.9 (38.6, 43.2) |
45.6 (42.5, 48.6) |
13.6 (11.4, 16.1) |
<0.001 |
0.76 |
| Non-Hispanic Black |
87.2 (86.0, 88.3) |
12.8 (11.7, 14.0) |
76.2 (73.9, 78.3) |
21.9 (19.8, 24.3) |
1.9 (1.3, 2.7) |
0.71 |
| Mexican American |
49.0 (46.9, 51.1) |
51.0 (48.9, 53.1) |
25.0 (22.3, 27.8) |
48.1 (46.3, 50.0) |
26.9 (25.2, 28.7) |
0.44 |
| Total* |
65.1 (63.3, 66.8) |
34.9 (33.2, 36.7) |
|
43.2 (41.0, 45.4) |
43.8 (41.3, 46.2) |
13.1 (11.2, 15.2) |
|
|
| rs1800450 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
14.6 (13.1, 16.2) |
85.4 (83.8, 86.9) |
<0.001 |
2.8 (2.1, 3.7) |
23.5 (21.1, 26.1) |
73.7 (70.8, 76.3) |
<0.001 |
0.01 |
| Non-Hispanic Black |
4.0 (3.3, 4.9) |
96.0 (95.1, 96.7) |
0.4 (0.2, 0.8) |
7.4 (6.0, 9.0) |
92.3 (90.6, 93.6) |
0.02 |
| Mexican American |
14.6 (12.9, 16.6) |
85.4 (83.4, 87.1) |
2.0 (1.3, 3.2) |
25.1 (22.8, 27.6) |
72.8 (69.7, 75.7) |
0.66 |
| Total* |
13.5 (12.3, 14.7) |
86.5 (85.3, 87.7) |
|
2.4 (1.9, 3.1) |
22.1 (20.3, 24.0) |
75.5 (73.4, 77.5) |
|
|
| rs1800451 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
2.0 (1.6, 2.4) |
98.0 (97.6, 98.4) |
<0.001 |
0.1 (0.0, 0.3) |
3.8 (3.1, 4.7) |
96.1 (95.2, 96.9) |
<0.001 |
0.16 |
| Non-Hispanic Black |
23.3 (21.7, 25.0) |
76.7 (75.0, 78.3) |
6.1 (4.6, 7.9) |
34.4 (32.3, 36.7) |
59.5 (57.2, 61.8) |
0.12 |
| Mexican American |
2.5 (1.9, 3.3) |
97.5 (96.7, 98.1) |
0.0 (NA) |
5.1 (3.9, 6.6) |
94.9 (93.4, 96.1) |
0.23 |
| Total* |
4.6 (3.9, 5.5) |
95.4 (94.5, 96.1) |
|
0.8 (0.6, 1.2) |
7.6 (6.3, 9.2) |
91.6 (90.0, 93.0) |
|
|
| rs5030737 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
92.6 (91.5, 93.6) |
7.4 (6.4, 8.5) |
<0.001 |
85.9 (83.7, 87.9) |
13.3 (11.3, 15.6) |
0.8 (0.4, 1.3) |
<0.001 |
0.27 |
| Non-Hispanic Black |
98.9 (98.5, 99.2) |
1.1 (0.8, 1.5) |
97.7 (97.0, 98.3) |
2.3 (1.7, 3.0) |
0.0 (NA) |
0.63 |
| Mexican American |
97.1 (96.5, 97.6) |
2.9 (2.4, 3.5) |
94.4 (93.2, 95.3) |
5.5 (4.6, 6.5) |
0.2 (0.1, 0.4) |
<0.01 |
| Total* |
93.9 (92.9, 94.7) |
6.1 (5.3, 7.1) |
|
88.3 (86.5, 89.9) |
11.1 (9.6, 12.9) |
0.6 (0.3, 1.0) |
|
|
| rs7096206 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
22.4 (20.4, 24.5) |
77.6 (75.5, 79.6) |
<0.001 |
5.2 (4.1, 6.5) |
34.4 (31.2, 37.6) |
60.4 (56.9, 63.8) |
<0.001 |
0.41 |
| Non-Hispanic Black |
15.1 (13.7, 16.7) |
84.9 (83.3, 86.3) |
2.2 (1.6, 3.0) |
25.8 (23.3, 28.5) |
71.9 (69.1, 74.6) |
0.97 |
| Mexican American |
11.4 (9.5, 13.5) |
88.6 (86.5, 90.5) |
2.2 (1.5, 3.4) |
18.3 (15.8, 21.1) |
79.5 (76.0, 82.5) |
<0.01 |
| Total* |
20.4 (18.9, 22.0) |
79.6 (78.0, 81.1) |
|
4.4 (3.6, 5.3) |
32.0 (29.7, 34.4) |
63.6 (61.0, 66.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs11003125 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
65.6 (61.6, 69.4) |
34.4 (30.6, 38.4) |
0.838 |
44.9 (39.9, 50.1) |
41.3 (36.5, 46.3) |
13.7 (10.2, 18.2) |
0.130 |
| 20-39 |
64.8 (61.6, 67.8) |
35.2 (32.2, 38.4) |
|
43.8 (40.5, 47.2) |
41.9 (38.8, 45.2) |
14.2 (10.9, 18.3) |
|
| 40-59 |
65.7 (63.6, 67.7) |
34.3 (32.3, 36.4) |
|
42.0 (38.6, 45.4) |
47.4 (42.9, 52.0) |
10.6 (8.2, 13.5) |
|
| >=60 |
64.3 (61.5, 67.1) |
35.7 (32.9, 38.5) |
|
42.4 (38.4, 46.5) |
43.9 (40.8, 47.0) |
13.7 (12.0, 15.7) |
|
| Total |
65.1 (63.3, 66.8) |
34.9 (33.2, 36.7) |
|
43.2 (41.0, 45.4) |
43.8 (41.3, 46.2) |
13.1 (11.2, 15.2) |
|
| rs1800450 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
13.8 (11.1, 17.0) |
86.2 (83.0, 88.9) |
0.604 |
3.1 (1.7, 5.6) |
21.4 (16.7, 26.9) |
75.5 (69.9, 80.3) |
0.286 |
| 20-39 |
12.7 (11.3, 14.3) |
87.3 (85.7, 88.7) |
|
2.3 (1.7, 3.1) |
20.8 (18.2, 23.6) |
76.9 (73.9, 79.6) |
|
| 40-59 |
14.0 (11.8, 16.5) |
86.0 (83.5, 88.2) |
|
1.6 (1.0, 2.6) |
24.7 (20.8, 29.1) |
73.7 (69.1, 77.8) |
|
| >=60 |
13.9 (12.5, 15.4) |
86.1 (84.6, 87.5) |
|
3.2 (1.9, 5.1) |
21.5 (18.9, 24.4) |
75.3 (72.9, 77.6) |
|
| Total |
13.5 (12.3, 14.7) |
86.5 (85.3, 87.7) |
|
2.4 (1.9, 3.1) |
22.1 (20.3, 24.0) |
75.5 (73.4, 77.5) |
|
| rs1800451 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
5.6 (3.7, 8.5) |
94.4 (91.5, 96.3) |
0.085 |
1.3 (0.6, 2.9) |
8.6 (5.6, 13.0) |
90.1 (85.2, 93.5) |
0.125 |
| 20-39 |
5.1 (4.1, 6.2) |
94.9 (93.8, 95.9) |
|
0.8 (0.6, 1.2) |
8.5 (6.8, 10.6) |
90.7 (88.5, 92.5) |
|
| 40-59 |
3.7 (3.0, 4.7) |
96.3 (95.3, 97.0) |
|
0.7 (0.5, 1.1) |
6.1 (4.5, 8.0) |
93.2 (91.3, 94.8) |
|
| >=60 |
4.3 (3.4, 5.3) |
95.7 (94.7, 96.6) |
|
0.6 (0.3, 1.2) |
7.3 (6.1, 8.8) |
92.1 (90.4, 93.5) |
|
| Total |
4.6 (3.9, 5.5) |
95.4 (94.5, 96.1) |
|
0.8 (0.6, 1.2) |
7.6 (6.3, 9.2) |
91.6 (90.0, 93.0) |
|
| rs5030737 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
92.8 (89.5, 95.1) |
7.2 (4.9, 10.5) |
0.487 |
86.4 (80.8, 90.6) |
12.7 (9.0, 17.7) |
0.8 (0.2, 3.3) |
0.269 |
| 20-39 |
93.5 (91.7, 94.9) |
6.5 (5.1, 8.3) |
|
87.7 (84.3, 90.5) |
11.5 (8.8, 15.0) |
0.8 (0.3, 1.7) |
|
| 40-59 |
94.5 (92.8, 95.8) |
5.5 (4.2, 7.2) |
|
89.2 (86.1, 91.7) |
10.6 (8.2, 13.6) |
0.2 (0.1, 0.9) |
|
| >=60 |
94.4 (93.1, 95.5) |
5.6 (4.5, 6.9) |
|
89.4 (86.7, 91.6) |
10.0 (7.8, 12.8) |
0.5 (0.3, 1.1) |
|
| Total |
93.9 (92.9, 94.7) |
6.1 (5.3, 7.1) |
|
88.3 (86.5, 89.9) |
11.1 (9.6, 12.9) |
0.6 (0.3, 1.0) |
|
| rs7096206 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
19.5 (17.1, 22.1) |
80.5 (77.9, 82.9) |
0.304 |
3.7 (2.0, 6.7) |
31.7 (27.1, 36.7) |
64.6 (60.2, 68.9) |
0.493 |
| 20-39 |
19.3 (17.0, 21.8) |
80.7 (78.2, 83.0) |
|
4.4 (3.4, 5.8) |
29.7 (25.8, 33.9) |
65.8 (61.4, 70.0) |
|
| 40-59 |
21.8 (18.7, 25.3) |
78.2 (74.7, 81.3) |
|
4.3 (2.7, 6.7) |
35.1 (30.6, 39.8) |
60.6 (55.2, 65.9) |
|
| >=60 |
21.1 (19.2, 23.2) |
78.9 (76.8, 80.8) |
|
4.9 (3.3, 7.3) |
32.4 (29.2, 35.8) |
62.6 (59.5, 65.7) |
|
| Total |
20.4 (18.9, 22.0) |
79.6 (78.0, 81.1) |
|
4.4 (3.6, 5.3) |
32.0 (29.7, 34.4) |
63.6 (61.0, 66.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs11003125 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
65.0 (62.8, 67.1) |
35.0 (32.9, 37.2) |
0.890 |
42.1 (39.5, 44.7) |
45.8 (43.5, 48.0) |
12.2 (10.1, 14.6) |
0.066 |
| Female |
65.2 (62.8, 67.4) |
34.8 (32.6, 37.2) |
|
44.2 (41.2, 47.3) |
41.9 (38.6, 45.2) |
13.9 (11.5, 16.7) |
|
| Total |
65.1 (63.3, 66.8) |
34.9 (33.2, 36.7) |
|
43.2 (41.0, 45.4) |
43.8 (41.3, 46.2) |
13.1 (11.2, 15.2) |
|
| rs1800450 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
13.4 (11.8, 15.2) |
86.6 (84.8, 88.2) |
0.882 |
2.2 (1.6, 3.1) |
22.3 (19.3, 25.5) |
75.5 (72.1, 78.5) |
0.811 |
| Female |
13.5 (12.4, 14.7) |
86.5 (85.3, 87.6) |
|
2.5 (1.8, 3.5) |
21.9 (20.3, 23.6) |
75.5 (73.6, 77.4) |
|
| Total |
13.5 (12.3, 14.7) |
86.5 (85.3, 87.7) |
|
2.4 (1.9, 3.1) |
22.1 (20.3, 24.0) |
75.5 (73.4, 77.5) |
|
| rs1800451 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
4.1 (3.3, 4.9) |
95.9 (95.1, 96.7) |
0.021 |
0.9 (0.5, 1.5) |
6.3 (5.1, 7.8) |
92.8 (91.3, 94.1) |
0.008 |
| Female |
5.1 (4.2, 6.3) |
94.9 (93.7, 95.8) |
|
0.8 (0.5, 1.1) |
8.8 (7.0, 11.0) |
90.5 (88.2, 92.3) |
|
| Total |
4.6 (3.9, 5.5) |
95.4 (94.5, 96.1) |
|
0.8 (0.6, 1.2) |
7.6 (6.3, 9.2) |
91.6 (90.0, 93.0) |
|
| rs5030737 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
94.1 (92.7, 95.2) |
5.9 (4.8, 7.3) |
0.410 |
88.4 (85.7, 90.7) |
11.4 (9.2, 14.1) |
0.2 (0.1, 0.8) |
0.140 |
| Female |
93.6 (92.9, 94.3) |
6.4 (5.7, 7.1) |
|
88.2 (86.6, 89.6) |
10.9 (9.3, 12.8) |
0.9 (0.5, 1.7) |
|
| Total |
93.9 (92.9, 94.7) |
6.1 (5.3, 7.1) |
|
88.3 (86.5, 89.9) |
11.1 (9.6, 12.9) |
0.6 (0.3, 1.0) |
|
| rs7096206 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
20.0 (18.2, 21.9) |
80.0 (78.1, 81.8) |
0.434 |
3.7 (2.4, 5.6) |
32.6 (28.4, 37.2) |
63.7 (59.9, 67.4) |
0.459 |
| Female |
20.8 (19.0, 22.7) |
79.2 (77.3, 81.0) |
|
5.1 (3.9, 6.6) |
31.4 (28.6, 34.4) |
63.5 (60.4, 66.5) |
|
| Total |
20.4 (18.9, 22.0) |
79.6 (78.0, 81.1) |
|
4.4 (3.6, 5.3) |
32.0 (29.7, 34.4) |
63.6 (61.0, 66.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs11003125 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
63.1 (58.5, 67.5) |
36.9 (32.5, 41.5) |
41.3 (36.1, 46.7) |
43.6 (37.7, 49.7) |
15.1 (10.4, 21.5) |
| 20-39 |
63.5 (59.7, 67.2) |
36.5 (32.8, 40.3) |
42.3 (38.4, 46.2) |
42.5 (38.3, 46.9) |
15.2 (11.1, 20.5) |
| 40-59 |
64.7 (62.1, 67.3) |
35.3 (32.7, 37.9) |
39.9 (35.6, 44.4) |
49.6 (44.0, 55.1) |
10.5 (7.8, 14.0) |
| >=60 |
62.7 (59.7, 65.5) |
37.3 (34.5, 40.3) |
39.5 (35.4, 43.7) |
46.4 (43.2, 49.6) |
14.1 (12.1, 16.5) |
| Non-Hispanic Black |
12-19 |
87.8 (84.5, 90.5) |
12.2 (9.5, 15.5) |
77.3 (71.7, 82.0) |
21.1 (16.9, 26.1) |
1.6 (0.7, 3.5) |
| 20-39 |
87.9 (86.1, 89.5) |
12.1 (10.5, 13.9) |
76.7 (72.9, 80.1) |
22.4 (18.7, 26.6) |
0.9 (0.3, 2.3) |
| 40-59 |
83.8 (80.3, 86.8) |
16.2 (13.2, 19.7) |
71.2 (65.8, 76.0) |
25.4 (21.2, 30.0) |
3.5 (1.9, 6.3) |
| >=60 |
89.9 (88.3, 91.3) |
10.1 (8.7, 11.7) |
82.1 (79.1, 84.8) |
15.5 (12.1, 19.6) |
2.4 (1.1, 5.1) |
| Mexican American |
12-19 |
50.0 (45.3, 54.8) |
50.0 (45.2, 54.7) |
26.4 (21.1, 32.4) |
47.3 (41.8, 52.8) |
26.3 (21.3, 32.0) |
| 20-39 |
47.7 (44.6, 50.8) |
52.3 (49.2, 55.4) |
23.0 (19.8, 26.5) |
49.3 (46.9, 51.8) |
27.7 (24.5, 31.1) |
| 40-59 |
50.0 (45.5, 54.5) |
50.0 (45.5, 54.5) |
27.1 (20.7, 34.7) |
45.8 (39.0, 52.7) |
27.1 (23.5, 31.1) |
| >=60 |
52.5 (47.5, 57.4) |
47.5 (42.6, 52.5) |
27.9 (23.2, 33.2) |
49.1 (43.8, 54.4) |
23.0 (17.4, 29.7) |
| rs1800450 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
15.6 (12.1, 19.9) |
84.4 (80.1, 87.9) |
3.9 (1.9, 7.6) |
23.5 (17.1, 31.4) |
72.6 (65.1, 79.0) |
| 20-39 |
13.7 (11.6, 16.0) |
86.3 (84.0, 88.4) |
2.8 (2.1, 3.9) |
21.7 (18.1, 25.7) |
75.5 (71.3, 79.3) |
| 40-59 |
15.1 (12.6, 18.1) |
84.9 (81.9, 87.4) |
1.8 (1.1, 3.1) |
26.6 (22.2, 31.5) |
71.6 (66.3, 76.3) |
| >=60 |
14.7 (13.2, 16.4) |
85.3 (83.6, 86.8) |
3.5 (2.2, 5.8) |
22.4 (19.4, 25.8) |
74.0 (71.3, 76.6) |
| Non-Hispanic Black |
12-19 |
6.2 (4.4, 8.6) |
93.8 (91.4, 95.6) |
0.7 (0.2, 2.5) |
11.0 (7.7, 15.4) |
88.4 (83.9, 91.7) |
| 20-39 |
3.4 (2.5, 4.5) |
96.6 (95.5, 97.5) |
0.3 (0.1, 0.9) |
6.2 (4.6, 8.2) |
93.5 (91.5, 95.1) |
| 40-59 |
3.8 (2.4, 5.8) |
96.2 (94.2, 97.6) |
0.4 (0.1, 1.9) |
6.6 (4.4, 9.9) |
92.9 (89.4, 95.3) |
| >=60 |
3.8 (2.5, 5.7) |
96.2 (94.3, 97.5) |
0.0 (NA) |
7.5 (4.9, 11.4) |
92.5 (88.6, 95.1) |
| Mexican American |
12-19 |
13.3 (9.8, 17.9) |
86.7 (82.1, 90.2) |
1.5 (0.7, 3.3) |
23.7 (17.9, 30.6) |
74.9 (67.1, 81.3) |
| 20-39 |
14.2 (11.9, 16.9) |
85.8 (83.1, 88.1) |
1.9 (0.9, 4.1) |
24.6 (20.7, 28.9) |
73.5 (68.9, 77.6) |
| 40-59 |
15.9 (14.0, 18.0) |
84.1 (82.0, 86.0) |
2.7 (1.3, 5.4) |
26.5 (21.8, 31.6) |
70.9 (66.7, 74.7) |
| >=60 |
16.8 (14.2, 19.8) |
83.2 (80.2, 85.8) |
2.5 (1.5, 4.0) |
28.7 (23.6, 34.4) |
68.9 (63.2, 74.0) |
| rs1800451 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
1.4 (0.8, 2.3) |
98.6 (97.7, 99.2) |
0.0 (NA) |
2.7 (1.6, 4.7) |
97.3 (95.3, 98.4) |
| 20-39 |
2.4 (1.7, 3.3) |
97.6 (96.7, 98.3) |
0.1 (0.0, 0.6) |
4.5 (3.3, 6.2) |
95.4 (93.6, 96.7) |
| 40-59 |
1.2 (0.8, 2.0) |
98.8 (98.0, 99.2) |
0.0 (NA) |
2.5 (1.5, 4.1) |
97.5 (95.9, 98.5) |
| >=60 |
2.6 (2.1, 3.2) |
97.4 (96.8, 97.9) |
0.2 (0.0, 1.1) |
4.8 (3.9, 6.0) |
94.9 (93.8, 95.9) |
| Non-Hispanic Black |
12-19 |
23.0 (19.4, 27.0) |
77.0 (73.0, 80.6) |
5.6 (3.6, 8.6) |
34.8 (29.0, 41.2) |
59.6 (53.0, 65.9) |
| 20-39 |
23.2 (21.5, 25.0) |
76.8 (75.0, 78.5) |
6.2 (4.2, 8.9) |
34.1 (29.5, 39.0) |
59.7 (56.3, 63.1) |
| 40-59 |
23.4 (20.9, 26.3) |
76.6 (73.7, 79.1) |
6.8 (4.4, 10.2) |
33.4 (29.5, 37.5) |
59.9 (56.0, 63.6) |
| >=60 |
23.6 (19.6, 28.2) |
76.4 (71.8, 80.4) |
5.2 (3.0, 9.0) |
36.8 (30.2, 43.9) |
58.0 (50.6, 65.0) |
| Mexican American |
12-19 |
2.1 (1.4, 3.1) |
97.9 (96.9, 98.6) |
0.0 (NA) |
4.3 (2.9, 6.2) |
95.7 (93.8, 97.1) |
| 20-39 |
2.3 (1.5, 3.6) |
97.7 (96.4, 98.5) |
0.0 (NA) |
4.7 (3.0, 7.2) |
95.3 (92.8, 97.0) |
| 40-59 |
3.2 (2.2, 4.6) |
96.8 (95.4, 97.8) |
0.0 (NA) |
6.4 (4.4, 9.2) |
93.6 (90.8, 95.6) |
| >=60 |
3.0 (2.0, 4.5) |
97.0 (95.5, 98.0) |
0.0 (NA) |
6.0 (4.0, 8.9) |
94.0 (91.1, 96.0) |
| rs5030737 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
90.9 (85.9, 94.3) |
9.1 (5.7, 14.1) |
83.1 (74.5, 89.2) |
15.7 (10.1, 23.6) |
1.2 (0.3, 4.9) |
| 20-39 |
91.6 (89.5, 93.4) |
8.4 (6.6, 10.5) |
84.4 (80.3, 87.7) |
14.6 (11.2, 18.8) |
1.1 (0.5, 2.3) |
| 40-59 |
93.6 (91.5, 95.2) |
6.4 (4.8, 8.5) |
87.5 (83.5, 90.7) |
12.2 (9.2, 16.1) |
0.3 (0.1, 1.1) |
| >=60 |
93.7 (92.1, 95.0) |
6.3 (5.0, 7.9) |
88.0 (84.8, 90.6) |
11.4 (8.8, 14.7) |
0.6 (0.3, 1.2) |
| Non-Hispanic Black |
12-19 |
98.6 (97.6, 99.2) |
1.4 (0.8, 2.4) |
97.2 (95.3, 98.3) |
2.8 (1.7, 4.7) |
0.0 (NA) |
| 20-39 |
98.8 (98.0, 99.3) |
1.2 (0.7, 2.0) |
97.7 (95.9, 98.7) |
2.3 (1.3, 4.1) |
0.0 (NA) |
| 40-59 |
98.8 (98.1, 99.3) |
1.2 (0.7, 1.9) |
97.7 (96.2, 98.6) |
2.3 (1.4, 3.8) |
0.0 (NA) |
| >=60 |
99.3 (97.8, 99.8) |
0.7 (0.2, 2.2) |
98.7 (95.6, 99.6) |
1.3 (0.4, 4.4) |
0.0 (NA) |
| Mexican American |
12-19 |
95.8 (94.3, 96.9) |
4.2 (3.1, 5.7) |
91.9 (89.6, 93.8) |
7.7 (6.1, 9.7) |
0.4 (0.1, 1.9) |
| 20-39 |
97.5 (96.3, 98.3) |
2.5 (1.7, 3.7) |
95.1 (92.9, 96.6) |
4.8 (3.3, 6.9) |
0.1 (0.0, 0.6) |
| 40-59 |
97.2 (95.8, 98.2) |
2.8 (1.8, 4.2) |
94.4 (91.6, 96.4) |
5.6 (3.6, 8.4) |
0.0 (NA) |
| >=60 |
97.7 (95.8, 98.8) |
2.3 (1.2, 4.2) |
95.8 (92.4, 97.7) |
3.8 (2.0, 7.1) |
0.4 (0.1, 2.4) |
| rs7096206 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
22.0 (18.2, 26.3) |
78.0 (73.7, 81.8) |
4.7 (2.1, 10.0) |
34.7 (28.3, 41.7) |
60.7 (54.0, 67.0) |
| 20-39 |
21.6 (18.7, 24.8) |
78.4 (75.2, 81.3) |
5.7 (4.3, 7.6) |
31.7 (26.4, 37.5) |
62.6 (56.8, 68.0) |
| 40-59 |
23.7 (19.8, 28.1) |
76.3 (71.9, 80.2) |
4.8 (2.8, 8.1) |
37.8 (32.4, 43.4) |
57.4 (50.8, 63.8) |
| >=60 |
22.3 (20.2, 24.4) |
77.7 (75.6, 79.8) |
5.2 (3.4, 7.8) |
34.1 (30.6, 37.9) |
60.7 (57.3, 63.9) |
| Non-Hispanic Black |
12-19 |
15.1 (13.0, 17.4) |
84.9 (82.6, 87.0) |
2.0 (1.2, 3.3) |
26.1 (21.6, 31.2) |
71.9 (67.2, 76.2) |
| 20-39 |
15.1 (12.8, 17.6) |
84.9 (82.4, 87.2) |
1.9 (1.1, 3.2) |
26.3 (22.9, 30.1) |
71.8 (67.5, 75.7) |
| 40-59 |
15.4 (13.6, 17.3) |
84.6 (82.7, 86.4) |
3.0 (1.7, 5.3) |
24.7 (21.7, 27.9) |
72.3 (69.2, 75.2) |
| >=60 |
15.2 (12.1, 18.9) |
84.8 (81.1, 87.9) |
2.2 (0.9, 5.1) |
26.0 (20.3, 32.7) |
71.8 (65.2, 77.6) |
| Mexican American |
12-19 |
12.7 (9.1, 17.6) |
87.3 (82.4, 90.9) |
3.7 (1.7, 8.2) |
18.0 (13.6, 23.3) |
78.3 (71.4, 83.9) |
| 20-39 |
11.1 (9.0, 13.7) |
88.9 (86.3, 91.0) |
1.9 (1.1, 3.5) |
18.4 (14.8, 22.6) |
79.7 (75.2, 83.5) |
| 40-59 |
9.8 (7.3, 12.9) |
90.2 (87.1, 92.7) |
1.6 (0.6, 4.2) |
16.2 (12.2, 21.3) |
82.1 (76.8, 86.5) |
| >=60 |
13.8 (11.5, 16.4) |
86.2 (83.6, 88.5) |
2.0 (0.9, 4.7) |
23.5 (19.6, 27.8) |
74.5 (70.1, 78.5) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs11003125 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
64.2 (62.2, 66.2) |
35.8 (33.8, 37.8) |
40.4 (37.9, 42.9) |
47.7 (45.2, 50.3) |
11.9 (9.8, 14.3) |
| Female |
63.1 (60.7, 65.4) |
36.9 (34.6, 39.3) |
41.3 (38.1, 44.7) |
43.5 (39.1, 48.0) |
15.2 (12.3, 18.6) |
| Non-Hispanic Black |
Male |
86.3 (84.3, 88.0) |
13.7 (12.0, 15.7) |
74.6 (70.9, 77.9) |
23.4 (19.9, 27.2) |
2.1 (1.2, 3.4) |
| Female |
87.9 (86.3, 89.3) |
12.1 (10.7, 13.7) |
77.5 (74.3, 80.4) |
20.8 (17.7, 24.3) |
1.7 (1.1, 2.7) |
| Mexican American |
Male |
48.3 (45.1, 51.5) |
51.7 (48.5, 54.9) |
24.1 (20.2, 28.4) |
48.6 (46.0, 51.1) |
27.4 (24.8, 30.1) |
| Female |
49.8 (47.7, 51.8) |
50.2 (48.2, 52.3) |
25.9 (22.9, 29.2) |
47.7 (44.1, 51.3) |
26.4 (24.2, 28.7) |
| rs1800450 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
14.3 (12.4, 16.6) |
85.7 (83.4, 87.6) |
2.7 (1.9, 3.7) |
23.4 (19.8, 27.5) |
74.0 (69.9, 77.7) |
| Female |
14.8 (13.2, 16.5) |
85.2 (83.5, 86.8) |
3.0 (2.1, 4.3) |
23.6 (21.4, 25.9) |
73.4 (70.8, 75.9) |
| Non-Hispanic Black |
Male |
4.5 (3.6, 5.7) |
95.5 (94.3, 96.4) |
0.3 (0.1, 1.1) |
8.4 (6.7, 10.5) |
91.3 (89.1, 93.0) |
| Female |
3.6 (2.6, 5.0) |
96.4 (95.0, 97.4) |
0.4 (0.1, 1.0) |
6.5 (4.8, 8.8) |
93.1 (90.7, 95.0) |
| Mexican American |
Male |
14.8 (13.0, 16.8) |
85.2 (83.2, 87.0) |
2.4 (1.4, 4.1) |
24.9 (22.4, 27.6) |
72.7 (69.7, 75.6) |
| Female |
14.4 (12.0, 17.1) |
85.6 (82.9, 88.0) |
1.7 (0.9, 3.0) |
25.4 (21.6, 29.7) |
72.9 (68.2, 77.2) |
| rs1800451 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
1.7 (1.2, 2.4) |
98.3 (97.6, 98.8) |
0.1 (0.0, 0.6) |
3.2 (2.2, 4.7) |
96.7 (95.3, 97.7) |
| Female |
2.2 (1.6, 3.1) |
97.8 (96.9, 98.4) |
0.1 (0.0, 0.4) |
4.3 (3.1, 5.9) |
95.6 (94.0, 96.8) |
| Non-Hispanic Black |
Male |
22.5 (19.8, 25.3) |
77.5 (74.7, 80.2) |
6.4 (4.5, 9.2) |
32.0 (28.6, 35.7) |
61.5 (57.5, 65.4) |
| Female |
24.0 (21.9, 26.1) |
76.0 (73.9, 78.1) |
5.8 (4.2, 7.8) |
36.4 (33.8, 39.1) |
57.8 (54.8, 60.8) |
| Mexican American |
Male |
2.4 (1.7, 3.3) |
97.6 (96.7, 98.3) |
0.0 (NA) |
4.8 (3.4, 6.7) |
95.2 (93.3, 96.6) |
| Female |
2.7 (2.1, 3.5) |
97.3 (96.5, 97.9) |
0.0 (NA) |
5.4 (4.1, 6.9) |
94.6 (93.1, 95.9) |
| rs5030737 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
93.0 (91.1, 94.5) |
7.0 (5.5, 8.9) |
86.2 (82.6, 89.1) |
13.6 (10.7, 17.1) |
0.2 (0.0, 1.2) |
| Female |
92.2 (91.2, 93.1) |
7.8 (6.9, 8.8) |
85.6 (83.8, 87.3) |
13.1 (11.2, 15.3) |
1.3 (0.7, 2.4) |
| Non-Hispanic Black |
Male |
99.2 (98.6, 99.5) |
0.8 (0.5, 1.4) |
98.3 (97.3, 99.0) |
1.7 (1.0, 2.7) |
0.0 (NA) |
| Female |
98.6 (98.0, 99.1) |
1.4 (0.9, 2.0) |
97.3 (95.9, 98.2) |
2.7 (1.8, 4.1) |
0.0 (NA) |
| Mexican American |
Male |
97.3 (96.3, 98.1) |
2.7 (1.9, 3.7) |
94.9 (92.9, 96.3) |
5.0 (3.6, 6.8) |
0.2 (0.1, 0.3) |
| Female |
96.8 (95.8, 97.6) |
3.2 (2.4, 4.2) |
93.8 (91.9, 95.3) |
6.0 (4.5, 7.9) |
0.2 (0.0, 0.7) |
| rs7096206 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
21.8 (19.7, 24.0) |
78.2 (76.0, 80.3) |
4.3 (2.5, 7.0) |
35.1 (30.1, 40.4) |
60.7 (56.3, 64.9) |
| Female |
22.9 (20.5, 25.6) |
77.1 (74.4, 79.5) |
6.1 (4.7, 8.0) |
33.7 (29.6, 38.0) |
60.2 (55.8, 64.5) |
| Non-Hispanic Black |
Male |
14.2 (12.3, 16.3) |
85.8 (83.7, 87.7) |
1.9 (1.1, 3.2) |
24.5 (21.2, 28.2) |
73.5 (69.8, 77.0) |
| Female |
15.9 (14.0, 18.1) |
84.1 (81.9, 86.0) |
2.5 (1.7, 3.7) |
26.9 (23.5, 30.6) |
70.6 (66.7, 74.2) |
| Mexican American |
Male |
10.4 (8.6, 12.7) |
89.6 (87.3, 91.4) |
2.4 (1.5, 3.9) |
16.1 (13.5, 19.1) |
81.5 (77.9, 84.6) |
| Female |
12.4 (10.1, 15.1) |
87.6 (84.9, 89.9) |
2.1 (1.2, 3.6) |
20.5 (16.9, 24.8) |
77.4 (72.7, 81.4) |
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