MTRR Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1801394
|
Ex2-64A>G
|
Ile22Met
Ile49Met
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1801394 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
47.2 (45.9, 48.5) |
52.8 (51.5, 54.1) |
<0.001 |
22.6 (20.9, 24.4) |
49.1 (47.1, 51.1) |
28.3 (26.7, 29.9) |
<0.001 |
0.74 |
| Non-Hispanic Black |
71.3 (69.1, 73.3) |
28.7 (26.7, 30.9) |
50.7 (47.8, 53.6) |
41.1 (39.2, 43.1) |
8.2 (6.8, 9.8) |
0.82 |
| Mexican American |
73.9 (72.0, 75.8) |
26.1 (24.2, 28.0) |
55.0 (51.8, 58.1) |
37.9 (34.7, 41.3) |
7.1 (5.7, 8.9) |
0.04 |
| Total* |
53.1 (51.5, 54.7) |
46.9 (45.3, 48.5) |
|
29.8 (27.7, 31.9) |
46.7 (45.0, 48.5) |
23.5 (22.0, 25.0) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801394 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
57.3 (51.0, 63.3) |
42.7 (36.7, 49.0) |
0.015 |
34.2 (27.9, 41.2) |
46.1 (41.6, 50.6) |
19.7 (14.0, 27.0) |
0.060 |
| 20-39 |
53.8 (51.4, 56.2) |
46.2 (43.8, 48.6) |
29.5 (26.0, 33.2) |
48.6 (45.0, 52.2) |
21.9 (19.7, 24.3) |
| 40-59 |
53.9 (50.7, 57.2) |
46.1 (42.8, 49.3) |
32.1 (27.5, 37.1) |
43.7 (38.2, 49.3) |
24.2 (20.7, 28.1) |
| >=60 |
47.8 (45.2, 50.3) |
52.2 (49.7, 54.8) |
23.9 (20.8, 27.4) |
47.7 (44.4, 50.9) |
28.4 (25.7, 31.2) |
| Total |
53.1 (51.5, 54.7) |
46.9 (45.3, 48.5) |
|
29.8 (27.7, 31.9) |
46.7 (45.0, 48.5) |
23.5 (22.0, 25.0) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801394 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
53.5 (50.7, 56.3) |
46.5 (43.7, 49.3) |
0.604 |
29.3 (26.3, 32.6) |
48.4 (45.5, 51.2) |
22.3 (19.3, 25.5) |
0.335 |
| Female |
52.8 (51.4, 54.2) |
47.2 (45.8, 48.6) |
30.2 (28.2, 32.4) |
45.2 (42.3, 48.0) |
24.6 (22.8, 26.6) |
| Total |
53.1 (51.5, 54.7) |
46.9 (45.3, 48.5) |
|
29.8 (27.7, 31.9) |
46.7 (45.0, 48.5) |
23.5 (22.0, 25.0) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801394 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
49.7 (42.6, 56.8) |
50.3 (43.2, 57.4) |
25.4 (18.5, 33.8) |
48.6 (42.1, 55.1) |
26.0 (18.8, 34.8) |
| 20-39 |
46.5 (43.6, 49.5) |
53.5 (50.5, 56.4) |
20.1 (15.9, 25.0) |
52.9 (47.8, 57.9) |
27.0 (24.0, 30.3) |
| 40-59 |
49.8 (45.9, 53.7) |
50.2 (46.3, 54.1) |
27.2 (21.7, 33.6) |
45.1 (38.7, 51.7) |
27.6 (23.8, 31.9) |
| >=60 |
43.5 (40.9, 46.0) |
56.5 (54.0, 59.1) |
19.4 (16.4, 22.7) |
48.2 (44.6, 51.9) |
32.4 (29.4, 35.6) |
| Non-Hispanic Black |
12-19 |
70.1 (66.5, 73.5) |
29.9 (26.5, 33.5) |
50.9 (46.2, 55.5) |
38.5 (34.7, 42.4) |
10.6 (7.8, 14.4) |
| 20-39 |
69.6 (66.5, 72.5) |
30.4 (27.5, 33.5) |
47.2 (42.8, 51.8) |
44.7 (40.8, 48.6) |
8.1 (6.1, 10.7) |
| 40-59 |
74.0 (69.5, 78.0) |
26.0 (22.0, 30.5) |
56.1 (49.7, 62.3) |
35.8 (30.9, 41.0) |
8.2 (5.5, 11.9) |
| >=60 |
73.1 (70.1, 76.0) |
26.9 (24.0, 29.9) |
51.5 (47.6, 55.3) |
43.3 (39.5, 47.3) |
5.2 (2.8, 9.4) |
| Mexican American |
12-19 |
73.8 (68.5, 78.5) |
26.2 (21.5, 31.5) |
54.2 (46.5, 61.7) |
39.2 (32.5, 46.4) |
6.6 (3.5, 12.1) |
| 20-39 |
74.6 (72.1, 76.9) |
25.4 (23.1, 27.9) |
55.8 (50.9, 60.6) |
37.6 (32.2, 43.3) |
6.6 (5.0, 8.8) |
| 40-59 |
72.8 (69.8, 75.6) |
27.2 (24.4, 30.2) |
54.6 (50.9, 58.4) |
36.4 (32.8, 40.1) |
9.0 (6.3, 12.6) |
| >=60 |
73.1 (69.7, 76.3) |
26.9 (23.7, 30.3) |
52.8 (48.1, 57.4) |
40.7 (36.1, 45.6) |
6.5 (3.8, 10.9) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801394 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
48.0 (45.7, 50.3) |
52.0 (49.7, 54.3) |
22.3 (19.9, 24.9) |
51.4 (47.9, 54.9) |
26.3 (23.3, 29.6) |
| Female |
46.4 (44.6, 48.3) |
53.6 (51.7, 55.4) |
23.0 (21.0, 25.1) |
46.9 (43.4, 50.5) |
30.1 (27.2, 33.1) |
| Non-Hispanic Black |
Male |
71.0 (68.0, 73.9) |
29.0 (26.1, 32.0) |
50.3 (45.8, 54.9) |
41.4 (37.8, 45.1) |
8.3 (6.5, 10.4) |
| Female |
71.5 (69.2, 73.6) |
28.5 (26.4, 30.8) |
51.0 (48.0, 54.0) |
40.9 (38.5, 43.4) |
8.1 (6.4, 10.1) |
| Mexican American |
Male |
74.3 (71.0, 77.4) |
25.7 (22.6, 29.0) |
55.5 (49.6, 61.3) |
37.6 (32.0, 43.5) |
6.9 (5.4, 8.8) |
| Female |
73.5 (71.4, 75.5) |
26.5 (24.5, 28.6) |
54.4 (51.7, 57.1) |
38.2 (36.0, 40.5) |
7.4 (5.7, 9.5) |
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