NAT2 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1041983
|
Ex2+288C>T
|
Tyr94Tyr
|
TaqMan
|
|
rs1208
|
Ex2-367A>G
|
Lys268Arg
|
TaqMan
|
|
rs1799930
|
Ex2-580G>A
|
Arg197Gln
|
TaqMan
|
|
rs1801279
|
Ex2+197G>A
|
Arg64Gln
|
TaqMan
|
|
rs1801280
|
Ex2+347T>C
|
Ile114Thr
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1041983 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
64.6 (62.9, 66.2) |
35.4 (33.8, 37.1) |
<0.001 |
41.4 (38.9, 43.9) |
46.3 (43.8, 48.9) |
12.3 (10.8, 13.8) |
<0.001 |
0.77 |
| Non-Hispanic Black |
53.9 (52.4, 55.4) |
46.1 (44.6, 47.6) |
30.8 (28.9, 32.8) |
46.2 (43.8, 48.5) |
23.0 (21.2, 24.9) |
0.03 |
| Mexican American |
68.1 (65.6, 70.6) |
31.9 (29.4, 34.4) |
46.7 (43.4, 50.1) |
42.8 (40.1, 45.6) |
10.5 (8.4, 12.9) |
0.66 |
| Total* |
63.6 (62.1, 65.0) |
36.4 (35.0, 37.9) |
|
40.4 (38.4, 42.4) |
46.3 (44.6, 48.1) |
13.3 (12.0, 14.7) |
|
|
| rs1208 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
59.0 (57.7, 60.1) |
41.0 (39.9, 42.3) |
<0.001 |
34.5 (33.1, 36.0) |
48.9 (47.3, 50.4) |
16.6 (15.2, 18.1) |
<0.001 |
0.67 |
| Non-Hispanic Black |
61.7 (60.3, 63.1) |
38.3 (36.9, 39.7) |
39.3 (37.3, 41.2) |
44.9 (42.7, 47.2) |
15.8 (14.2, 17.5) |
0.06 |
| Mexican American |
64.3 (62.1, 66.5) |
35.7 (33.5, 37.9) |
41.2 (38.2, 44.4) |
46.2 (43.5, 48.9) |
12.6 (10.8, 14.6) |
0.68 |
| Total* |
60.6 (59.8, 61.5) |
39.4 (38.5, 40.2) |
|
37.2 (35.9, 38.5) |
46.8 (45.4, 48.2) |
15.9 (15.1, 16.8) |
|
|
| rs1799930 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
32.3 (30.5, 34.1) |
67.7 (65.9, 69.5) |
<0.001 |
10.1 (8.7, 11.7) |
44.4 (42.0, 46.7) |
45.5 (42.8, 48.2) |
<0.001 |
0.83 |
| Non-Hispanic Black |
28.0 (25.8, 30.3) |
72.0 (69.7, 74.2) |
8.7 (7.1, 10.5) |
38.6 (35.6, 41.8) |
52.7 (49.2, 56.2) |
0.04 |
| Mexican American |
18.0 (16.0, 20.1) |
82.0 (79.9, 84.0) |
3.2 (2.2, 4.7) |
29.5 (26.0, 33.2) |
67.3 (63.5, 70.9) |
0.70 |
| Total* |
30.2 (28.9, 31.5) |
69.8 (68.5, 71.1) |
|
8.9 (7.9, 10.1) |
42.6 (40.8, 44.5) |
48.5 (46.5, 50.5) |
|
|
| rs1801279 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
0.0 (0.0, 0.1) |
100.0 (99.9, 100.0) |
<0.001 |
0.0 (NA) |
0.1 (0.0, 0.3) |
99.9 (99.7, 100.0) |
<0.001 |
0.97 |
| Non-Hispanic Black |
7.8 (6.9, 8.8) |
92.2 (91.2, 93.1) |
0.4 (0.2, 0.9) |
14.9 (13.1, 16.8) |
84.7 (82.8, 86.5) |
0.05 |
| Mexican American |
0.5 (0.3, 0.9) |
99.5 (99.1, 99.7) |
0.0 (0.0, 0.1) |
1.0 (0.6, 1.8) |
99.0 (98.2, 99.4) |
<0.01 |
| Total* |
1.0 (0.8, 1.3) |
99.0 (98.7, 99.2) |
|
0.0 (0.0, 0.1) |
2.0 (1.5, 2.6) |
98.0 (97.4, 98.4) |
|
|
| rs1801280 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
42.1 (40.9, 43.3) |
57.9 (56.7, 59.1) |
<0.001 |
17.5 (15.9, 19.2) |
49.3 (47.4, 51.3) |
33.2 (31.8, 34.7) |
<0.001 |
0.85 |
| Non-Hispanic Black |
29.3 (27.7, 30.9) |
70.7 (69.1, 72.3) |
9.1 (7.8, 10.7) |
40.3 (37.5, 43.1) |
50.6 (48.0, 53.3) |
0.65 |
| Mexican American |
32.4 (29.5, 35.3) |
67.6 (64.7, 70.5) |
10.1 (7.9, 12.9) |
44.4 (41.5, 47.4) |
45.4 (41.6, 49.3) |
0.60 |
| Total* |
38.9 (37.8, 40.0) |
61.1 (60.0, 62.2) |
|
15.7 (14.5, 16.8) |
46.5 (44.7, 48.2) |
37.9 (36.2, 39.6) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1041983 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
62.6 (58.6, 66.5) |
37.4 (33.5, 41.4) |
0.841 |
38.6 (33.5, 43.8) |
48.2 (42.1, 54.4) |
13.3 (9.1, 18.9) |
0.909 |
| 20-39 |
63.3 (61.0, 65.5) |
36.7 (34.5, 39.0) |
40.3 (37.4, 43.3) |
45.9 (43.3, 48.6) |
13.7 (11.7, 16.1) |
| 40-59 |
63.9 (61.1, 66.6) |
36.1 (33.4, 38.9) |
40.2 (35.9, 44.7) |
47.4 (42.4, 52.4) |
12.4 (9.8, 15.6) |
| >=60 |
64.3 (61.8, 66.7) |
35.7 (33.3, 38.2) |
42.2 (38.0, 46.5) |
44.2 (39.6, 48.8) |
13.6 (11.7, 15.8) |
| Total |
63.6 (62.1, 65.0) |
36.4 (35.0, 37.9) |
|
40.4 (38.4, 42.4) |
46.3 (44.6, 48.1) |
13.3 (12.0, 14.7) |
|
| rs1208 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
61.2 (57.6, 64.8) |
38.8 (35.2, 42.4) |
0.876 |
38.2 (33.1, 43.6) |
46.1 (41.8, 50.5) |
15.7 (13.0, 18.8) |
0.989 |
| 20-39 |
60.6 (58.5, 62.7) |
39.4 (37.3, 41.5) |
37.3 (33.6, 41.1) |
46.7 (42.4, 51.0) |
16.1 (14.3, 18.0) |
| 40-59 |
60.9 (59.1, 62.7) |
39.1 (37.3, 40.9) |
37.1 (34.1, 40.3) |
47.5 (42.9, 52.2) |
15.3 (12.7, 18.3) |
| >=60 |
59.9 (57.8, 62.0) |
40.1 (38.0, 42.2) |
36.6 (34.5, 38.7) |
46.6 (44.2, 49.1) |
16.8 (14.2, 19.7) |
| Total |
60.6 (59.8, 61.5) |
39.4 (38.5, 40.2) |
|
37.2 (35.9, 38.5) |
46.8 (45.4, 48.2) |
15.9 (15.1, 16.8) |
|
| rs1799930 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
30.2 (26.7, 34.1) |
69.8 (65.9, 73.3) |
0.823 |
8.7 (6.1, 12.4) |
43.0 (38.0, 48.2) |
48.2 (42.7, 53.8) |
0.574 |
| 20-39 |
29.6 (27.5, 31.9) |
70.4 (68.1, 72.5) |
8.9 (7.1, 11.1) |
41.5 (38.7, 44.3) |
49.6 (46.5, 52.8) |
| 40-59 |
30.5 (28.3, 32.8) |
69.5 (67.2, 71.7) |
8.1 (6.0, 11.0) |
44.7 (40.1, 49.4) |
47.1 (43.3, 50.9) |
| >=60 |
30.9 (29.2, 32.7) |
69.1 (67.3, 70.8) |
10.2 (8.6, 12.1) |
41.5 (37.4, 45.7) |
48.3 (45.0, 51.7) |
| Total |
30.2 (28.9, 31.5) |
69.8 (68.5, 71.1) |
|
8.9 (7.9, 10.1) |
42.6 (40.8, 44.5) |
48.5 (46.5, 50.5) |
|
| rs1801279 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
1.3 (0.9, 1.9) |
98.7 (98.1, 99.1) |
0.147 |
0.1 (0.0, 0.7) |
2.4 (1.7, 3.3) |
97.5 (96.4, 98.3) |
0.197 |
| 20-39 |
1.1 (0.8, 1.6) |
98.9 (98.4, 99.2) |
0.1 (0.0, 0.2) |
2.1 (1.4, 3.0) |
97.9 (97.0, 98.5) |
| 40-59 |
1.1 (0.8, 1.5) |
98.9 (98.5, 99.2) |
0.0 (0.0, 0.2) |
2.1 (1.5, 3.0) |
97.9 (97.0, 98.5) |
| >=60 |
0.7 (0.4, 1.1) |
99.3 (98.9, 99.6) |
0.0 (0.0, 0.1) |
1.3 (0.8, 2.1) |
98.7 (97.9, 99.1) |
| Total |
1.0 (0.8, 1.3) |
99.0 (98.7, 99.2) |
|
0.0 (0.0, 0.1) |
2.0 (1.5, 2.6) |
98.0 (97.4, 98.4) |
|
| rs1801280 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
37.6 (34.3, 41.0) |
62.4 (59.0, 65.7) |
0.540 |
13.4 (10.5, 16.9) |
48.5 (43.4, 53.6) |
38.2 (33.3, 43.3) |
0.591 |
| 20-39 |
38.7 (36.2, 41.2) |
61.3 (58.8, 63.8) |
15.7 (13.8, 17.7) |
46.0 (42.3, 49.8) |
38.3 (34.5, 42.3) |
| 40-59 |
38.7 (37.0, 40.5) |
61.3 (59.5, 63.0) |
15.3 (12.6, 18.5) |
46.8 (42.5, 51.1) |
37.9 (35.4, 40.5) |
| >=60 |
40.5 (37.9, 43.1) |
59.5 (56.9, 62.1) |
17.8 (14.8, 21.2) |
45.4 (42.2, 48.6) |
36.8 (34.0, 39.8) |
| Total |
38.9 (37.8, 40.0) |
61.1 (60.0, 62.2) |
|
15.7 (14.5, 16.8) |
46.5 (44.7, 48.2) |
37.9 (36.2, 39.6) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1041983 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
64.1 (62.1, 66.0) |
35.9 (34.0, 37.9) |
0.239 |
41.2 (38.8, 43.6) |
45.8 (43.9, 47.7) |
13.0 (11.2, 15.1) |
0.419 |
| Female |
63.1 (61.6, 64.6) |
36.9 (35.4, 38.4) |
39.7 (37.5, 41.9) |
46.8 (44.6, 48.9) |
13.5 (12.2, 15.0) |
| Total |
63.6 (62.1, 65.0) |
36.4 (35.0, 37.9) |
|
40.4 (38.4, 42.4) |
46.3 (44.6, 48.1) |
13.3 (12.0, 14.7) |
|
| rs1208 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
59.8 (58.2, 61.3) |
40.2 (38.7, 41.8) |
0.108 |
35.8 (33.6, 38.1) |
47.8 (45.2, 50.5) |
16.3 (14.6, 18.2) |
0.245 |
| Female |
61.5 (60.2, 62.7) |
38.5 (37.3, 39.8) |
38.5 (36.6, 40.5) |
45.9 (43.5, 48.4) |
15.6 (14.1, 17.1) |
| Total |
60.6 (59.8, 61.5) |
39.4 (38.5, 40.2) |
|
37.2 (35.9, 38.5) |
46.8 (45.4, 48.2) |
15.9 (15.1, 16.8) |
|
| rs1799930 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
29.7 (28.0, 31.4) |
70.3 (68.6, 72.0) |
0.154 |
8.2 (7.0, 9.6) |
42.9 (40.5, 45.3) |
48.9 (46.3, 51.5) |
0.128 |
| Female |
30.7 (29.4, 32.0) |
69.3 (68.0, 70.6) |
9.5 (8.4, 10.9) |
42.3 (40.0, 44.7) |
48.1 (46.0, 50.3) |
| Total |
30.2 (28.9, 31.5) |
69.8 (68.5, 71.1) |
|
8.9 (7.9, 10.1) |
42.6 (40.8, 44.5) |
48.5 (46.5, 50.5) |
|
| rs1801279 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
0.9 (0.7, 1.1) |
99.1 (98.9, 99.3) |
0.053 |
0.0 (0.0, 0.2) |
1.7 (1.3, 2.2) |
98.3 (97.8, 98.7) |
0.191 |
| Female |
1.2 (0.9, 1.6) |
98.8 (98.4, 99.1) |
0.1 (0.0, 0.2) |
2.3 (1.6, 3.2) |
97.7 (96.8, 98.3) |
| Total |
1.0 (0.8, 1.3) |
99.0 (98.7, 99.2) |
|
0.0 (0.0, 0.1) |
2.0 (1.5, 2.6) |
98.0 (97.4, 98.4) |
|
| rs1801280 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
39.8 (38.1, 41.6) |
60.2 (58.4, 61.9) |
0.092 |
16.2 (14.5, 18.0) |
47.2 (44.7, 49.8) |
36.6 (34.1, 39.2) |
0.281 |
| Female |
38.0 (36.7, 39.4) |
62.0 (60.6, 63.3) |
15.2 (13.8, 16.7) |
45.7 (43.1, 48.4) |
39.1 (36.9, 41.4) |
| Total |
38.9 (37.8, 40.0) |
61.1 (60.0, 62.2) |
|
15.7 (14.5, 16.8) |
46.5 (44.7, 48.2) |
37.9 (36.2, 39.6) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1041983 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
62.6 (58.1, 66.9) |
37.4 (33.1, 41.9) |
37.4 (29.6, 46.0) |
50.3 (39.5, 61.2) |
12.2 (7.7, 18.9) |
| 20-39 |
64.5 (61.9, 67.1) |
35.5 (32.9, 38.1) |
41.7 (38.3, 45.2) |
45.7 (42.4, 49.0) |
12.6 (10.1, 15.6) |
| 40-59 |
65.1 (61.7, 68.3) |
34.9 (31.7, 38.3) |
41.5 (36.7, 46.5) |
47.1 (41.6, 52.6) |
11.4 (8.2, 15.7) |
| >=60 |
65.1 (62.3, 67.7) |
34.9 (32.3, 37.7) |
42.9 (38.2, 47.8) |
44.2 (39.1, 49.5) |
12.8 (10.8, 15.2) |
| Non-Hispanic Black |
12-19 |
53.8 (48.4, 59.1) |
46.2 (40.9, 51.6) |
30.6 (24.8, 37.2) |
46.3 (41.6, 51.1) |
23.1 (18.0, 29.0) |
| 20-39 |
53.6 (51.7, 55.6) |
46.4 (44.4, 48.3) |
30.5 (28.1, 32.9) |
46.3 (43.1, 49.7) |
23.2 (20.6, 26.0) |
| 40-59 |
54.2 (49.5, 58.8) |
45.8 (41.2, 50.5) |
31.1 (25.8, 36.8) |
46.2 (41.8, 50.7) |
22.7 (18.3, 27.9) |
| >=60 |
54.5 (47.9, 60.9) |
45.5 (39.1, 52.1) |
31.8 (24.8, 39.8) |
45.3 (38.6, 52.2) |
22.9 (16.4, 30.9) |
| Mexican American |
12-19 |
69.8 (64.0, 75.0) |
30.2 (25.0, 36.0) |
50.6 (42.2, 58.9) |
38.4 (30.3, 47.2) |
11.0 (6.9, 17.1) |
| 20-39 |
68.1 (64.9, 71.1) |
31.9 (28.9, 35.1) |
46.8 (42.5, 51.2) |
42.6 (38.8, 46.4) |
10.6 (8.1, 13.7) |
| 40-59 |
67.8 (63.9, 71.4) |
32.2 (28.6, 36.1) |
44.9 (39.2, 50.7) |
45.7 (40.2, 51.3) |
9.4 (6.7, 13.0) |
| >=60 |
65.1 (61.7, 68.4) |
34.9 (31.6, 38.3) |
41.6 (35.6, 47.8) |
47.2 (40.6, 53.8) |
11.3 (8.9, 14.2) |
| rs1208 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
60.4 (56.5, 64.2) |
39.6 (35.8, 43.5) |
36.4 (30.3, 43.0) |
48.1 (41.3, 54.8) |
15.5 (12.3, 19.4) |
| 20-39 |
58.5 (55.4, 61.6) |
41.5 (38.4, 44.6) |
33.5 (28.6, 38.9) |
49.9 (44.9, 55.0) |
16.5 (14.3, 19.0) |
| 40-59 |
58.7 (55.9, 61.5) |
41.3 (38.5, 44.1) |
34.3 (30.2, 38.7) |
48.8 (42.8, 54.9) |
16.9 (13.2, 21.2) |
| >=60 |
59.2 (56.8, 61.5) |
40.8 (38.5, 43.2) |
35.4 (33.5, 37.4) |
47.5 (44.6, 50.4) |
17.1 (14.0, 20.7) |
| Non-Hispanic Black |
12-19 |
61.8 (56.4, 67.0) |
38.2 (33.0, 43.6) |
40.0 (33.7, 46.6) |
43.7 (39.3, 48.2) |
16.3 (12.0, 21.8) |
| 20-39 |
61.7 (59.6, 63.7) |
38.3 (36.3, 40.4) |
40.0 (36.7, 43.3) |
43.4 (39.6, 47.3) |
16.6 (14.4, 19.0) |
| 40-59 |
62.2 (58.8, 65.4) |
37.8 (34.6, 41.2) |
39.3 (34.5, 44.2) |
45.8 (40.7, 51.0) |
14.9 (11.8, 18.7) |
| >=60 |
60.9 (56.3, 65.4) |
39.1 (34.6, 43.7) |
36.1 (29.2, 43.6) |
49.7 (41.8, 57.6) |
14.2 (10.3, 19.4) |
| Mexican American |
12-19 |
64.8 (60.6, 68.7) |
35.2 (31.3, 39.4) |
40.9 (36.5, 45.6) |
47.6 (41.0, 54.3) |
11.4 (6.8, 18.7) |
| 20-39 |
63.2 (59.9, 66.5) |
36.8 (33.5, 40.1) |
39.7 (34.7, 45.0) |
47.0 (42.5, 51.6) |
13.3 (11.0, 15.9) |
| 40-59 |
67.3 (65.0, 69.5) |
32.7 (30.5, 35.0) |
44.8 (40.1, 49.5) |
45.1 (38.9, 51.4) |
10.2 (7.7, 13.3) |
| >=60 |
62.3 (56.6, 67.7) |
37.7 (32.3, 43.4) |
42.1 (36.8, 47.5) |
40.5 (35.0, 46.3) |
17.4 (11.5, 25.6) |
| rs1799930 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
33.7 (28.9, 38.9) |
66.3 (61.1, 71.1) |
10.7 (7.1, 15.8) |
46.0 (37.2, 55.1) |
43.3 (35.0, 52.0) |
| 20-39 |
32.4 (29.7, 35.3) |
67.6 (64.7, 70.3) |
10.4 (8.0, 13.5) |
44.0 (40.6, 47.4) |
45.6 (41.9, 49.4) |
| 40-59 |
31.8 (29.1, 34.6) |
68.2 (65.4, 70.9) |
9.0 (6.3, 12.7) |
45.5 (39.9, 51.3) |
45.4 (40.8, 50.1) |
| >=60 |
32.0 (30.0, 34.1) |
68.0 (65.9, 70.0) |
10.7 (8.9, 12.9) |
42.6 (38.1, 47.2) |
46.7 (42.9, 50.5) |
| Non-Hispanic Black |
12-19 |
28.1 (23.3, 33.5) |
71.9 (66.5, 76.7) |
9.8 (6.6, 14.5) |
36.6 (30.8, 42.9) |
53.6 (46.1, 60.9) |
| 20-39 |
27.9 (25.3, 30.7) |
72.1 (69.3, 74.7) |
8.9 (6.7, 11.6) |
38.1 (35.5, 40.9) |
53.0 (49.5, 56.5) |
| 40-59 |
26.9 (23.1, 31.1) |
73.1 (68.9, 76.9) |
6.2 (4.4, 8.6) |
41.4 (34.2, 49.0) |
52.4 (44.9, 59.7) |
| >=60 |
29.8 (25.4, 34.6) |
70.2 (65.4, 74.6) |
10.9 (6.9, 16.8) |
37.8 (30.7, 45.5) |
51.3 (44.6, 58.0) |
| Mexican American |
12-19 |
16.8 (13.1, 21.3) |
83.2 (78.7, 86.9) |
3.2 (1.7, 5.8) |
27.3 (20.5, 35.2) |
69.6 (61.5, 76.6) |
| 20-39 |
17.8 (15.6, 20.2) |
82.2 (79.8, 84.4) |
2.9 (1.6, 5.3) |
29.8 (25.7, 34.2) |
67.3 (63.1, 71.2) |
| 40-59 |
18.2 (14.9, 22.0) |
81.8 (78.0, 85.1) |
3.4 (1.5, 7.5) |
29.6 (24.2, 35.6) |
67.0 (60.9, 72.7) |
| >=60 |
21.0 (17.1, 25.6) |
79.0 (74.4, 82.9) |
4.7 (2.8, 7.6) |
32.6 (25.0, 41.3) |
62.7 (54.3, 70.3) |
| rs1801279 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
100.0 (NA) |
| 20-39 |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
100.0 (NA) |
| 40-59 |
0.1 (0.0, 0.5) |
99.9 (99.5, 100.0) |
0.0 (NA) |
0.1 (0.0, 1.0) |
99.9 (99.0, 100.0) |
| >=60 |
0.1 (0.0, 0.3) |
99.9 (99.7, 100.0) |
0.0 (NA) |
0.2 (0.1, 0.7) |
99.8 (99.3, 99.9) |
| Non-Hispanic Black |
12-19 |
7.7 (5.3, 11.2) |
92.3 (88.8, 94.7) |
0.6 (0.1, 3.9) |
14.3 (10.6, 19.0) |
85.1 (79.5, 89.4) |
| 20-39 |
7.8 (6.6, 9.3) |
92.2 (90.7, 93.4) |
0.4 (0.1, 1.5) |
14.8 (12.4, 17.5) |
84.8 (82.1, 87.2) |
| 40-59 |
8.6 (6.9, 10.6) |
91.4 (89.4, 93.1) |
0.2 (0.0, 1.5) |
16.7 (13.1, 21.0) |
83.1 (78.9, 86.6) |
| >=60 |
6.6 (5.4, 8.2) |
93.4 (91.8, 94.6) |
0.2 (0.0, 2.1) |
12.8 (10.1, 16.1) |
87.0 (83.8, 89.6) |
| Mexican American |
12-19 |
0.6 (0.2, 1.7) |
99.4 (98.3, 99.8) |
0.0 (NA) |
1.2 (0.5, 3.3) |
98.8 (96.7, 99.5) |
| 20-39 |
0.4 (0.2, 0.9) |
99.6 (99.1, 99.8) |
0.0 (NA) |
0.7 (0.3, 1.8) |
99.3 (98.2, 99.7) |
| 40-59 |
0.7 (0.3, 1.9) |
99.3 (98.1, 99.7) |
0.0 (NA) |
1.5 (0.5, 3.8) |
98.5 (96.2, 99.5) |
| >=60 |
0.5 (0.2, 1.2) |
99.5 (98.8, 99.8) |
0.1 (0.0, 0.7) |
0.8 (0.2, 3.6) |
99.1 (97.2, 99.7) |
| rs1801280 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
40.4 (36.7, 44.2) |
59.6 (55.8, 63.3) |
14.1 (10.1, 19.2) |
52.7 (45.2, 60.0) |
33.3 (27.5, 39.5) |
| 20-39 |
42.5 (39.3, 45.7) |
57.5 (54.3, 60.7) |
17.3 (14.8, 20.1) |
50.3 (46.3, 54.3) |
32.4 (28.0, 37.2) |
| 40-59 |
42.2 (39.4, 45.0) |
57.8 (55.0, 60.6) |
17.8 (14.1, 22.1) |
48.8 (43.6, 54.1) |
33.4 (29.8, 37.2) |
| >=60 |
42.4 (39.6, 45.3) |
57.6 (54.7, 60.4) |
19.2 (15.6, 23.4) |
46.5 (42.8, 50.3) |
34.3 (31.5, 37.2) |
| Non-Hispanic Black |
12-19 |
28.8 (24.4, 33.5) |
71.2 (66.5, 75.6) |
9.0 (6.1, 12.9) |
39.6 (34.7, 44.7) |
51.5 (44.9, 58.0) |
| 20-39 |
30.2 (28.3, 32.2) |
69.8 (67.8, 71.7) |
10.5 (8.3, 13.2) |
39.4 (35.9, 43.0) |
50.1 (47.2, 53.0) |
| 40-59 |
28.3 (25.7, 31.1) |
71.7 (68.9, 74.3) |
8.6 (6.3, 11.5) |
39.5 (33.9, 45.5) |
51.9 (46.9, 56.9) |
| >=60 |
28.7 (25.8, 31.8) |
71.3 (68.2, 74.2) |
6.1 (3.0, 12.1) |
45.2 (36.4, 54.4) |
48.7 (42.3, 55.0) |
| Mexican American |
12-19 |
32.1 (27.3, 37.4) |
67.9 (62.6, 72.7) |
9.1 (4.5, 17.5) |
46.1 (40.8, 51.5) |
44.8 (39.7, 50.0) |
| 20-39 |
33.2 (30.1, 36.6) |
66.8 (63.4, 69.9) |
10.7 (8.2, 13.8) |
45.1 (40.8, 49.6) |
44.2 (39.5, 49.1) |
| 40-59 |
30.1 (26.0, 34.6) |
69.9 (65.4, 74.0) |
8.5 (5.8, 12.3) |
43.2 (37.4, 49.1) |
48.3 (41.7, 55.0) |
| >=60 |
33.5 (28.8, 38.5) |
66.5 (61.5, 71.2) |
13.8 (9.3, 19.8) |
39.3 (34.2, 44.7) |
46.9 (41.1, 52.7) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1041983 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
65.2 (63.3, 67.1) |
34.8 (32.9, 36.7) |
42.0 (39.4, 44.7) |
46.4 (43.7, 49.1) |
11.6 (9.7, 13.7) |
| Female |
63.9 (61.9, 65.9) |
36.1 (34.1, 38.1) |
40.8 (37.6, 44.1) |
46.2 (43.1, 49.4) |
12.9 (11.4, 14.7) |
| Non-Hispanic Black |
Male |
53.6 (50.2, 56.9) |
46.4 (43.1, 49.8) |
31.1 (27.0, 35.5) |
45.0 (41.3, 48.9) |
23.9 (20.6, 27.5) |
| Female |
54.2 (52.6, 55.7) |
45.8 (44.3, 47.4) |
30.6 (28.7, 32.6) |
47.1 (44.4, 49.8) |
22.3 (20.2, 24.5) |
| Mexican American |
Male |
67.7 (64.7, 70.6) |
32.3 (29.4, 35.3) |
45.6 (41.6, 49.8) |
44.2 (41.1, 47.3) |
10.2 (8.0, 12.8) |
| Female |
68.5 (65.8, 71.2) |
31.5 (28.8, 34.2) |
47.9 (44.1, 51.6) |
41.3 (37.7, 45.1) |
10.8 (8.4, 13.8) |
| rs1208 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
58.4 (56.5, 60.2) |
41.6 (39.8, 43.5) |
33.4 (30.5, 36.4) |
50.0 (46.7, 53.2) |
16.6 (14.8, 18.7) |
| Female |
59.5 (57.7, 61.3) |
40.5 (38.7, 42.3) |
35.6 (33.7, 37.6) |
47.8 (44.9, 50.7) |
16.6 (14.2, 19.4) |
| Non-Hispanic Black |
Male |
61.9 (59.5, 64.4) |
38.1 (35.6, 40.5) |
39.9 (36.3, 43.7) |
44.1 (39.9, 48.3) |
16.0 (13.5, 18.9) |
| Female |
61.5 (59.9, 63.2) |
38.5 (36.8, 40.1) |
38.7 (36.4, 41.1) |
45.7 (43.3, 48.0) |
15.6 (14.0, 17.4) |
| Mexican American |
Male |
64.7 (61.4, 67.9) |
35.3 (32.1, 38.6) |
41.4 (37.2, 45.6) |
46.7 (43.1, 50.4) |
11.9 (9.1, 15.5) |
| Female |
63.9 (61.6, 66.1) |
36.1 (33.9, 38.4) |
41.1 (37.8, 44.5) |
45.6 (42.7, 48.6) |
13.3 (11.6, 15.2) |
| rs1799930 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
31.7 (29.9, 33.6) |
68.3 (66.4, 70.1) |
9.2 (7.6, 11.0) |
45.1 (42.4, 47.8) |
45.7 (43.0, 48.5) |
| Female |
32.9 (30.7, 35.1) |
67.1 (64.9, 69.3) |
11.0 (9.4, 12.9) |
43.7 (40.7, 46.7) |
45.3 (42.0, 48.6) |
| Non-Hispanic Black |
Male |
28.7 (25.4, 32.3) |
71.3 (67.7, 74.6) |
9.6 (7.5, 12.2) |
38.2 (33.5, 43.2) |
52.2 (46.6, 57.7) |
| Female |
27.4 (25.8, 29.0) |
72.6 (71.0, 74.2) |
7.9 (6.5, 9.6) |
38.9 (35.8, 42.1) |
53.2 (50.4, 55.9) |
| Mexican American |
Male |
18.1 (16.2, 20.3) |
81.9 (79.7, 83.8) |
3.1 (1.8, 5.2) |
30.1 (26.7, 33.9) |
66.8 (63.2, 70.2) |
| Female |
17.8 (14.9, 21.1) |
82.2 (78.9, 85.1) |
3.4 (2.0, 5.7) |
28.8 (24.8, 33.1) |
67.8 (62.7, 72.6) |
| rs1801279 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
0.0 (0.0, 0.3) |
100.0 (99.7, 100.0) |
0.0 (NA) |
0.1 (0.0, 0.6) |
99.9 (99.4, 100.0) |
| Female |
0.0 (0.0, 0.1) |
100.0 (99.9, 100.0) |
0.0 (NA) |
0.1 (0.0, 0.3) |
99.9 (99.7, 100.0) |
| Non-Hispanic Black |
Male |
7.5 (6.6, 8.5) |
92.5 (91.5, 93.4) |
0.3 (0.1, 1.6) |
14.4 (12.6, 16.4) |
85.3 (83.4, 87.1) |
| Female |
8.1 (6.9, 9.5) |
91.9 (90.5, 93.1) |
0.4 (0.1, 1.2) |
15.3 (12.8, 18.3) |
84.3 (81.4, 86.7) |
| Mexican American |
Male |
0.5 (0.2, 1.2) |
99.5 (98.8, 99.8) |
0.0 (0.0, 0.1) |
1.1 (0.5, 2.4) |
98.9 (97.6, 99.5) |
| Female |
0.5 (0.2, 1.0) |
99.5 (99.0, 99.8) |
0.0 (NA) |
0.9 (0.4, 2.0) |
99.1 (98.0, 99.6) |
| rs1801280 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
42.5 (40.5, 44.5) |
57.5 (55.5, 59.5) |
17.5 (15.6, 19.6) |
50.0 (46.8, 53.3) |
32.5 (29.5, 35.6) |
| Female |
41.8 (40.0, 43.5) |
58.2 (56.5, 60.0) |
17.4 (15.0, 20.1) |
48.7 (45.6, 51.8) |
33.9 (31.9, 36.0) |
| Non-Hispanic Black |
Male |
30.2 (28.1, 32.5) |
69.8 (67.5, 71.9) |
10.2 (8.7, 11.9) |
40.0 (36.2, 44.0) |
49.8 (46.0, 53.5) |
| Female |
28.5 (26.5, 30.5) |
71.5 (69.5, 73.5) |
8.2 (6.5, 10.4) |
40.4 (37.6, 43.3) |
51.3 (48.4, 54.2) |
| Mexican American |
Male |
31.6 (28.2, 35.2) |
68.4 (64.8, 71.8) |
9.7 (7.0, 13.2) |
43.8 (41.1, 46.5) |
46.5 (42.2, 50.9) |
| Female |
33.2 (30.3, 36.2) |
66.8 (63.8, 69.7) |
10.6 (8.6, 13.1) |
45.1 (40.9, 49.4) |
44.3 (39.7, 48.9) |
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