NOS2A Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1800482
|
G>C in promoter
|
|
MGB Eclipse
|
|
rs9282799
|
-2892C>T
-1173C>T
|
|
MGB Eclipse
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1800482 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
0.1 (0.0, 0.1) |
99.9 (99.9, 100.0) |
<0.001 |
0.0 (NA) |
0.1 (0.0, 0.3) |
99.9 (99.7, 100.0) |
<0.001 |
0.96 |
| Non-Hispanic Black |
6.3 (5.0, 7.8) |
93.7 (92.2, 95.0) |
0.5 (0.3, 1.0) |
11.5 (9.2, 14.2) |
88.0 (85.1, 90.4) |
0.81 |
| Mexican American |
0.3 (0.1, 0.7) |
99.7 (99.3, 99.9) |
0.1 (0.0, 0.7) |
0.4 (0.2, 0.9) |
99.5 (98.9, 99.8) |
<0.01 |
| Total* |
1.0 (0.7, 1.3) |
99.0 (98.7, 99.3) |
|
0.1 (0.0, 0.1) |
1.8 (1.3, 2.5) |
98.2 (97.5, 98.7) |
|
|
| rs9282799 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
100.0 (99.9, 100.0) |
0.0 (0.0, 0.1) |
<0.001 |
99.9 (99.7, 100.0) |
0.1 (0.0, 0.3) |
0.0 (NA) |
<0.001 |
0.96 |
| Non-Hispanic Black |
95.5 (94.9, 96.1) |
4.5 (3.9, 5.1) |
91.2 (90.1, 92.3) |
8.5 (7.5, 9.6) |
0.2 (0.1, 0.6) |
0.65 |
| Mexican American |
99.6 (99.3, 99.8) |
0.4 (0.2, 0.7) |
99.2 (98.5, 99.6) |
0.8 (0.4, 1.5) |
0.0 (NA) |
0.89 |
| Total* |
99.3 (99.1, 99.5) |
0.7 (0.5, 0.9) |
|
98.7 (98.2, 99.1) |
1.3 (0.9, 1.8) |
0.0 (0.0, 0.1) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
Top of Page
By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800482 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
0.9 (0.5, 1.5) |
99.1 (98.5, 99.5) |
0.500 |
0.0 (NA) |
1.8 (1.1, 2.9) |
98.2 (97.1, 98.9) |
0.020 |
| 20-39 |
1.1 (0.7, 1.7) |
98.9 (98.3, 99.3) |
0.1 (0.0, 0.2) |
2.1 (1.4, 3.2) |
97.9 (96.7, 98.6) |
| 40-59 |
0.9 (0.6, 1.5) |
99.1 (98.5, 99.4) |
0.1 (0.0, 0.3) |
1.7 (1.0, 2.8) |
98.2 (97.1, 98.9) |
| >=60 |
0.8 (0.5, 1.2) |
99.2 (98.8, 99.5) |
0.1 (0.0, 0.3) |
1.4 (0.9, 2.1) |
98.6 (97.7, 99.1) |
| Total |
1.0 (0.7, 1.3) |
99.0 (98.7, 99.3) |
|
0.1 (0.0, 0.1) |
1.8 (1.3, 2.5) |
98.2 (97.5, 98.7) |
|
| rs9282799 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
99.2 (98.7, 99.5) |
0.8 (0.5, 1.3) |
0.021 |
98.6 (97.6, 99.1) |
1.3 (0.8, 2.1) |
0.1 (0.0, 0.4) |
0.230 |
| 20-39 |
99.1 (98.6, 99.5) |
0.9 (0.5, 1.4) |
98.3 (97.3, 99.0) |
1.7 (1.0, 2.7) |
0.0 (0.0, 0.1) |
| 40-59 |
99.4 (99.2, 99.6) |
0.6 (0.4, 0.8) |
98.9 (98.4, 99.2) |
1.1 (0.8, 1.6) |
0.0 (NA) |
| >=60 |
99.7 (99.4, 99.8) |
0.3 (0.2, 0.6) |
99.4 (98.9, 99.6) |
0.6 (0.4, 1.1) |
0.0 (NA) |
| Total |
99.3 (99.1, 99.5) |
0.7 (0.5, 0.9) |
|
98.7 (98.2, 99.1) |
1.3 (0.9, 1.8) |
0.0 (0.0, 0.1) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800482 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
1.2 (0.8, 1.6) |
98.8 (98.4, 99.2) |
0.001 |
0.1 (0.0, 0.2) |
2.2 (1.6, 3.1) |
97.7 (96.8, 98.4) |
0.008 |
| Female |
0.8 (0.5, 1.1) |
99.2 (98.9, 99.5) |
0.1 (0.0, 0.1) |
1.4 (1.0, 2.0) |
98.5 (97.9, 99.0) |
| Total |
1.0 (0.7, 1.3) |
99.0 (98.7, 99.3) |
|
0.1 (0.0, 0.1) |
1.8 (1.3, 2.5) |
98.2 (97.5, 98.7) |
|
| rs9282799 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
99.4 (99.1, 99.5) |
0.6 (0.5, 0.9) |
0.846 |
98.7 (98.3, 99.1) |
1.2 (0.9, 1.7) |
0.0 (0.0, 0.1) |
0.945 |
| Female |
99.3 (98.8, 99.6) |
0.7 (0.4, 1.2) |
98.7 (97.7, 99.2) |
1.3 (0.7, 2.2) |
0.0 (0.0, 0.1) |
| Total |
99.3 (99.1, 99.5) |
0.7 (0.5, 0.9) |
|
98.7 (98.2, 99.1) |
1.3 (0.9, 1.8) |
0.0 (0.0, 0.1) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800482 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
0.1 (0.0, 0.9) |
99.9 (99.1, 100.0) |
0.0 (NA) |
0.2 (0.0, 1.8) |
99.8 (98.2, 100.0) |
| 20-39 |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
100.0 (NA) |
| 40-59 |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
100.0 (NA) |
| >=60 |
0.2 (0.0, 0.6) |
99.8 (99.4, 100.0) |
0.0 (NA) |
0.3 (0.1, 1.1) |
99.7 (98.9, 99.9) |
| Non-Hispanic Black |
12-19 |
4.9 (3.2, 7.3) |
95.1 (92.7, 96.8) |
0.0 (NA) |
9.7 (6.4, 14.5) |
90.3 (85.5, 93.6) |
| 20-39 |
6.0 (4.5, 7.9) |
94.0 (92.1, 95.5) |
0.5 (0.1, 1.5) |
11.0 (8.5, 14.1) |
88.6 (85.1, 91.3) |
| 40-59 |
7.5 (5.6, 10.1) |
92.5 (89.9, 94.4) |
0.7 (0.2, 3.0) |
13.6 (10.1, 18.2) |
85.6 (81.0, 89.3) |
| >=60 |
6.7 (5.1, 8.7) |
93.3 (91.3, 94.9) |
0.9 (0.2, 3.4) |
11.6 (8.9, 14.9) |
87.5 (84.1, 90.3) |
| Mexican American |
12-19 |
0.1 (0.0, 0.9) |
99.9 (99.1, 100.0) |
0.0 (NA) |
0.2 (0.0, 1.7) |
99.8 (98.3, 100.0) |
| 20-39 |
0.3 (0.1, 0.8) |
99.7 (99.2, 99.9) |
0.0 (NA) |
0.7 (0.3, 1.5) |
99.3 (98.5, 99.7) |
| 40-59 |
0.4 (0.1, 3.2) |
99.6 (96.8, 99.9) |
0.4 (0.1, 3.2) |
0.0 (NA) |
99.6 (96.8, 99.9) |
| >=60 |
0.0 (0.0, 0.3) |
100.0 (99.7, 100.0) |
0.0 (NA) |
0.1 (0.0, 0.5) |
99.9 (99.5, 100.0) |
| rs9282799 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
100.0 (NA) |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
| 20-39 |
100.0 (NA) |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
| 40-59 |
100.0 (99.7, 100.0) |
0.0 (0.0, 0.3) |
99.9 (99.4, 100.0) |
0.1 (0.0, 0.6) |
0.0 (NA) |
| >=60 |
99.9 (99.5, 100.0) |
0.1 (0.0, 0.5) |
99.8 (99.0, 99.9) |
0.2 (0.1, 1.0) |
0.0 (NA) |
| Non-Hispanic Black |
12-19 |
95.5 (93.1, 97.0) |
4.5 (3.0, 6.9) |
91.7 (87.6, 94.5) |
7.5 (5.0, 11.3) |
0.8 (0.2, 2.5) |
| 20-39 |
94.9 (93.9, 95.8) |
5.1 (4.2, 6.1) |
90.1 (88.1, 91.8) |
9.7 (8.0, 11.7) |
0.2 (0.1, 0.9) |
| 40-59 |
95.1 (94.0, 96.0) |
4.9 (4.0, 6.0) |
90.2 (88.1, 92.0) |
9.8 (8.0, 11.9) |
0.0 (NA) |
| >=60 |
97.9 (96.7, 98.7) |
2.1 (1.3, 3.3) |
95.8 (93.3, 97.4) |
4.2 (2.6, 6.7) |
0.0 (NA) |
| Mexican American |
12-19 |
99.2 (98.0, 99.7) |
0.8 (0.3, 2.0) |
98.4 (96.0, 99.4) |
1.6 (0.6, 4.0) |
0.0 (NA) |
| 20-39 |
99.6 (99.0, 99.9) |
0.4 (0.1, 1.0) |
99.2 (98.0, 99.7) |
0.8 (0.3, 2.0) |
0.0 (NA) |
| 40-59 |
100.0 (NA) |
0.0 (NA) |
100.0 (NA) |
0.0 (NA) |
0.0 (NA) |
| >=60 |
99.5 (96.5, 99.9) |
0.5 (0.1, 3.5) |
99.0 (93.2, 99.9) |
1.0 (0.1, 6.8) |
0.0 (NA) |
Top of Page
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800482 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
0.1 (0.0, 0.3) |
99.9 (99.7, 100.0) |
0.0 (NA) |
0.2 (0.1, 0.6) |
99.8 (99.4, 99.9) |
| Female |
0.0 (0.0, 0.1) |
100.0 (99.9, 100.0) |
0.0 (NA) |
0.0 (0.0, 0.2) |
100.0 (99.8, 100.0) |
| Non-Hispanic Black |
Male |
7.0 (5.3, 9.2) |
93.0 (90.8, 94.7) |
0.6 (0.2, 1.9) |
12.7 (9.9, 16.3) |
86.6 (82.8, 89.7) |
| Female |
5.6 (4.4, 7.1) |
94.4 (92.9, 95.6) |
0.4 (0.2, 0.9) |
10.5 (8.1, 13.5) |
89.1 (86.2, 91.5) |
| Mexican American |
Male |
0.2 (0.1, 0.6) |
99.8 (99.4, 99.9) |
0.0 (NA) |
0.4 (0.2, 1.1) |
99.6 (98.9, 99.8) |
| Female |
0.3 (0.1, 1.3) |
99.7 (98.7, 99.9) |
0.2 (0.0, 1.4) |
0.3 (0.1, 1.5) |
99.5 (98.3, 99.9) |
| rs9282799 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
100.0 (99.9, 100.0) |
0.0 (0.0, 0.1) |
99.9 (99.8, 100.0) |
0.1 (0.0, 0.2) |
0.0 (NA) |
| Female |
100.0 (99.8, 100.0) |
0.0 (0.0, 0.2) |
99.9 (99.6, 100.0) |
0.1 (0.0, 0.4) |
0.0 (NA) |
| Non-Hispanic Black |
Male |
94.6 (93.4, 95.7) |
5.4 (4.3, 6.6) |
89.5 (87.0, 91.6) |
10.3 (8.2, 12.9) |
0.2 (0.1, 0.9) |
| Female |
96.2 (95.3, 97.0) |
3.8 (3.0, 4.7) |
92.7 (90.7, 94.2) |
7.1 (5.4, 9.2) |
0.3 (0.1, 0.9) |
| Mexican American |
Male |
99.7 (99.0, 99.9) |
0.3 (0.1, 1.0) |
99.4 (98.0, 99.8) |
0.6 (0.2, 2.0) |
0.0 (NA) |
| Female |
99.5 (99.1, 99.7) |
0.5 (0.3, 0.9) |
99.0 (98.2, 99.5) |
1.0 (0.5, 1.8) |
0.0 (NA) |
Top of Page