NOS3 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations |
Genotyping method
|
| Nucleotide change |
Amino acid |
|
rs1799983
|
Ex8-63G>T
-786T>C
|
Glu298Asp
|
TaqMan
|
|
rs2070744
|
IVS1-762T>C
-786T>C
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1799983 |
|
G |
T |
|
GG |
GT |
TT |
|
|
| Non-Hispanic White |
67.5 (65.6, 69.3) |
32.5 (30.7, 34.4) |
<0.001 |
45.5 (42.4, 48.6) |
43.9 (40.8, 47.1) |
10.6 (9.2, 12.1) |
<0.001 |
0.35 |
| Non-Hispanic Black |
86.9 (85.3, 88.3) |
13.1 (11.7, 14.7) |
74.9 (71.8, 77.7) |
24.0 (21.2, 27.1) |
1.1 (0.7, 1.6) |
0.10 |
| Mexican American |
80.4 (78.4, 82.3) |
19.6 (17.7, 21.6) |
65.0 (61.6, 68.2) |
30.8 (27.9, 33.9) |
4.2 (3.2, 5.4) |
0.11 |
| Total* |
71.5 (70.3, 72.6) |
28.5 (27.4, 29.7) |
|
51.5 (49.4, 53.6) |
39.9 (37.6, 42.2) |
8.6 (7.7, 9.7) |
|
|
| rs2070744 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
39.1 (37.1, 41.1) |
60.9 (58.9, 62.9) |
<0.001 |
15.3 (13.5, 17.3) |
47.6 (45.3, 49.9) |
37.1 (34.5, 39.8) |
<0.001 |
0.31 |
| Non-Hispanic Black |
15.1 (13.8, 16.5) |
84.9 (83.5, 86.2) |
1.6 (1.2, 2.0) |
27.2 (24.6, 29.9) |
71.3 (68.5, 73.8) |
0.07 |
| Mexican American |
25.1 (22.9, 27.5) |
74.9 (72.5, 77.1) |
7.3 (6.0, 8.8) |
35.7 (32.3, 39.2) |
57.0 (53.2, 60.8) |
0.01 |
| Total* |
34.2 (32.2, 36.3) |
65.8 (63.7, 67.8) |
|
12.6 (11.1, 14.2) |
43.3 (40.8, 45.8) |
44.1 (41.1, 47.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1799983 |
|
G |
T |
|
GG |
GT |
TT |
|
| 12-19 |
72.5 (68.4, 76.2) |
27.5 (23.8, 31.6) |
0.222 |
52.9 (46.9, 58.8) |
39.2 (33.3, 45.4) |
7.9 (5.1, 12.2) |
0.249 |
| 20-39 |
70.8 (68.8, 72.7) |
29.2 (27.3, 31.2) |
50.7 (47.6, 53.9) |
40.1 (36.5, 43.7) |
9.2 (7.4, 11.4) |
| 40-59 |
72.9 (70.8, 75.0) |
27.1 (25.0, 29.2) |
54.0 (50.4, 57.6) |
37.9 (33.5, 42.5) |
8.1 (6.0, 10.9) |
| >=60 |
70.1 (68.8, 71.4) |
29.9 (28.6, 31.2) |
48.7 (46.1, 51.4) |
42.7 (39.2, 46.2) |
8.6 (7.1, 10.3) |
| Total |
71.5 (70.3, 72.6) |
28.5 (27.4, 29.7) |
|
51.5 (49.4, 53.6) |
39.9 (37.6, 42.2) |
8.6 (7.7, 9.7) |
|
| rs2070744 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
30.8 (26.9, 35.0) |
69.2 (65.0, 73.1) |
0.182 |
10.9 (7.8, 15.0) |
39.8 (35.6, 44.2) |
49.3 (43.9, 54.7) |
0.149 |
| 20-39 |
34.7 (32.2, 37.2) |
65.3 (62.8, 67.8) |
12.8 (10.4, 15.6) |
43.7 (40.3, 47.2) |
43.5 (40.1, 46.9) |
| 40-59 |
34.2 (30.6, 38.1) |
65.8 (61.9, 69.4) |
12.2 (9.6, 15.4) |
44.1 (40.7, 47.5) |
43.7 (38.8, 48.8) |
| >=60 |
35.7 (33.4, 38.0) |
64.3 (62.0, 66.6) |
13.8 (11.6, 16.3) |
43.7 (41.0, 46.5) |
42.4 (39.5, 45.5) |
| Total |
34.2 (32.2, 36.3) |
65.8 (63.7, 67.8) |
|
12.6 (11.1, 14.2) |
43.3 (40.8, 45.8) |
44.1 (41.1, 47.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1799983 |
|
G |
T |
|
GG |
GT |
TT |
|
| Male |
71.5 (69.1, 73.8) |
28.5 (26.2, 30.9) |
0.974 |
52.0 (48.2, 55.7) |
39.0 (35.3, 42.8) |
9.0 (7.1, 11.3) |
0.674 |
| Female |
71.4 (69.6, 73.2) |
28.6 (26.8, 30.4) |
51.1 (48.5, 53.7) |
40.6 (38.3, 43.1) |
8.2 (6.7, 10.1) |
| Total |
71.5 (70.3, 72.6) |
28.5 (27.4, 29.7) |
|
51.5 (49.4, 53.6) |
39.9 (37.6, 42.2) |
8.6 (7.7, 9.7) |
|
| rs2070744 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
33.2 (30.2, 36.4) |
66.8 (63.6, 69.8) |
0.164 |
11.7 (9.5, 14.4) |
43.0 (39.1, 46.9) |
45.3 (40.8, 49.9) |
0.375 |
| Female |
35.1 (33.3, 37.0) |
64.9 (63.0, 66.7) |
13.4 (11.7, 15.2) |
43.6 (40.6, 46.6) |
43.1 (40.2, 46.0) |
| Total |
34.2 (32.2, 36.3) |
65.8 (63.7, 67.8) |
|
12.6 (11.1, 14.2) |
43.3 (40.8, 45.8) |
44.1 (41.1, 47.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1799983 |
|
|
G |
T |
GG |
GT |
TT |
| Non-Hispanic White |
12-19 |
67.8 (62.7, 72.4) |
32.2 (27.6, 37.3) |
46.1 (38.5, 53.9) |
43.4 (35.3, 51.8) |
10.5 (6.8, 16.1) |
| 20-39 |
65.5 (62.6, 68.3) |
34.5 (31.7, 37.4) |
43.4 (39.4, 47.5) |
44.3 (40.0, 48.6) |
12.4 (9.6, 15.7) |
| 40-59 |
69.7 (67.3, 72.0) |
30.3 (28.0, 32.7) |
48.6 (44.0, 53.2) |
42.3 (36.9, 47.8) |
9.2 (7.1, 11.7) |
| >=60 |
67.8 (65.9, 69.6) |
32.2 (30.4, 34.1) |
44.9 (41.6, 48.1) |
45.8 (41.9, 49.7) |
9.3 (7.6, 11.4) |
| Non-Hispanic Black |
12-19 |
86.6 (84.5, 88.5) |
13.4 (11.5, 15.5) |
74.1 (70.0, 77.8) |
25.0 (21.3, 29.2) |
0.9 (0.4, 2.1) |
| 20-39 |
86.6 (84.1, 88.7) |
13.4 (11.3, 15.9) |
74.4 (69.8, 78.6) |
24.3 (20.2, 29.0) |
1.3 (0.6, 2.7) |
| 40-59 |
88.4 (85.7, 90.6) |
11.6 (9.4, 14.3) |
77.0 (71.6, 81.6) |
22.8 (18.1, 28.2) |
0.3 (0.0, 1.9) |
| >=60 |
85.6 (83.2, 87.7) |
14.4 (12.3, 16.8) |
73.5 (69.1, 77.4) |
24.2 (19.6, 29.5) |
2.3 (0.9, 6.0) |
| Mexican American |
12-19 |
80.1 (77.3, 82.6) |
19.9 (17.4, 22.7) |
65.4 (61.0, 69.6) |
29.4 (24.7, 34.6) |
5.2 (3.1, 8.8) |
| 20-39 |
81.1 (77.8, 84.1) |
18.9 (15.9, 22.2) |
65.7 (59.8, 71.0) |
30.9 (26.0, 36.3) |
3.4 (2.4, 5.0) |
| 40-59 |
80.7 (77.3, 83.7) |
19.3 (16.3, 22.7) |
65.8 (60.0, 71.1) |
29.9 (24.7, 35.8) |
4.3 (2.5, 7.3) |
| >=60 |
75.9 (72.3, 79.2) |
24.1 (20.8, 27.7) |
57.8 (50.7, 64.6) |
36.3 (28.7, 44.6) |
5.9 (3.9, 8.9) |
| rs2070744 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
36.4 (32.0, 41.0) |
63.6 (59.0, 68.0) |
14.3 (10.3, 19.6) |
44.1 (39.4, 49.0) |
41.5 (36.1, 47.2) |
| 20-39 |
40.8 (37.9, 43.8) |
59.2 (56.2, 62.1) |
16.2 (13.0, 20.1) |
49.2 (45.5, 52.9) |
34.6 (31.2, 38.1) |
| 40-59 |
38.0 (33.7, 42.4) |
62.0 (57.6, 66.3) |
14.2 (11.1, 18.1) |
47.5 (43.9, 51.1) |
38.3 (32.8, 44.1) |
| >=60 |
39.2 (36.6, 41.9) |
60.8 (58.1, 63.4) |
15.7 (12.9, 18.9) |
47.0 (44.0, 50.0) |
37.3 (34.3, 40.4) |
| Non-Hispanic Black |
12-19 |
13.0 (10.8, 15.6) |
87.0 (84.4, 89.2) |
1.6 (0.8, 3.1) |
22.9 (19.2, 27.1) |
75.5 (71.0, 79.6) |
| 20-39 |
15.8 (14.1, 17.6) |
84.2 (82.4, 85.9) |
1.8 (1.0, 3.2) |
27.9 (24.7, 31.4) |
70.3 (66.9, 73.4) |
| 40-59 |
15.6 (12.6, 19.0) |
84.4 (81.0, 87.4) |
0.9 (0.3, 2.4) |
29.4 (24.4, 35.0) |
69.7 (63.6, 75.2) |
| >=60 |
15.3 (12.1, 19.3) |
84.7 (80.7, 87.9) |
2.1 (1.2, 3.4) |
26.5 (20.5, 33.6) |
71.4 (64.2, 77.7) |
| Mexican American |
12-19 |
27.5 (23.0, 32.5) |
72.5 (67.5, 77.0) |
8.9 (5.3, 14.6) |
37.3 (30.4, 44.7) |
53.8 (46.7, 60.8) |
| 20-39 |
24.3 (22.2, 26.4) |
75.7 (73.6, 77.8) |
6.6 (5.3, 8.3) |
35.2 (31.6, 39.0) |
58.1 (54.4, 61.7) |
| 40-59 |
23.6 (20.7, 26.7) |
76.4 (73.3, 79.3) |
5.8 (4.0, 8.3) |
35.6 (29.9, 41.6) |
58.7 (53.0, 64.1) |
| >=60 |
28.6 (24.9, 32.7) |
71.4 (67.3, 75.1) |
11.1 (8.8, 13.9) |
35.1 (30.0, 40.6) |
53.8 (47.6, 59.9) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1799983 |
|
|
G |
T |
GG |
GT |
TT |
| Non-Hispanic White |
Male |
67.8 (64.2, 71.1) |
32.2 (28.9, 35.8) |
46.2 (41.1, 51.4) |
43.2 (38.3, 48.2) |
10.7 (8.0, 14.1) |
| Female |
67.2 (65.0, 69.3) |
32.8 (30.7, 35.0) |
44.9 (41.8, 48.0) |
44.7 (41.7, 47.7) |
10.5 (8.7, 12.5) |
| Non-Hispanic Black |
Male |
86.8 (85.2, 88.3) |
13.2 (11.7, 14.8) |
74.8 (71.5, 77.8) |
24.2 (21.0, 27.6) |
1.1 (0.6, 2.0) |
| Female |
86.9 (84.5, 89.0) |
13.1 (11.0, 15.5) |
75.0 (70.6, 78.9) |
24.0 (20.3, 28.1) |
1.1 (0.6, 1.9) |
| Mexican American |
Male |
79.6 (76.9, 82.1) |
20.4 (17.9, 23.1) |
64.5 (60.0, 68.7) |
30.3 (26.4, 34.4) |
5.2 (4.0, 6.9) |
| Female |
81.2 (79.1, 83.1) |
18.8 (16.9, 20.9) |
65.5 (62.0, 68.8) |
31.4 (28.5, 34.6) |
3.1 (2.2, 4.3) |
| rs2070744 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
37.8 (34.6, 41.1) |
62.2 (58.9, 65.4) |
14.0 (11.1, 17.5) |
47.5 (43.3, 51.7) |
38.5 (34.1, 43.0) |
| Female |
40.3 (38.3, 42.5) |
59.7 (57.5, 61.7) |
16.5 (14.4, 18.8) |
47.7 (44.6, 50.8) |
35.8 (32.9, 38.9) |
| Non-Hispanic Black |
Male |
15.6 (13.8, 17.6) |
84.4 (82.4, 86.2) |
1.8 (1.2, 2.8) |
27.5 (24.3, 31.0) |
70.6 (67.0, 74.0) |
| Female |
14.8 (12.8, 17.0) |
85.2 (83.0, 87.2) |
1.3 (0.9, 2.0) |
26.9 (23.0, 31.1) |
71.8 (67.5, 75.7) |
| Mexican American |
Male |
25.7 (23.2, 28.3) |
74.3 (71.7, 76.8) |
8.3 (6.9, 10.0) |
34.7 (30.8, 38.7) |
57.0 (52.6, 61.3) |
| Female |
24.6 (22.1, 27.2) |
75.4 (72.8, 77.9) |
6.2 (4.6, 8.2) |
36.8 (32.6, 41.2) |
57.0 (52.6, 61.4) |
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