NQO1 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs10517
|
Ex6-457C>T
|
|
TaqMan
|
|
rs1800566
|
Ex6+40C>T
609C>T
|
Pro187Ser
Pro149Ser
Pro153Ser
|
TaqMan
|
|
rs34755915
|
IVS3+20G>A
|
|
TaqMan
|
|
rs689452
|
IVS1-27C>G
|
|
TaqMan
|
|
rs689453
|
Ex2+65G>A
|
Glu24Glu
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs10517 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
86.8 (85.7, 87.9) |
13.2 (12.1, 14.3) |
<0.001 |
75.5 (73.5, 77.3) |
22.8 (21.0, 24.7) |
1.8 (1.2, 2.6) |
0.001 |
0.65 |
| Non-Hispanic Black |
86.1 (84.6, 87.5) |
13.9 (12.5, 15.4) |
73.9 (71.4, 76.3) |
24.3 (22.2, 26.6) |
1.7 (1.1, 2.7) |
0.65 |
| Mexican American |
93.5 (91.7, 94.9) |
6.5 (5.1, 8.3) |
87.2 (83.8, 90.0) |
12.6 (9.8, 16.0) |
0.2 (0.1, 0.5) |
0.20 |
| Total* |
86.4 (85.1, 87.7) |
13.6 (12.3, 14.9) |
|
75.0 (73.0, 77.0) |
22.9 (21.4, 24.4) |
2.1 (1.5, 3.0) |
|
|
| rs1800566 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
80.6 (78.7, 82.4) |
19.4 (17.6, 21.3) |
<0.001 |
64.7 (61.2, 68.0) |
31.8 (28.7, 35.1) |
3.5 (2.8, 4.3) |
<0.001 |
0.51 |
| Non-Hispanic Black |
81.2 (80.0, 82.3) |
18.8 (17.7, 20.0) |
65.8 (64.1, 67.5) |
30.7 (29.1, 32.3) |
3.5 (2.7, 4.6) |
0.93 |
| Mexican American |
63.2 (61.2, 65.1) |
36.8 (34.9, 38.8) |
40.4 (37.5, 43.4) |
45.6 (42.8, 48.4) |
14.0 (12.4, 15.8) |
0.93 |
| Total* |
78.5 (76.8, 80.2) |
21.5 (19.8, 23.2) |
|
61.8 (58.8, 64.7) |
33.4 (30.8, 36.2) |
4.8 (4.1, 5.6) |
|
|
| rs34755915 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
1.8 (1.5, 2.3) |
98.2 (97.7, 98.5) |
<0.001 |
0.0 (0.0, 0.4) |
3.5 (2.9, 4.4) |
96.4 (95.6, 97.1) |
<0.001 |
0.81 |
| Non-Hispanic Black |
0.4 (0.2, 0.8) |
99.6 (99.2, 99.8) |
0.0 (NA) |
0.8 (0.4, 1.6) |
99.2 (98.4, 99.6) |
0.88 |
| Mexican American |
0.5 (0.3, 0.9) |
99.5 (99.1, 99.7) |
0.0 (NA) |
1.1 (0.6, 1.8) |
98.9 (98.2, 99.4) |
0.82 |
| Total* |
1.4 (1.1, 1.8) |
98.6 (98.2, 98.9) |
|
0.0 (0.0, 0.3) |
2.8 (2.2, 3.5) |
97.2 (96.5, 97.8) |
|
|
| rs689452 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
88.1 (87.1, 89.0) |
11.9 (11.0, 12.9) |
<0.001 |
77.5 (75.7, 79.3) |
21.1 (19.4, 23.0) |
1.3 (0.9, 2.0) |
<0.001 |
0.23 |
| Non-Hispanic Black |
86.3 (84.7, 87.7) |
13.7 (12.3, 15.3) |
74.2 (71.7, 76.6) |
24.1 (21.9, 26.4) |
1.7 (1.1, 2.6) |
0.63 |
| Mexican American |
93.7 (91.8, 95.1) |
6.3 (4.9, 8.2) |
87.5 (83.9, 90.4) |
12.3 (9.4, 15.8) |
0.2 (0.1, 0.5) |
0.25 |
| Total* |
87.5 (86.3, 88.6) |
12.5 (11.4, 13.7) |
|
76.6 (74.8, 78.4) |
21.6 (20.2, 23.2) |
1.7 (1.2, 2.5) |
|
|
| rs689453 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
7.9 (6.7, 9.2) |
92.1 (90.8, 93.3) |
<0.001 |
0.5 (0.2, 1.1) |
14.7 (12.7, 17.0) |
84.8 (82.4, 86.9) |
0.005 |
0.23 |
| Non-Hispanic Black |
5.1 (4.2, 6.2) |
94.9 (93.8, 95.8) |
0.4 (0.1, 1.1) |
9.5 (7.5, 11.9) |
90.2 (87.9, 92.1) |
0.25 |
| Mexican American |
5.2 (3.8, 7.0) |
94.8 (93.0, 96.2) |
0.6 (0.3, 1.3) |
9.2 (7.1, 12.0) |
90.2 (87.0, 92.6) |
0.21 |
| Total* |
7.0 (6.1, 8.1) |
93.0 (91.9, 93.9) |
|
0.4 (0.2, 0.9) |
13.2 (11.4, 15.1) |
86.4 (84.4, 88.2) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs10517 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
85.7 (83.4, 87.8) |
14.3 (12.2, 16.6) |
0.894 |
74.3 (70.3, 77.8) |
22.9 (19.2, 27.1) |
2.8 (1.4, 5.4) |
0.864 |
| 20-39 |
86.7 (84.3, 88.7) |
13.3 (11.3, 15.7) |
75.2 (71.4, 78.7) |
22.9 (20.0, 26.1) |
1.9 (1.2, 3.0) |
| 40-59 |
86.3 (84.4, 88.1) |
13.7 (11.9, 15.6) |
74.7 (71.4, 77.8) |
23.2 (20.2, 26.6) |
2.0 (1.2, 3.6) |
| >=60 |
86.6 (84.7, 88.3) |
13.4 (11.7, 15.3) |
75.5 (72.4, 78.4) |
22.2 (19.5, 25.2) |
2.3 (1.2, 4.1) |
| Total |
86.4 (85.1, 87.7) |
13.6 (12.3, 14.9) |
|
75.0 (73.0, 77.0) |
22.9 (21.4, 24.4) |
2.1 (1.5, 3.0) |
|
| rs1800566 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
76.1 (72.2, 79.5) |
23.9 (20.5, 27.8) |
0.108 |
57.5 (50.9, 63.9) |
37.1 (31.0, 43.6) |
5.4 (3.8, 7.6) |
0.185 |
| 20-39 |
77.9 (75.5, 80.1) |
22.1 (19.9, 24.5) |
61.1 (57.2, 65.0) |
33.5 (30.1, 37.1) |
5.4 (4.3, 6.7) |
| 40-59 |
80.1 (77.3, 82.6) |
19.9 (17.4, 22.7) |
64.2 (59.3, 68.7) |
31.9 (27.5, 36.6) |
4.0 (2.8, 5.6) |
| >=60 |
79.3 (77.1, 81.4) |
20.7 (18.6, 22.9) |
62.9 (59.2, 66.5) |
32.9 (29.5, 36.4) |
4.2 (3.2, 5.6) |
| Total |
78.5 (76.8, 80.2) |
21.5 (19.8, 23.2) |
|
61.8 (58.8, 64.7) |
33.4 (30.8, 36.2) |
4.8 (4.1, 5.6) |
|
| rs34755915 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
1.4 (0.7, 2.8) |
98.6 (97.2, 99.3) |
0.969 |
0.0 (NA) |
2.7 (1.3, 5.6) |
97.3 (94.4, 98.7) |
0.976 |
| 20-39 |
1.4 (0.9, 2.2) |
98.6 (97.8, 99.1) |
0.0 (NA) |
2.8 (1.8, 4.4) |
97.2 (95.6, 98.2) |
| 40-59 |
1.4 (0.9, 2.1) |
98.6 (97.9, 99.1) |
0.0 (NA) |
2.8 (1.8, 4.2) |
97.2 (95.8, 98.2) |
| >=60 |
1.5 (1.0, 2.4) |
98.5 (97.6, 99.0) |
0.2 (0.0, 1.5) |
2.7 (1.9, 3.9) |
97.1 (95.7, 98.0) |
| Total |
1.4 (1.1, 1.8) |
98.6 (98.2, 98.9) |
|
0.0 (0.0, 0.3) |
2.8 (2.2, 3.5) |
97.2 (96.5, 97.8) |
|
| rs689452 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
86.9 (84.9, 88.7) |
13.1 (11.3, 15.1) |
0.923 |
76.2 (72.8, 79.3) |
21.3 (17.9, 25.2) |
2.5 (1.2, 5.1) |
0.867 |
| 20-39 |
87.6 (85.5, 89.5) |
12.4 (10.5, 14.5) |
76.6 (73.2, 79.7) |
22.0 (19.4, 24.7) |
1.4 (0.8, 2.5) |
| 40-59 |
87.4 (85.7, 89.0) |
12.6 (11.0, 14.3) |
76.6 (73.4, 79.5) |
21.7 (18.8, 25.0) |
1.7 (0.9, 3.2) |
| >=60 |
87.6 (85.7, 89.3) |
12.4 (10.7, 14.3) |
77.1 (73.8, 80.1) |
21.1 (18.3, 24.3) |
1.8 (1.0, 3.2) |
| Total |
87.5 (86.3, 88.6) |
12.5 (11.4, 13.7) |
|
76.6 (74.8, 78.4) |
21.6 (20.2, 23.2) |
1.7 (1.2, 2.5) |
|
| rs689453 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
7.4 (5.2, 10.3) |
92.6 (89.7, 94.8) |
0.205 |
0.8 (0.2, 2.5) |
13.2 (9.2, 18.6) |
86.0 (80.6, 90.1) |
0.090 |
| 20-39 |
6.2 (5.2, 7.5) |
93.8 (92.5, 94.8) |
0.3 (0.1, 1.0) |
11.8 (9.7, 14.3) |
87.9 (85.4, 89.9) |
| 40-59 |
7.6 (6.5, 9.0) |
92.4 (91.0, 93.5) |
0.3 (0.1, 1.0) |
14.7 (12.6, 17.1) |
85.0 (82.5, 87.2) |
| >=60 |
7.5 (6.2, 9.0) |
92.5 (91.0, 93.8) |
0.7 (0.3, 1.4) |
13.6 (11.1, 16.6) |
85.7 (82.8, 88.2) |
| Total |
7.0 (6.1, 8.1) |
93.0 (91.9, 93.9) |
|
0.4 (0.2, 0.9) |
13.2 (11.4, 15.1) |
86.4 (84.4, 88.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs10517 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
86.1 (84.2, 87.7) |
13.9 (12.3, 15.8) |
0.500 |
74.1 (71.2, 76.9) |
23.8 (21.3, 26.5) |
2.0 (1.1, 3.6) |
0.696 |
| Female |
86.8 (85.0, 88.4) |
13.2 (11.6, 15.0) |
|
75.8 (72.6, 78.8) |
22.0 (19.2, 25.0) |
2.2 (1.7, 2.9) |
|
| Total |
86.4 (85.1, 87.7) |
13.6 (12.3, 14.9) |
|
75.0 (73.0, 77.0) |
22.9 (21.4, 24.4) |
2.1 (1.5, 3.0) |
|
| rs1800566 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
78.7 (76.2, 81.0) |
21.3 (19.0, 23.8) |
0.770 |
61.8 (57.5, 65.9) |
33.8 (29.8, 38.1) |
4.4 (3.2, 6.0) |
0.694 |
| Female |
78.4 (76.7, 79.9) |
21.6 (20.1, 23.3) |
|
61.9 (59.0, 64.7) |
33.0 (30.3, 35.9) |
5.1 (4.3, 6.0) |
|
| Total |
78.5 (76.8, 80.2) |
21.5 (19.8, 23.2) |
|
61.8 (58.8, 64.7) |
33.4 (30.8, 36.2) |
4.8 (4.1, 5.6) |
|
| rs34755915 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
1.6 (1.2, 2.1) |
98.4 (97.9, 98.8) |
0.320 |
0.0 (NA) |
3.1 (2.4, 4.2) |
96.9 (95.8, 97.6) |
0.206 |
| Female |
1.3 (0.9, 1.8) |
98.7 (98.2, 99.1) |
|
0.1 (0.0, 0.5) |
2.4 (1.8, 3.3) |
97.5 (96.5, 98.2) |
|
| Total |
1.4 (1.1, 1.8) |
98.6 (98.2, 98.9) |
|
0.0 (0.0, 0.3) |
2.8 (2.2, 3.5) |
97.2 (96.5, 97.8) |
|
| rs689452 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
87.2 (85.5, 88.7) |
12.8 (11.3, 14.5) |
0.545 |
76.0 (73.4, 78.5) |
22.3 (20.1, 24.6) |
1.7 (0.9, 3.1) |
0.815 |
| Female |
87.8 (86.2, 89.2) |
12.2 (10.8, 13.8) |
|
77.2 (74.4, 79.9) |
21.1 (18.5, 23.9) |
1.7 (1.2, 2.5) |
|
| Total |
87.5 (86.3, 88.6) |
12.5 (11.4, 13.7) |
|
76.6 (74.8, 78.4) |
21.6 (20.2, 23.2) |
1.7 (1.2, 2.5) |
|
| rs689453 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
7.6 (6.2, 9.3) |
92.4 (90.7, 93.8) |
0.086 |
0.6 (0.3, 1.5) |
13.9 (11.4, 16.9) |
85.4 (82.3, 88.1) |
0.252 |
| Female |
6.5 (5.7, 7.3) |
93.5 (92.7, 94.3) |
|
0.3 (0.1, 0.6) |
12.4 (10.9, 14.1) |
87.3 (85.6, 88.9) |
|
| Total |
7.0 (6.1, 8.1) |
93.0 (91.9, 93.9) |
|
0.4 (0.2, 0.9) |
13.2 (11.4, 15.1) |
86.4 (84.4, 88.2) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs10517 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
85.9 (82.3, 88.9) |
14.1 (11.1, 17.7) |
74.5 (68.6, 79.5) |
23.0 (18.6, 28.1) |
2.6 (1.3, 5.0) |
| 20-39 |
86.7 (84.1, 89.0) |
13.3 (11.0, 15.9) |
74.8 (70.0, 79.1) |
23.8 (19.7, 28.5) |
1.4 (0.9, 2.1) |
| 40-59 |
87.0 (84.4, 89.2) |
13.0 (10.8, 15.6) |
76.0 (72.1, 79.6) |
22.0 (18.9, 25.4) |
2.0 (0.9, 4.4) |
| >=60 |
87.3 (85.7, 88.8) |
12.7 (11.2, 14.3) |
76.4 (73.4, 79.1) |
22.0 (19.2, 24.9) |
1.7 (0.9, 3.1) |
| Non-Hispanic Black |
12-19 |
85.9 (82.8, 88.5) |
14.1 (11.5, 17.2) |
73.9 (68.6, 78.5) |
24.0 (19.3, 29.4) |
2.1 (0.8, 5.6) |
| 20-39 |
86.2 (84.1, 88.1) |
13.8 (11.9, 15.9) |
74.1 (70.4, 77.5) |
24.2 (20.8, 28.0) |
1.7 (0.8, 3.6) |
| 40-59 |
86.5 (84.2, 88.5) |
13.5 (11.5, 15.8) |
73.9 (69.7, 77.7) |
25.3 (21.7, 29.3) |
0.8 (0.3, 2.1) |
| >=60 |
85.4 (81.5, 88.7) |
14.6 (11.3, 18.5) |
73.7 (66.5, 79.7) |
23.6 (17.6, 30.8) |
2.8 (1.4, 5.2) |
| Mexican American |
12-19 |
94.5 (90.5, 96.8) |
5.5 (3.2, 9.5) |
89.5 (82.3, 94.0) |
9.9 (5.6, 16.8) |
0.6 (0.1, 2.6) |
| 20-39 |
93.8 (92.3, 95.1) |
6.2 (4.9, 7.7) |
87.7 (84.7, 90.1) |
12.3 (9.9, 15.3) |
0.0 (NA) |
| 40-59 |
92.2 (89.6, 94.2) |
7.8 (5.8, 10.4) |
84.5 (79.4, 88.4) |
15.4 (11.4, 20.5) |
0.1 (0.0, 1.0) |
| >=60 |
92.5 (90.1, 94.4) |
7.5 (5.6, 9.9) |
85.9 (82.0, 89.1) |
13.2 (10.3, 16.8) |
0.8 (0.2, 3.4) |
| rs1800566 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
78.1 (73.4, 82.1) |
21.9 (17.9, 26.6) |
60.2 (52.4, 67.5) |
35.7 (28.9, 43.2) |
4.1 (2.1, 7.6) |
| 20-39 |
80.9 (78.1, 83.3) |
19.1 (16.7, 21.9) |
64.6 (59.6, 69.3) |
32.5 (28.1, 37.2) |
2.9 (2.2, 3.9) |
| 40-59 |
81.4 (78.0, 84.4) |
18.6 (15.6, 22.0) |
66.8 (60.8, 72.3) |
29.1 (23.8, 35.0) |
4.1 (2.7, 6.1) |
| >=60 |
80.6 (78.0, 83.0) |
19.4 (17.0, 22.0) |
64.5 (60.0, 68.7) |
32.2 (28.5, 36.2) |
3.3 (2.4, 4.6) |
| Non-Hispanic Black |
12-19 |
82.5 (80.2, 84.5) |
17.5 (15.5, 19.8) |
67.8 (63.6, 71.8) |
29.2 (24.6, 34.3) |
2.9 (1.5, 5.6) |
| 20-39 |
79.4 (77.6, 81.2) |
20.6 (18.8, 22.4) |
63.1 (59.7, 66.3) |
32.7 (29.2, 36.4) |
4.2 (3.0, 6.0) |
| 40-59 |
82.8 (79.5, 85.7) |
17.2 (14.3, 20.5) |
68.1 (62.2, 73.4) |
29.5 (24.4, 35.1) |
2.5 (1.4, 4.4) |
| >=60 |
81.9 (78.6, 84.7) |
18.1 (15.3, 21.4) |
67.6 (62.6, 72.3) |
28.5 (24.1, 33.3) |
3.9 (2.1, 7.0) |
| Mexican American |
12-19 |
60.6 (56.1, 64.9) |
39.4 (35.1, 43.9) |
39.4 (32.9, 46.3) |
42.3 (35.5, 49.4) |
18.3 (14.4, 22.9) |
| 20-39 |
64.5 (62.3, 66.7) |
35.5 (33.3, 37.7) |
42.4 (39.3, 45.6) |
44.3 (41.5, 47.2) |
13.3 (11.5, 15.3) |
| 40-59 |
61.9 (58.8, 64.8) |
38.1 (35.2, 41.2) |
36.2 (31.6, 41.1) |
51.4 (45.4, 57.2) |
12.4 (9.3, 16.5) |
| >=60 |
64.7 (60.8, 68.4) |
35.3 (31.6, 39.2) |
41.5 (35.7, 47.6) |
46.4 (40.5, 52.4) |
12.1 (9.2, 15.9) |
| rs34755915 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
2.0 (0.9, 4.2) |
98.0 (95.8, 99.1) |
0.0 (NA) |
4.0 (1.9, 8.4) |
96.0 (91.6, 98.1) |
| 20-39 |
1.8 (1.2, 2.8) |
98.2 (97.2, 98.8) |
0.0 (NA) |
3.7 (2.4, 5.6) |
96.3 (94.4, 97.6) |
| 40-59 |
1.7 (1.1, 2.6) |
98.3 (97.4, 98.9) |
0.0 (NA) |
3.4 (2.2, 5.3) |
96.6 (94.7, 97.8) |
| >=60 |
1.8 (1.2, 2.8) |
98.2 (97.2, 98.8) |
0.2 (0.0, 1.8) |
3.2 (2.3, 4.5) |
96.6 (95.0, 97.7) |
| Non-Hispanic Black |
12-19 |
0.1 (0.0, 0.7) |
99.9 (99.3, 100.0) |
0.0 (NA) |
0.2 (0.0, 1.4) |
99.8 (98.6, 100.0) |
| 20-39 |
0.6 (0.2, 1.7) |
99.4 (98.3, 99.8) |
0.0 (NA) |
1.2 (0.4, 3.3) |
98.8 (96.7, 99.6) |
| 40-59 |
0.3 (0.1, 1.0) |
99.7 (99.0, 99.9) |
0.0 (NA) |
0.7 (0.2, 2.0) |
99.3 (98.0, 99.8) |
| >=60 |
0.3 (0.1, 1.4) |
99.7 (98.6, 99.9) |
0.0 (NA) |
0.6 (0.2, 2.7) |
99.4 (97.3, 99.8) |
| Mexican American |
12-19 |
0.5 (0.1, 2.2) |
99.5 (97.8, 99.9) |
0.0 (NA) |
1.0 (0.2, 4.3) |
99.0 (95.7, 99.8) |
| 20-39 |
0.6 (0.3, 1.2) |
99.4 (98.8, 99.7) |
0.0 (NA) |
1.2 (0.6, 2.3) |
98.8 (97.7, 99.4) |
| 40-59 |
0.5 (0.2, 1.6) |
99.5 (98.4, 99.8) |
0.0 (NA) |
1.0 (0.3, 3.2) |
99.0 (96.8, 99.7) |
| >=60 |
0.5 (0.2, 1.3) |
99.5 (98.7, 99.8) |
0.0 (NA) |
0.9 (0.3, 2.7) |
99.1 (97.3, 99.7) |
| rs689452 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
87.3 (84.0, 90.0) |
12.7 (10.0, 16.0) |
76.6 (71.3, 81.2) |
21.3 (17.2, 26.1) |
2.0 (0.9, 4.5) |
| 20-39 |
88.0 (85.5, 90.1) |
12.0 (9.9, 14.5) |
77.0 (72.4, 80.9) |
22.1 (18.3, 26.3) |
1.0 (0.5, 1.8) |
| 40-59 |
88.3 (86.0, 90.2) |
11.7 (9.8, 14.0) |
78.1 (74.5, 81.4) |
20.3 (17.3, 23.7) |
1.6 (0.6, 4.1) |
| >=60 |
88.5 (86.8, 90.0) |
11.5 (10.0, 13.2) |
78.2 (75.0, 81.1) |
20.5 (17.7, 23.7) |
1.2 (0.7, 2.3) |
| Non-Hispanic Black |
12-19 |
85.7 (82.6, 88.3) |
14.3 (11.7, 17.4) |
73.6 (68.3, 78.2) |
24.3 (19.6, 29.7) |
2.1 (0.8, 5.7) |
| 20-39 |
86.3 (84.4, 87.9) |
13.7 (12.1, 15.6) |
74.2 (70.8, 77.3) |
24.2 (20.9, 27.8) |
1.6 (0.8, 3.5) |
| 40-59 |
86.9 (84.5, 89.0) |
13.1 (11.0, 15.5) |
74.7 (70.3, 78.6) |
24.5 (20.7, 28.6) |
0.8 (0.3, 2.1) |
| >=60 |
85.8 (81.8, 89.1) |
14.2 (10.9, 18.2) |
74.4 (67.0, 80.5) |
22.9 (16.9, 30.2) |
2.8 (1.4, 5.2) |
| Mexican American |
12-19 |
94.6 (90.8, 96.9) |
5.4 (3.1, 9.2) |
89.9 (82.9, 94.2) |
9.5 (5.4, 16.1) |
0.6 (0.1, 2.6) |
| 20-39 |
93.9 (92.2, 95.3) |
6.1 (4.7, 7.8) |
87.8 (84.4, 90.6) |
12.2 (9.4, 15.6) |
0.0 (NA) |
| 40-59 |
92.4 (89.9, 94.4) |
7.6 (5.6, 10.1) |
85.0 (80.1, 88.9) |
14.9 (11.0, 19.8) |
0.1 (0.0, 1.0) |
| >=60 |
92.8 (90.0, 94.8) |
7.2 (5.2, 10.0) |
86.4 (81.7, 90.1) |
12.7 (9.3, 17.1) |
0.8 (0.2, 3.4) |
| rs689453 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
8.6 (5.5, 13.0) |
91.4 (87.0, 94.5) |
1.1 (0.3, 3.8) |
14.9 (9.3, 23.0) |
84.0 (75.8, 89.8) |
| 20-39 |
6.9 (5.6, 8.5) |
93.1 (91.5, 94.4) |
0.4 (0.1, 1.3) |
13.1 (10.5, 16.2) |
86.5 (83.5, 89.1) |
| 40-59 |
8.5 (7.0, 10.4) |
91.5 (89.6, 93.0) |
0.3 (0.1, 1.5) |
16.5 (13.8, 19.8) |
83.2 (79.8, 86.1) |
| >=60 |
8.2 (6.7, 10.0) |
91.8 (90.0, 93.3) |
0.7 (0.3, 1.6) |
15.0 (12.0, 18.5) |
84.3 (80.9, 87.2) |
| Non-Hispanic Black |
12-19 |
5.5 (4.1, 7.3) |
94.5 (92.7, 95.9) |
0.3 (0.1, 1.1) |
10.4 (7.6, 14.0) |
89.3 (85.8, 92.1) |
| 20-39 |
4.3 (3.3, 5.5) |
95.7 (94.5, 96.7) |
0.2 (0.0, 0.7) |
8.2 (6.3, 10.8) |
91.6 (89.1, 93.6) |
| 40-59 |
5.3 (3.8, 7.5) |
94.7 (92.5, 96.2) |
0.5 (0.1, 3.6) |
9.7 (6.6, 14.1) |
89.8 (85.7, 92.9) |
| >=60 |
6.6 (4.7, 9.2) |
93.4 (90.8, 95.3) |
0.8 (0.2, 3.4) |
11.5 (7.5, 17.1) |
87.7 (82.5, 91.5) |
| Mexican American |
12-19 |
5.0 (2.7, 9.1) |
95.0 (90.9, 97.3) |
0.0 (NA) |
10.1 (5.4, 18.0) |
89.9 (82.0, 94.6) |
| 20-39 |
5.5 (4.0, 7.5) |
94.5 (92.5, 96.0) |
0.7 (0.3, 1.8) |
9.5 (7.1, 12.6) |
89.8 (86.3, 92.5) |
| 40-59 |
5.6 (4.0, 7.8) |
94.4 (92.2, 96.0) |
0.8 (0.2, 3.1) |
9.5 (6.6, 13.6) |
89.7 (85.7, 92.6) |
| >=60 |
3.1 (2.5, 3.9) |
96.9 (96.1, 97.5) |
0.6 (0.1, 3.8) |
5.0 (3.2, 7.8) |
94.4 (92.7, 95.7) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs10517 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
86.6 (84.8, 88.1) |
13.4 (11.9, 15.2) |
74.5 (71.0, 77.8) |
24.1 (20.6, 28.0) |
1.4 (0.8, 2.5) |
| Female |
87.1 (85.1, 88.8) |
12.9 (11.2, 14.9) |
76.3 (73.0, 79.4) |
21.5 (18.8, 24.5) |
2.1 (1.4, 3.2) |
| Non-Hispanic Black |
Male |
85.2 (82.9, 87.2) |
14.8 (12.8, 17.1) |
72.0 (67.9, 75.8) |
26.3 (22.7, 30.3) |
1.7 (0.9, 3.2) |
| Female |
86.9 (84.5, 89.0) |
13.1 (11.0, 15.5) |
75.5 (71.6, 79.1) |
22.7 (19.5, 26.3) |
1.7 (0.8, 3.7) |
| Mexican American |
Male |
93.8 (91.2, 95.7) |
6.2 (4.3, 8.8) |
87.7 (82.6, 91.5) |
12.2 (8.4, 17.3) |
0.1 (0.0, 0.7) |
| Female |
93.2 (91.5, 94.5) |
6.8 (5.5, 8.5) |
86.7 (83.5, 89.3) |
13.0 (10.4, 16.1) |
0.3 (0.1, 0.8) |
| rs1800566 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
81.2 (78.7, 83.4) |
18.8 (16.6, 21.3) |
65.1 (60.3, 69.6) |
32.2 (27.6, 37.3) |
2.7 (1.8, 4.2) |
| Female |
80.1 (78.0, 82.0) |
19.9 (18.0, 22.0) |
64.3 (60.8, 67.7) |
31.5 (28.2, 35.0) |
4.2 (3.1, 5.7) |
| Non-Hispanic Black |
Male |
80.6 (78.0, 82.9) |
19.4 (17.1, 22.0) |
65.2 (61.6, 68.5) |
30.9 (28.0, 33.9) |
4.0 (2.3, 6.8) |
| Female |
81.6 (80.4, 82.8) |
18.4 (17.2, 19.6) |
66.4 (64.3, 68.5) |
30.5 (28.5, 32.6) |
3.1 (2.5, 3.9) |
| Mexican American |
Male |
62.1 (59.6, 64.6) |
37.9 (35.4, 40.4) |
38.8 (35.6, 42.1) |
46.7 (43.7, 49.7) |
14.5 (12.1, 17.3) |
| Female |
64.3 (61.8, 66.7) |
35.7 (33.3, 38.2) |
42.1 (38.2, 46.0) |
44.4 (40.8, 48.2) |
13.5 (11.7, 15.5) |
| rs34755915 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
2.0 (1.5, 2.6) |
98.0 (97.4, 98.5) |
0.0 (NA) |
4.0 (3.0, 5.3) |
96.0 (94.7, 97.0) |
| Female |
1.7 (1.2, 2.3) |
98.3 (97.7, 98.8) |
0.1 (0.0, 0.7) |
3.1 (2.3, 4.2) |
96.8 (95.6, 97.6) |
| Non-Hispanic Black |
Male |
0.5 (0.2, 1.3) |
99.5 (98.7, 99.8) |
0.0 (NA) |
0.9 (0.4, 2.5) |
99.1 (97.5, 99.6) |
| Female |
0.3 (0.2, 0.7) |
99.7 (99.3, 99.8) |
0.0 (NA) |
0.7 (0.3, 1.4) |
99.3 (98.6, 99.7) |
| Mexican American |
Male |
0.6 (0.3, 1.3) |
99.4 (98.7, 99.7) |
0.0 (NA) |
1.3 (0.6, 2.5) |
98.7 (97.5, 99.4) |
| Female |
0.4 (0.3, 0.7) |
99.6 (99.3, 99.7) |
0.0 (NA) |
0.9 (0.5, 1.4) |
99.1 (98.6, 99.5) |
| rs689452 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
87.9 (86.1, 89.4) |
12.1 (10.6, 13.9) |
76.9 (73.4, 80.0) |
22.0 (18.8, 25.5) |
1.2 (0.7, 2.0) |
| Female |
88.3 (86.6, 89.8) |
11.7 (10.2, 13.4) |
78.2 (75.2, 80.9) |
20.3 (17.8, 23.1) |
1.5 (0.9, 2.6) |
| Non-Hispanic Black |
Male |
85.1 (82.7, 87.3) |
14.9 (12.7, 17.3) |
72.0 (67.6, 75.9) |
26.4 (22.5, 30.6) |
1.7 (0.9, 3.2) |
| Female |
87.2 (84.8, 89.3) |
12.8 (10.7, 15.2) |
76.1 (72.2, 79.6) |
22.2 (19.1, 25.7) |
1.7 (0.8, 3.6) |
| Mexican American |
Male |
93.8 (91.2, 95.7) |
6.2 (4.3, 8.8) |
87.8 (82.6, 91.6) |
12.1 (8.4, 17.3) |
0.1 (0.0, 0.7) |
| Female |
93.5 (91.7, 94.9) |
6.5 (5.1, 8.3) |
87.3 (83.8, 90.1) |
12.4 (9.6, 15.9) |
0.3 (0.1, 0.8) |
| rs689453 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
8.7 (7.0, 10.8) |
91.3 (89.2, 93.0) |
0.8 (0.3, 1.8) |
15.9 (12.9, 19.5) |
83.3 (79.5, 86.5) |
| Female |
7.0 (6.2, 8.0) |
93.0 (92.0, 93.8) |
0.3 (0.1, 0.7) |
13.6 (11.8, 15.5) |
86.2 (84.2, 87.9) |
| Non-Hispanic Black |
Male |
4.5 (3.4, 5.9) |
95.5 (94.1, 96.6) |
0.2 (0.0, 1.0) |
8.5 (6.2, 11.6) |
91.3 (88.3, 93.6) |
| Female |
5.6 (4.4, 7.0) |
94.4 (93.0, 95.6) |
0.5 (0.1, 1.4) |
10.2 (7.8, 13.3) |
89.3 (86.4, 91.6) |
| Mexican American |
Male |
5.3 (3.6, 7.6) |
94.7 (92.4, 96.4) |
0.9 (0.3, 2.4) |
8.7 (6.2, 12.1) |
90.4 (86.5, 93.3) |
| Female |
5.2 (3.9, 6.7) |
94.8 (93.3, 96.1) |
0.3 (0.1, 1.1) |
9.8 (7.5, 12.7) |
89.9 (87.0, 92.3) |
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