OGG1 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1052133
|
Ex6-315C>G
|
Ser326Cys
Pro332Ala
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1052133 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
78.5 (76.5, 80.5) |
21.5 (19.5, 23.5) |
<0.001 |
61.3 (57.9, 64.6) |
34.4 (31.5, 37.5) |
4.3 (3.3, 5.5) |
<0.001 |
0.11 |
| Non-Hispanic Black |
83.6 (82.2, 84.8) |
16.4 (15.2, 17.8) |
69.6 (67.3, 71.8) |
28.0 (25.8, 30.3) |
2.5 (1.6, 3.7) |
0.14 |
| Mexican American |
67.0 (64.8, 69.2) |
33.0 (30.8, 35.2) |
44.3 (40.8, 47.8) |
45.5 (42.6, 48.4) |
10.2 (9.0, 11.6) |
0.12 |
| Total* |
77.0 (75.3, 78.7) |
23.0 (21.3, 24.7) |
|
59.6 (56.8, 62.4) |
34.8 (32.5, 37.1) |
5.6 (4.7, 6.6) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1052133 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
76.9 (73.5, 80.0) |
23.1 (20.0, 26.5) |
0.955 |
58.6 (53.7, 63.4) |
36.6 (32.6, 40.8) |
4.8 (2.9, 7.7) |
0.728 |
| 20-39 |
77.0 (74.4, 79.4) |
23.0 (20.6, 25.6) |
59.5 (55.5, 63.5) |
34.9 (31.6, 38.4) |
5.6 (4.3, 7.2) |
| 40-59 |
77.5 (74.4, 80.3) |
22.5 (19.7, 25.6) |
61.2 (56.5, 65.6) |
32.6 (28.2, 37.4) |
6.2 (4.0, 9.5) |
| >=60 |
76.6 (73.9, 79.1) |
23.4 (20.9, 26.1) |
58.4 (53.9, 62.7) |
36.4 (32.4, 40.5) |
5.2 (3.8, 7.1) |
| Total |
77.0 (75.3, 78.7) |
23.0 (21.3, 24.7) |
|
59.6 (56.8, 62.4) |
34.8 (32.5, 37.1) |
5.6 (4.7, 6.6) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1052133 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
77.3 (74.9, 79.5) |
22.7 (20.5, 25.1) |
0.683 |
59.9 (56.4, 63.3) |
34.8 (32.2, 37.4) |
5.3 (4.1, 6.9) |
0.876 |
| Female |
76.8 (74.9, 78.6) |
23.2 (21.4, 25.1) |
59.4 (56.3, 62.4) |
34.8 (32.1, 37.6) |
5.8 (4.7, 7.1) |
| Total |
77.0 (75.3, 78.7) |
23.0 (21.3, 24.7) |
|
59.6 (56.8, 62.4) |
34.8 (32.5, 37.1) |
5.6 (4.7, 6.6) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1052133 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
78.8 (74.4, 82.7) |
21.2 (17.3, 25.6) |
60.9 (54.1, 67.4) |
35.8 (30.2, 41.7) |
3.3 (1.5, 7.0) |
| 20-39 |
79.1 (75.6, 82.2) |
20.9 (17.8, 24.4) |
62.1 (56.4, 67.5) |
33.9 (29.3, 38.8) |
4.0 (2.7, 5.8) |
| 40-59 |
78.5 (74.8, 81.9) |
21.5 (18.1, 25.2) |
62.0 (56.2, 67.5) |
33.0 (27.7, 38.8) |
4.9 (2.7, 8.7) |
| >=60 |
77.5 (74.7, 80.1) |
22.5 (19.9, 25.3) |
59.3 (54.7, 63.7) |
36.4 (32.3, 40.6) |
4.3 (2.9, 6.3) |
| Non-Hispanic Black |
12-19 |
84.4 (81.8, 86.7) |
15.6 (13.3, 18.2) |
70.8 (65.8, 75.4) |
27.2 (22.2, 32.8) |
2.0 (0.8, 4.6) |
| 20-39 |
82.4 (79.9, 84.6) |
17.6 (15.4, 20.1) |
67.4 (62.9, 71.6) |
30.0 (25.8, 34.6) |
2.6 (1.5, 4.5) |
| 40-59 |
86.0 (83.3, 88.3) |
14.0 (11.7, 16.7) |
74.8 (70.9, 78.3) |
22.3 (18.9, 26.2) |
2.9 (1.3, 6.5) |
| >=60 |
81.6 (78.7, 84.2) |
18.4 (15.8, 21.3) |
65.1 (59.9, 70.1) |
33.0 (28.3, 38.1) |
1.9 (1.1, 3.2) |
| Mexican American |
12-19 |
70.0 (64.7, 74.8) |
30.0 (25.2, 35.3) |
47.7 (40.5, 54.9) |
44.7 (39.5, 50.0) |
7.7 (4.9, 11.9) |
| 20-39 |
66.5 (63.7, 69.1) |
33.5 (30.9, 36.3) |
44.3 (39.6, 49.0) |
44.4 (39.9, 49.0) |
11.4 (9.6, 13.4) |
| 40-59 |
65.4 (61.3, 69.3) |
34.6 (30.7, 38.7) |
40.7 (36.1, 45.5) |
49.4 (45.5, 53.2) |
9.9 (6.4, 14.9) |
| >=60 |
67.4 (63.8, 70.9) |
32.6 (29.1, 36.2) |
45.4 (39.6, 51.4) |
44.0 (37.9, 50.3) |
10.5 (7.9, 13.9) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1052133 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
78.5 (76.0, 80.8) |
21.5 (19.2, 24.0) |
61.1 (57.1, 64.9) |
34.8 (31.6, 38.2) |
4.1 (2.9, 5.6) |
| Female |
78.6 (76.4, 80.6) |
21.4 (19.4, 23.6) |
61.6 (57.8, 65.2) |
34.0 (30.4, 37.8) |
4.4 (3.2, 6.1) |
| Non-Hispanic Black |
Male |
83.9 (82.1, 85.5) |
16.1 (14.5, 17.9) |
70.3 (67.6, 72.9) |
27.1 (24.5, 29.8) |
2.6 (1.5, 4.6) |
| Female |
83.3 (81.2, 85.2) |
16.7 (14.8, 18.8) |
68.9 (65.1, 72.5) |
28.7 (25.1, 32.6) |
2.3 (1.3, 4.1) |
| Mexican American |
Male |
68.0 (65.5, 70.3) |
32.0 (29.7, 34.5) |
45.6 (41.3, 49.9) |
44.8 (40.4, 49.2) |
9.7 (8.2, 11.4) |
| Female |
66.1 (63.2, 68.8) |
33.9 (31.2, 36.8) |
42.9 (38.7, 47.3) |
46.3 (42.9, 49.7) |
10.8 (9.2, 12.6) |
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