PON1 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs662
|
Ex6+78A>G
|
Gln192Arg
|
TaqMan
|
|
rs854560
|
Ex3+18T>A
|
Leu55Met
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs662 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
68.5 (66.8, 70.3) |
31.5 (29.7, 33.2) |
<0.001 |
47.3 (44.4, 50.3) |
42.4 (39.4, 45.4) |
10.3 (9.0, 11.7) |
<0.001 |
0.37 |
| Non-Hispanic Black |
32.9 (31.2, 34.6) |
67.1 (65.4, 68.8) |
11.3 (9.9, 12.8) |
43.2 (41.5, 44.9) |
45.5 (43.3, 47.7) |
0.98 |
| Mexican American |
53.5 (51.9, 55.0) |
46.5 (45.0, 48.1) |
28.6 (25.4, 32.1) |
49.6 (45.4, 53.9) |
21.7 (20.1, 23.4) |
0.90 |
| Total* |
61.5 (59.4, 63.6) |
38.5 (36.4, 40.6) |
|
40.0 (37.3, 42.8) |
43.0 (40.8, 45.2) |
17.0 (15.2, 19.0) |
|
|
| rs854560 |
|
A |
T |
|
AA |
AT |
TT |
|
|
| Non-Hispanic White |
35.6 (33.6, 37.7) |
64.4 (62.3, 66.4) |
<0.001 |
13.5 (12.2, 14.9) |
44.3 (41.4, 47.2) |
42.2 (39.0, 45.6) |
<0.001 |
0.40 |
| Non-Hispanic Black |
17.9 (16.5, 19.3) |
82.1 (80.7, 83.5) |
2.9 (2.3, 3.7) |
30.0 (27.7, 32.3) |
67.1 (64.6, 69.5) |
0.30 |
| Mexican American |
23.0 (21.3, 24.8) |
77.0 (75.2, 78.7) |
5.0 (4.0, 6.1) |
36.1 (33.2, 39.2) |
58.9 (55.8, 61.9) |
0.55 |
| Total* |
31.5 (29.4, 33.6) |
68.5 (66.4, 70.6) |
|
11.1 (10.0, 12.2) |
40.8 (38.2, 43.5) |
48.1 (44.8, 51.5) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
Top of Page
By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs662 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
62.6 (58.9, 66.2) |
37.4 (33.8, 41.1) |
0.044 |
40.2 (35.0, 45.6) |
44.8 (39.8, 50.0) |
15.0 (11.9, 18.7) |
0.015 |
| 20-39 |
59.5 (56.8, 62.1) |
40.5 (37.9, 43.2) |
37.6 (34.2, 41.1) |
43.8 (40.5, 47.2) |
18.6 (16.0, 21.5) |
| 40-59 |
61.8 (58.3, 65.1) |
38.2 (34.9, 41.7) |
41.1 (36.5, 45.9) |
41.3 (36.9, 45.7) |
17.6 (14.7, 21.0) |
| >=60 |
64.3 (61.7, 66.8) |
35.7 (33.2, 38.3) |
43.1 (39.5, 46.8) |
42.4 (38.5, 46.4) |
14.5 (12.0, 17.5) |
| Total |
61.5 (59.4, 63.6) |
38.5 (36.4, 40.6) |
|
40.0 (37.3, 42.8) |
43.0 (40.8, 45.2) |
17.0 (15.2, 19.0) |
|
| rs854560 |
|
A |
T |
|
AA |
AT |
TT |
|
| 12-19 |
31.7 (26.8, 37.1) |
68.3 (62.9, 73.2) |
0.330 |
10.4 (6.7, 15.9) |
42.6 (36.9, 48.4) |
47.0 (40.1, 54.0) |
0.092 |
| 20-39 |
29.9 (26.5, 33.5) |
70.1 (66.5, 73.5) |
10.6 (8.4, 13.4) |
38.6 (34.6, 42.7) |
50.8 (45.6, 55.9) |
| 40-59 |
32.0 (28.9, 35.3) |
68.0 (64.7, 71.1) |
11.3 (9.0, 14.1) |
41.5 (37.5, 45.7) |
47.2 (42.5, 51.9) |
| >=60 |
33.6 (31.9, 35.4) |
66.4 (64.6, 68.1) |
12.1 (10.1, 14.5) |
43.0 (39.3, 46.9) |
44.9 (41.9, 47.8) |
| Total |
31.5 (29.4, 33.6) |
68.5 (66.4, 70.6) |
|
11.1 (10.0, 12.2) |
40.8 (38.2, 43.5) |
48.1 (44.8, 51.5) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
VariantSexAllele
% (95% CI)Chi-square
P-valueGenotype
% (95% CI)Chi-square
P-value
By Sex
| rs662 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
61.9 (58.7, 65.0) |
38.1 (35.0, 41.3) |
0.604 |
40.0 (35.5, 44.7) |
43.8 (40.2, 47.5) |
16.2 (14.0, 18.6) |
0.268 |
| Female |
61.1 (58.9, 63.3) |
38.9 (36.7, 41.1) |
40.0 (37.4, 42.7) |
42.2 (39.9, 44.4) |
17.8 (15.7, 20.2) |
| Total |
61.5 (59.4, 63.6) |
38.5 (36.4, 40.6) |
|
40.0 (37.3, 42.8) |
43.0 (40.8, 45.2) |
17.0 (15.2, 19.0) |
|
| rs854560 |
|
A |
T |
|
AA |
AT |
TT |
|
| Male |
32.4 (29.1, 35.8) |
67.6 (64.2, 70.9) |
0.289 |
12.2 (10.4, 14.4) |
40.3 (36.4, 44.2) |
47.5 (42.4, 52.7) |
0.222 |
| Female |
30.7 (28.9, 32.5) |
69.3 (67.5, 71.1) |
10.0 (8.6, 11.6) |
41.4 (38.9, 43.9) |
48.7 (46.0, 51.4) |
| Total |
31.5 (29.4, 33.6) |
68.5 (66.4, 70.6) |
|
11.1 (10.0, 12.2) |
40.8 (38.2, 43.5) |
48.1 (44.8, 51.5) |
|
* Includes all participants, regardless of race/ethnicity.
Top of Page
By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs662 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
72.6 (68.0, 76.7) |
27.4 (23.3, 32.0) |
51.8 (44.1, 59.4) |
41.6 (33.8, 49.8) |
6.7 (4.0, 10.8) |
| 20-39 |
67.7 (65.4, 70.0) |
32.3 (30.0, 34.6) |
45.5 (41.5, 49.6) |
44.4 (39.9, 48.9) |
10.1 (8.1, 12.4) |
| 40-59 |
67.0 (63.5, 70.4) |
33.0 (29.6, 36.5) |
46.8 (41.8, 51.9) |
40.4 (35.5, 45.5) |
12.7 (9.8, 16.5) |
| >=60 |
69.7 (66.7, 72.5) |
30.3 (27.5, 33.3) |
48.6 (44.0, 53.2) |
42.1 (37.6, 46.8) |
9.3 (7.1, 12.1) |
| Non-Hispanic Black |
12-19 |
34.4 (31.5, 37.4) |
65.6 (62.6, 68.5) |
12.6 (9.7, 16.2) |
43.6 (38.7, 48.7) |
43.8 (39.4, 48.3) |
| 20-39 |
32.4 (30.2, 34.6) |
67.6 (65.4, 69.8) |
11.0 (8.3, 14.4) |
42.7 (40.0, 45.5) |
46.3 (44.2, 48.4) |
| 40-59 |
33.6 (30.0, 37.4) |
66.4 (62.6, 70.0) |
11.7 (8.7, 15.7) |
43.7 (38.8, 48.6) |
44.6 (39.5, 49.9) |
| >=60 |
31.2 (27.4, 35.2) |
68.8 (64.8, 72.6) |
9.6 (5.9, 15.3) |
43.2 (36.9, 49.7) |
47.2 (41.8, 52.7) |
| Mexican American |
12-19 |
54.0 (50.0, 58.1) |
46.0 (41.9, 50.0) |
25.7 (20.0, 32.3) |
56.8 (50.1, 63.2) |
17.6 (13.8, 22.1) |
| 20-39 |
52.7 (50.1, 55.2) |
47.3 (44.8, 49.9) |
27.9 (23.5, 32.8) |
49.5 (44.5, 54.6) |
22.6 (20.5, 24.8) |
| 40-59 |
55.5 (50.8, 60.1) |
44.5 (39.9, 49.2) |
32.8 (27.7, 38.4) |
45.3 (39.9, 50.8) |
21.9 (16.9, 27.8) |
| >=60 |
51.5 (47.4, 55.5) |
48.5 (44.5, 52.6) |
29.4 (24.3, 35.1) |
44.1 (36.8, 51.7) |
26.5 (21.2, 32.5) |
| rs854560 |
|
|
A |
T |
AA |
AT |
TT |
| Non-Hispanic White |
12-19 |
38.7 (33.2, 44.6) |
61.3 (55.4, 66.8) |
13.9 (9.1, 20.6) |
49.7 (43.0, 56.5) |
36.4 (29.3, 44.1) |
| 20-39 |
34.7 (30.3, 39.3) |
65.3 (60.7, 69.7) |
13.5 (10.3, 17.6) |
42.3 (37.3, 47.4) |
44.2 (37.9, 50.6) |
| 40-59 |
35.1 (31.4, 38.9) |
64.9 (61.1, 68.6) |
13.1 (10.3, 16.5) |
44.0 (38.4, 49.7) |
42.9 (37.2, 48.9) |
| >=60 |
36.2 (34.4, 38.1) |
63.8 (61.9, 65.6) |
13.7 (11.7, 16.1) |
45.0 (41.6, 48.5) |
41.3 (38.5, 44.1) |
| Non-Hispanic Black |
12-19 |
17.3 (14.6, 20.3) |
82.7 (79.7, 85.4) |
2.9 (1.8, 4.5) |
28.9 (23.7, 34.6) |
68.3 (62.6, 73.4) |
| 20-39 |
18.0 (16.3, 19.9) |
82.0 (80.1, 83.7) |
3.1 (2.0, 4.8) |
29.8 (27.0, 32.8) |
67.1 (64.1, 70.0) |
| 40-59 |
18.0 (15.1, 21.4) |
82.0 (78.6, 84.9) |
2.6 (1.3, 5.2) |
30.9 (25.4, 37.0) |
66.5 (60.5, 72.0) |
| >=60 |
18.1 (16.0, 20.4) |
81.9 (79.6, 84.0) |
2.9 (1.6, 5.2) |
30.4 (25.7, 35.5) |
66.7 (62.2, 70.9) |
| Mexican American |
12-19 |
24.9 (21.6, 28.6) |
75.1 (71.4, 78.4) |
5.6 (3.3, 9.3) |
38.7 (34.0, 43.5) |
55.7 (50.4, 60.9) |
| 20-39 |
21.3 (18.7, 24.1) |
78.7 (75.9, 81.3) |
4.3 (2.9, 6.3) |
34.1 (30.1, 38.3) |
61.6 (57.0, 66.0) |
| 40-59 |
24.8 (20.6, 29.5) |
75.2 (70.5, 79.4) |
5.4 (3.4, 8.4) |
38.9 (33.2, 44.9) |
55.8 (48.6, 62.7) |
| >=60 |
24.3 (21.5, 27.5) |
75.7 (72.5, 78.5) |
6.8 (3.6, 12.2) |
35.2 (30.2, 40.4) |
58.1 (54.2, 61.8) |
Top of Page
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs662 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
68.1 (65.0, 71.1) |
31.9 (28.9, 35.0) |
46.4 (41.2, 51.6) |
43.5 (38.7, 48.4) |
10.2 (8.4, 12.2) |
| Female |
68.9 (66.6, 71.2) |
31.1 (28.8, 33.4) |
48.3 (44.5, 52.0) |
41.4 (37.8, 45.1) |
10.4 (8.8, 12.2) |
| Non-Hispanic Black |
Male |
32.6 (30.4, 34.9) |
67.4 (65.1, 69.6) |
11.1 (9.1, 13.6) |
43.0 (39.9, 46.1) |
45.9 (42.8, 49.1) |
| Female |
33.1 (30.8, 35.5) |
66.9 (64.5, 69.2) |
11.4 (9.6, 13.5) |
43.4 (40.5, 46.3) |
45.2 (41.9, 48.6) |
| Mexican American |
Male |
54.2 (51.5, 56.8) |
45.8 (43.2, 48.5) |
28.7 (24.2, 33.7) |
50.9 (45.5, 56.3) |
20.4 (18.0, 23.0) |
| Female |
52.7 (50.5, 54.9) |
47.3 (45.1, 49.5) |
28.6 (24.9, 32.5) |
48.3 (42.7, 53.9) |
23.1 (20.0, 26.6) |
| rs854560 |
|
|
A |
T |
AA |
AT |
TT |
| Non-Hispanic White |
Male |
35.9 (32.1, 40.0) |
64.1 (60.0, 67.9) |
14.5 (12.0, 17.4) |
42.8 (38.7, 47.0) |
42.7 (37.1, 48.4) |
| Female |
35.3 (33.5, 37.2) |
64.7 (62.8, 66.5) |
12.5 (10.7, 14.5) |
45.6 (42.7, 48.6) |
41.9 (39.1, 44.6) |
| Non-Hispanic Black |
Male |
16.9 (14.5, 19.6) |
83.1 (80.4, 85.5) |
2.4 (1.6, 3.6) |
28.9 (24.8, 33.4) |
68.7 (63.9, 73.1) |
| Female |
18.8 (17.2, 20.4) |
81.2 (79.6, 82.8) |
3.3 (2.4, 4.7) |
30.9 (28.3, 33.6) |
65.8 (63.1, 68.5) |
| Mexican American |
Male |
24.8 (22.8, 26.9) |
75.2 (73.1, 77.2) |
5.7 (4.5, 7.2) |
38.2 (34.4, 42.2) |
56.1 (52.3, 59.8) |
| Female |
21.2 (19.4, 23.1) |
78.8 (76.9, 80.6) |
4.2 (3.4, 5.3) |
34.0 (31.1, 37.0) |
61.8 (58.6, 65.0) |
Top of Page