PPARG Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1801282
|
Ex4-49C>G
|
Pro12Ala
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1801282 |
|
C |
G |
|
CC |
CG |
GG |
|
|
| Non-Hispanic White |
86.8 (85.7, 87.8) |
13.2 (12.2, 14.3) |
<0.001 |
75.8 (73.9, 77.6) |
22.0 (20.2, 23.9) |
2.2 (1.6, 3.0) |
<0.001 |
0.93 |
| Non-Hispanic Black |
97.5 (96.6, 98.1) |
2.5 (1.9, 3.4) |
95.0 (93.3, 96.3) |
4.9 (3.7, 6.6) |
0.0 (0.0, 0.4) |
0.95 |
| Mexican American |
87.6 (86.6, 88.6) |
12.4 (11.4, 13.4) |
76.7 (75.0, 78.3) |
21.8 (20.4, 23.4) |
1.5 (1.0, 2.2) |
0.79 |
| Total* |
88.4 (87.3, 89.4) |
11.6 (10.6, 12.7) |
|
78.5 (76.6, 80.3) |
19.7 (18.0, 21.5) |
1.8 (1.3, 2.4) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801282 |
|
C |
G |
|
CC |
CG |
GG |
|
| 12-19 |
88.6 (85.6, 91.0) |
11.4 (9.0, 14.4) |
0.689 |
78.2 (73.0, 82.6) |
20.8 (16.7, 25.5) |
1.1 (0.3, 3.3) |
0.050 |
| 20-39 |
88.0 (86.4, 89.5) |
12.0 (10.5, 13.6) |
78.7 (75.7, 81.4) |
18.6 (15.8, 21.8) |
2.6 (1.8, 3.8) |
| 40-59 |
88.1 (85.8, 90.0) |
11.9 (10.0, 14.2) |
77.7 (73.8, 81.2) |
20.7 (17.3, 24.7) |
1.5 (0.7, 3.6) |
| >=60 |
89.3 (88.1, 90.4) |
10.7 (9.6, 11.9) |
79.4 (77.1, 81.6) |
19.7 (17.4, 22.2) |
0.9 (0.4, 1.8) |
| Total |
88.4 (87.3, 89.4) |
11.6 (10.6, 12.7) |
|
78.5 (76.6, 80.3) |
19.7 (18.0, 21.5) |
1.8 (1.3, 2.4) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1801282 |
|
C |
G |
|
CC |
CG |
GG |
|
| Male |
88.6 (86.8, 90.1) |
11.4 (9.9, 13.2) |
0.713 |
79.3 (75.9, 82.3) |
18.6 (15.6, 22.0) |
2.1 (1.4, 3.1) |
0.312 |
| Female |
88.2 (86.8, 89.4) |
11.8 (10.6, 13.2) |
77.8 (75.6, 79.8) |
20.8 (19.0, 22.7) |
1.4 (0.9, 2.4) |
| Total |
88.4 (87.3, 89.4) |
11.6 (10.6, 12.7) |
|
78.5 (76.6, 80.3) |
19.7 (18.0, 21.5) |
1.8 (1.3, 2.4) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801282 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
12-19 |
86.5 (82.1, 90.0) |
13.5 (10.0, 17.9) |
74.5 (67.2, 80.6) |
24.2 (18.6, 30.7) |
1.4 (0.3, 5.6) |
| 20-39 |
86.3 (84.2, 88.2) |
13.7 (11.8, 15.8) |
76.1 (72.5, 79.4) |
20.4 (17.3, 24.0) |
3.5 (2.4, 5.0) |
| 40-59 |
86.4 (84.1, 88.5) |
13.6 (11.5, 15.9) |
74.7 (70.4, 78.7) |
23.4 (19.2, 28.2) |
1.9 (0.7, 4.5) |
| >=60 |
88.2 (86.8, 89.4) |
11.8 (10.6, 13.2) |
77.4 (74.7, 79.8) |
21.6 (19.1, 24.5) |
1.0 (0.5, 2.1) |
| Non-Hispanic Black |
12-19 |
97.7 (95.5, 98.8) |
2.3 (1.2, 4.5) |
95.4 (91.1, 97.6) |
4.6 (2.4, 8.9) |
0.0 (NA) |
| 20-39 |
97.4 (96.6, 98.0) |
2.6 (2.0, 3.4) |
94.9 (93.4, 96.1) |
5.0 (3.8, 6.5) |
0.1 (0.0, 0.9) |
| 40-59 |
97.2 (95.6, 98.3) |
2.8 (1.7, 4.4) |
94.5 (91.3, 96.5) |
5.5 (3.5, 8.7) |
0.0 (NA) |
| >=60 |
98.0 (95.9, 99.0) |
2.0 (1.0, 4.1) |
95.9 (91.9, 98.0) |
4.1 (2.0, 8.1) |
0.0 (NA) |
| Mexican American |
12-19 |
87.9 (84.7, 90.5) |
12.1 (9.5, 15.3) |
77.9 (73.0, 82.1) |
20.0 (16.1, 24.6) |
2.1 (0.7, 6.2) |
| 20-39 |
87.0 (85.3, 88.5) |
13.0 (11.5, 14.7) |
75.6 (72.6, 78.3) |
22.8 (20.2, 25.5) |
1.7 (1.1, 2.6) |
| 40-59 |
88.2 (86.6, 89.6) |
11.8 (10.4, 13.4) |
76.9 (73.8, 79.8) |
22.5 (19.6, 25.7) |
0.6 (0.2, 1.9) |
| >=60 |
89.2 (85.3, 92.2) |
10.8 (7.8, 14.7) |
79.6 (73.1, 84.8) |
19.2 (14.3, 25.4) |
1.2 (0.2, 7.0) |
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By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1801282 |
|
|
C |
G |
CC |
CG |
GG |
| Non-Hispanic White |
Male |
86.9 (84.5, 88.9) |
13.1 (11.1, 15.5) |
76.4 (72.2, 80.2) |
20.8 (17.1, 25.1) |
2.7 (1.8, 4.1) |
| Female |
86.7 (85.3, 88.1) |
13.3 (11.9, 14.7) |
75.2 (72.9, 77.3) |
23.1 (21.1, 25.3) |
1.7 (0.9, 3.2) |
| Non-Hispanic Black |
Male |
97.2 (95.9, 98.1) |
2.8 (1.9, 4.1) |
94.6 (92.1, 96.3) |
5.3 (3.7, 7.7) |
0.1 (0.0, 0.8) |
| Female |
97.7 (96.9, 98.3) |
2.3 (1.7, 3.1) |
95.4 (93.8, 96.6) |
4.6 (3.4, 6.2) |
0.0 (NA) |
| Mexican American |
Male |
88.2 (86.2, 89.9) |
11.8 (10.1, 13.8) |
78.0 (74.7, 81.0) |
20.4 (17.8, 23.3) |
1.6 (1.1, 2.4) |
| Female |
87.0 (85.1, 88.7) |
13.0 (11.3, 14.9) |
75.3 (72.1, 78.2) |
23.4 (20.7, 26.3) |
1.3 (0.6, 2.8) |
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