SERPINE1 Allele and Genotype Frequencies
>
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1799762
rs1799768
rs1799889
|
4G/5G insertion/deletion
in promoter
|
|
MGB Eclipse
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1799762§ |
|
4G |
5G |
|
4G/4G |
4G/5G |
5G/5G |
|
|
| Non-Hispanic White |
52.5 (50.8, 54.3) |
47.5 (45.7, 49.2) |
<0.001 |
27.7 (25.8, 29.6) |
49.7 (47.8, 51.7) |
22.6 (20.6, 24.7) |
<0.001 |
0.92 |
| Non-Hispanic Black |
26.7 (25.0, 28.4) |
73.3 (71.6, 75.0) |
6.6 (5.3, 8.3) |
40.1 (37.8, 42.5) |
53.3 (50.8, 55.7) |
0.17 |
| Mexican American |
34.0 (31.5, 36.6) |
66.0 (63.4, 68.5) |
11.9 (9.5, 14.9) |
44.2 (41.9, 46.5) |
43.9 (41.0, 46.9) |
0.46 |
| Total* |
47.9 (46.0, 49.8) |
52.1 (50.2, 54.0) |
|
24.0 (22.4, 25.6) |
47.8 (46.1, 49.6) |
28.2 (25.8, 30.7) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
§ Variant also known as rs1799768 and rs1799889.
Top of Page
By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1799762† |
|
4G |
5G |
|
4G/4G |
4G/5G |
5G/5G |
|
| 12-19 |
45.4 (41.3, 49.5) |
54.6 (50.5, 58.7) |
0.024 |
21.2 (17.3, 25.7) |
48.4 (44.4, 52.3) |
30.4 (25.8, 35.5) |
0.013 |
| 20-39 |
46.6 (44.3, 48.9) |
53.4 (51.1, 55.7) |
22.4 (20.2, 24.8) |
48.4 (44.8, 52.0) |
29.2 (25.9, 32.7) |
| 40-59 |
49.9 (47.2, 52.6) |
50.1 (47.4, 52.8) |
26.7 (23.8, 29.7) |
46.5 (43.8, 49.3) |
26.8 (23.8, 30.0) |
| >=60 |
49.3 (47.6, 51.0) |
50.7 (49.0, 52.4) |
25.3 (22.4, 28.3) |
48.1 (44.1, 52.1) |
26.6 (24.4, 29.0) |
| Total |
47.9 (46.0, 49.8) |
52.1 (50.2, 54.0) |
|
24.0 (22.4, 25.6) |
47.8 (46.1, 49.6) |
28.2 (25.8, 30.7) |
|
* Includes all participants, regardless of race/ethnicity.
† Variant also known as rs1799768 and rs1799889.
Top of Page
By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1799762† |
|
4G |
5G |
|
4G/4G |
4G/5G |
5G/5G |
|
| Male |
48.0 (45.3, 50.8) |
52.0 (49.2, 54.7) |
0.833 |
25.3 (22.6, 28.2) |
45.4 (42.2, 48.7) |
29.2 (25.8, 32.9) |
0.050 |
| Female |
47.7 (45.8, 49.7) |
52.3 (50.3, 54.2) |
22.7 (20.8, 24.8) |
50.1 (48.4, 51.7) |
27.2 (25.1, 29.5) |
| Total |
47.9 (46.0, 49.8) |
52.1 (50.2, 54.0) |
|
24.0 (22.4, 25.6) |
47.8 (46.1, 49.6) |
28.2 (25.8, 30.7) |
|
* Includes all participants, regardless of race/ethnicity.
† Variant also known as rs1799768 and rs1799889.
Top of Page
By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1799762* |
|
|
4G |
5G |
4G/4G |
4G/5G |
5G/5G |
| Non-Hispanic White |
12-19 |
50.0 (45.7, 54.2) |
50.0 (45.8, 54.3) |
24.8 (19.9, 30.5) |
50.4 (44.1, 56.6) |
24.8 (20.0, 30.4) |
| 20-39 |
52.7 (49.8, 55.6) |
47.3 (44.4, 50.2) |
27.0 (23.7, 30.5) |
51.5 (47.4, 55.6) |
21.5 (18.0, 25.5) |
| 40-59 |
53.7 (50.7, 56.6) |
46.3 (43.4, 49.3) |
29.7 (26.6, 33.0) |
48.0 (44.9, 51.0) |
22.3 (19.1, 25.9) |
| >=60 |
52.1 (49.9, 54.3) |
47.9 (45.7, 50.1) |
27.7 (24.7, 30.9) |
48.7 (45.1, 52.4) |
23.5 (21.1, 26.2) |
| Non-Hispanic Black |
12-19 |
25.8 (23.1, 28.8) |
74.2 (71.2, 76.9) |
5.6 (3.5, 9.1) |
40.3 (37.7, 43.0) |
54.0 (50.5, 57.5) |
| 20-39 |
26.8 (23.5, 30.3) |
73.2 (69.7, 76.5) |
7.2 (4.7, 10.8) |
39.1 (36.1, 42.2) |
53.7 (49.3, 58.0) |
| 40-59 |
27.6 (24.5, 31.0) |
72.4 (69.0, 75.5) |
7.1 (4.8, 10.4) |
41.1 (35.1, 47.3) |
51.8 (46.1, 57.6) |
| >=60 |
25.7 (22.5, 29.3) |
74.3 (70.7, 77.5) |
5.1 (2.5, 10.2) |
41.2 (34.3, 48.5) |
53.7 (47.7, 59.6) |
| Mexican American |
12-19 |
36.7 (30.3, 43.6) |
63.3 (56.4, 69.7) |
14.0 (9.3, 20.6) |
45.3 (40.2, 50.6) |
40.6 (32.5, 49.3) |
| 20-39 |
31.6 (29.1, 34.2) |
68.4 (65.8, 70.9) |
10.0 (7.8, 12.8) |
43.1 (38.3, 48.2) |
46.8 (42.4, 51.3) |
| 40-59 |
36.0 (30.4, 41.9) |
64.0 (58.1, 69.6) |
13.3 (7.5, 22.4) |
45.4 (38.4, 52.6) |
41.3 (35.4, 47.6) |
| >=60 |
36.9 (33.2, 40.7) |
63.1 (59.3, 66.8) |
14.4 (11.0, 18.7) |
44.9 (41.0, 48.8) |
40.7 (36.1, 45.4) |
* Variant also known as rs1799768 and rs1799889.
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1799762* |
|
|
4G |
5G |
4G/4G |
4G/5G |
5G/5G |
| Non-Hispanic White |
Male |
52.5 (49.5, 55.5) |
47.5 (44.5, 50.5) |
28.8 (25.3, 32.6) |
47.5 (43.7, 51.2) |
23.7 (20.5, 27.3) |
| Female |
52.5 (50.8, 54.3) |
47.5 (45.7, 49.2) |
26.6 (24.2, 29.1) |
51.9 (49.3, 54.5) |
21.5 (19.7, 23.4) |
| Non-Hispanic Black |
Male |
27.2 (25.3, 29.1) |
72.8 (70.9, 74.7) |
6.1 (4.4, 8.5) |
42.0 (38.3, 45.9) |
51.8 (48.6, 55.1) |
| Female |
26.3 (24.2, 28.5) |
73.7 (71.5, 75.8) |
7.0 (5.7, 8.6) |
38.5 (35.6, 41.6) |
54.5 (51.0, 57.9) |
| Mexican American |
Male |
33.2 (30.5, 36.1) |
66.8 (63.9, 69.5) |
12.0 (9.2, 15.4) |
42.5 (38.8, 46.2) |
45.5 (42.0, 49.1) |
| Female |
34.8 (31.8, 38.0) |
65.2 (62.0, 68.2) |
11.8 (9.4, 14.7) |
46.0 (43.3, 48.8) |
42.2 (38.2, 46.3) |
* Variant also known as rs1799768 and rs1799889
Top of Page