TLR4 Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Common Designations
Nucleotide change Amino acid
|
Genotyping method
|
|
rs4986790
|
Ex4+636A>G
|
Asp299Gly
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs4986790 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
93.2 (92.5, 93.8) |
6.8 (6.2, 7.5) |
<0.001 |
86.9 (85.7, 88.1) |
12.5 (11.3, 13.8) |
0.5 (0.3, 1.0) |
<0.001 |
0.50 |
| Non-Hispanic Black |
92.5 (91.8, 93.2) |
7.5 (6.8, 8.2) |
85.7 (84.3, 87.0) |
13.7 (12.3, 15.2) |
0.6 (0.3, 1.2) |
0.73 |
| Mexican American |
97.5 (96.7, 98.2) |
2.5 (1.8, 3.3) |
95.1 (93.5, 96.4) |
4.8 (3.6, 6.5) |
0.0 (0.0, 0.2) |
0.39 |
| Total* |
93.6 (93.0, 94.2) |
6.4 (5.8, 7.0) |
|
87.7 (86.5, 88.9) |
11.8 (10.7, 13.1) |
0.5 (0.3, 0.8) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs4986790 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
93.2 (91.2, 94.8) |
6.8 (5.2, 8.8) |
0.852 |
86.6 (82.6, 89.8) |
13.3 (10.1, 17.3) |
0.1 (0.0, 0.3) |
0.013 |
| 20-39 |
93.5 (92.4, 94.4) |
6.5 (5.6, 7.6) |
87.7 (85.6, 89.6) |
11.5 (9.6, 13.9) |
0.7 (0.3, 1.7) |
| 40-59 |
94.1 (92.6, 95.2) |
5.9 (4.8, 7.4) |
88.4 (85.5, 90.8) |
11.3 (8.9, 14.2) |
0.3 (0.1, 0.8) |
| >=60 |
93.5 (91.6, 95.0) |
6.5 (5.0, 8.4) |
87.4 (84.2, 90.1) |
12.1 (9.8, 14.9) |
0.5 (0.1, 1.7) |
| Total |
93.6 (93.0, 94.2) |
6.4 (5.8, 7.0) |
|
87.7 (86.5, 88.9) |
11.8 (10.7, 13.1) |
0.5 (0.3, 0.8) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs4986790 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
93.6 (92.3, 94.6) |
6.4 (5.4, 7.7) |
0.904 |
87.7 (85.2, 89.8) |
11.8 (9.7, 14.3) |
0.5 (0.2, 1.0) |
0.953 |
| Female |
93.7 (93.1, 94.2) |
6.3 (5.8, 6.9) |
87.8 (86.7, 88.7) |
11.8 (10.9, 12.8) |
0.4 (0.2, 0.9) |
| Total |
93.6 (93.0, 94.2) |
6.4 (5.8, 7.0) |
|
87.7 (86.5, 88.9) |
11.8 (10.7, 13.1) |
0.5 (0.3, 0.8) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs4986790 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
92.6 (89.3, 94.9) |
7.4 (5.1, 10.7) |
85.1 (78.7, 89.9) |
14.9 (10.1, 21.3) |
0.0 (NA) |
| 20-39 |
93.1 (91.8, 94.3) |
6.9 (5.7, 8.2) |
87.2 (84.6, 89.4) |
11.9 (9.6, 14.8) |
0.9 (0.3, 2.3) |
| 40-59 |
93.5 (91.8, 94.8) |
6.5 (5.2, 8.2) |
87.2 (84.0, 89.9) |
12.5 (9.8, 15.7) |
0.3 (0.1, 0.9) |
| >=60 |
93.3 (91.2, 95.0) |
6.7 (5.0, 8.8) |
87.2 (83.6, 90.1) |
12.2 (9.8, 15.2) |
0.6 (0.2, 2.0) |
| Non-Hispanic Black |
12-19 |
92.1 (89.9, 93.9) |
7.9 (6.1, 10.1) |
84.8 (80.4, 88.4) |
14.5 (10.8, 19.3) |
0.6 (0.2, 2.1) |
| 20-39 |
91.8 (90.2, 93.1) |
8.2 (6.9, 9.8) |
84.3 (81.4, 86.8) |
15.0 (12.5, 17.9) |
0.7 (0.3, 1.9) |
| 40-59 |
93.8 (91.8, 95.4) |
6.2 (4.6, 8.2) |
88.5 (85.0, 91.2) |
10.7 (8.2, 13.8) |
0.8 (0.3, 2.3) |
| >=60 |
93.1 (90.4, 95.1) |
6.9 (4.9, 9.6) |
86.2 (80.9, 90.2) |
13.8 (9.8, 19.1) |
0.0 (NA) |
| Mexican American |
12-19 |
98.2 (96.3, 99.1) |
1.8 (0.9, 3.7) |
96.4 (92.7, 98.3) |
3.6 (1.7, 7.3) |
0.0 (NA) |
| 20-39 |
97.3 (96.2, 98.0) |
2.7 (2.0, 3.8) |
94.6 (92.6, 96.1) |
5.4 (3.9, 7.4) |
0.1 (0.0, 0.4) |
| 40-59 |
97.7 (94.8, 99.0) |
2.3 (1.0, 5.2) |
95.4 (89.8, 98.0) |
4.6 (2.0, 10.2) |
0.0 (NA) |
| >=60 |
97.2 (94.9, 98.5) |
2.8 (1.5, 5.1) |
94.7 (89.9, 97.2) |
5.2 (2.6, 10.2) |
0.2 (0.0, 1.4) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs4986790 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
93.0 (91.6, 94.3) |
7.0 (5.7, 8.4) |
86.6 (83.8, 89.0) |
12.8 (10.4, 15.7) |
0.5 (0.2, 1.2) |
| Female |
93.3 (92.5, 94.1) |
6.7 (5.9, 7.5) |
87.2 (85.8, 88.6) |
12.2 (11.0, 13.6) |
0.5 (0.3, 1.1) |
| Non-Hispanic Black |
Male |
92.5 (91.3, 93.6) |
7.5 (6.4, 8.7) |
86.0 (83.5, 88.1) |
13.2 (10.8, 15.9) |
0.9 (0.4, 2.1) |
| Female |
92.5 (91.6, 93.4) |
7.5 (6.6, 8.4) |
85.5 (83.7, 87.0) |
14.1 (12.6, 15.8) |
0.4 (0.2, 1.0) |
| Mexican American |
Male |
98.0 (97.2, 98.6) |
2.0 (1.4, 2.8) |
96.0 (94.4, 97.2) |
4.0 (2.8, 5.6) |
0.0 (NA) |
| Female |
97.1 (95.4, 98.1) |
2.9 (1.9, 4.6) |
94.2 (91.0, 96.3) |
5.7 (3.6, 9.0) |
0.1 (0.0, 0.4) |
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