TNF Allele and Genotype Frequencies
Available polymorphism(s)
|
rs number
|
Nucleotide change Amino acid
|
Genotyping method
|
|
rs1800629
|
-487G>A
-308G>A
|
|
TaqMan
|
|
rs1800750
|
-555G>A
|
|
TaqMan
|
|
rs361525
|
-417G>A
-238G>A
|
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1800629 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
17.2 (15.6, 19.0) |
82.8 (81.0, 84.4) |
<0.001 |
2.9 (2.1, 4.0) |
28.7 (26.1, 31.5) |
68.4 (65.4, 71.3) |
<0.001 |
0.78 |
| Non-Hispanic Black |
13.1 (11.9, 14.5) |
86.9 (85.5, 88.1) |
1.8 (1.3, 2.5) |
22.7 (20.8, 24.6) |
75.5 (73.2, 77.7) |
0.87 |
| Mexican American |
7.3 (5.9, 9.1) |
92.7 (90.9, 94.1) |
0.5 (0.3, 0.8) |
13.6 (10.8, 16.9) |
85.9 (82.5, 88.7) |
0.88 |
| Total* |
15.3 (14.0, 16.8) |
84.7 (83.2, 86.0) |
|
2.4 (1.8, 3.2) |
25.9 (23.7, 28.2) |
71.7 (69.2, 74.1) |
|
|
| rs1800750 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
1.3 (0.9, 2.0) |
98.7 (98.0, 99.1) |
0.007 |
0.1 (0.0, 0.2) |
2.5 (1.6, 3.9) |
97.4 (96.0, 98.3) |
<0.001 |
<0.01 |
| Non-Hispanic Black |
2.3 (1.9, 2.9) |
97.7 (97.1, 98.1) |
0.1 (0.0, 0.3) |
4.5 (3.6, 5.6) |
95.4 (94.3, 96.3) |
0.41 |
| Mexican American |
2.5 (2.1, 2.9) |
97.5 (97.1, 97.9) |
0.0 (NA) |
5.0 (4.3, 5.7) |
95.0 (94.3, 95.7) |
0.22 |
| Total* |
1.6 (1.2, 2.1) |
98.4 (97.9, 98.8) |
|
0.1 (0.0, 0.2) |
3.0 (2.3, 4.1) |
96.9 (95.8, 97.7) |
|
|
| rs361525 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
5.8 (5.0, 6.6) |
94.2 (93.4, 95.0) |
0.005 |
0.7 (0.4, 1.1) |
10.1 (8.9, 11.4) |
89.2 (87.7, 90.5) |
0.022 |
0.06 |
| Non-Hispanic Black |
4.1 (3.3, 5.2) |
95.9 (94.8, 96.7) |
0.1 (0.0, 0.6) |
8.0 (6.4, 9.8) |
91.9 (89.9, 93.5) |
0.53 |
| Mexican American |
5.8 (5.2, 6.5) |
94.2 (93.5, 94.8) |
0.2 (0.1, 0.5) |
11.2 (9.9, 12.6) |
88.6 (87.2, 89.8) |
0.20 |
| Total* |
5.5 (4.9, 6.2) |
94.5 (93.8, 95.1) |
|
0.5 (0.4, 0.8) |
10.0 (8.8, 11.2) |
89.5 (88.2, 90.7) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age*
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800629 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
14.9 (12.1, 18.1) |
85.1 (81.9, 87.9) |
0.579 |
0.9 (0.3, 2.4) |
27.9 (22.6, 33.8) |
71.2 (65.1, 76.6) |
0.004 |
| 20-39 |
15.8 (13.5, 18.5) |
84.2 (81.5, 86.5) |
2.8 (1.7, 4.6) |
26.1 (22.4, 30.1) |
71.1 (66.7, 75.1) |
| 40-59 |
14.4 (12.4, 16.6) |
85.6 (83.4, 87.6) |
2.8 (2.0, 3.9) |
23.1 (19.8, 26.9) |
74.0 (70.1, 77.6) |
| >=60 |
16.1 (14.3, 18.0) |
83.9 (82.0, 85.7) |
2.1 (1.3, 3.5) |
27.9 (24.5, 31.6) |
70.0 (66.4, 73.3) |
| Total |
15.3 (14.0, 16.8) |
84.7 (83.2, 86.0) |
|
2.4 (1.8, 3.2) |
25.9 (23.7, 28.2) |
71.7 (69.2, 74.1) |
|
| rs1800750 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
1.2 (0.6, 2.2) |
98.8 (97.8, 99.4) |
0.743 |
0.0 (NA) |
2.3 (1.2, 4.4) |
97.7 (95.6, 98.8) |
0.103 |
| 20-39 |
1.6 (1.1, 2.3) |
98.4 (97.7, 98.9) |
0.1 (0.0, 0.5) |
3.0 (2.1, 4.5) |
96.9 (95.5, 97.8) |
| 40-59 |
1.6 (1.0, 2.6) |
98.4 (97.4, 99.0) |
0.0 (NA) |
3.2 (2.0, 5.3) |
96.8 (94.7, 98.0) |
| >=60 |
1.8 (1.0, 3.4) |
98.2 (96.6, 99.0) |
0.2 (0.0, 0.9) |
3.3 (1.7, 6.3) |
96.5 (93.5, 98.2) |
| Total |
1.6 (1.2, 2.1) |
98.4 (97.9, 98.8) |
|
0.1 (0.0, 0.2) |
3.0 (2.3, 4.1) |
96.9 (95.8, 97.7) |
|
| rs361525 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
5.2 (4.0, 6.7) |
94.8 (93.3, 96.0) |
0.277 |
0.0 (0.0, 0.3) |
10.3 (7.9, 13.3) |
89.7 (86.7, 92.0) |
<0.001 |
| 20-39 |
6.3 (5.1, 7.7) |
93.7 (92.3, 94.9) |
1.0 (0.6, 1.6) |
10.6 (8.6, 13.0) |
88.4 (85.9, 90.6) |
| 40-59 |
4.8 (3.7, 6.2) |
95.2 (93.8, 96.3) |
0.4 (0.1, 1.3) |
8.8 (6.8, 11.3) |
90.8 (88.2, 92.9) |
| >=60 |
5.3 (4.0, 6.9) |
94.7 (93.1, 96.0) |
0.3 (0.1, 0.9) |
10.1 (7.5, 13.4) |
89.7 (86.4, 92.2) |
| Total |
5.5 (4.9, 6.2) |
94.5 (93.8, 95.1) |
|
0.5 (0.4, 0.8) |
10.0 (8.8, 11.2) |
89.5 (88.2, 90.7) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1800629 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
14.3 (12.5, 16.4) |
85.7 (83.6, 87.5) |
0.103 |
2.0 (1.3, 2.9) |
24.7 (21.3, 28.5) |
73.3 (69.5, 76.8) |
0.233 |
| Female |
16.3 (14.6, 18.2) |
83.7 (81.8, 85.4) |
2.8 (2.0, 4.1) |
26.9 (24.3, 29.8) |
70.2 (67.1, 73.1) |
| Total |
15.3 (14.0, 16.8) |
84.7 (83.2, 86.0) |
|
2.4 (1.8, 3.2) |
25.9 (23.7, 28.2) |
71.7 (69.2, 74.1) |
|
| rs1800750 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
1.6 (1.2, 2.3) |
98.4 (97.7, 98.8) |
0.762 |
0.1 (0.0, 0.5) |
3.2 (2.2, 4.5) |
96.8 (95.5, 97.7) |
0.887 |
| Female |
1.6 (1.1, 2.2) |
98.4 (97.8, 98.9) |
0.1 (0.0, 0.3) |
2.9 (2.0, 4.2) |
97.0 (95.7, 97.9) |
| Total |
1.6 (1.2, 2.1) |
98.4 (97.9, 98.8) |
|
0.1 (0.0, 0.2) |
3.0 (2.3, 4.1) |
96.9 (95.8, 97.7) |
|
| rs361525 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
5.0 (4.1, 6.0) |
95.0 (94.0, 95.9) |
0.050 |
0.3 (0.1, 0.9) |
9.3 (7.8, 11.2) |
90.4 (88.5, 92.0) |
0.122 |
| Female |
6.0 (5.3, 6.9) |
94.0 (93.1, 94.7) |
0.8 (0.5, 1.3) |
10.5 (9.3, 11.9) |
88.7 (87.2, 90.0) |
| Total |
5.5 (4.9, 6.2) |
94.5 (93.8, 95.1) |
|
0.5 (0.4, 0.8) |
10.0 (8.8, 11.2) |
89.5 (88.2, 90.7) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800629 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
16.8 (13.1, 21.3) |
83.2 (78.7, 86.9) |
0.7 (0.1, 4.8) |
32.2 (25.1, 40.2) |
67.1 (58.9, 74.3) |
| 20-39 |
18.3 (15.3, 21.7) |
81.7 (78.3, 84.7) |
3.7 (2.1, 6.4) |
29.2 (24.3, 34.6) |
67.1 (61.5, 72.3) |
| 40-59 |
16.4 (14.2, 18.7) |
83.6 (81.3, 85.8) |
3.3 (2.3, 4.6) |
26.2 (22.6, 30.2) |
70.5 (66.4, 74.4) |
| >=60 |
17.0 (15.0, 19.1) |
83.0 (80.9, 85.0) |
2.3 (1.3, 4.0) |
29.3 (25.4, 33.4) |
68.4 (64.5, 72.1) |
| Non-Hispanic Black |
12-19 |
14.1 (11.5, 17.2) |
85.9 (82.8, 88.5) |
2.5 (1.2, 5.2) |
23.3 (18.2, 29.3) |
74.2 (68.6, 79.2) |
| 20-39 |
14.1 (12.2, 16.3) |
85.9 (83.7, 87.8) |
1.8 (1.1, 2.9) |
24.7 (21.8, 28.0) |
73.5 (69.8, 76.9) |
| 40-59 |
11.9 (10.2, 13.8) |
88.1 (86.2, 89.8) |
2.1 (1.1, 4.0) |
19.6 (16.8, 22.8) |
78.3 (75.1, 81.1) |
| >=60 |
11.0 (8.4, 14.3) |
89.0 (85.7, 91.6) |
0.6 (0.1, 2.7) |
20.8 (16.3, 26.1) |
78.6 (72.8, 83.4) |
| Mexican American |
12-19 |
8.5 (5.2, 13.6) |
91.5 (86.4, 94.8) |
0.6 (0.1, 2.9) |
15.8 (10.2, 23.6) |
83.6 (74.9, 89.7) |
| 20-39 |
6.8 (5.4, 8.7) |
93.2 (91.3, 94.6) |
0.1 (0.0, 1.0) |
13.4 (10.5, 17.0) |
86.5 (82.9, 89.4) |
| 40-59 |
6.8 (4.9, 9.4) |
93.2 (90.6, 95.1) |
1.1 (0.6, 2.2) |
11.3 (7.7, 16.3) |
87.6 (82.6, 91.3) |
| >=60 |
8.6 (5.9, 12.2) |
91.4 (87.8, 94.1) |
0.9 (0.3, 2.9) |
15.4 (10.6, 21.8) |
83.8 (77.1, 88.8) |
| rs1800750 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
1.0 (0.3, 2.8) |
99.0 (97.2, 99.7) |
0.0 (NA) |
1.9 (0.7, 5.6) |
98.1 (94.4, 99.3) |
| 20-39 |
1.5 (0.9, 2.6) |
98.5 (97.4, 99.1) |
0.1 (0.0, 0.8) |
2.8 (1.5, 5.1) |
97.1 (94.9, 98.4) |
| 40-59 |
1.2 (0.6, 2.6) |
98.8 (97.4, 99.4) |
0.0 (NA) |
2.4 (1.1, 5.3) |
97.6 (94.7, 98.9) |
| >=60 |
1.4 (0.8, 2.6) |
98.6 (97.4, 99.2) |
0.2 (0.1, 1.1) |
2.3 (1.2, 4.5) |
97.4 (95.3, 98.6) |
| Non-Hispanic Black |
12-19 |
2.0 (1.2, 3.5) |
98.0 (96.5, 98.8) |
0.0 (NA) |
4.1 (2.4, 6.9) |
95.9 (93.1, 97.6) |
| 20-39 |
3.0 (2.3, 4.1) |
97.0 (95.9, 97.7) |
0.2 (0.0, 0.8) |
5.7 (4.3, 7.6) |
94.1 (92.1, 95.6) |
| 40-59 |
1.5 (0.8, 2.6) |
98.5 (97.4, 99.2) |
0.0 (NA) |
2.9 (1.6, 5.3) |
97.1 (94.7, 98.4) |
| >=60 |
2.1 (1.0, 4.5) |
97.9 (95.5, 99.0) |
0.0 (NA) |
4.2 (1.9, 8.9) |
95.8 (91.1, 98.1) |
| Mexican American |
12-19 |
1.9 (1.3, 2.9) |
98.1 (97.1, 98.7) |
0.0 (NA) |
3.9 (2.6, 5.7) |
96.1 (94.3, 97.4) |
| 20-39 |
2.2 (1.6, 3.2) |
97.8 (96.8, 98.4) |
0.0 (NA) |
4.4 (3.1, 6.3) |
95.6 (93.7, 96.9) |
| 40-59 |
3.1 (1.9, 4.9) |
96.9 (95.1, 98.1) |
0.0 (NA) |
6.1 (3.8, 9.8) |
93.9 (90.2, 96.2) |
| >=60 |
3.9 (2.5, 6.0) |
96.1 (94.0, 97.5) |
0.0 (NA) |
7.7 (4.9, 12.0) |
92.3 (88.0, 95.1) |
| rs361525 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
5.4 (3.9, 7.6) |
94.6 (92.4, 96.1) |
0.0 (NA) |
10.9 (7.7, 15.2) |
89.1 (84.8, 92.3) |
| 20-39 |
7.1 (5.6, 8.9) |
92.9 (91.1, 94.4) |
1.4 (0.8, 2.4) |
11.4 (9.0, 14.2) |
87.3 (84.1, 89.9) |
| 40-59 |
4.6 (3.4, 6.1) |
95.4 (93.9, 96.6) |
0.4 (0.1, 1.8) |
8.4 (6.2, 11.2) |
91.2 (88.4, 93.4) |
| >=60 |
5.3 (4.3, 6.5) |
94.7 (93.5, 95.7) |
0.3 (0.1, 1.1) |
10.0 (7.9, 12.5) |
89.7 (87.3, 91.8) |
| Non-Hispanic Black |
12-19 |
5.1 (3.5, 7.4) |
94.9 (92.6, 96.5) |
0.0 (NA) |
10.2 (7.0, 14.7) |
89.8 (85.3, 93.0) |
| 20-39 |
4.7 (3.6, 6.1) |
95.3 (93.9, 96.4) |
0.0 (NA) |
9.3 (7.1, 12.1) |
90.7 (87.9, 92.9) |
| 40-59 |
3.1 (1.9, 5.0) |
96.9 (95.0, 98.1) |
0.5 (0.1, 2.5) |
5.1 (3.1, 8.2) |
94.4 (91.1, 96.4) |
| >=60 |
3.0 (1.7, 5.2) |
97.0 (94.8, 98.3) |
0.0 (NA) |
6.0 (3.4, 10.3) |
94.0 (89.7, 96.6) |
| Mexican American |
12-19 |
5.5 (4.2, 7.0) |
94.5 (93.0, 95.8) |
0.4 (0.0, 2.9) |
10.2 (7.9, 13.1) |
89.4 (86.6, 91.7) |
| 20-39 |
6.2 (5.2, 7.4) |
93.8 (92.6, 94.8) |
0.0 (NA) |
12.4 (10.4, 14.8) |
87.6 (85.2, 89.6) |
| 40-59 |
5.1 (3.2, 8.1) |
94.9 (91.9, 96.8) |
0.6 (0.1, 2.5) |
9.1 (5.9, 13.8) |
90.4 (85.1, 93.9) |
| >=60 |
6.3 (4.6, 8.6) |
93.7 (91.4, 95.4) |
0.5 (0.1, 3.4) |
11.6 (8.8, 15.0) |
87.9 (84.1, 90.9) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1800629 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
16.2 (13.9, 18.7) |
83.8 (81.3, 86.1) |
2.4 (1.6, 3.6) |
27.5 (23.4, 32.1) |
70.1 (65.4, 74.4) |
| Female |
18.3 (16.0, 20.8) |
81.7 (79.2, 84.0) |
3.4 (2.2, 5.2) |
29.8 (26.4, 33.5) |
66.8 (62.8, 70.6) |
| Non-Hispanic Black |
Male |
11.7 (9.9, 13.8) |
88.3 (86.2, 90.1) |
1.1 (0.5, 2.2) |
21.3 (18.3, 24.6) |
77.6 (74.0, 80.9) |
| Female |
14.3 (12.8, 16.0) |
85.7 (84.0, 87.2) |
2.4 (1.8, 3.3) |
23.8 (21.6, 26.1) |
73.8 (71.1, 76.3) |
| Mexican American |
Male |
6.5 (4.8, 8.7) |
93.5 (91.3, 95.2) |
0.3 (0.1, 0.9) |
12.3 (8.7, 17.0) |
87.4 (82.8, 90.9) |
| Female |
8.2 (6.7, 9.9) |
91.8 (90.1, 93.3) |
0.7 (0.3, 1.4) |
15.0 (12.3, 18.2) |
84.3 (81.0, 87.1) |
| rs1800750 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
1.3 (0.9, 2.0) |
98.7 (98.0, 99.1) |
0.1 (0.0, 0.7) |
2.5 (1.6, 3.8) |
97.4 (96.1, 98.3) |
| Female |
1.3 (0.7, 2.4) |
98.7 (97.6, 99.3) |
0.1 (0.0, 0.5) |
2.5 (1.3, 4.6) |
97.4 (95.4, 98.6) |
| Non-Hispanic Black |
Male |
2.4 (1.7, 3.5) |
97.6 (96.5, 98.3) |
0.0 (NA) |
4.9 (3.4, 7.0) |
95.1 (93.0, 96.6) |
| Female |
2.3 (1.7, 3.0) |
97.7 (97.0, 98.3) |
0.1 (0.0, 0.6) |
4.2 (3.1, 5.7) |
95.6 (94.1, 96.8) |
| Mexican American |
Male |
2.6 (2.0, 3.2) |
97.4 (96.8, 98.0) |
0.0 (NA) |
5.1 (4.0, 6.4) |
94.9 (93.6, 96.0) |
| Female |
2.4 (1.8, 3.2) |
97.6 (96.8, 98.2) |
0.0 (NA) |
4.8 (3.6, 6.4) |
95.2 (93.6, 96.4) |
| rs361525 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
5.1 (4.2, 6.2) |
94.9 (93.8, 95.8) |
0.4 (0.1, 1.3) |
9.5 (8.0, 11.3) |
90.1 (88.2, 91.7) |
| Female |
6.3 (5.4, 7.4) |
93.7 (92.6, 94.6) |
1.0 (0.6, 1.7) |
10.7 (9.3, 12.2) |
88.3 (86.6, 89.8) |
| Non-Hispanic Black |
Male |
3.9 (3.0, 5.1) |
96.1 (94.9, 97.0) |
0.1 (0.0, 1.0) |
7.6 (5.8, 10.0) |
92.3 (89.9, 94.1) |
| Female |
4.3 (3.2, 5.7) |
95.7 (94.3, 96.8) |
0.1 (0.0, 1.2) |
8.3 (6.2, 10.9) |
91.6 (88.9, 93.7) |
| Mexican American |
Male |
5.2 (4.2, 6.5) |
94.8 (93.5, 95.8) |
0.1 (0.0, 0.8) |
10.2 (8.1, 12.7) |
89.7 (87.2, 91.8) |
| Female |
6.5 (5.7, 7.4) |
93.5 (92.6, 94.3) |
0.4 (0.2, 0.7) |
12.2 (10.6, 14.0) |
87.4 (85.7, 89.0) |
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