XRCC1 Allele and Genotype Frequencies
Available polymorphism(s)
|
Common Designations |
|
|
rs number
|
Nucleotide change |
Amino acid |
Genotyping method
|
|
rs1001581
|
IVS2-216G>A
|
|
MGB Eclipse
|
|
rs1799782
|
Ex6-22C>T
|
Arg194Trp
|
TaqMan
|
|
rs25486
|
IVS9-59A>G
|
|
TaqMan
|
|
rs25487
|
Ex10-4G>A
|
Arg399Gln
|
TaqMan
|
|
rs25489
|
Ex9+16G>A
|
Arg280His
|
TaqMan
|
| Variant |
Race-ethnicity |
Allele
% (95% CI) |
Chi-square
P-value† |
Genotype
% (95% CI) |
Chi-square
P-value† |
HW
P-value‡ |
| rs1001581 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
39.9 (38.0, 41.9) |
60.1 (58.1, 62.0) |
<0.001 |
15.3 (13.6, 17.3) |
49.2 (46.0, 52.4) |
35.5 (32.5, 38.5) |
<0.001 |
0.69 |
| Non-Hispanic Black |
36.7 (34.9, 38.5) |
63.3 (61.5, 65.1) |
14.6 (13.1, 16.2) |
44.2 (41.7, 46.7) |
41.2 (38.6, 43.9) |
0.20 |
| Mexican American |
30.2 (27.8, 32.7) |
69.8 (67.3, 72.2) |
9.2 (7.6, 10.9) |
42.1 (38.8, 45.4) |
48.8 (44.9, 52.6) |
0.92 |
| Total* |
38.9 (37.5, 40.3) |
61.1 (59.7, 62.5) |
|
14.9 (13.6, 16.3) |
47.9 (45.6, 50.2) |
37.2 (35.0, 39.4) |
|
|
| rs1799782 |
|
C |
T |
|
CC |
CT |
TT |
|
|
| Non-Hispanic White |
95.0 (94.4, 95.7) |
5.0 (4.3, 5.6) |
<0.001 |
90.4 (89.1, 91.6) |
9.3 (8.1, 10.6) |
0.3 (0.1, 0.8) |
<0.001 |
0.97 |
| Non-Hispanic Black |
93.8 (92.9, 94.7) |
6.2 (5.3, 7.1) |
88.2 (86.6, 89.6) |
11.3 (10.0, 12.6) |
0.5 (0.2, 1.3) |
0.13 |
| Mexican American |
85.2 (83.6, 86.7) |
14.8 (13.3, 16.4) |
73.0 (70.7, 75.1) |
24.4 (23.0, 25.9) |
2.6 (1.8, 3.8) |
0.12 |
| Total* |
93.0 (92.3, 93.6) |
7.0 (6.4, 7.7) |
|
86.7 (85.6, 87.7) |
12.6 (11.6, 13.7) |
0.7 (0.5, 1.1) |
|
|
| rs25486 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
64.0 (62.2, 65.8) |
36.0 (34.2, 37.8) |
<0.001 |
40.6 (37.4, 43.8) |
46.9 (43.3, 50.5) |
12.5 (11.0, 14.3) |
<0.001 |
0.70 |
| Non-Hispanic Black |
75.9 (73.7, 77.9) |
24.1 (22.1, 26.3) |
57.9 (54.9, 60.8) |
35.9 (33.7, 38.3) |
6.2 (4.7, 8.0) |
0.26 |
| Mexican American |
74.2 (72.4, 76.0) |
25.8 (24.0, 27.6) |
55.3 (52.3, 58.3) |
37.8 (35.4, 40.3) |
6.9 (6.0, 7.9) |
0.88 |
| Total* |
66.4 (65.1, 67.6) |
33.6 (32.4, 34.9) |
|
44.0 (41.8, 46.2) |
44.7 (42.1, 47.2) |
11.3 (10.1, 12.6) |
|
|
| rs25487 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
36.1 (34.3, 37.9) |
63.9 (62.1, 65.7) |
<0.001 |
12.7 (11.1, 14.4) |
46.9 (43.3, 50.5) |
40.5 (37.3, 43.7) |
<0.001 |
0.67 |
| Non-Hispanic Black |
15.9 (14.4, 17.5) |
84.1 (82.5, 85.6) |
2.8 (2.0, 4.1) |
26.1 (24.2, 28.2) |
71.0 (68.6, 73.4) |
0.16 |
| Mexican American |
25.6 (23.9, 27.5) |
74.4 (72.5, 76.1) |
6.8 (5.8, 7.8) |
37.7 (35.3, 40.2) |
55.5 (52.6, 58.4) |
0.76 |
| Total* |
32.6 (31.2, 34.1) |
67.4 (65.9, 68.8) |
|
11.0 (9.8, 12.4) |
43.3 (40.6, 46.0) |
45.7 (43.2, 48.2) |
|
|
| rs25489 |
|
A |
G |
|
AA |
AG |
GG |
|
|
| Non-Hispanic White |
4.0 (3.3, 4.8) |
96.0 (95.2, 96.7) |
<0.001 |
0.1 (0.0, 0.3) |
7.8 (6.4, 9.4) |
92.2 (90.5, 93.5) |
<0.001 |
0.99 |
| Non-Hispanic Black |
3.5 (2.9, 4.2) |
96.5 (95.8, 97.1) |
0.2 (0.1, 0.4) |
6.5 (5.2, 8.0) |
93.3 (91.8, 94.5) |
0.25 |
| Mexican American |
12.4 (10.8, 14.2) |
87.6 (85.8, 89.2) |
1.6 (1.3, 2.1) |
21.6 (18.8, 24.6) |
76.8 (73.5, 79.8) |
0.44 |
| Total* |
4.7 (4.0, 5.4) |
95.3 (94.6, 96.0) |
|
0.2 (0.2, 0.4) |
8.8 (7.6, 10.2) |
90.9 (89.6, 92.1) |
|
|
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
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By Age
| Variant |
Age (years) |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1001581 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
36.0 (31.7, 40.5) |
64.0 (59.5, 68.3) |
0.360 |
13.4 (10.7, 16.5) |
45.2 (39.7, 50.8) |
41.4 (34.9, 48.3) |
0.539 |
| 20-39 |
39.7 (37.4, 42.0) |
60.3 (58.0, 62.6) |
14.8 (12.7, 17.2) |
49.8 (46.4, 53.2) |
35.4 (32.2, 38.8) |
| 40-59 |
39.1 (36.3, 41.9) |
60.9 (58.1, 63.7) |
15.7 (13.4, 18.4) |
46.7 (42.9, 50.5) |
37.6 (33.5, 41.8) |
| >=60 |
39.0 (37.1, 41.0) |
61.0 (59.0, 62.9) |
15.1 (12.7, 17.9) |
47.8 (43.3, 52.3) |
37.1 (33.8, 40.4) |
| Total |
38.9 (37.5, 40.3) |
61.1 (59.7, 62.5) |
|
14.9 (13.6, 16.3) |
47.9 (45.6, 50.2) |
37.2 (35.0, 39.4) |
|
| rs1799782 |
|
C |
T |
|
CC |
CT |
TT |
|
| 12-19 |
91.9 (89.9, 93.6) |
8.1 (6.4, 10.1) |
0.683 |
84.7 (81.0, 87.8) |
14.4 (11.4, 18.1) |
0.8 (0.3, 2.1) |
0.244 |
| 20-39 |
93.1 (91.9, 94.0) |
6.9 (6.0, 8.1) |
|
86.7 (84.5, 88.6) |
12.8 (10.9, 14.9) |
0.6 (0.3, 1.0) |
| 40-59 |
93.2 (90.9, 95.0) |
6.8 (5.0, 9.1) |
|
87.4 (83.6, 90.4) |
11.7 (9.1, 14.8) |
1.0 (0.4, 2.2) |
| >=60 |
93.2 (91.9, 94.3) |
6.8 (5.7, 8.1) |
|
87.1 (84.6, 89.2) |
12.2 (10.1, 14.8) |
0.7 (0.3, 1.5) |
| Total |
93.0 (92.3, 93.6) |
7.0 (6.4, 7.7) |
|
86.7 (85.6, 87.7) |
12.6 (11.6, 13.7) |
0.7 (0.5, 1.1) |
|
| rs25486 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
68.9 (64.1, 73.3) |
31.1 (26.7, 35.9) |
0.521 |
48.2 (42.3, 54.1) |
41.4 (37.5, 45.4) |
10.4 (7.1, 15.0) |
0.335 |
| 20-39 |
66.0 (63.7, 68.3) |
34.0 (31.7, 36.3) |
42.8 (39.1, 46.6) |
46.4 (42.3, 50.6) |
10.8 (8.7, 13.2) |
| 40-59 |
65.8 (63.2, 68.3) |
34.2 (31.7, 36.8) |
44.2 (40.4, 48.1) |
43.1 (39.2, 47.1) |
12.7 (10.3, 15.4) |
| >=60 |
66.1 (64.2, 68.0) |
33.9 (32.0, 35.8) |
43.3 (40.5, 46.1) |
45.6 (42.3, 49.0) |
11.0 (9.0, 13.5) |
| Total |
66.4 (65.1, 67.6) |
33.6 (32.4, 34.9) |
|
44.0 (41.8, 46.2) |
44.7 (42.1, 47.2) |
11.3 (10.1, 12.6) |
|
| rs25487 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
29.4 (24.8, 34.5) |
70.6 (65.5, 75.2) |
0.281 |
9.5 (6.3, 14.1) |
39.8 (36.1, 43.6) |
50.7 (44.5, 56.9) |
0.265 |
| 20-39 |
32.7 (30.4, 35.2) |
67.3 (64.8, 69.6) |
10.3 (8.2, 12.8) |
44.9 (40.2, 49.7) |
44.8 (40.7, 49.0) |
| 40-59 |
33.6 (31.0, 36.2) |
66.4 (63.8, 69.0) |
12.7 (10.3, 15.4) |
41.8 (37.6, 46.1) |
45.5 (41.5, 49.6) |
| >=60 |
33.5 (31.5, 35.4) |
66.5 (64.6, 68.5) |
11.1 (8.8, 13.9) |
44.7 (41.0, 48.5) |
44.2 (41.3, 47.1) |
| Total |
32.6 (31.2, 34.1) |
67.4 (65.9, 68.8) |
|
11.0 (9.8, 12.4) |
43.3 (40.6, 46.0) |
45.7 (43.2, 48.2) |
|
| rs25489 |
|
A |
G |
|
AA |
AG |
GG |
|
| 12-19 |
4.4 (3.4, 5.9) |
95.6 (94.1, 96.6) |
0.411 |
0.2 (0.0, 0.9) |
8.5 (6.7, 10.8) |
91.3 (88.8, 93.3) |
0.392 |
| 20-39 |
5.2 (4.1, 6.6) |
94.8 (93.4, 95.9) |
0.2 (0.2, 0.3) |
10.0 (7.8, 12.8) |
89.8 (87.0, 92.0) |
| 40-59 |
4.2 (3.2, 5.6) |
95.8 (94.4, 96.8) |
0.2 (0.1, 0.8) |
7.9 (5.8, 10.7) |
91.8 (89.1, 93.9) |
| >=60 |
4.3 (3.5, 5.3) |
95.7 (94.7, 96.5) |
0.4 (0.1, 1.0) |
7.9 (6.1, 10.2) |
91.7 (89.7, 93.4) |
| Total |
4.7 (4.0, 5.4) |
95.3 (94.6, 96.0) |
|
0.2 (0.2, 0.4) |
8.8 (7.6, 10.2) |
90.9 (89.6, 92.1) |
|
* Includes all participants, regardless of race/ethnicity.
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By Sex
| Variant |
Sex |
Allele
% (95% CI) |
Chi-square
P-value |
Genotype
% (95% CI) |
Chi-square
P-value |
| rs1001581 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
38.7 (36.4, 41.1) |
61.3 (58.9, 63.6) |
0.832 |
14.3 (12.2, 16.7) |
48.9 (45.1, 52.7) |
36.9 (33.3, 40.6) |
0.518 |
| Female |
39.0 (37.3, 40.8) |
61.0 (59.2, 62.7) |
15.5 (14.1, 17.0) |
47.0 (44.0, 50.1) |
37.5 (34.6, 40.5) |
| Total |
38.9 (37.5, 40.3) |
61.1 (59.7, 62.5) |
|
14.9 (13.6, 16.3) |
47.9 (45.6, 50.2) |
37.2 (35.0, 39.4) |
|
| rs1799782 |
|
C |
T |
|
CC |
CT |
TT |
|
| Male |
93.3 (92.0, 94.3) |
6.7 (5.7, 8.0) |
0.510 |
87.0 (84.8, 89.0) |
12.4 (10.7, 14.4) |
0.5 (0.3, 1.1) |
0.684 |
| Female |
92.7 (91.7, 93.6) |
7.3 (6.4, 8.3) |
86.3 (84.8, 87.7) |
12.7 (11.6, 13.9) |
0.9 (0.4, 1.9) |
| Total |
93.0 (92.3, 93.6) |
7.0 (6.4, 7.7) |
|
86.7 (85.6, 87.7) |
12.6 (11.6, 13.7) |
0.7 (0.5, 1.1) |
|
| rs25486 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
65.7 (63.6, 67.7) |
34.3 (32.3, 36.4) |
0.356 |
43.1 (40.0, 46.2) |
45.2 (41.6, 48.8) |
11.7 (9.6, 14.2) |
0.652 |
| Female |
67.0 (65.1, 68.9) |
33.0 (31.1, 34.9) |
44.9 (41.2, 48.7) |
44.2 (39.9, 48.5) |
10.9 (9.4, 12.6) |
| Total |
66.4 (65.1, 67.6) |
33.6 (32.4, 34.9) |
|
44.0 (41.8, 46.2) |
44.7 (42.1, 47.2) |
11.3 (10.1, 12.6) |
|
| rs25487 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
33.3 (31.1, 35.6) |
66.7 (64.4, 68.9) |
0.413 |
11.4 (9.2, 14.0) |
43.8 (40.3, 47.4) |
44.8 (41.6, 48.1) |
0.714 |
| Female |
32.0 (30.0, 34.2) |
68.0 (65.8, 70.0) |
10.6 (9.1, 12.3) |
42.9 (38.6, 47.2) |
46.5 (42.6, 50.5) |
| Total |
32.6 (31.2, 34.1) |
67.4 (65.9, 68.8) |
|
11.0 (9.8, 12.4) |
43.3 (40.6, 46.0) |
45.7 (43.2, 48.2) |
|
| rs25489 |
|
A |
G |
|
AA |
AG |
GG |
|
| Male |
4.6 (3.7, 5.8) |
95.4 (94.2, 96.3) |
0.984 |
0.3 (0.1, 0.6) |
8.8 (6.8, 11.2) |
91.0 (88.7, 92.8) |
0.927 |
| Female |
4.7 (3.9, 5.5) |
95.3 (94.5, 96.1) |
0.2 (0.1, 0.4) |
8.9 (7.5, 10.5) |
90.9 (89.3, 92.3) |
| Total |
4.7 (4.0, 5.4) |
95.3 (94.6, 96.0) |
|
0.2 (0.2, 0.4) |
8.8 (7.6, 10.2) |
90.9 (89.6, 92.1) |
|
* Includes all participants, regardless of race/ethnicity.
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By Race/Ethnicity and Age
| Variant |
Race-ethnicity |
Age (years) |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1001581 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
34.9 (27.2, 43.4) |
65.1 (56.6, 72.8) |
12.0 (7.4, 18.9) |
45.7 (38.9, 52.7) |
42.3 (31.7, 53.6) |
| 20-39 |
41.9 (39.0, 44.9) |
58.1 (55.1, 61.0) |
16.1 (13.0, 19.7) |
51.7 (46.8, 56.5) |
32.2 (28.2, 36.6) |
| 40-59 |
40.3 (36.9, 43.7) |
59.7 (56.3, 63.1) |
16.1 (13.6, 19.1) |
48.2 (43.1, 53.4) |
35.6 (30.4, 41.2) |
| >=60 |
38.9 (37.3, 40.6) |
61.1 (59.4, 62.7) |
14.9 (12.3, 18.0) |
48.1 (42.6, 53.6) |
37.0 (33.5, 40.6) |
| Non-Hispanic Black |
12-19 |
36.6 (33.4, 39.9) |
63.4 (60.1, 66.6) |
14.5 (11.7, 17.8) |
44.2 (38.7, 49.7) |
41.3 (36.2, 46.6) |
| 20-39 |
35.3 (32.1, 38.7) |
64.7 (61.3, 67.9) |
13.4 (11.3, 15.8) |
43.9 (40.5, 47.3) |
42.8 (38.1, 47.5) |
| 40-59 |
36.0 (32.8, 39.3) |
64.0 (60.7, 67.2) |
14.6 (11.5, 18.3) |
42.9 (38.0, 47.9) |
42.5 (37.9, 47.3) |
| >=60 |
42.2 (37.1, 47.4) |
57.8 (52.6, 62.9) |
18.4 (13.6, 24.5) |
47.5 (42.1, 53.0) |
34.1 (28.1, 40.5) |
| Mexican American |
12-19 |
31.4 (26.5, 36.7) |
68.6 (63.3, 73.5) |
8.7 (5.9, 12.8) |
45.3 (36.8, 54.1) |
45.9 (37.3, 54.8) |
| 20-39 |
29.3 (26.6, 32.3) |
70.7 (67.7, 73.4) |
8.4 (6.5, 10.7) |
41.9 (37.3, 46.7) |
49.7 (44.9, 54.5) |
| 40-59 |
30.6 (26.8, 34.7) |
69.4 (65.3, 73.2) |
10.9 (8.5, 13.9) |
39.4 (33.2, 45.9) |
49.7 (43.1, 56.4) |
| >=60 |
31.3 (27.5, 35.5) |
68.7 (64.5, 72.5) |
10.3 (7.8, 13.5) |
42.1 (34.9, 49.8) |
47.6 (40.5, 54.8) |
| rs1799782 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
12-19 |
94.2 (91.0, 96.3) |
5.8 (3.7, 9.0) |
88.6 (82.2, 92.9) |
11.1 (6.7, 17.9) |
0.3 (0.0, 1.9) |
| 20-39 |
95.9 (95.2, 96.6) |
4.1 (3.4, 4.8) |
92.1 (90.7, 93.4) |
7.6 (6.4, 9.1) |
0.3 (0.1, 0.8) |
| 40-59 |
95.1 (92.5, 96.8) |
4.9 (3.2, 7.5) |
90.5 (86.1, 93.7) |
9.1 (6.2, 13.1) |
0.4 (0.0, 2.9) |
| >=60 |
93.9 (92.5, 95.1) |
6.1 (4.9, 7.5) |
88.2 (85.4, 90.5) |
11.5 (9.2, 14.2) |
0.3 (0.1, 1.2) |
| Non-Hispanic Black |
12-19 |
94.2 (92.6, 95.5) |
5.8 (4.5, 7.4) |
89.4 (87.0, 91.4) |
9.7 (7.8, 12.0) |
0.9 (0.2, 3.4) |
| 20-39 |
93.7 (92.3, 94.8) |
6.3 (5.2, 7.7) |
87.5 (84.9, 89.7) |
12.3 (10.2, 14.7) |
0.2 (0.0, 1.1) |
| 40-59 |
92.6 (90.6, 94.3) |
7.4 (5.7, 9.4) |
86.0 (82.5, 88.9) |
13.2 (10.4, 16.6) |
0.7 (0.2, 3.5) |
| >=60 |
95.8 (94.1, 97.1) |
4.2 (2.9, 5.9) |
92.4 (89.3, 94.7) |
6.8 (4.7, 9.7) |
0.8 (0.4, 1.6) |
| Mexican American |
12-19 |
86.8 (82.8, 90.0) |
13.2 (10.0, 17.2) |
75.5 (68.9, 81.2) |
22.5 (17.3, 28.8) |
1.9 (0.7, 5.5) |
| 20-39 |
84.9 (82.4, 87.1) |
15.1 (12.9, 17.6) |
72.8 (69.2, 76.1) |
24.3 (22.0, 26.9) |
2.9 (1.7, 4.9) |
| 40-59 |
85.4 (83.5, 87.1) |
14.6 (12.9, 16.5) |
72.3 (68.7, 75.7) |
26.0 (22.7, 29.7) |
1.6 (1.0, 2.5) |
| >=60 |
82.4 (76.6, 87.0) |
17.6 (13.0, 23.4) |
69.8 (61.0, 77.4) |
25.2 (18.7, 33.2) |
4.9 (2.4, 9.8) |
| rs25486 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
67.7 (59.5, 74.9) |
32.3 (25.1, 40.5) |
46.5 (36.7, 56.5) |
42.4 (36.9, 48.2) |
11.1 (6.3, 18.7) |
| 20-39 |
62.5 (59.5, 65.4) |
37.5 (34.6, 40.5) |
37.5 (33.0, 42.2) |
50.0 (44.8, 55.2) |
12.5 (9.7, 16.0) |
| 40-59 |
63.9 (60.6, 67.1) |
36.1 (32.9, 39.4) |
41.5 (36.6, 46.6) |
44.8 (39.6, 50.1) |
13.7 (10.9, 17.0) |
| >=60 |
64.7 (62.9, 66.4) |
35.3 (33.6, 37.1) |
41.3 (38.3, 44.3) |
46.8 (42.8, 50.9) |
11.9 (9.7, 14.4) |
| Non-Hispanic Black |
12-19 |
76.1 (73.3, 78.6) |
23.9 (21.4, 26.7) |
60.0 (56.3, 63.6) |
32.2 (28.9, 35.6) |
7.8 (5.6, 10.8) |
| 20-39 |
77.5 (74.8, 80.0) |
22.5 (20.0, 25.2) |
60.1 (55.6, 64.5) |
34.8 (31.1, 38.7) |
5.1 (4.1, 6.4) |
| 40-59 |
73.4 (70.4, 76.2) |
26.6 (23.8, 29.6) |
54.1 (50.1, 58.1) |
38.6 (33.3, 44.2) |
7.3 (4.2, 12.3) |
| >=60 |
74.8 (71.3, 78.0) |
25.2 (22.0, 28.7) |
55.0 (49.9, 60.0) |
39.7 (35.6, 44.0) |
5.3 (3.4, 8.3) |
| Mexican American |
12-19 |
74.3 (69.8, 78.3) |
25.7 (21.7, 30.2) |
54.5 (47.8, 61.0) |
39.7 (34.5, 45.0) |
5.9 (3.8, 9.1) |
| 20-39 |
74.7 (72.4, 76.9) |
25.3 (23.1, 27.6) |
55.8 (52.1, 59.4) |
37.9 (34.4, 41.5) |
6.4 (4.9, 8.2) |
| 40-59 |
73.5 (70.0, 76.8) |
26.5 (23.2, 30.0) |
55.8 (49.3, 62.1) |
35.4 (29.4, 41.9) |
8.8 (7.6, 10.2) |
| >=60 |
73.2 (68.7, 77.2) |
26.8 (22.8, 31.3) |
53.6 (45.9, 61.1) |
39.2 (31.4, 47.5) |
7.2 (4.6, 11.1) |
| rs25487 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
32.1 (24.7, 40.4) |
67.9 (59.6, 75.3) |
10.7 (6.1, 18.0) |
42.8 (37.0, 48.8) |
46.5 (36.4, 57.0) |
| 20-39 |
37.2 (34.3, 40.2) |
62.8 (59.8, 65.7) |
12.3 (9.3, 15.9) |
49.9 (44.4, 55.4) |
37.9 (33.3, 42.6) |
| 40-59 |
36.7 (33.8, 39.8) |
63.3 (60.2, 66.2) |
14.4 (11.7, 17.5) |
44.7 (39.4, 50.1) |
40.9 (36.1, 45.9) |
| >=60 |
35.6 (33.9, 37.3) |
64.4 (62.7, 66.1) |
12.2 (9.7, 15.1) |
46.9 (42.4, 51.5) |
40.9 (38.0, 43.9) |
| Non-Hispanic Black |
12-19 |
16.6 (14.0, 19.6) |
83.4 (80.4, 86.0) |
4.1 (2.4, 6.8) |
25.1 (20.5, 30.3) |
70.8 (65.8, 75.4) |
| 20-39 |
14.5 (12.5, 16.7) |
85.5 (83.3, 87.5) |
2.5 (1.6, 3.8) |
24.0 (21.1, 27.2) |
73.5 (69.9, 76.8) |
| 40-59 |
17.1 (14.9, 19.5) |
82.9 (80.5, 85.1) |
2.5 (1.4, 4.4) |
29.1 (24.9, 33.6) |
68.4 (64.0, 72.5) |
| >=60 |
17.2 (13.8, 21.2) |
82.8 (78.8, 86.2) |
2.8 (1.2, 6.4) |
28.8 (24.4, 33.6) |
68.5 (62.5, 73.8) |
| Mexican American |
12-19 |
25.9 (21.9, 30.4) |
74.1 (69.6, 78.1) |
6.0 (3.8, 9.3) |
39.9 (35.5, 44.5) |
54.1 (47.8, 60.3) |
| 20-39 |
25.2 (23.2, 27.3) |
74.8 (72.7, 76.8) |
6.3 (4.9, 8.2) |
37.7 (34.0, 41.6) |
56.0 (52.3, 59.5) |
| 40-59 |
25.8 (22.5, 29.4) |
74.2 (70.6, 77.5) |
7.9 (6.4, 9.8) |
35.7 (29.7, 42.1) |
56.4 (50.0, 62.6) |
| >=60 |
27.1 (23.3, 31.2) |
72.9 (68.8, 76.7) |
8.3 (5.5, 12.2) |
37.6 (30.0, 45.8) |
54.2 (46.9, 61.3) |
| rs25489 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
12-19 |
3.9 (2.5, 6.0) |
96.1 (94.0, 97.5) |
0.0 (NA) |
7.8 (5.0, 12.0) |
92.2 (88.0, 95.0) |
| 20-39 |
4.1 (3.1, 5.5) |
95.9 (94.5, 96.9) |
0.0 (NA) |
8.3 (6.1, 11.1) |
91.7 (88.9, 93.9) |
| 40-59 |
3.8 (2.6, 5.7) |
96.2 (94.3, 97.4) |
0.1 (0.0, 0.5) |
7.5 (5.0, 11.2) |
92.4 (88.7, 95.0) |
| >=60 |
3.9 (3.1, 5.0) |
96.1 (95.0, 96.9) |
0.4 (0.1, 1.2) |
7.1 (5.2, 9.8) |
92.5 (90.1, 94.3) |
| Non-Hispanic Black |
12-19 |
3.8 (2.5, 5.8) |
96.2 (94.2, 97.5) |
0.0 (NA) |
7.6 (5.0, 11.6) |
92.4 (88.4, 95.0) |
| 20-39 |
3.4 (2.7, 4.3) |
96.6 (95.7, 97.3) |
0.4 (0.1, 1.6) |
6.1 (4.7, 7.9) |
93.5 (91.9, 94.9) |
| 40-59 |
2.7 (1.9, 3.9) |
97.3 (96.1, 98.1) |
0.2 (0.0, 2.0) |
4.9 (3.5, 6.9) |
94.8 (92.7, 96.3) |
| >=60 |
4.6 (2.9, 7.3) |
95.4 (92.7, 97.1) |
0.1 (0.0, 1.0) |
9.0 (5.5, 14.5) |
90.9 (85.6, 94.4) |
| Mexican American |
12-19 |
12.9 (9.6, 17.1) |
87.1 (82.9, 90.4) |
0.5 (0.1, 2.4) |
24.8 (18.2, 32.8) |
74.7 (66.7, 81.4) |
| 20-39 |
13.2 (11.4, 15.3) |
86.8 (84.7, 88.6) |
2.2 (1.6, 3.0) |
22.2 (19.4, 25.1) |
75.7 (72.1, 78.9) |
| 40-59 |
10.4 (8.5, 12.7) |
89.6 (87.3, 91.5) |
1.3 (0.7, 2.3) |
18.3 (14.8, 22.3) |
80.4 (76.2, 84.0) |
| >=60 |
11.6 (9.5, 14.2) |
88.4 (85.8, 90.5) |
2.3 (1.1, 4.6) |
18.7 (15.2, 22.9) |
79.0 (74.8, 82.7) |
By Race/Ethnicity and Sex
| Variant |
Race-ethnicity |
Sex |
Allele
% (95% CI) |
Genotype
% (95% CI) |
| rs1001581 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
40.2 (37.1, 43.4) |
59.8 (56.6, 62.9) |
15.2 (12.4, 18.5) |
50.1 (44.8, 55.5) |
34.7 (29.8, 39.9) |
| Female |
39.6 (37.3, 42.0) |
60.4 (58.0, 62.7) |
15.5 (14.0, 17.1) |
48.3 (44.7, 51.8) |
36.2 (32.5, 40.2) |
| Non-Hispanic Black |
Male |
36.5 (34.3, 38.8) |
63.5 (61.2, 65.7) |
14.8 (13.0, 16.8) |
43.5 (39.3, 47.9) |
41.7 (37.8, 45.7) |
| Female |
36.8 (35.0, 38.6) |
63.2 (61.4, 65.0) |
14.4 (12.5, 16.6) |
44.7 (42.6, 46.9) |
40.8 (38.7, 43.0) |
| Mexican American |
Male |
30.2 (27.1, 33.4) |
69.8 (66.6, 72.9) |
8.6 (6.8, 11.0) |
43.1 (37.9, 48.3) |
48.3 (43.0, 53.7) |
| Female |
30.2 (27.6, 33.0) |
69.8 (67.0, 72.4) |
9.7 (8.0, 11.7) |
41.1 (37.4, 44.8) |
49.2 (45.0, 53.5) |
| rs1799782 |
|
|
C |
T |
CC |
CT |
TT |
| Non-Hispanic White |
Male |
95.7 (94.4, 96.8) |
4.3 (3.2, 5.6) |
91.6 (88.9, 93.7) |
8.3 (6.2, 10.9) |
0.1 (0.0, 0.6) |
| Female |
94.4 (93.6, 95.1) |
5.6 (4.9, 6.4) |
89.2 (87.9, 90.5) |
10.3 (9.1, 11.6) |
0.5 (0.1, 1.4) |
| Non-Hispanic Black |
Male |
93.2 (91.5, 94.7) |
6.8 (5.3, 8.5) |
87.3 (84.5, 89.7) |
11.8 (9.7, 14.2) |
0.9 (0.3, 2.6) |
| Female |
94.3 (93.5, 95.0) |
5.7 (5.0, 6.5) |
88.9 (87.4, 90.2) |
10.9 (9.6, 12.3) |
0.3 (0.1, 0.9) |
| Mexican American |
Male |
85.5 (83.5, 87.3) |
14.5 (12.7, 16.5) |
73.1 (69.9, 76.0) |
24.7 (22.3, 27.3) |
2.2 (1.3, 3.5) |
| Female |
84.9 (82.8, 86.8) |
15.1 (13.2, 17.2) |
72.9 (69.7, 75.8) |
24.1 (21.7, 26.7) |
3.1 (2.0, 4.7) |
| rs25486 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
62.8 (60.0, 65.7) |
37.2 (34.3, 40.0) |
39.4 (34.8, 44.2) |
46.9 (41.7, 52.2) |
13.7 (11.1, 16.7) |
| Female |
65.1 (62.8, 67.4) |
34.9 (32.6, 37.2) |
41.7 (37.1, 46.4) |
46.8 (41.7, 52.1) |
11.5 (10.0, 13.1) |
| Non-Hispanic Black |
Male |
75.3 (72.6, 77.8) |
24.7 (22.2, 27.4) |
56.8 (53.3, 60.3) |
36.9 (34.5, 39.4) |
6.3 (4.6, 8.5) |
| Female |
76.3 (73.9, 78.6) |
23.7 (21.4, 26.1) |
58.7 (55.2, 62.2) |
35.1 (31.9, 38.5) |
6.1 (4.4, 8.4) |
| Mexican American |
Male |
73.3 (70.6, 75.9) |
26.7 (24.1, 29.4) |
53.4 (48.9, 57.8) |
39.9 (36.0, 43.8) |
6.7 (5.6, 8.1) |
| Female |
75.2 (73.3, 77.0) |
24.8 (23.0, 26.7) |
57.4 (54.4, 60.2) |
35.7 (33.3, 38.1) |
7.0 (6.0, 8.1) |
| rs25487 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
37.3 (34.5, 40.1) |
62.7 (59.9, 65.5) |
13.8 (11.2, 16.8) |
47.0 (42.1, 52.0) |
39.2 (34.9, 43.8) |
| Female |
35.0 (32.8, 37.2) |
65.0 (62.8, 67.2) |
11.6 (10.2, 13.2) |
46.8 (41.7, 51.9) |
41.6 (37.2, 46.2) |
| Non-Hispanic Black |
Male |
16.3 (14.1, 18.7) |
83.7 (81.3, 85.9) |
3.0 (2.0, 4.6) |
26.5 (23.4, 29.9) |
70.5 (66.5, 74.1) |
| Female |
15.6 (13.8, 17.5) |
84.4 (82.5, 86.2) |
2.6 (1.7, 4.1) |
25.9 (23.0, 28.9) |
71.5 (68.3, 74.5) |
| Mexican American |
Male |
26.5 (24.1, 28.9) |
73.5 (71.1, 75.9) |
6.6 (5.4, 8.0) |
39.8 (36.3, 43.4) |
53.6 (49.6, 57.6) |
| Female |
24.7 (22.7, 26.8) |
75.3 (73.2, 77.3) |
7.0 (5.9, 8.2) |
35.5 (33.0, 38.1) |
57.5 (54.3, 60.7) |
| rs25489 |
|
|
A |
G |
AA |
AG |
GG |
| Non-Hispanic White |
Male |
3.9 (3.0, 5.2) |
96.1 (94.8, 97.0) |
0.1 (0.0, 0.5) |
7.6 (5.6, 10.3) |
92.3 (89.7, 94.3) |
| Female |
4.0 (3.2, 5.0) |
96.0 (95.0, 96.8) |
0.1 (0.0, 0.4) |
7.9 (6.3, 9.8) |
92.0 (90.1, 93.7) |
| Non-Hispanic Black |
Male |
2.9 (2.1, 4.0) |
97.1 (96.0, 97.9) |
0.3 (0.0, 1.7) |
5.3 (3.8, 7.2) |
94.4 (92.5, 95.9) |
| Female |
4.0 (2.8, 5.6) |
96.0 (94.4, 97.2) |
0.2 (0.1, 0.8) |
7.5 (5.0, 11.0) |
92.3 (88.9, 94.7) |
| Mexican American |
Male |
11.7 (10.0, 13.6) |
88.3 (86.4, 90.0) |
1.2 (0.7, 2.0) |
21.0 (17.8, 24.5) |
77.8 (74.2, 81.1) |
| Female |
13.2 (10.9, 16.0) |
86.8 (84.0, 89.1) |
2.1 (1.4, 3.3) |
22.2 (18.5, 26.5) |
75.7 (70.9, 79.9) |
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