Part IV: CASE STUDIES: Using Human Genome Epidemiology Information to Improve Health Chapter 24 Tables
Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease
From Epidemiology to Clinical Practice: The Connexin Connection
Aileen Kenneson, Coleen Boyle
Table 24-1
The prevalence of GJB2 variants and specific common alleles individuals with nonsyndromic prelingual hearing loss and in general population controls in European, white American, Ashkenazi Jewish, and Korean and Japanese populations.
|
Population
|
% cases with 1 or 2 GJB2 variant alleles*
|
Most common allele in population
|
% cases with 1 or 2 copies of the most common allele
|
References for case data
|
% controls with 1 copy of most common allele
|
References for control data
|
|
Ashkenazi Jews
|
50%
|
167ΔT
|
31%
|
23,70
|
8%
|
23,24,69,70
|
|
European and North American white
|
38%
|
35ΔG
|
34%
|
19,26-28,30,31,40,41,
47,55,57
|
2%
|
24,27,28,57,
63,64,66-68
|
|
Japan
|
21%
|
235ΔC
|
17%
|
34-36
|
1%
|
34-36
|
|
Korea
|
11%
|
235ΔC
|
7%
|
33
|
1%
|
33
|
* excluding the V27I, E114G, I203T polymorphisms
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