Genomics Translation Projects Supported by AHRQ

Evidence evaluation for clinical guidelines/recommendations
Evidence evaluation for other stakeholders
Creating new evidence
Knowledge dissemination
Methods and conceptual frameworks

Evidence evaluation for clinical guidelines/recommendations:

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Evidence evaluation for other stakeholders:

  • Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-based Drugs
  • Genomic testing in ovarian cancer – CDC (Completed October 2006)
  • Horizon scan on use of genetic testing in cancer – CMS (Completed January 2006)
  • Horizon scan on genetic tests in non-cancer diseases – CMS [PDF – 171 KB] (Completed August 2007)
  • Selected pharmacogenetic tests for non-cancer and cancer conditions – CMS [PDF – 2.3 MB] (Completed November 2008)
  • BNP testing in heart failure – AACC, ACP, ACEP, ACCP (Completed September 2006)
  • HER2/Neu testing in breast and other solid tumors – AACC (Completed November 2008)
  • Cancer family history – CDC
    • Cancer family history: collection and use (Completed October 2007)
    • Cancer family history: clinical utility (Completed April 2009)
  • Family history in primary care – NIH (state of science conference) (Completed September 2009)

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Creating new evidence:

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Knowledge dissemination:

  • Personalized Health Care Report 2008: Warfarin and genetic testing (Completed 2008)

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Methods and conceptual frameworks:

  • Analytic validity, quality rating and evaluation frameworks for genetic and other laboratory tests
  • Genetic testing – draft chapter in methods guide for comparative effectiveness reviews (Completed August 2009)
  • DARTNet (distributed ambulatory research in therapeutics network): a new electronic infrastructure for conducting comparative effectiveness studies in EMR-enabled clinics in primary practice (Completed May 2008)
  • HMORN distributed research project (Completed 2009)

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