Over the past two decades, the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) has saved millions of lives as a leader in the global response to HIV. As a key implementing agency of PEPFAR, CDC is at the forefront of global efforts to end HIV worldwide. According to a new analysis, CDC’s efforts accounted for more than 50 percent of all key PEPFAR outcomes to treat and prevent HIV and TB in 2022 – those interventions known to have the greatest impact on new annual HIV infections and deaths.