PUBLIC HEALTH ASSESSMENT
MCCLELLAN AIR FORCE BASE
SACRAMENTO, SACRAMENTO COUNTY, CALIFORNIA
ID | DESCRIPTION | LOCATION | IDENTIFIED/ POTENTIAL CONTAMINANTS |
OPERABLE UNIT A | |||
CS 24 | Landfill | E of Bldg. 621 | Priority pollutants |
CS 34 | Waste solvent storage tanks | E of Bldg. 640 | Priority pollutants |
CS 37 | Landfill | Adj. to taxiway 7165 | Solvents, oil/grease |
CS 38 | Underground tanks/sludge landfill | Bldg. 475 | Solvents, priority pollutants, metals |
CS 40 | Industrial wastewater sludge | NE of Sanitary WTP | Solvents |
CS B-5 | Landfill | S of Bldg. 375 | Solvents, petroleum products |
CS P-5 | Open ditch | N of Bldg. 475 | Solvents, other |
CS P-6 | Open ditch | N of Bldg. 475 | Solvents, other |
CS S-7 | IWTP #3 | NE of Bldg. 475 | Solvents, other |
CS S-21 | Degreaser/spray booths | In Bldg. 351 | Solvents, petroleum products |
CS S-24 | Depaint washrack | At Bldg. 375 | Solvents, petroleum products |
CS S-26 | Maintenance shop/spray booth | Bldg. 473 | Solvents, petroleum products |
CS S-27 | Solvent recovery stills | Bldg. 478 | Solvents |
CS T-12 | Waste oil/solvent tank | Bldg. 342 | Solvents |
CS T-16 | Tank farm | N of Bldg. 475 | Solvents, petroleum products |
CS T-17 | Tank farm | S of Bldg. 350 | Solvents, petroleum products |
CS T-20 | Tank farm | W of Bldg. 475 | Solvents, petroleum products |
CS T-21 | Underground solvent tank | W of Bldg. 342 | Solvents, petroleum products |
CS T-30 | Underground solvent tank | S of Bldg. 252 | Solvents |
CS T-36 | 500-gallon Stoddard solvent tank | Near Bldg. 329 | Solvents |
CS T-37 | Stoddard solvent tank | S of Bldg. 360 | Solvents |
CS T-47 | Oil/water separator | E of Bldg. 346A | Petroleum products |
CS T-57 | IWL drain at Bldg. 431 | W of Bldg. 431 | Priority pollutants |
CS T-59 | Underground storage tank | Near Bldg. 340 | Petroleum products |
CS T-61 | Underground storage tank | Bldg. 614 | Gasoline |
PRL 25 | Landfill | S end of N/S runway | None detected |
PRL L-2 | Industrial wastewater line | Area A1 | Priority pollutants |
PRL L-3 | Industrial wastewater line | Area A2 | Priority pollutants |
PRL L-4 | Industrial wastewater line | Area A2 | Priority pollutants |
PRL P-3 | Oil pit | S of Bldg. 251 | Solvents, petroleum products |
PRL P-4 | Sump | E of Bldg. 351 | Solvents, petroleum products |
PRL P-8 | Acid and cyanide pit | S end of N/S runway | Acid, metals |
PRL S-1 | Plating shop | In Bldg. 343 | Solvents, metals, cyanide |
PRL S-2 | Chemical warehouse | In Bldg. 447 | Solvents |
PRL S-3 | Acid storage warehouse | W of Bldg. 447 | Acids |
PRL S-4 | Treatment plant/sludge beds | N of Bldg. 431 | Solvents, metals, petroleum products |
PRL S-6 | IWTP #1 | E of Bldg. 346 | Solvents, metals |
PRL S-9 | Asbestos storage | E of Bldg. 642 | Asbestos |
PRL S-14 | Paint shop/spray booths | Bldg. 22 | Solvents, petroleum products |
PRL S-16 | Solvents/paint spray booths | Bldg. 250 | Solvents, petroleum products |
PRL S-17 | Repair shop/spray booths | Bldg. 251 | Solvents, petroleum products |
PRL S-18 | Repair shop/cleaning shop | Bldg. 252 | Solvents, petroleum products |
PRL S-19 | Entomology storage area | NE of Sanitary WTP | Pesticides |
PRL S-20 | Photo lab | Bldg. 336 | Solvents, metals |
PRL S-22 | Repair shop/spray booths | In Bldg. 355 | Solvents, petroleum products |
PRL S-25 | Transformer shop | Bldg. 440 | PCBs, solvents, petroleum products |
PRL S-36 | Oil drum storage | N of Bldg. 410 | Solvents, petroleum products |
PRL S-37 | Oil drum storage | N of Bldg. 410 | Solvents, petroleum products |
PRL S-38 | Drum storage | N of Bldg. 431 | Solvents |
PRL T-6 | Underground solvent tank | Bldg. 640 | Solvents |
PRL T-7 | Solvent pit/waste thinner tank | Bldg. 640 | Solvents |
PRL T-10 | Solvent tank | Bldg. 362 | Solvents |
PRL T-15 | Tank farm | N of Bldg. 447 | Solvents, petroleum products |
PRL T-18 | Tank farm | E of Bldg. 343 | Solvents, petroleum products |
PRL T-19 | Tank farm | E of Bldg. 344 | Solvents, petroleum products |
SA 35 | Underground storage tank | Potential contaminant source | |
SA 37 | Motor pool | Potential contaminant source | |
SA 38 | Fuel lines, USTs, and gas pumps | Potential contaminant source | |
SA 40 | Electrical shop | Potential contaminant source | |
SA 41 | Metal fabrication processes | Potential contaminant source | |
SA 43 | Waste oil or jet fuel | Potential contaminant source | |
SA 44 | Sump and bowser | Potential contaminant source | |
SA 45 | Soil contamination | Additional data needed to characterize | |
SA 46 | Underground storage tank | Potential contaminant source | |
SA 47 | Soil contamination | Additional data needed to characterize | |
SA 48 | Underground storage tank | Potential contaminant source | |
SA 49 | Underground storage tank | Potential contaminant source | |
SA 52 | Underground storage tanks | Potential contaminant source | |
SA 53 | Washrack | Potential contaminant source | |
SA 54 | Aboveground storage tank, pipeline | Potential contaminant source | |
SA 55 | Laboratory waste spills on soil | Potential contaminant source | |
SA 56 | Wastewater flowed onto soil | Potential contaminant source | |
SA 58 | Chemical storage and treatment | Potential contaminant source | |
SA 59 | Underground storage tank | Potential contaminant source | |
SA 60 | Industrial wastewater drain and washrack | Potential contaminant sources | |
SA 61 | Solvent spray booth | Potential contaminant source | |
SA 64 | Chemical handling may have resulted in | Potential contaminant source | |
SA 65 | IWL may have leaked | Potential contaminant source | |
SA 66 | Motor pool operations | Potential contaminant source | |
SA 67 | Contamination detected in soil | Additional data needed to characterize | |
SA 68 | Spills on cracked concrete foundation | Potential contaminant source | |
SA 69 | Abandoned UST, sumps, and IWL | Potential contaminant sources | |
SA 70 | IWL or hydraulic pump unit | Potential contaminant sources | |
SA 71 | Hazardous material storage | Potential contaminant source | |
SA 73 | Sump may have leaked | Potential contaminant source | |
SA 74 | Underground storage tank | Potential contaminant source | |
SA 75 | IWL may have leaked | Potential contaminant source | |
SA 76 | Hazardous materials stored at lot | Potential contaminant source | |
SA 77 | Aboveground storage tanks | Potential contaminant source | |
SA 78 | Locomotive washrack and UST | Potential contaminant sources | |
SA 79 | Former underground storage tanks | Potential contaminant source | |
SA 80 | Soil contamination from spill | Additional data needed to characterize | |
SA 81 | Fuel lines | Potential contaminant source | |
SA 84 | Paint spray booth drains | Potential contaminant source | |
SA 85 | Sump and underground wastelines | Potential contaminant source | |
SA 86 | Underground storage tanks and sump | Potential contaminant source | |
SA 87 | Former underground storage tanks or IWL | Potential contaminant source | |
SA 88 | Contamination detected in soil | Additional data needed to characterize | |
SA 89 | Former material storage and handling area | Potential contaminant source | |
SA 90 | Washrack and hazardous storage activities | Potential contaminant source | |
SA 91 | Contaminants detected in soil | Additional data needed to characterize | |
SA 93 | Laboratory radionuclide contamination | Potential contaminant source | |
SA 94 | Underground fuel lines | Potential contaminant source | |
SA 95 | Underground storage tank | Potential contaminant source | |
SA 96 | Underground sump and tanks | Potential contaminant source | |
SA 97 | Contaminated washwater | Potential contaminant source | |
SA 98 | Indoor storage area and spray booths | Potential contaminant source | |
SA 99 | Underground storage tanks | Potential contaminant source | |
SA 100 | UST and former disposal pit | Potential contaminant sources | |
SA 101 | Sump | Potential contaminant source | |
SA 103 | Contamination detected in soil | Additional data needed to characterize | |
SA 105 | Former laboratory activities | Potential contaminant source | |
SA 106 | Underground storage tank | Potential contaminant source | |
SA 107 | Contaminants detected in soil | Additional data needed to characterize | |
SA 108 | Oils, hydraulic fluid, and jet fuel | Potential contaminant source | |
SA 109 | Stream sediment contamination | Additional data needed to characterize | |
OPERABLE UNIT B | |||
CS 23 | Landfill | Bldg. 781 | Priority pollutants |
CS 30 | Radio/chem lab/landfill | E of Bldg. 628 | Solvents, metals |
CS 31 | Incinerator ash burial pit | Near Bldg. 680 | Arsenic |
CS 36 | Open storage area | N of Bldg. 666 | Solvents, cyanide |
CS 47 | Abandoned plating shop | Bldg. 666 | Solvents, metals |
CS 48 | Abandoned IWTP | IWTP #4 | Solvents, metals, oil/grease |
PRL 29 | Landfill | NE of Bldg. 700 | None detected |
PRL L-5 | Industrial wastewater line | Area B2 | Priority pollutants |
PRL L-6 | Industrial wastewater line | Area B2 | Priority pollutants |
PRL P-2 | Waste pond | S of Bldg. 687 | Solvents, petroleum products |
PRL P-9 | Open drainage ditch | W of Bldg. 660 | Solvents, metals |
PRL S-13 | Open storage | Bldgs. 709, 727, 729 | Solvents |
PRL S-28 | Oil/paint storage | N of Bldg. 600 | Oil/grease |
PRL S-29 | PCB storage | In Bldg. 655 | PCBs |
PRL S-30 | Depaint washrack | Bldg. 658 | Solvents, petroleum products |
PRL S-33 | Hazardous materials storage | Bldg. 786 | Solvents, other |
PRL S-34 | Degreaser/paint spray booth | Bldg. 652 | Solvents, other |
PRL S-35 | Solvent spray booth | Bldg. 654 | Solvents, other |
PRL T-8 | Fuel tank | Bldg. 756 | Solvents, petroleum products |
PRL T-45 | Oil/water separator | N of Bldg. 74 | Petroleum products |
PRL T-46 | Oil/water separator | S of Bldg. 764 | Petroleum products |
PRL T-48 | Oil/water separator | S of Bldg. 765 | Petroleum products |
PRL T-60 | Underground storage tank | NW Bldg. 656 | Petroleum products |
SA 1 | Freon waste reportedly dumped | Potential contaminant source | |
SA 2 | Laboratory and outdoor radioactive storage | Potential contaminant sources | |
SA 3 | Washrack | Suspected contaminant source | |
SA 4 | Paints and solvents | Potential contaminant source | |
SA 5 | Unable to conduct site visit. | Further investigation necessary | |
SA 6 | Underground fuel storage tanks | Potential contaminant source | |
SA 7 | Underground fuel storage tanks | Further investigation of USTs necessary | |
SA 8 | Underground storage tanks | Potential contaminant source | |
SA 9 | Contamination detected in soil | Additional data needed to characterize | |
SA 10 | Concrete wastewater sump | Potential contaminant source | |
SA 11 | Underground storage tank and piping | Potential contaminant source | |
SA 12 | Contamination detected in soil | Additional data needed to characterize | |
SA 13 | Open storage of hazardous materials | Suspected contaminant source | |
SA 14 | Ditch transported wastewater | Suspected contaminant source | |
SA 15 | Fire in a chemical storage area | Potential contaminant release | |
SA 16 | Underground tanks and piping | Potential contaminant source | |
SA 17 | Open storage of hazardous materials | Suspected contaminant source | |
SA 18 | Open storage of hazardous materials | Suspected contaminant source | |
SA 19 | Former spray booth | Suspected contaminant source | |
OPERABLE UNIT C | |||
CS 7 | Sludge/oil pit | E of Bldg. 701 | Priority pollutants, oil/grease, PCBs |
CS 10 | Landfill | W of Bldg. 774 | Priority pollutants, PCBs |
CS 11 | Landfill | W of Bldg. 774 | Priority pollutants |
CS 12 | Landfill | SW of Bldg. 774 | Priority pollutants |
CS 13 | Landfill | W of Bldg. 774 | Priority pollutants |
CS 14 | Landfill | S of Bldg. 701 | Priority pollutants |
CS 22 | Burn pit/landfill | S of IWTP Aeration Basin | Priority pollutants, PCBs, oil/grease |
CS 42 | Oil storage/landfill | IWTP Aeration Basin | Priority pollutants, oil/grease, PCBs |
CS 43 | Landfill | NW of Bldg. 704 | Priority pollutants |
CS 52 | Burn pit | NW of Bldg. 704 | Priority pollutants |
CS 67 | Landfill | NW of Bldg. 702 | Priority pollutants, petroleum products |
CS 69 | Burn pit | SE of Bldg. 704 | Priority pollutants |
PRL 8 | Sludge/refuse landfill | NW of Bldg. 774 | Solvents, priority pollutants |
PRL 9 | Landfill | W of Bldg. 774 | Priority pollutants |
PRL 15 | Sodium valve trench | SW of Bldg. 774 | None detected |
PRL 16 | Sodium valve trench | S of Bldg. 701 | None detected |
PRL 17 | Landfill | SE of Bldg. 704 | Solvents |
PRL 18 | Landfill | SE of Bldg. 704 | None detected |
PRL 19 | Landfill | SE of Bldg. 704 | None detected |
PRL 20 | Sludge/oil pit | SE of Bldg. 704 | Solvents |
PRL 21 | Sludge/oil pit | SE of Bldg. 704 | Solvents |
PRL 28 | Sludge pit | W of IWTP | Priority pollutants |
PRL 32 | Radio/hazardous waste storage | S of IWTP | Priority pollutants |
PRL 41 | Landfill | Bldg. 704 | Priority pollutants |
PRL 49 | Landfill | NE of Bldg. 704 | None detected |
PRL 50 | Settling pond | NW of Bldg. 704 | None detected |
PRL 51 | Holding pond | NW of IWTP | None detected |
PRL 53 | Settling pond | NW of Bldg. 704 | Solvents |
PRL 54 | Storage area | S of Bldg. 704 | None detected |
PRL 55 | Acid storage area/landfill | S of Bldg. 704 | Solvents |
PRL 56 | Storage area | S of Bldg. 704 | None detected |
PRL 57 | Landfill | S of Bldg. 704 | None detected |
PRL 60 | Holding pond | S of IWTP | None detected |
PRL 61 | Chemical waste pit | E of Bldg. 722 | None detected |
PRL 62 | Chemical waste pit | E of Bldg. 722 | None detected |
PRL 63 | Unlined ditch | SE of Bldg. 704 | None detected |
PRL 64 | Unlined ditch | SE of Bldg. 704 | None detected |
PRL 65 | Landfill | E of Bldg. 692 | None detected |
PRL 66 | Ditches and pond | W of Bldg. 721 | None detected |
PRL 68 | Sludge ponds | W of Site 42 | Priority pollutants |
PRL L-7 | Industrial wastewater line | Area C2 | Priority pollutants |
PRL P-10 | Magpie Creek | N of Bldg. 783 | Volatile organic compounds |
PRL S-11 | BCE/PCE storage | Bldg. 636 | PCBs, solvents, petroleum products |
PRL S-31 | Aircraft paint hangar | Bldg. 692 | Paints, solvents, petroleum products |
PRL S-32 | Paint storage area | Bldg. 694 | Paints, solvents, petroleum products |
PRL S-46 | Unknown | N of Bldg. 774 | Volatile organic compounds |
PRL S-48 | Unknown | W of Bldg. 720 | Volatile organic compounds |
OPERABLE UNIT D | |||
CS A | Sludge disposal pit | NW corner of base | Solvents, priority pollutants, metals |
CS S | Fuel/solvent/oil burn pit | NW corner of base | Solvents, priority pollutants, petroleum products |
CS T | Fuel/solvent sludge pit | NW corner of base | Solvents, priority pollutants, metals, petroleum |
CS 1 | Landfill | NW corner of base | Priority pollutants |
CS 2 | Sludge/oil pit | NW corner of base | Priority pollutants |
CS 3 | Sludge/oil pit | NW corner of base | Priority pollutants |
CS 4 | Sludge/oil pit | NW corner of base | Priority pollutants |
CS 5 | Sludge/oil pit | NW corner of base | Priority pollutants |
CS 6 | Oil burn pit | NW corner of base | Solvents, metals |
CS 26 | Sludge/oil burn pit | NW corner of base | Solvents, metals |
PRL 27 | Sodium valve trench | Bldg. 1085 | None detected |
PRL 33 | IWTP sludge landfarm | NW corner of base | Solvents |
PRL T-11 | Underground storage tank | Bldg. 1093 | Solvents |
OPERABLE UNITS D, E, G, H | |||
PRL P-7 | Open ditch | NE to Area D | Petroleum products, solvents |
OPERABLE UNIT E | |||
PRL 45 | Paint waste landfill | N end of base | None detected |
PRL S-10 | Storage area | NW of Bldg. 1086 | Solvents, radiation |
OPERABLE UNIT F | |||
PRL B-6 | Waste area | N of N/S runway | Unknown |
OPERABLE UNIT G | |||
PRL L-1 | Industrial wastewater line | Area G | Priority pollutants |
PRL S-42 | Hobby shop/M&R washrack | N of Bldg. 1439 | Solvents, petroleum products |
PRL S-43 | Aircraft washrack | NE corner of Mat V | Solvents, petroleum products |
PRL S-44 | Aircraft maintenance area | S of Bldg. 1071/Mat U | Solvents, petroleum products |
PRL T-31 | Underground storage tank | Near Bldg. 1028 | Solvents |
PRL T-32 | Underground storage tank | Near Bldg. 1023 | Solvents |
PRL T-33 | Underground storage tank | Near Bldg. 1021 | Solvents |
PRL T-44 | Stoddard solvent tank | NW of Bldg. 1048 | Solvents |
PRL T-62 | Underground storage tank | NE of Bldg. 1075 | Volatile organic compounds |
OPERABLE UNIT H | |||
PRL B-7 | Spoil area | N of Bldg. 243 | Unknown |
PRL P-1 | Drainage ditch/ponds | W of Bldg. 878 | Solvents, petroleum products |
PRL S-8 | Electroplating shop | In Bldg. 243G | Solvents, metals, cyanide |
PRL S-15 | Degreaser/spray booths | Bldg. 243 | Solvents, petroleum products |
PRL S-39 | New museum site | Dudley Blvd./Palm St. | Solvents |
PRL S-40 | Troop issue site | NW of Bldg. 910 | Unknown |
PRL S-45 | Aircraft maintenance area | W of Bldg. 878 | Solvents, petroleum products |
PRL S-47 | Unknown | NE of Bldg. 943 | Volatile organic compounds |
CS = Confirmed Site
PRL = Potential Release Location
SA = Study Area
IWL = Industrial Wastewater Line
IWTP = Industrial Wastewater Treatment Plant
UST = Underground Storage Tank
Ref (3)
South Area | North Area | Impact Area | Sacramento County | |
|
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Total persons | 4,847 | 1,757 | 6,604 | 1,041,219 |
Total area, square miles | 1.33 | 2.83 | 4.16 | 965.69 |
Persons per square mile | 3,640 | 621 | 1,588 | 1,078 |
|
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% Male | 48.0 | 52.1 | 49.1 | 48.9 |
% Female | 52.0 | 47.9 | 50.9 | 51.1 |
|
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% White | 79.0 | 87.7 | 81.3 | 75.1 |
% Black | 9.9 | 4.2 | 8.4 | 9.3 |
% American Indian, Eskimo, or Aleut | 2.5 | 1.8 | 2.3 | 1.2 |
% Asian or Pacific Islander | 2.7 | 3.0 | 2.8 | 9.3 |
% Other races | 5.9 | 3.4 | 5.2 | 5.1 |
|
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% Hispanic origin | 12.4 | 10.3 | 11.8 | 11.7 |
|
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% Under age 10 | 18.2 | 15.2 | 17.4 | 15.9 |
% Age 65 and older | 11.5 | 12.0 | 11.6 | 10.6 |
|
South Area | North Area | Impact Area | Sacramento County | |
|
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Households* | 1,769 | 589 | 2,358 | 394,530 |
Persons per household | 2.74 | 2.98 | 2.80 | 2.58 |
|
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% Households owner-occupied | 60.4 | 71.1 | 63.1 | 56.6 |
% Households renter-occupied | 39.6 | 28.9 | 36.9 | 43.4 |
|
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% Households mobile homes | 11.9 | 3.2 | 9.8 | 3.1 |
|
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% Persons in group quarters | 0.0 | 0.0 | 0.0 | 2.1 |
|
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Median value, owner-occupied households, $ | 61,200 | ~119,000 | ~80,000 | 129,800 |
Median rent paid, renter-occupied households, $ | 382 | ~425 | ~390 | 462 |
|
* A household is an occupied housing unit, but does not include group quarters such as military barracks, prisons, and college dormitories.
Source: 1990 Census of Population and Housing, Summary Tape File 1 (California). Prepared by Bureau of the Census, Washington, DC, 1991.
TABLE III. YEAR HOUSEHOLDER MOVED INTO CURRENT HOUSING
UNIT
|
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All Households (percent)
|
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Year Occupied | North Area | South Area | California |
|
|||
1989-90 | 26.8 | 24.1 | 25.6 |
1985-88 | 25.4 | 28.3 | 31.7 |
1980-84 | 9.4 | 12.0 | 13.1 |
1970-79 | 17.6 | 19.5 | 17.0 |
1960-69 | 10.6 | 6.7 | 7.3 |
Before 1960 | 10.2 | 9.4 | 5.4 |
|
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Owner Occupied Households (percent)
|
|||
Year Occupied | North Area | South Area | California |
|
|||
1989-90 | 17.4 | 11.8 | 12.0 |
1985-88 | 23.0 | 21.2 | 28.2 |
1980-84 | 10.6 | 12.8 | 14.4 |
1970-79 | 21.9 | 28.7 | 24.4 |
1960-69 | 14.2 | 10.0 | 11.8 |
Before 1960 | 13.0 | 15.5 | 9.2 |
|
|||
Renter Occupied Households (percent)
|
|||
Year Occupied | North Area | South Area | California |
|
|||
1989-90 | 49.9 | 42.8 | 42.7 |
1985-88 | 31.3 | 39.1 | 36.0 |
1980-84 | 6.4 | 10.8 | 11.4 |
1970-79 | 7.0 | 5.6 | 7.6 |
1960-69 | 1.9 | 1.7 | 1.6 |
Before 1960 | 3.5 | 0.0 | 0.7 |
|
Source: 1990 Census of Population and Housing, Summary Tape File 3 (California). Prepared by Bureau of the Census, Washington, DC, 1992.
APPENDIX C: HEALTH EVALUATION GUIDANCE
To link a site's human exposure potential with health effects that may occur under site-specific conditions, ATSDR estimates human exposure to site contaminants from ingestion and/or inhalation of different environmental media. The following relationship is used to determine the estimated exposure to the site contaminant:
ED | = (C x IR x EF) / BW |
ED | = exposure dose (mg/kg/day) |
C | = contaminant concentration |
IR | = intake rate |
EF | = exposure factor |
BW | = body weight |
ATSDR uses standard intake rates for ingestion of water and soil. The intake rate for drinking water is 2 L/day for adults and 1 L/day for children. For incidental ingestion of soil and sediment, the intake rate is 100 mg/day for adults, 500 mg/day for school age children, and 5000 mg/day for children with pica behavior (repeated ingestion of non-nutritive substances). The intake rate for inhalation is 23 m3/day for adults and 3.8 m3/day for children. Standard body weights for adults, school age children, and pre-school age children are 70 kg, 35 kg, and 10 kg, respectively. The maximum contaminant concentration detected in a specific medium at a site is used to determine the estimated exposure; use of the maximum concentration results in an evaluation that is most protective of human health. When unknown, the biological absorption from environmental media (soil, water, etc.) is assumed to be 100%. Some exposure may occur on an intermittent or irregular basis. For these kinds of exposures, an exposure factor can be calculated to average the exposure dose over the exposure interval.
Cancer risk is evaluated using weight-of-evidence classifications of carcinogenicity and EPA's cancer slope factor. The slope factor is the cancer risk per unit of estimated exposure dose. The slope factor can be used to compare the relative potency of different chemical substances on the basis of estimated exposure does.
CANCER RISK = CHRONIC DAILY INTAKE (lifetime average dose) x CANCER SLOPE FACTOR
Where sufficient toxicologic information is available, ATSDR has derived minimal risk levels (MRLs) for inhalation and oral routes of entry at each duration of exposure (acute, intermediate, and chronic). These MRLs are not meant to support regulatory action; but to acquaint health professionals with exposure levels at which adverse health effects are not expected to occur in humans.
The most suitable endpoint for deriving a MRL is the no-observed-adverse-effect-level (NOAEL). The calculation is as follows:
MRL = NOAEL/UFwhere: NOAEL = no-observed-adverse-effect-level UF = uncertainty factor
To derive an MRL, ATSDR generally selects the most sensitive endpoint (judgement of ATSDR) which represents the most sensitive human health effect for a given exposure route and duration. ATSDR cannot derive an MRL unless (quantitative or qualitative) is available for potential systemic, neurological, and developmental effects. ATSDR derives an MRL using the most sensitive species with the highest NOAEL that does not exceed any adverse effect levels. When a NOAEL is unavailable, a lowest-observed-adverse-effect-level (LOAEL) is used. Uncertainty factors (multiples of 10) are employed in the derivation of an MRL. Uncertainty factors are used for derivation from a LOAEL, human variability, and for interspecies variability. In deriving the MRL, these individual UFs are multiplied together. The concentration from the study is divided by the product of the UFs.
REFERENCES
Agency for Toxic Substances and Disease Registry. Public Health Assessment Guidance Manual. Atlanta: ATSDR, March 1992.
IRIS. 1992. Integrated Risk Information System (IRIS). Online Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati.
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